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1 October 2024
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Cover Image
Cover Image
The cover image features a section of a resection specimen from a patient with undifferentiated pleomorphic sarcoma (UPS). Multiplex immunofluorescence staining highlights the diverse cell populations within the tumor microenvironment. For further details, refer to the article by Luthria and colleagues on page 4530 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
CCR Translations
CCR Drug Updates
FDA Approval Summary: Asciminib for Ph+ CML in Chronic Phase Treated with Two or More Tyrosine Kinase Inhibitors and for the T315I Mutation
Gulsum E. Pamuk; Edwin C.Y. Chow; Alexei C. Ionan; Haiyan Chen; Shwu-Luan Lee; Vicky Hsu; Manuela Grimstein; Nan Zheng; Jielin Sun; Rosane Charlab; Brenda J. Gehrke; Jonathon Vallejo; Lori A. Ehrlich; R. Angelo de Claro; Marc R. Theoret
Reviews
Update on Recommendations for Surveillance for Children with Predisposition to Hematopoietic Malignancy
Luke D. Maese; Marcin W. Wlodarski; Sun Young Kim; Alison A. Bertuch; Gaelle Bougeard; Vivian Y. Chang; Lucy A. Godley; Payal P. Khincha; Roland P. Kuiper; Harry Lesmana; Rose B. McGee; Lisa J. McReynolds; Julia Meade; Sharon E. Plon; Sharon A. Savage; Sarah R. Scollon; Hamish S. Scott; Michael F. Walsh; Kim E. Nichols; Christopher C. Porter
Special Report
Clinical Trials: Targeted Therapy
Elacestrant in ER+, HER2− Metastatic Breast Cancer with ESR1-Mutated Tumors: Subgroup Analyses from the Phase III EMERALD Trial by Prior Duration of Endocrine Therapy plus CDK4/6 Inhibitor and in Clinical Subgroups
Aditya Bardia; Javier Cortés; François-Clément Bidard; Patrick Neven; José Garcia-Sáenz; Phillipe Aftimos; Joyce O’Shaughnessy; Janice Lu; Giulia Tonini; Simona Scartoni; Alessandro Paoli; Monica Binaschi; Tomer Wasserman; Virginia Kaklamani
Abiraterone, Olaparib, or Abiraterone + Olaparib in First-Line Metastatic Castration-Resistant Prostate Cancer with DNA Repair Defects (BRCAAway)
Maha Hussain; Masha Kocherginsky; Neeraj Agarwal; Nabil Adra; Jingsong Zhang; Channing J. Paller; Joel Picus; Zachery R. Reichert; Russell Z. Szmulewitz; Scott T. Tagawa; Timothy M. Kuzel; Latifa A. Bazzi; Stephanie Daignault-Newton; Young E. Whang; Robert Dreicer; Ryan D. Stephenson; Matthew B. Rettig; Daniel Shevrin; Travis Gerke; Arul M. Chinnaiyan; Emmanuel S. Antonarakis
Ipatasertib plus Paclitaxel for Patients with PIK3CA/AKT1/PTEN-Altered Locally Advanced Unresectable or Metastatic Triple-Negative Breast Cancer in the IPATunity130 Phase III Trial
Rebecca A. Dent; Sung-Bae Kim; Mafalda Oliveira; Carlos Barrios; Joyce O’Shaughnessy; Steven J. Isakoff; Shigehira Saji; Ruffo Freitas-Junior; Manuel Philco; Igor Bondarenko; Qinshu Lian; Denise Bradley; Heather Hinton; Matthew J. Wongchenko; Sarah-Jayne Reilly; Nicholas Turner
Clinical Trials: Immunotherapy
The Innate Immune Landscape of dMMR/MSI Cancers Predicts the Outcome of Nivolumab Treatment: Results from the Drug Rediscovery Protocol
