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15 February 2024
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Cover Image
Cover Image
The cover shows a section of a lymph node metastasis from a responding patient with cervical squamous cell carcinoma post-treatment. The yellow immunohistochemical staining shows infiltrating CD8 T cells in tumor tissue at a density relevant to response. For details, see the article by Dejardin and colleagues on page 877 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Perspective
Research Briefs: Clinical Trial Brief Reports
Evaluation of the SSTR2-targeted Radiopharmaceutical 177Lu-DOTATATE and SSTR2-specific 68Ga-DOTATATE PET as Imaging Biomarker in Patients with Intracranial Meningioma
Sylvia C. Kurz; Elcin Zan; Christine Cordova; Andrea B. Troxel; Marissa Barbaro; Joshua S. Silverman; Matija Snuderl; David Zagzag; Douglas Kondziolka; John G. Golfinos; Andrew S. Chi; Erik P. Sulman
Development of a Practical Nomogram for Personalized Anemia Management in Patients Treated with Ataxia Telangiectasia and Rad3-related Inhibitor Camonsertib
Ezra Rosen; Timothy A. Yap; Elizabeth K. Lee; Martin Højgaard; Niharika B. Mettu; Stephanie Lheureux; Benedito A. Carneiro; Ruth Plummer; Adrian J. Fretland; Danielle Ulanet; Yi Xu; Robin McDougall; Maria Koehler; Elisa Fontana
A Phase Ib Study of the DNA-PK Inhibitor Peposertib Combined with Neoadjuvant Chemoradiation in Patients with Locally Advanced Rectal Cancer
Paul B. Romesser; Jaume Capdevila; Rocio Garcia-Carbonero; Tony Philip; Carlos Fernandez Martos; Richard Tuli; Almudena Rodriguez-Gutierrez; Mirjam Kuipers; Andreas Becker; Anna Coenen-Stass; Barbara Sarholz; Xiaoli You; Eric D. Miller
Clinical Trials: Targeted Therapy
Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma
Caroline E. Gleason; Mark A. Dickson; Mary E. Klein (Dooley); Cristina R. Antonescu; Rodrigo Gularte-Mérida; Marimar Benitez; Juliana I. Delgado; Raghu P. Kataru; Mark Wei Yi Tan; Martina Bradic; Travis E. Adamson; Kenneth Seier; Allison L. Richards; Marta Palafox; Eric Chan; Sandra P. D'Angelo; Mrinal M. Gounder; Mary Louise Keohan; Ciara M. Kelly; Ping Chi; Sujana Movva; Jonathan Landa; Aimee M. Crago; Mark T.A. Donoghue; Li-Xuan Qin; Violetta Serra; Mesruh Turkekul; Afsar Barlas; Daniel M. Firester; Katia Manova-Todorova; Babak J. Mehrara; Marta Kovatcheva; Nguan Soon Tan; Samuel Singer; William D. Tap; Andrew Koff
Clinical Benefit of Avapritinib in KIT-Mutant Gastrointestinal Stromal Tumors: A Post Hoc Analysis of the Phase I NAVIGATOR and Phase I/II CS3007–001 Studies
Michael C. Heinrich; Xinhua Zhang; Robin L. Jones; Suzanne George; César Serrano; Yanhong Deng; Sebastian Bauer; Shirong Cai; Xin Wu; Yongjian Zhou; Kaixiong Tao; Zhichao Zheng; Jun Zhang; Yuehong Cui; Hui Cao; Meining Wang; Jin Hu; Jason Yang; Jian Li; Lin Shen
Neoadjuvant Trebananib plus Paclitaxel-based Chemotherapy for Stage II/III Breast Cancer in the Adaptively Randomized I-SPY2 Trial—Efficacy and Biomarker Discovery
Kathy S. Albain; Christina Yau; Emanuel F. Petricoin; Denise M. Wolf; Julie E. Lang; A. Jo Chien; Tufia Haddad; Andres Forero-Torres; Anne M. Wallace; Henry Kaplan; Lajos Pusztai; David Euhus; Rita Nanda; Anthony D. Elias; Amy S. Clark; Constantine Godellas; Judy C. Boughey; Claudine Isaacs; Debu Tripathy; Janice Lu; Rachel L. Yung; Rosa I. Gallagher; Julia D. Wulfkuhle; Lamorna Brown-Swigart; Gregor Krings; Yunn Yi Chen; David A. Potter; Erica Stringer-Reasor; Sarah Blair; Smita M. Asare; Amy Wilson; Gillian L. Hirst; Ruby Singhrao; Meredith Buxton; Julia L. Clennell; Ashish Sanil; Scott Berry; Adam L. Asare; Jeffrey B. Matthews; Angela M. DeMichele; Nola M. Hylton; Michelle Melisko; Jane Perlmutter; Hope S. Rugo; W. Fraser Symmans; Laura J. van't Veer; Douglas Yee; Donald A. Berry; Laura J. Esserman
