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1 November 2024
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Cover Image
Cover Image
The cover shows a section of peritumoral edematous tissue from a brain metastasis in a patient with lung cancer. Immunohistochemical staining shows significantly elevated AQP4 expression within the peritumoral edematous tissue. For details, see the article by Gao and colleagues on page 4876 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
CCR Translations
CCR Drug Updates
FDA Approval Summary: Enfortumab Vedotin plus Pembrolizumab for Locally Advanced or Metastatic Urothelial Carcinoma
Michael H. Brave; William F. Maguire; Chana Weinstock; Hui Zhang; Xin Gao; Fang Li; Jingyu Yu; Wentao Fu; Hong Zhao; William F. Pierce; Elaine Chang; Jeannette Dinin; Mallorie H. Fiero; Nam Atiqur Rahman; Shenghui Tang; Richard Pazdur; Paul G. Kluetz; Laleh Amiri-Kordestani; Daniel L. Suzman
Reviews
Update on Pediatric Cancer Surveillance Recommendations for Patients with Neurofibromatosis Type 1, Noonan Syndrome, CBL Syndrome, Costello Syndrome, and Related RASopathies
Melissa R. Perrino; Anirban Das; Sarah R. Scollon; Sarah G. Mitchell; Mary-Louise C. Greer; Marielle E. Yohe; Jordan R. Hansford; Jennifer M. Kalish; Kris Ann P. Schultz; Suzanne P. MacFarland; Wendy K. Kohlmann; Philip J. Lupo; Kara N. Maxwell; Stefan M. Pfister; Rosanna Weksberg; Orli Michaeli; Marjolijn C.J. Jongmans; Gail E. Tomlinson; Jack Brzezinski; Uri Tabori; Gina M. Ney; Karen W. Gripp; Andrea M. Gross; Brigitte C. Widemann; Douglas R. Stewart; Emma R. Woodward; Christian P. Kratz
Clinical Trials: Targeted Therapy
A Phase 1 First-in-Human Study of the MCL-1 Inhibitor AZD5991 in Patients with Relapsed/Refractory Hematologic Malignancies
Pinkal Desai; Sagar Lonial; Amanda Cashen; Manali Kamdar; Ian Flinn; Susan O’Brien; Jacqueline S. Garcia; Neha Korde; Javid Moslehi; Margaret Wey; Patricia Cheung; Shringi Sharma; Damilola Olabode; Hong Chen; Firasath Ali Syed; Mary Liu; Jamal Saeh; Marcio Andrade-Campos; Tapan M. Kadia; James S. Blachly
Clinical Trials: Immunotherapy
A Phase II Study of Atezolizumab, Pertuzumab, and High-Dose Trastuzumab for Central Nervous System Metastases in Patients with HER2-Positive Breast Cancer
Antonio Giordano; Priya U. Kumthekar; Qingchun Jin; Busem Binboga Kurt; Siyang Ren; Tianyu Li; Jose Pablo Leone; Elizabeth A. Mittendorf; Alyssa M. Pereslete; Laura Sharp; Raechel Davis; Molly DiLullo; Nabihah Tayob; Erica L. Mayer; Eric P. Winer; Sara M. Tolaney; Nancy U. Lin
Precision Medicine and Imaging
Incorporating Supramaximal Resection into Survival Stratification of IDH-wildtype Glioblastoma: A Refined Multi-institutional Recursive Partitioning Analysis
Yae Won Park; Kyu Sung Choi; Martha Foltyn-Dumitru; Gianluca Brugnara; Rouzbeh Banan; Sooyon Kim; Kyunghwa Han; Ji Eun Park; Tobias Kessler; Martin Bendszus; Sandro Krieg; Wolfgang Wick; Felix Sahm; Seung Hong Choi; Ho Sung Kim; Jong Hee Chang; Se Hoon Kim; Doonyaporn Wongsawaeng; Jeffrey Michael Pollock; Seung-Koo Lee; Ramon Francisco Barajas, Jr; Philipp Vollmuth; Sung Soo Ahn
Multiomics Profiling Distinguishes Sebaceous Carcinoma from Benign Sebaceous Neoplasms and Provides Insight into the Genetic Evolution of Sebaceous Carcinogenesis
