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1 September 2024
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Cover Image
Cover Image
The cover shows a multiplexed immunofluorescence image of a lymph node biopsy from a patient with syncytial classic Hodgkin lymphoma. The malignant Hodgkin Reed-Sternberg cells (red) are surrounded by B cells (yellow), T cells (magenta), and B7-H3 (white) positive myeloid cells (cyan). For details, see the article by Pourmaleki and colleagues on page 3881 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Issue Sections
CCR Translations
CCR Perspectives in Regulatory Science and Policy
Perspectives on Drug Development for the Treatment of Chronic Myeloid Leukemia in Pregnant Patients and Patients Who Are Breastfeeding
Jorge E. Cortes; Elisabetta Abruzzese; Elyce H. Cardonick; Sonia Hernández-Díaz; Jamie Gutierrez; Mary S. Sardegna; Erica Torres-Chavez; Miriam Dinatale; Catherine C. Lerro; Brenda J. Gehrke; Stacy S. Shord; R. Angelo De Claro; Marc R. Theoret; Peter J. DeMaria; Kelly J. Norsworthy
Reviews
Research Briefs: Clinical Trial Brief Reports
A Phase I/II Study of Valemetostat (DS-3201b), an EZH1/2 Inhibitor, in Combination with Irinotecan in Patients with Recurrent Small-Cell Lung Cancer
Noura J. Choudhury; W. Victoria Lai; Alex Makhnin; Glenn Heller; Juliana Eng; Bob Li; Isabel Preeshagul; Fernando C. Santini; Michael Offin; Kenneth Ng; Paul Paik; Christina Larsen; Michelle S. Ginsberg; Yvonne Lau; Xinyuan Zhang; Marina K. Baine; Natasha Rekhtman; Charles M. Rudin
Clinical Trials: Targeted Therapy
Ibrutinib in Combination with R-GemOx in Patients with Relapsed or Refractory Diffuse Large B-cell Lymphoma of Nongerminal Center B-cell–like Type: Phase II Clinical Trial of the Spanish GELTAMO Group
Beatriz Rey-Búa; Carlos Grande; José J. Sánchez Blanco; Pau Abrisqueta; Antonio Gutiérrez; Ángel Ramírez Páyer; Eva Giné; Izaskun Zeberio Etxetxipia; Maria J. Terol; Fátima de la Cruz Vicente; Rafel Andreu; Maria J. Ramirez; Adolfo de la Fuente; Maria C. Viguria; María J. Peñarrubia; Ana Jiménez-Ubieto; Santiago Montes-Moreno; Armando López-Guillermo; María D. Caballero; Alejandro Martín García-Sancho
Clinical Trials: Immunotherapy
Safety, Efficacy, and Biological Data of T-Cell–Enabling Oncolytic Adenovirus TILT-123 in Advanced Solid Cancers from the TUNIMO Monotherapy Phase I Trial
Santeri A. Pakola; Katriina J. Peltola; James H.A. Clubb; Elise Jirovec; Lyna Haybout; Tatiana V. Kudling; Tuomo Alanko; Riitta Korpisaari; Susanna Juteau; Marjut Jaakkola; Jorma Sormunen; Jukka Kemppainen; Annabrita Hemmes; Teijo Pellinen; Mirte van der Heijden; Dafne C.A. Quixabeira; Claudia Kistler; Suvi Sorsa; Riikka Havunen; Joao M. Santos; Victor Cervera-Carrascon; Akseli Hemminki
Eftilagimod Alpha (Soluble LAG3 Protein) Combined with Pembrolizumab as Second-Line Therapy for Patients with Metastatic Head and Neck Squamous Cell Carcinoma
Martin Forster; Irene Brana; Antonio L. Pousa; Bernard Doger; Patricia Roxburgh; Pawan Bajaj; Julio Peguero; Matthew Krebs; Enric Carcereny; Grisma Patel; Christian Mueller; Chrystelle Brignone; Frederic Triebel
Efficacy of Pembrolizumab and Biomarker Analysis in Patients with WGS-Based Intermediate to High Tumor Mutational Load: Results from the Drug Rediscovery Protocol
Birgit S. Geurts; Laurien J. Zeverijn; Lindsay V.M. Leek; Jade M. van Berge Henegouwen; Louisa R. Hoes; Hanneke van der Wijngaart; Vincent van der Noort; Joris van de Haar; Annemiek van Ommen-Nijhof; Marleen Kok; Paul Roepman; Anne M.L. Jansen; Wendy W.J. de Leng; Maja J.A. de Jonge; Ann Hoeben; Carla M.L. van Herpen; Hans M. Westgeest; Lodewyk F.A. Wessels; Henk M.W. Verheul; Hans Gelderblom; Emile E. Voest