Phase I/II Study of the WEE1 Inhibitor Adavosertib (AZD1775) in Combination with Carboplatin in Children with Advanced Malignancies: Arm C of the AcSé-ESMART Trial
Susanne A. Gatz; Anne C. Harttrampf; Caroline Brard; Francisco Bautista; Nicolas André; Samuel Abbou; Jonathan Rubino; Windy Rondof; Marc Deloger; Marc Rübsam; Lynley V. Marshall; Daniel Hübschmann; Souad Nebchi; Isabelle Aerts; Estelle Thebaud; Emilie De Carli; Anne Sophie Defachelles; Xavier Paoletti; Robert Godin; Kowser Miah; Peter G.S. Mortimer; Gilles Vassal; Birgit Geoerger
Phase Ia/b Study of Giredestrant ± Palbociclib and ± Luteinizing Hormone-Releasing Hormone Agonists in Estrogen Receptor–Positive, HER2-Negative, Locally Advanced/Metastatic Breast Cancer
Komal L. Jhaveri; Meritxell Bellet; Nicholas C. Turner; Sherene Loi; Aditya Bardia; Valentina Boni; Joohyuk Sohn; Tomas G. Neilan; Rafael Villanueva-Vázquez; Peter Kabos; Laura García-Estévez; Elena López-Miranda; J. Alejandro Pérez-Fidalgo; Jose M. Pérez-García; Jiajie Yu; Jill Fredrickson; Heather M. Moore; Ching-Wei Chang; John W. Bond; Jennifer Eng-Wong; Mary R. Gates; Elgene Lim
First-Line Ipatasertib, Atezolizumab, and Taxane Triplet for Metastatic Triple-Negative Breast Cancer: Clinical and Biomarker Results
Peter Schmid; Nicholas C. Turner; Carlos H. Barrios; Steven J. Isakoff; Sung-Bae Kim; Marie-Paule Sablin; Shigehira Saji; Peter Savas; Gregory A. Vidal; Mafalda Oliveira; Joyce O'Shaughnessy; Antoine Italiano; Enrique Espinosa; Valentina Boni; Shane White; Beatriz Rojas; Ruffo Freitas-Junior; Yeesoo Chae; Igor Bondarenko; Jieun Lee; Cesar Torres Mattos; Jorge Luis Martinez Rodriguez; Lisa H. Lam; Surai Jones; Sarah-Jayne Reilly; Xiayu Huang; Kalpit Shah; Rebecca Dent
Research Briefs: Precision Medicine and Therapeutics
TROP2 Is Associated with Primary Resistance to Immune Checkpoint Inhibition in Patients with Advanced Non–Small Cell Lung Cancer
Alban Bessede; Florent Peyraud; Benjamin Besse; Sophie Cousin; Mathilde Cabart; François Chomy; Christophe Rey; Oren Lara; Ophélie Odin; Imane Nafia; Lucile Vanhersecke; Fabrice Barlesi; Jean-Philippe Guégan; Antoine Italiano
Precision Medicine and Imaging
Intrinsic Subtype and Overall Survival of Patients with Advanced HR+/HER2− Breast Cancer Treated with Ribociclib and ET: Correlative Analysis of MONALEESA-2, -3, -7
Aleix Prat; Nadia Solovieff; Fabrice André; Joyce O'Shaughnessy; David A. Cameron; Wolfgang Janni; Gabe S. Sonke; Yoon-Sim Yap; Denise A. Yardley; Ann H. Partridge; Astrid Thuerigen; Juan Pablo Zarate; Agnes Lteif; Fei Su; Lisa A. Carey
PD-1 Expression on Intratumoral Regulatory T Cells Is Associated with Lack of Benefit from Anti–PD-1 Therapy in Metastatic Clear-Cell Renal Cell Carcinoma Patients
Thomas Denize; Opeyemi A. Jegede; Sayed Matar; Nourhan El Ahmar; Destiny J. West; Emily Walton; Aseman Sheshdeh Bagheri; Varunika Savla; Yasmin Nabil Laimon; Saurabh Gupta; Sai Vikram Vemula; David A. Braun; Kelly P. Burke; Paul J. Catalano; Gordon J. Freeman; Robert J. Motzer; Michael B. Atkins; David F. McDermott; Arlene H. Sharpe; Toni K. Choueiri; Sabina Signoretti
A Dysfunctional T-cell Gene Signature for Predicting Nonresponse to PD-1 Blockade in Non–small Cell Lung Cancer That Is Suitable for Routine Clinical Diagnostics
Karlijn Hummelink; Renaud Tissier; Linda J.W. Bosch; Oscar Krijgsman; Michel M. van den Heuvel; Willemijn S.M.E. Theelen; Diane Damotte; François Goldwasser; Karen Leroy; Egbert F. Smit; Gerrit A. Meijer; Daniela S. Thommen; Kim Monkhorst
Durvalumab ± Tremelimumab + Platinum-Etoposide in Extensive-Stage Small Cell Lung Cancer (CASPIAN): Outcomes by PD-L1 Expression and Tissue Tumor Mutational Burden