Laurien J. Zeverijn; Birgit S. Geurts; Thomas W. Battaglia; Jade M. van Berge Henegouwen; Gijs F. de Wit; Louisa R. Hoes; Hanneke van der Wijngaart; Vincent van der Noort; Paul Roepman; Wendy W.J. de Leng; Anne M.L. Jansen; Myriam Chalabi; Carla M.L. van Herpen; Lot A. Devriese; Frans L.G. Erdkamp; Mariette Labots; Maja J.A. de Jonge; Emile D. Kerver; Adriaan D. Bins; Lindsay V.M. Leek; Jessica C.L. Notohardjo; Alfonsus J.M. van den Eertwegh; Lodewyk F.A. Wessels; Henk M.W. Verheul; Hans Gelderblom; Joris van de Haar; Emile E. Voest
Precision Medicine and Imaging
Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics
R. Taylor Sundby; Jeffrey J. Szymanski; Alexander C. Pan; Paul A. Jones; Sana Z. Mahmood; Olivia H. Reid; Divya Srihari; Amy E. Armstrong; Stacey Chamberlain; Sanita Burgic; Kara Weekley; Béga Murray; Sneh Patel; Faridi Qaium; Andrea N. Lucas; Margaret Fagan; Anne Dufek; Christian F. Meyer; Natalie B. Collins; Christine A. Pratilas; Eva Dombi; Andrea M. Gross; AeRang Kim; John S.A. Chrisinger; Carina A. Dehner; Brigitte C. Widemann; Angela C. Hirbe; Aadel A. Chaudhuri; Jack F. Shern
Colorectal Cancer Recurrence Prediction Using a Tissue-Free Epigenomic Minimal Residual Disease Assay
Yoshiaki Nakamura; Yuichiro Tsukada; Nobuhisa Matsuhashi; Tatsuro Murano; Manabu Shiozawa; Yusuke Takahashi; Eiji Oki; Masahiro Goto; Yoshinori Kagawa; Akiyoshi Kanazawa; Takashi Ohta; Akira Ouchi; Hideaki Bando; Hiroshi Uchigata; Chiemi Notake; Hiroaki Ikematsu; Takayuki Yoshino
Pharmacogenomic Score Effectively Personalizes Treatment of Acute Myeloid Leukemia
Richard J. Marrero; Huiyun Wu; Xueyuan Cao; Phani Krishna Parcha; Abdelrahman H. Elsayed; Hiroto Inaba; Dennis John Kuo; Barbara A. Degar; Kenneth Heym; Jeffrey W. Taub; Norman Lacayo; Ching-Hon Pui; Raul C. Ribeiro; Jeffrey E. Rubnitz; Stanley B. Pounds; Jatinder K. Lamba
Transcriptional Phenocopies of Deleterious KEAP1 Mutations Correlate with Survival Outcomes in Lung Cancer Treated with Immunotherapy
Stefano Scalera; Biagio Ricciuti; Daniele Marinelli; Marco Mazzotta; Laura Cipriani; Giulia Bon; Giulia Schiavoni; Irene Terrenato; Alessandro Di Federico; Joao V. Alessi; Maurizio Fanciulli; Ludovica Ciuffreda; Francesca De Nicola; Frauke Goeman; Giulio Caravagna; Daniele Santini; Ruggero De Maria; Federico Cappuzzo; Gennaro Ciliberto; Mariam Jamal-Hanjani; Mark M. Awad; Nicholas McGranahan; Marcello Maugeri-Saccà
Tyrosine Protein Kinase SYK-Related Gene Signature in Baseline Immune Cells Associated with Adjuvant Immunotherapy–Induced Immune-Related Adverse Events in Melanoma
Kelsey R. Monson; Robert Ferguson; Joanna E. Handzlik; Jiahan Xiong; Sasha Dagayev; Leah Morales; Vylyny Chat; Anabelle Bunis; Chaitra Sreenivasaiah; Sonia Dolfi; Daniel J. Tenney; Yongzhao Shao; Iman Osman; Jeffrey S. Weber; Tomas Kirchhoff
Translational Cancer Mechanisms and Therapy
Redirecting B7-H3.CAR T Cells to Chemokines Expressed in Osteosarcoma Enhances Homing and Antitumor Activity in Preclinical Models
Lindsay J. Talbot; Ashley Chabot; Aaron B. Ross; Alexandra Beckett; Phuong Nguyen; Andrew Fleming; Peter J. Chockley; Heather Shepphard; Jian Wang; Stephen Gottschalk; Christopher DeRenzo