Combination Targeted Therapy with Pembrolizumab and Lenvatinib in Progressive, Radioiodine-Refractory Differentiated Thyroid Cancers
Jena D. French; Bryan R. Haugen; Francis P. Worden; Daniel W. Bowles; Andrew G. Gianoukakis; Bhavana Konda; Ramona Dadu; Eric J. Sherman; Shaylene McCue; Nathan R. Foster; Yuri E. Nikiforov; Ticiana D.J. Farias; Paul J. Norman; Lori J. Wirth
A Phase II Study of Potentiation of Pembrolizumab with Binimetinib and Bevacizumab in Refractory Microsatellite-Stable Colorectal Cancer
Robert W. Lentz; Tyler J. Friedrich; Patrick J. Blatchford; Kimberly R. Jordan; Todd M. Pitts; Hannah R. Robinson; S. Lindsey Davis; Sunnie S. Kim; Alexis D. Leal; Mathew R. Lee; Meredith R.N. Waring; Anne C. Martin; Adrian T.A. Dominguez; Stacey M. Bagby; Sarah J. Hartman; S. Gail Eckhardt; Wells A. Messersmith; Christopher H. Lieu
Research Briefs: Precision Medicine and Therapeutics
Computational Model Predicts Patient Outcomes in Luminal B Breast Cancer Treated with Endocrine Therapy and CDK4/6 Inhibition
Leonard Schmiester; Fara Brasó-Maristany; Blanca González-Farré; Tomás Pascual; Joaquín Gavilá; Xavier Tekpli; Jürgen Geisler; Vessela N. Kristensen; Arnoldo Frigessi; Aleix Prat; Alvaro Köhn-Luque
Precision Medicine and Imaging
Circulating Tumor DNA Dynamics Reveal KRAS G12C Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors
Yoonha Choi; Neekesh V. Dharia; Tomi Jun; Julie Chang; Stephanie Royer-Joo; Kenneth K. Yau; Zoe J. Assaf; Junko Aimi; Smruthy Sivakumar; Meagan Montesion; Adrian Sacher; Patricia LoRusso; Jayesh Desai; Jennifer L. Schutzman; Zhen Shi; and the GO42144 study group
Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling
Talal El Zarif; Catherine B. Meador; Xintao Qiu; Ji-Heui Seo; Matthew P. Davidsohn; Hunter Savignano; Gitanjali Lakshminarayanan; Heather M. McClure; John Canniff; Brad Fortunato; Rong Li; Mandeep K. Banwait; Karl Semaan; Marc Eid; Henry Long; Yin P. Hung; Navin R. Mahadevan; David A. Barbie; Matthew G. Oser; Zofia Piotrowska; Toni K. Choueiri; Sylvan C. Baca; Aaron N. Hata; Matthew L. Freedman; Jacob E. Berchuck
Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets
Monica F. Chen; Soo-Ryum Yang; Jessica J. Tao; Antoine Desilets; Eli L. Diamond; Clare Wilhelm; Ezra Rosen; Yixiao Gong; Kerry Mullaney; Jean Torrisi; Robert J. Young; Romel Somwar; Helena A. Yu; Mark G. Kris; Gregory J. Riely; Maria E. Arcila; Marc Ladanyi; Mark T.A. Donoghue; Neal Rosen; Rona Yaeger; Alexander Drilon; Yonina R. Murciano-Goroff; Michael Offin
Streamlined Intraoperative Brain Tumor Classification and Molecular Subtyping in Stereotactic Biopsies Using Stimulated Raman Histology and Deep Learning
David Reinecke; Daniel Ruess; Anna-Katharina Meissner; Gina Fürtjes; Niklas von Spreckelsen; Adrian Ion-Margineanu; Florian Khalid; Tobias Blau; Thomas Stehle; Abdulkader Al-Shugri; Reinhard Büttner; Roland Goldbrunner; Maximilian I. Ruge; Volker Neuschmelting
Differences in the Prognostic Role of Age, Extent of Resection, and Tumor Grade between Astrocytoma IDHmt and Oligodendroglioma: A Single-Center Cohort Study
Thijs van der Vaart; Maarten M.J. Wijnenga; Karin van Garderen; Hendrikus J. Dubbink; Pim J. French; Marion Smits; Clemens M.F. Dirven; Johan M. Kros; Arnaud J.P.E. Vincent; Martin J. van den Bent
Translational Cancer Mechanisms and Therapy
Targeting AKR1B10 by Drug Repurposing with Epalrestat Overcomes Chemoresistance in Non–Small Cell Lung Cancer Patient-Derived Tumor Organoids
