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15 October 2024
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Cover Image
Cover Image
The cover shows a portion of the coronal section of the mouse brain that displays syngeneic SB28 glioblastoma in the cortex. Importantly, immune cells that are highlighted in yellow and purple do not only increase in the direct vicinity of the tumor (green) but also in the contralateral hemisphere (top). Involvement of the corpus callosum (center) indicates migration of contralateral immune cells to the tumor. For details, see the article by Bartos and colleagues on page 4618 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
CCR Translations
Review
Perspective
Pediatric Cancer Screening in Hereditary Gastrointestinal Cancer Risk Syndromes: An Update from the AACR Childhood Cancer Predisposition Working Group
Suzanne P. MacFarland; Kerri Becktell; Kami Wolfe Schneider; Roland P. Kuiper; Harry Lesmana; Julia Meade; Kim E. Nichols; Christopher C. Porter; Sharon A. Savage; Kris Ann Schultz; Hamish Scott; Lisa States; Uri Tabori; Chieko Tamura; Gail Tomlinson; Kristin Zelley; Carol Durno; Andrew Bauer; Sharon E. Plon
Clinical Trials: Targeted Therapy
Evaluating Debio 1347 in Patients with FGFR Fusion-Positive Advanced Solid Tumors from the FUZE Multicenter, Open-Label, Phase II Basket Trial
Petros Grivas; Elena Garralda; Funda Meric-Bernstam; Ingo K. Mellinghoff; Lipika Goyal; James J. Harding; E. Claire Dees; Rastislav Bahleda; Nilofer S. Azad; Asha Karippot; Razelle Kurzrock; Josep Tabernero; Juha Kononen; Matthew C.H. Ng; Rutika Mehta; Nataliya V. Uboha; Frédéric Bigot; Valentina Boni; Samantha E. Bowyer; Valeriy Breder; Andrés Cervantes; Nancy Chan; James M. Cleary; Mallika Dhawan; Rikke L. Eefsen; James Ewing; Donna M. Graham; Tormod K. Guren; Jin Won Kim; Krassimir Koynov; Do-Youn Oh; Rebecca Redman; Chia-Jui Yen; David Spetzler; Marie-Claude Roubaudi-Fraschini; Valerie Nicolas-Metral; Rafik Ait-Sarkouh; Claudio Zanna; Abdallah Ennaji; Anna Pokorska-Bocci; Keith T. Flaherty
A Single-Arm Phase 2 Trial of Trametinib in Patients with Locally Advanced or Metastatic Epithelioid Hemangioendothelioma
Scott M. Schuetze; Karla V. Ballman; Rachel Heise; Kristen N. Ganjoo; Elizabeth J. Davis; Suzanne George; Melissa A. Burgess; Edwin Choy; Dale R. Shepard; Gabriel Tinoco; Angela Hirbe; Ciara M. Kelly; Steven Attia; Hari A. Deshpande; Gary K. Schwartz; Brittany L. Siontis; Richard F. Riedel; Margaret von Mehren; Erin Kozlowski; Helen X. Chen; Caroline Astbury; Brian P. Rubin
Clinical Trials: Immunotherapy
Pembrolizumab and Cabozantinib in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Long-term Survival Update with a Biomarker Analysis
Nabil F. Saba; Ritu Chaudhary; Kedar Kirtane; Angelo Marra; Asari Ekpenyong; Ashley McCook-Veal; Nicole C. Schmitt; Jennifer H. Gross; Mihir R. Patel; Jill Remick; James E. Bates; Mark W. McDonald; Soumon F. Rudra; William A. Stokes; Maria Biernacki; Xiaofei Song; Robbert J.C. Slebos; Yuan Liu; Conor E. Steuer; Dong M. Shin; Yong Teng; Christine H. Chung
A Phase Ib/II Randomized Clinical Trial of Oleclumab with or without Durvalumab plus Chemotherapy in Patients with Metastatic Pancreatic Ductal Adenocarcinoma
