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1 March 2024
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Cover Image
Cover Image
The cover shows a multiplexed immunofluorescence caption for tumor-infiltrating lymphocytes (TILs) in a primary non-small cell lung cancer specimen with features of immune exclusion and the presence of a tertiary lymphoid structure adjacent to a cancer-cell nest. The markers used for staining are DAPI (blue) for all cell nuclei, pancytokeratin (green) that highlights tumor epithelial cells, CD20 (yellow) that stains B-cells, CD4 (cyan) for helper T cells, and CD8 (red) to recognize effector T cells. For details, see the article by Lopez de Rodas and colleagues on page 998 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
Review
Research Briefs: Clinical Trial Brief Reports
Niraparib plus Dostarlimab in Pleural Mesothelioma or Non–Small Cell Lung Cancer Harboring HRR Mutations: Interim Results of the UNITO-001 Phase II Prospective Trial
Francesco Passiglia; Luisella Righi; Paolo Bironzo; Angela Listì; Giovanni Farinea; Enrica Capelletto; Silvia Novello; Alessandra Merlini; Giorgio V. Scagliotti
Clinical Trials: Targeted Therapy
The Effect of Diet on Breast Cancer Recurrence: The DIANA-5 Randomized Trial
Franco Berrino; Anna Villarini; Giuliana Gargano; Vittorio Krogh; Sara Grioni; Manuela Bellegotti; Elisabetta Venturelli; Milena Raimondi; Adele Traina; Maurizio Zarcone; Rosalba Amodio; Maria Piera Mano; Harriet Johansson; Salvatore Panico; Maria Santucci de Magistris; Maggiorino Barbero; Cristina Gavazza; Angelica Mercandino; Elena Consolaro; Rocco Galasso; Luciana Del Riccio; Maria Chiara Bassi; Milena Simeoni; Paolo Premoli; Patrizia Pasanisi; Bernardo Bonanni; Eleonora Bruno
Clinical Trials: Immunotherapy
Phase I Trial of First-line Bintrafusp Alfa in Patients with Locally Advanced or Persistent/Recurrent/Metastatic Cervical Cancer
Ana Oaknin; Sharad A. Ghamande; Yuka Kasamatsu; Marta Gil-Martin; Juan Francisco Grau-Bejar; Carmen Garcia-Duran; Masashi Sato; Abdul Siddiqui; Surendra Pal Chaudhary; Yulia Vugmeyster; Kosei Hasegawa
Precision Medicine and Imaging
Spatiotemporal Quantification of HER2-targeting Antibody–Drug Conjugate Bystander Activity and Enhancement of Solid Tumor Penetration
Qing Wei; Teng Yang; Jiayu Zhu; Ziwen Zhang; Le Yang; Yuchao Zhang; Can Hu; Jiahui Chen; Jinchao Wang; Xuefei Tian; Takaya Shimura; Jianmin Fang; Jieer Ying; Mengyang Fan; Peng Guo; Xiangdong Cheng
Objective Analysis and Clinical Significance of the Spatial Tumor-Infiltrating Lymphocyte Patterns in Non–Small Cell Lung Cancer
Miguel Lopez de Rodas; Yvonne Wang; Gang Peng; Jianlei Gu; Mari Mino-Kenudson; Jonathan W. Riess; Vamsidhar Velcheti; Matthew Hellmann; Justin F. Gainor; Hongyu Zhao; Kurt A. Schalper
CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma
Anju Wadhwa; Sinan Wang; Bonell Patiño-Escobar; Anil P. Bidkar; Kondapa Naidu Bobba; Emily Chan; Niranjan Meher; Scott Bidlingmaier; Yang Su; Suchi Dhrona; Huimin Geng; Vishesh Sarin; Henry F. VanBrocklin; David M. Wilson; Jiang He; Li Zhang; Veronica Steri; Sandy W. Wong; Thomas G. Martin; Youngho Seo; Bin Liu; Arun P. Wiita; Robert R. Flavell
Translational Cancer Mechanisms and Therapy
Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma
Brian Mooney; Gian Luca Negri; Taras Shyp; Alberto Delaidelli; Hai-Feng Zhang; Sandra E. Spencer Miko; Amber K. Weiner; Alexander B. Radaoui; Rawan Shraim; Michael M. Lizardo; Christopher S. Hughes; Amy Li; Amal M. El-Naggar; Melanie Rouleau; Wei Li; Dimiter S. Dimitrov; Raushan T. Kurmasheva; Peter J. Houghton; Sharon J. Diskin; John M. Maris; Gregg B. Morin; Poul H. Sorensen
Spatial Gene-Expression Profiling Unveils Immuno-oncogenic Programs of NF1-Associated Peripheral Nerve Sheath Tumor Progression
Dana K. Mitchell; Breanne Burgess; Emily E. White; Abbi E. Smith; Elizabeth A. Sierra Potchanant; Henry Mang; Brooke E. Hickey; Qingbo Lu; Shaomin Qian; Waylan Bessler; Xiaohong Li; Li Jiang; Kylee Brewster; Constance Temm; Andrew Horvai; Eric A. Albright; Melissa L. Fishel; Christine A. Pratilas; Steven P. Angus; D. Wade Clapp; Steven D. Rhodes
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