Kanve N. Suvilesh; Yariswamy Manjunath; Yulia I. Nussbaum; Mohamed Gadelkarim; Murugesan Raju; Akhil Srivastava; Guangfu Li; Wesley C. Warren; Chi-Ren Shyu; Feng Gao; Matthew A. Ciorba; Jonathan B. Mitchem; Satyanarayana Rachagani; Jussuf T. Kaifi
An Analysis of PIK3CA Hotspot Mutations and Response to Neoadjuvant Therapy in Patients with Breast Cancer from Four Prospective Clinical Trials
Paul Jank; Thomas Karn; Marion van Mackelenbergh; Judith Lindner; Denise Treue; Jens Huober; Knut Engels; Christine Solbach; Kurt Diebold; Frederik Marmé; Volkmar Müller; Andreas Schneeweiss; Hans-Peter Sinn; Tanja Fehm; Christian Schem; Elmar Stickeler; Peter Fasching; Jan Budczies; Bärbel Felder; Valentina Nekljudova; Johannes Holtschmidt; Michael Untch; Carsten Denkert; Sibylle Loibl
Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma
Maryam Pourmaleki; Caitlin J. Jones; Sabrina D. Mellinghoff; Brian D. Greenstein; Priyadarshini Kumar; Miguel Foronda; Daniel A. Navarrete; Carl Campos; Mikhail Roshal; Nikolaus Schultz; Sohrab P. Shah; Andrea Schietinger; Nicholas D. Socci; Travis J. Hollmann; Ahmet Dogan; Ingo K. Mellinghoff
Microsatellite Instability, Tumor Mutational Burden, and Response to Immune Checkpoint Blockade in Patients with Prostate Cancer
Andrew T. Lenis; Vignesh Ravichandran; Samantha Brown; Syed M. Alam; Andrew Katims; Hong Truong; Peter A. Reisz; Samantha Vasselman; Barbara Nweji; Karen A. Autio; Michael J. Morris; Susan F. Slovin; Dana Rathkopf; Daniel Danila; Sungmin Woo; Hebert A. Vargas; Vincent P. Laudone; Behfar Ehdaie; Victor Reuter; Maria Arcila; Michael F. Berger; Agnes Viale; Howard I. Scher; Nikolaus Schultz; Anuradha Gopalan; Mark T.A. Donoghue; Irina Ostrovnaya; Konrad H. Stopsack; David B. Solit; Wassim Abida
Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma
Horace H.Y. Lee; Kin Long Chow; Ho Shing Wong; Tsz Yan Chong; Alice S.T. Wong; Grace H.W. Cheng; Jasmine M.K. Ko; Hoi Cheong Siu; Maximus C.F. Yeung; Michael S.Y. Huen; Ka Yu Tse; Mark R. Bray; Tak Wah Mak; Suet Yi Leung; Philip P.C. Ip
Identification of Therapy-Induced Clonal Evolution and Resistance Pathways in Minimal Residual Clones in Multiple Myeloma through Single-Cell Sequencing
Jian Cui; Xiaoyun Li; Shuhui Deng; Chenxing Du; Huishou Fan; Wenqiang Yan; Jingyu Xu; Xiaoqing Li; Tengteng Yu; Shuaishuai Zhang; Rui Lv; Weiwei Sui; Mu Hao; Xin Du; Yan Xu; Shuhua Yi; Dehui Zou; Tao Cheng; Lugui Qiu; Xin Gao; Gang An
Maximizing Treatment Opportunities: Assessing Protocol Waivers’ Impact on Safety and Outcome in the Drug Rediscovery Protocol
Jade M. van Berge Henegouwen; Laurien J. Zeverijn; Birgit S. Geurts; Louisa R. Hoes; Hanneke van der Wijngaart; Vincent van der Noort; Alwin D.R. Huitema; Filip Y.F. de Vos; Katrien Grünberg; Haiko J. Bloemendal; Henk M.W. Verheul; Emile E. Voest; Hans Gelderblom
Increased PVR Expression on Bone Marrow Macrophages May Promote Resistance to TIGIT Blockade in Multiple Myeloma
Ester Lozano; Mari-Pau Mena; Glòria Garrabou; Oriol Cardús; Tania Díaz; David F. Moreno; Joan Mañé-Pujol; Aina Oliver-Caldés; Anthony Battram; Natalia Tovar; María-Teresa Cibeira; Luis-Gerardo Rodríguez-Lobato; Joan Bladé; Carlos Fernández de Larrea; Laura Rosiñol
Corrections
Correction: Phase I/Ib Clinical Trial of Sabatolimab, an Anti–TIM-3 Antibody, Alone and in Combination with Spartalizumab, an Anti–PD-1 Antibody, in Advanced Solid Tumors
Giuseppe Curigliano; Hans Curigliano; Nicolas Mach; Toshihiko Doi; David Tai; Patrick M. Forde; John Sarantopoulos; Philippe L. Bedard; Chia-Chi Lin; F. Stephen Hodi; Sofie Wilgenhof; Armando Santoro; Catherine A. Sabatos-Peyton; Tyler A. Longmire; Alexandros Xyrafas; Haiying Sun; Sabine Gutzwiller; Luigi Manenti; Aung Naing
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