Targeting the Dendritic Cell-Secreted Immunoregulatory Cytokine CCL22 Alleviates Radioresistance
Jason Bugno; Liangliang Wang; Xianbin Yu; Xuezhi Cao; Jiaai Wang; Xiaona Huang; Kaiting Yang; Andras Piffko; Katherine Chen; Stephen Y. Luo; Emile Naccasha; Yuzhu Hou; Sherry Fu; Chuan He; Yang-xin Fu; Hua L. Liang; Ralph R. Weichselbaum
Pharmacologic Inhibition of EIF4A Blocks NRF2 Synthesis to Prevent Osteosarcoma Metastasis
Michael M. Lizardo; Christopher Hughes; Yue Z. Huang; Taras Shyp; Alberto Delaidelli; Hai-Feng Zhang; Sol Snir Shaool; Annalena F. Renner; Farez Burwag; Leanne C. Sayles; Alex G. Lee; Alejandro Sweet-Cordero; Poul H. Sorensen
Genomic Profiling to Contextualize the Results of Intervention for Smoldering Multiple Myeloma
Dickran Kazandjian; Benjamin Diamond; Marios Papadimitriou; Elizabeth Hill; Romanos Sklavenitis-Pistofidis; Bachisio Ziccheddu; Patrick Blaney; Monika Chojnacka; Michael Durante; Kylee Maclachlan; Ryan Young; Saad Usmani; Faith Davies; Gad Getz; Irene Ghobrial; Neha Korde; Gareth Morgan; Francesco Maura; Ola Landgren
Clinical Value of Liquid Biopsy in Patients with FGFR2 Fusion–Positive Cholangiocarcinoma During Targeted Therapy
Alberto González-Medina; Maria Vila-Casadesús; Marina Gomez-Rey; Carles Fabregat-Franco; Alexandre Sierra; Tian V. Tian; Florian Castet; Gloria Castillo; Judit Matito; Paola Martinez; Josep M. Miquel; Paolo Nuciforo; Raquel Pérez-López; Teresa Macarulla; Ana Vivancos
Cervical Cancer Evades the Host Immune System through the Inhibition of Type I Interferon and CXCL9 by LIF
Ester Bonfill-Teixidor; Almudena Neva-Alejo; Alexandra Arias; Isabel Cuartas; Raffaella Iurlaro; Ester Planas-Rigol; Laura Solé; Irene Pecharromán; Silvia Cabrera; Ángel García; David Garcia-Illescas; Lluís Espinosa; Antonio Gil-Moreno; Ana Oaknin; Joan Seoane
Single-Cell Profiling of Sarcomas from Archival Tissue Reveals Programs Associated with Resistance to Immune Checkpoint Blockade
Karan Luthria; Parin Shah; Blake Caldwell; Johannes C. Melms; Sinan Abuzaid; Viktoria Jakubikova; D. Zack Brodtman; Sminu Bose; Amit Dipak Amin; Patricia Ho; Jana Biermann; Somnath Tagore; Matthew Ingham; Gary K. Schwartz; Benjamin Izar
Correction
Correction: Randomized Phase II Trial of Dendritic Cell/Myeloma Fusion Vaccine with Lenalidomide Maintenance after Upfront Autologous Hematopoietic Cell Transplantation for Multiple Myeloma: BMT CTN 1401
David J. Chung; Nina Shah; Juan Wu; Brent Logan; Lina Bisharat; Natalie Callander; Giulia Cheloni; Kenneth Anderson; Thinle Chodon; Binod Dhakal; Steve Devine; Poorvi Somaiya Dutt; Yvonne Efebera; Nancy Geller; Haider Ghiasuddin; Peiman Hematti; Leona Holmberg; Alan Howard; Bryon Johnson; Dimitra Karagkouni; Hillard M. Lazarus; Ehsan Malek; Philip McCarthy; David McKenna; Adam Mendizabal; Ajay Nooka; Nikhil Munshi; Lynn O’Donnell; Krina Patel; Aaron P. Rapoport; Jane Reese; Jacalyn Rosenblatt; Robert Soiffer; Dina Stroopinsky; Lynne Uhl; Ioannis S. Vlachos; Edmund K. Waller; James W. Young; Marcelo C. Pasquini; David Avigan
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