Andrew L. Coveler; Matthew J. Reilley; Mark Zalupski; Teresa Macarulla; Christos Fountzilas; Mariano Ponz-Sarvisé; Adnan Nagrial; Nataliya V. Uboha; Sophia Frentzas; Michael Overman; Anne Noonan; Wells A. Messersmith; Nick Pavlakis; Niharika B. Mettu; Ina Bisha; Ying Wang; Paul Smith; Elina Murtomaki; Agata A. Bielska; Veronique Bragulat; Zachary A. Cooper; Rakesh Kumar; David R. Spigel
Precision Medicine and Imaging
Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome
Laura M. Bartos; Stefanie Quach; Valerio Zenatti; Sabrina V. Kirchleitner; Jens Blobner; Karin Wind-Mark; Zeynep Ilgin Kolabas; Selin Ulukaya; Adrien Holzgreve; Viktoria C. Ruf; Lea H. Kunze; Sebastian T. Kunte; Leonie Hoermann; Marlies Härtel; Ha Eun Park; Mattes Groß; Nicolai Franzmeier; Artem Zatcepin; Adrian Zounek; Lena Kaiser; Markus J. Riemenschneider; Robert Perneczky; Boris-Stephan Rauchmann; Sophia Stöcklein; Sibylle Ziegler; Jochen Herms; Ali Ertürk; Joerg C. Tonn; Niklas Thon; Louisa von Baumgarten; Matthias Prestel; Sabina Tahirovic; Nathalie L. Albert; Matthias Brendel
Artificial Intelligence-Powered Spatial Analysis of Tumor-Infiltrating Lymphocytes as a Potential Biomarker for Immune Checkpoint Inhibitors in Patients with Biliary Tract Cancer
Yeong Hak Bang; Choong-kun Lee; Kyunghye Bang; Hyung-Don Kim; Kyu-pyo Kim; Jae Ho Jeong; Inkeun Park; Baek-Yeol Ryoo; Dong Ki Lee; Hye Jin Choi; Taek Chung; Seung Hyuck Jeon; Eui-Cheol Shin; Chiyoon Oum; Seulki Kim; Yoojoo Lim; Gahee Park; Chang Ho Ahn; Taebum Lee; Richard S. Finn; Chan-Young Ock; Jinho Shin; Changhoon Yoo
Effectiveness of PARP Inhibitor Maintenance Therapy in Ovarian Cancer by BRCA1/2 and a Scar-Based HRD Signature in Real-World Practice
Debra L. Richardson; Julia C. F. Quintanilha; Natalie Danziger; Gerald Li; Ethan Sokol; Alexa B. Schrock; Ericka Ebot; Neeru Bhardwaj; Tanesha Norris; Anosheh Afghahi; Anthony Frachioni; Christina Washington; Lauren Dockery; Julia Elvin; Ryon P. Graf; Kathleen N. Moore
Metabolomic Prediction of Breast Cancer Treatment–Induced Neurologic and Metabolic Toxicities
Max Piffoux; Jérémie Jacquemin; Mélanie Pétéra; Stéphanie Durand; Angélique Abila; Delphine Centeno; Charlotte Joly; Bernard Lyan; Anne-Laure Martin; Sibille Everhard; Sandrine Boyault; Barbara Pistilli; Marion Fournier; Philippe Rouanet; Julie Havas; Baptiste Sauterey; Mario Campone; Carole Tarpin; Marie-Ange Mouret-Reynier; Olivier Rigal; Thierry Petit; Christine Lasset; Aurélie Bertaut; Paul Cottu; Fabrice André; Ines Vaz-Luis; Estelle Pujos-Guillot; Youenn Drouet; Olivier Trédan
Translational Cancer Mechanisms and Therapy
Clinical and Molecular Risk Factors in Extracranial Malignant Rhabdoid Tumors: Toward an Integrated Model of High-Risk Tumors
Victoria E. Fincke; Mona Steinbügl; Hye-Jung E. Chun; Karolina Nemes; Marlena Mucha; Maurice Loßner; Felix Dorn; Katharina Gastberger; Sebastian Bühner; Martin Sill; Thomas Kröncke; Reiner Siebert; Patrick Melchior; Rhoikos Furtwängler; Matthias Schlesner; Christian Vokuhl; Christoph Röcken; Pascal D. Johann; Michael C. Frühwald
HER2 Antibody–Drug Conjugates Are Active against Desmoplastic Small Round Cell Tumor
