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15 November 2024
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Cover Image
Cover Image
The cover shows a section of an endometrial biopsy from a patient with endometrial cancer used for spatial transcriptomic profiling. The image shows immunofluorescent staining for PanCK (green), CD10 (red), and CD45 (yellow) to visualize epithelial, stromal, and immune compartments, respectively, with counterstaining by Syto13 (blue) to show nuclei. For details, see the article by Bowen and colleagues on page 5073 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
CCR Translations
CCR Drug Updates
FDA Approval Summary: Belzutifan for Patients with Advanced Renal Cell Carcinoma
Jaleh Fallah; Brian L. Heiss; Hee-Koung Joeng; Chana Weinstock; Xin Gao; William F. Pierce; Benjamin Chukwurah; Vishal Bhatnagar; Mallorie H. Fiero; Laleh Amiri-Kordestani; Richard Pazdur; Paul G. Kluetz; Daniel L. Suzman
Reviews
Update on Recommendations for Cancer Screening and Surveillance in Children with Genomic Instability Disorders
Yoshiko Nakano; Roland P. Kuiper; Kim E. Nichols; Christopher C. Porter; Harry Lesmana; Julia Meade; Christian P. Kratz; Lucy A. Godley; Luke D. Maese; Maria Isabel Achatz; Payal P. Khincha; Sharon A. Savage; Andrea S. Doria; Mary-Louise C. Greer; Vivian Y. Chang; Lisa L. Wang; Sharon E. Plon; Michael F. Walsh
Plasma ctDNA as a Treatment Response Biomarker in Metastatic Cancers: Evaluation by the RECIST Working Group
Alexander W. Wyatt; Saskia Litiere; Francois-Clément Bidard; Luc Cabel; Lars Dyrskjøt; Chris A. Karlovich; Klaus Pantel; Joan Petrie; Reena Philip; Hillary S. Andrews; Paz J. Vellanki; Sofie H. Tolmeijer; Xenia Villalobos Alberu; Christian Alfano; Jan Bogaerts; Emiliano Calvo; Alice P. Chen; Rodrigo A. Toledo; Elisabeth G.E. de Vries; Lesley Seymour; Scott A. Laurie; Elena Garralda; for the RECIST ctDNA workshop group
Clinical Trials: Targeted Therapy
A Phase I First-in-Human Study of ABBV-011, a Seizure-Related Homolog Protein 6–Targeting Antibody–Drug Conjugate, in Patients with Small Cell Lung Cancer
Daniel Morgensztern; Neal Ready; Melissa L. Johnson; Afshin Dowlati; Noura Choudhury; David P. Carbone; Eric Schaefer; Susanne M. Arnold; Sonam Puri; Zofia Piotrowska; Aparna Hegde; Anne C. Chiang; Wade Iams; Anthony Tolcher; Kaname Nosaki; Toshiyuki Kozuki; Tianhong Li; Rafael Santana-Davila; Hiroaki Akamatsu; Haruyasu Murakami; Hiroshi Yokouchi; Song Wang; Jiuhong Zha; Rui Li; Randy R. Robinson; Pooja Hingorani; Edwin E. Jeng; Muhammad Furqan
A First-in-Human Phase I Study of BXQ-350, a First-in-Class Sphingolipid Metabolism Regulator, in Patients with Advanced/Recurrent Solid Tumors or High-Grade Gliomas
Olivier Rixe; John L. Villano; Robert Wesolowski; Anne M. Noonan; Vinay K. Puduvalli; Trisha M. Wise-Draper; Richard Curry, III; Emrullah Yilmaz; Charlie Cruze; Besim Ogretmen; Gilles Tapolsky; Ray Takigiku
Clinical Trials: Immunotherapy
Chemoradiotherapy and Subsequent Immunochemotherapy as Conversion Therapy in Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma: A Phase II NEXUS-1 Trial
Xin Wang; Xiaozheng Kang; Ruixiang Zhang; Liyan Xue; Jiaqi Xu; Xiaotian Zhao; Qiuxiang Ou; Nuo Yu; Guojie Feng; Jiao Li; Ziyu Zheng; Xiankai Chen; Zhen Wang; Qingfeng Zheng; Yong Li; Jianjun Qin; Nan Bi; Yin Li
Precision Medicine and Imaging
Long-Term Follow-up of Levonorgestrel Intrauterine Device for Atypical Hyperplasia and Early Endometrial Cancer Reveals Relapse Characterized by Immune Exhaustion
Mikayla B. Bowen; Brenda Melendez; Qian Zhang; Richard K. Yang; Bryan M. Fellman; Barrett C. Lawson; Naomi N. Adjei; Joseph Celestino; Khalida M. Wani; Bhavana Singh; Diana L. Urbauer; Alexander J. Lazar; Karen H. Lu; Jennifer A. Wargo; Shannon N. Westin; Melinda S. Yates
Metabolic Tumor Volume Response after Bridging Therapy Determines Chimeric Antigen Receptor T-Cell Outcomes in Large B-Cell Lymphoma