Gabriel J. Starrett; Brittany C. Baikie; Benjamin K. Stoff; Hans E. Grossniklaus; Inga Van Buren; Elizabeth G. Berry; Roberto A. Novoa; Kerri E. Rieger; Kavita Y. Sarin; Charles F. Lynch; Michael C. Royer; Mary L. Piaskowski; Isaac Brownell; Emily Y. Chu; Rama Godse; Suephy C. Chen; Kelly J. Yu; Alisa M. Goldstein; Eric A. Engels; Michael R. Sargen
The Immune-Related 27-Gene Signature DetermaIO Predicts Response to Neoadjuvant Atezolizumab plus Chemotherapy in Triple-Negative Breast Cancer
Matteo Dugo; Chiun-Sheng Huang; Daniel Egle; Begoña Bermejo; Claudio Zamagni; Robert S. Seitz; Tyler J. Nielsen; Marc Thill; Antonio Antón-Torres; Stefania Russo; Eva Maria Ciruelos; Brock L. Schweitzer; Douglas T. Ross; Barbara Galbardi; Richard Greil; Vladimir Semiglazov; Balázs Gyorffy; Marco Colleoni; Catherine M. Kelly; Gabriella Mariani; Lucia Del Mastro; Olivia Blasi; Maurizio Callari; Lajos Pusztai; Pinuccia Valagussa; Giuseppe Viale; Luca Gianni; Giampaolo Bianchini
Translational Cancer Mechanisms and Therapy
Clonal Hematopoiesis and Clinical Outcomes in Metastatic Castration-Resistant Prostate Cancer Patients Given Androgen Receptor Pathway Inhibitors (Alliance A031201)
Jeffrey L. Jensen; Olivia Bobek; Irenaeus C. C. Chan; Brian C. Miller; David W. Hillman; Glenn Heller; Todd Druley; Andrew J. Armstrong; Michael J. Morris; Matthew I. Milowsky; Himisha Beltran; Kelly L. Bolton; Catherine C. Coombs
Clinical and Genomic Features of Classical and Basal Transcriptional Subtypes in Pancreatic Cancer
Harshabad Singh; Joanne Xiu; Kevin S. Kapner; Chen Yuan; Raja R. Narayan; Matthew Oberley; Alex Farrell; Rishi Surana; Brandon M. Huffman; Kimberly Perez; James M. Cleary; Alexander C. Jordan; Andressa Dias Costa; Hannah L. Williams; Srivatsan Raghavan; Benjamin Weinberg; Michael J. Pishvaian; Rachna T. Shroff; Sanjay Goel; Stephanie K. Dougan; Jonathan A. Nowak; David Spetzler; George Sledge; Brian M. Wolpin; Andrew J. Aguirre
Understanding and Overcoming Resistance to Selective FGFR Inhibitors across FGFR2-Driven Malignancies
Francesco Facchinetti; Yohann Loriot; Floriane Brayé; Damien Vasseur; Rastislav Bahleda; Ludovic Bigot; Rémy Barbé; Catline Nobre; David Combarel; Stefan Michiels; Antoine Italiano; Cristina Smolenschi; Lambros Tselikas; Jean-Yves Scoazec; Santiago Ponce-Aix; Benjamin Besse; Fabrice André; Ken A. Olaussen; Antoine Hollebecque; Luc Friboulet
Genetic Screen in a Preclinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities
Jack Freeland; Maria Muñoz; Edmond O’Donnell, III; Justin Langerman; Morgan Darrow; Jessica Bergonio; Julissa Suarez-Navarro; Steven Thorpe; Robert Canter; Robert Lor Randall; Kathrin Plath; Kermit L. Carraway, III; Owen N. Witte; Thomas G. Graeber; Janai R. Carr-Ascher
Exploiting WEE1 Kinase Activity as FUS::DDIT3-Dependent Therapeutic Vulnerability in Myxoid Liposarcoma
Lorena Heinst; Kwang Seok Lee; Ruth Berthold; Ilka Isfort; Svenja Wosnig; Anna Kuntze; Susanne Hafner; Bianca Altvater; Claudia Rossig; Pierre Åman; Eva Wardelmann; Claudia Scholl; Wolfgang Hartmann; Stefan Fröhling; Marcel Trautmann
Tumor-Infiltrating Lymphocytes in Necrotic Tumors after Melanoma Neoadjuvant Anti–PD-1 Therapy Correlate with Pathologic Response and Recurrence-Free Survival
Kevin L. Ma; Tara C. Mitchell; Meaghan Dougher; Cimarron E. Sharon; Gabriella N. Tortorello; David E. Elder; Eric E. Morgan; Phyllis A. Gimotty; Alexander C. Huang; Ravi K. Amaravadi; Lynn M. Schuchter; Ahron Flowers; John T. Miura; Giorgos C. Karakousis; Xiaowei Xu
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