Luis Paz-Ares; Marina Chiara Garassino; Yuanbin Chen; Niels Reinmuth; Katsuyuki Hotta; Artem Poltoratskiy; Dmytro Trukhin; Maximilian J. Hochmair; Mustafa Özgüroğlu; Jun Ho Ji; Galina Statsenko; Nikolay Conev; Igor Bondarenko; Libor Havel; György Losonczy; Mingchao Xie; Zhongwu Lai; Nadia Godin-Heymann; Helen Mann; Haiyi Jiang; Yashaswi Shrestha; Jonathan W. Goldman
Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types
Pashtoon M. Kasi; Jessica K. Lee; Lincoln W. Pasquina; Brennan Decker; Pierre Vanden Borre; Dean C. Pavlick; Justin M. Allen; Christine Parachoniak; Julia C. F. Quintanilha; Ryon P. Graf; Alexa B. Schrock; Geoffrey R. Oxnard; Christine M. Lovly; Hanna Tukachinsky; Vivek Subbiah
Translational Cancer Mechanisms and Therapy
Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach
Courtney R. Schott; Amanda L. Koehne; Leanne C. Sayles; Elizabeth P. Young; Cuyler Luck; Katherine Yu; Alex G. Lee; Marcus R. Breese; Stanley G. Leung; Hang Xu; Avanthi Tayi Shah; Heng-Yi Liu; Aviv Spillinger; Inge H. Behroozfard; Kieren D. Marini; Phuong T. Dinh; María V. Pons Ventura; Emma N. Vanderboon; Florette K. Hazard; Soo-Jin Cho; Raffi S. Avedian; David G. Mohler; Melissa Zimel; Rosanna Wustrack; Christina Curtis; Marina Sirota; E. Alejandro Sweet-Cordero
Functional Contribution and Clinical Implication of Cancer-Associated Fibroblasts in Glioblastoma
Phillip M. Galbo, Jr; Anne Tranberg Madsen; Yang Liu; Mou Peng; Yao Wei; Michael J. Ciesielski; Robert A. Fenstermaker; Sarah Graff; Cristina Montagna; Jeffrey E. Segall; Simone Sidoli; Xingxing Zang; Deyou Zheng
Comparison of Circulating Tumor DNA Assays for Molecular Residual Disease Detection in Early-Stage Triple-Negative Breast Cancer
Maria Coakley; Guillermo Villacampa; Prithika Sritharan; Claire Swift; Kathryn Dunne; Lucy Kilburn; Katie Goddard; Christodoulos Pipinikas; Patricia Rojas; Warren Emmett; Peter Hall; Catherine Harper-Wynne; Tamas Hickish; Iain Macpherson; Alicia Okines; Andrew Wardley; Duncan Wheatley; Simon Waters; Carlo Palmieri; Matthew Winter; Rosalind J. Cutts; Isaac Garcia-Murillas; Judith Bliss; Nicholas C. Turner
Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma
Alba Rodríguez-García; Andrés Arroyo; Roberto García-Vicente; María Luz Morales; Rubén Gómez-Gordo; Pablo Justo; Clara Cuéllar; José Sánchez-Pina; Nieves López; Rafael Alonso; Noemí Puig; María-Victoria Mateos; Rosa Ayala; Dulcenombre Gómez-Garre; Joaquín Martínez-López; María Linares
Editor's Notes
Editor's Note: Cyclin-Dependent Kinase 5 Decreases in Gastric Cancer and its Nuclear Accumulation Suppresses Gastric Tumorigenesis
Longlong Cao; Jiechao Zhou; Junrong Zhang; Sijin Wu; Xintao Yang; Xin Zhao; Huifang Li; Ming Luo; Qian Yu; Guangtan Lin; Huizhong Lin; Jianwei Xie; Ping Li; Xiaoqing Hu; Chaohui Zheng; Guojun Bu; Yun-wu Zhang; Huaxi Xu; Yongliang Yang; Changming Huang; Jie Zhang
Editor's Note: Eph-B2/Ephrin-B2 Interaction Plays a Major Role in the Adhesion and Proliferation of Waldenstrom's Macroglobulinemia
Feda Azab; Abdel Kareem Azab; Patricia Maiso; Teresa Calimeri; Ludmila Flores; Yang Liu; Phong Quang; Aldo M. Roccaro; Antonio Sacco; Hai T. Ngo; Yong Zhang; Brittany L. Morgan; Ruben D. Carrasco; Irene M. Ghobrial
Editor's Note: Targeting Akt and Heat Shock Protein 90 Produces Synergistic Multiple Myeloma Cell Cytotoxicity in the Bone Marrow Microenvironment
Alissa Huston; Xavier Leleu; Xiaoying Jia; Anne-Sophie Moreau; Hai T. Ngo; Judith Runnels; Judy Anderson; Yazan Alsayed; Aldo Roccaro; Sonia Vallet; Evdoxia Hatjiharissi; Yu-Tsu Tai; Peter Sportelli; Nikhil Munshi; Paul Richardson; Teru Hideshima; David G. Roodman; Kenneth C. Anderson; Irene M. Ghobrial
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