Tom Zhang; Christopher A. Febres-Aldana; Zebing Liu; Jenna-Marie Dix; Ryan Cheng; Raymond G. Dematteo; Allan J.W. Lui; Inna Khodos; Leo Gili; Marissa S. Mattar; Jeanine Lisanti; Charlene Kwong; Irina Linkov; Murray J. Tipping; Elisa de Stanchina; Igor Odintsov; Marc Ladanyi; Romel Somwar
Tumor-Secreted Extracellular Vesicles Counteract Therapy Response by Triggering Inflammatory Mesenchymal Stem Cell Development
Crescenzo Massaro; Hilal N. Sensoy; Manon Mulders; Celine De Schrijver; Cristina Gómez-Martín; Juan Simon Nieto; Tonny Lagerweij; Alisha Atmopawiro; Jennifer Pérez-Boza; Maarten Bebelman; Leontien Bosch; Simone Foderaro; Mafalda Neves Ferreira; Monique A.J. van Eijndhoven; Jan R.T. van Weering; Carmela Dell’Aversana; Lucia Altucci; Cemile Dilara Savci-Heijink; Niels W.C.J. van de Donk; Cristina Giorgio; Laura Brandolini; Marcello Allegretti; Dirk Michiel Pegtel; Serena Rubina Baglio
YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities
C. Allison Stewart; Lixia Diao; Yuanxin Xi; Runsheng Wang; Kavya Ramkumar; Alejandra G. Serrano; Azusa Tanimoto; B. Leticia Rodriguez; Benjamin B. Morris; Li Shen; Bingnan Zhang; Yan Yang; Samera H. Hamad; Robert J. Cardnell; Alberto Duarte, Jr; Moushumi Sahu; Veronica Y. Novegil; Bernard E. Weissman; Michael Frumovitz; Neda Kalhor; Luisa Solis Soto; Pedro da Rocha; Natalie Vokes; Don L. Gibbons; Jing Wang; John V. Heymach; Bonnie Glisson; Lauren Averett Byers; Carl M. Gay
KIR2DL2/DL3+NKs and Helios+Tregs in Peripheral Blood Predict Nivolumab Response in Patients with Metastatic Renal Cell Cancer
Sara Santagata; Anna Maria Trotta; Crescenzo D’Alterio; Maria Napolitano; Giuseppina Rea; Marilena Di Napoli; Luigi Portella; Caterina Ieranò; Giuseppe Guardascione; Elisabetta Coppola; Christophe Caux; Bertrand Dubois; Helen J. Boyle; Joan Carles; Sabrina Rossetti; Rosa Azzaro; Florinda Feroce; Sisto Perdonà; Mario Fordellone; Anna Maria Bello; Daniela Califano; Paolo Chiodini; Sandro Pignata; Stefania Scala
Integrative Multiomic Profiling of Triple-Negative Breast Cancer for Identifying Suitable Therapies
Bojana Jovanović; Sarah E. Church; Kara M. Gorman; Khrystyna North; Edward T. Richardson, III; Molly DiLullo; Victoria Attaya; Julie Kasparian; Ayesha Mohammed-Abreu; Gregory Kirkner; Melissa E. Hughes; Nancy U. Lin; Elizabeth A. Mittendorf; Stuart J. Schnitt; Sara M. Tolaney; Shom Goel
Proportional Hazards Violations in Phase III Cancer Clinical Trials: A Potential Source of Trial Misinterpretation
Timothy A. Lin; Zachary R. McCaw; Alex Koong; Christine Lin; Joseph Abi Jaoude; Roshal Patel; Ramez Kouzy; Molly B. El Alam; Alexander D. Sherry; Sonal S. Noticewala; Clifton D. Fuller; Charles R. Thomas, Jr; Ryan Sun; J. Jack Lee; Ruitao Lin; Ying Yuan; Yu Shyr; Tomer Meirson; Ethan B. Ludmir
Editor’s Note
Retractions
Retraction: KMT2C Mutations in Diffuse-Type Gastric Adenocarcinoma Promote Epithelial-to-Mesenchymal Transition
Soo-Jeong Cho; Changhwan Yoon; Jun Ho Lee; Kevin K. Chang; Jian-xian Lin; Young-Ho Kim; Myeong-Cherl Kook; Bülent Arman Aksoy; Do Joong Park; Hassan Ashktorab; Duane T. Smoot; Nikolaus Schultz; Sam S. Yoon
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