Harper Hubbeling; Doris Leithner; Emily A. Silverman; Jessica Flynn; Sean Devlin; Gunjan Shah; Beatrice Fregonese; Beatriz Wills; Akshay Bedmutha; Ana Alarcon Tomas; Allison Parascondola; Amethyst Saldia; Ivan Landego; Carla Hajj; Alexander P. Boardman; Parastoo B. Dahi; Arnab Ghosh; Sergio Giralt; Richard J. Lin; Jae Park; Michael Scordo; Gilles Salles; Joachim Yahalom; Maria L. Palomba; Heiko Schöder; Miguel-Angel Perales; Roni Shouval; Brandon S. Imber
High Mechanical Conditioning by Tumor Extracellular Matrix Stiffness Is a Predictive Biomarker for Antifibrotic Therapy in HER2-Negative Breast Cancer
Miguel Quintela-Fandino; Begoña Bermejo; Esther Zamora; Fernando Moreno; José Ángel García-Saenz; Sonia Pernas; Noelia Martínez-Jañez; Desirée Jiménez; Encarna Adrover; Raquel de Andrés; Silvana Mourón; Maria J. Bueno; Luis Manso; Gemma Viñas; Emilio Alba; Antonio Llombart-Cussac; Javier Cortés; Cristina Tebar; Denise J. Roe; Adam Grant; Adam Watson; Ramon Colomer; Ghassan Mouneimne
Translational Cancer Mechanisms and Therapy
GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression
Silvia Stacchiotti; Silvia Martini; Sandro Pasquali; Anna M. Frezza; Alessia Beretta; Stefano Percio; Mara Lecchi; Monica Tortoreto; Marta Barisella; Paola Collini; Gian Paolo Dagrada; Alessandra Merlini; Paul H. Huang; Andrew Jenks; Robin L. Jones; William D. Tap; Matilde Ingrosso; Carlo Morosi; Silvia Brich; Claudia Giani; Paolo Verderio; Paolo G. Casali; Hugh Leonard; Alessandro Gronchi; Valentina Zuco; Nadia Zaffaroni
TAK1 Promotes an Immunosuppressive Tumor Microenvironment through Cancer-Associated Fibroblast Phenotypic Conversion in Pancreatic Ductal Adenocarcinoma
Nan Sheng; Koji Shindo; Kenoki Ohuchida; Tomohiko Shinkawa; Bo Zhang; Haimin Feng; Takeo Yamamoto; Taiki Moriyama; Naoki Ikenaga; Kohei Nakata; Yoshinao Oda; Masafumi Nakamura
MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor
Miguel A. Miranda-Román; Cindy J. Lee; Eve Fishinevich; Leili Ran; Amish J. Patel; Juan Yan; Makhzuna N. Khudoynazarova; Sarah Warda; Mohini R. Pachai; Yu Chen; Ping Chi
Epigenome Reprogramming Through H3K27 and H3K4 Trimethylation as a Resistance Mechanism to DNA Methylation Inhibition in BRAFV600E-Mutated Colorectal Cancer
Hey Min Lee; Ajay Kumar Saw; Van K. Morris; Stefania Napolitano; Christopher Bristow; Sanjana Srinivasan; Micheal Peoples; Alexey Sorokin; Preeti Kanikarla Marie; Jonathan Schulz; Anand K. Singh; Christopher Terranova; Oluwadara Coker; Abhinav Jain; Scott Kopetz; Kunal Rai
ctDNA Dynamics and Mechanisms of Acquired Resistance in Patients Treated with Osimertinib with or without Bevacizumab from the Randomized Phase II ETOP-BOOSTER Trial
Ross A. Soo; Urania Dafni; Ji-Youn Han; Byoung Chul Cho; Ernest Nadal; Chong Ming Yeo; Enric Carcereny; Javier de Castro; Maria Angeles Sala; Linda Coate; Mariano Provencio; Christian Britschgi; Patrick Vagenknecht; Georgia Dimopoulou; Roswitha Kammler; Stephen P. Finn; Solange Peters; Rolf A. Stahel; for the ETOP 10-16 BOOSTER Collaborators
Predictive and Dynamic Signature for Antiangiogenics in Combination with a PD1 Inhibitor in Soft-Tissue Sarcoma: Correlative Studies Linked to the IMMUNOSARC Trial
David S. Moura; Jesus M. Lopez-Marti; Iva Benesova; Carlos de Andrea; Davide di Lernia; Serena Lacerenza; Jose L. Mondaza-Hernandez; Marta Martin-Ruiz; Marta Ramirez-Calvo; Giovanni Grignani; Javier Martinez-Trufero; Andres Redondo; Claudia Valverde; Silvia Stacchiotti; Antonio Lopez-Pousa; José A. Lopez-Guerrero; Antonio Gutierrez; Victor Encinas-Tobajas; Nadia Hindi; Dario Sangiolo; Jose A. Lopez-Martin; Zuzana Ozaniak Strizova; Javier Martin-Broto
The Epstein–Barr Virus Nuclear Antigen 1 Variant Associated with Nasopharyngeal Carcinoma Defines the Sequence Criteria for Serologic Risk Prediction
Benjamin E. Warner; Japan Patel; Renwei Wang; Jennifer Adams-Haduch; Yu-Tang Gao; Woon-Puay Koh; Ka Wo Wong; Alan K.S. Chiang; Jian-Min Yuan; Kathy H.Y. Shair
Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer
Matthew C. Dallos; Aleksandar Z. Obradovic; Patrick McCann; Nivedita Chowdhury; Aditya Pratapa; David H. Aggen; Christopher Gaffney; Karen A. Autio; Renu K. Virk; Angelo M. De Marzo; Emmanuel S. Antonarakis; Howard I. Scher; Charles G. Drake; Dana E. Rathkopf
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