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15 August 2024
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Cover Image
Cover Image
The cover shows a retinal section of a retinoblastoma-bearing mouse treated with intravenous GPC2-directed CAR T cells. Immunohistochemical staining shows substantial intraocular GPC2 CAR T-cell infiltration selectively to the tumor-involved eye quantified by human CD3. For details, see the article by Pascual-Pasto and colleagues on page 3578 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Issue Sections
CCR Translations
CCR Drug Updates
FDA Approval Summary: Repotrectinib for Locally Advanced or Metastatic ROS1-Positive Non–Small Cell Lung Cancer
Michael I. Barbato; Diana Bradford; Yi Ren; Stephanie L. Aungst; Claudia P. Miller; Lili Pan; Jeanne F. Zirkelbach; Yangbing Li; Youwei Bi; Jianghong Fan; Manuela Grimstein; Sarah E. Dorff; Anup K. Amatya; Pallavi S. Mishra-Kalyani; Barbara Scepura; Peter Schotland; Opeyemi Udoka; Idara Ojofeitimi; John K. Leighton; Nam A. Rahman; Richard Pazdur; Harpreet Singh; Paul G. Kluetz; Nicole Drezner
FDA Approval Summary: Durvalumab and Pembrolizumab, Immune Checkpoint Inhibitors for the Treatment of Biliary Tract Cancer
Sandra J. Casak; Vaibhav Kumar; Chi Song; Mengdie Yuan; Anup K. Amatya; Joyce Cheng; Pallavi S. Mishra-Kalyani; Shenghui Tang; Steven J. Lemery; Doris Auth; Gina Davis; Paul G. Kluetz; Richard Pazdur; Lola A. Fashoyin-Aje
Review
Clinical Updates and Surveillance Recommendations for DNA Replication Repair Deficiency Syndromes in Children and Young Adults
Anirban Das; Suzanne P. MacFarland; Julia Meade; Jordan R. Hansford; Kami W. Schneider; Roland P. Kuiper; Marjolijn C.J. Jongmans; Harry Lesmana; Kris Ann P. Schultz; Kim E. Nichols; Carol Durno; Kristin Zelley; Christopher C. Porter; Lisa J. States; Shay Ben-Shachar; Sharon A. Savage; Jennifer M. Kalish; Michael F. Walsh; Hamish S. Scott; Sharon E. Plon; Uri Tabori
Perspectives
Biological Sample Collection to Advance Research and Treatment: A Fight Osteosarcoma Through European Research and Euro Ewing Consortium Statement
Darrell Green; Roelof van Ewijk; Elisa Tirtei; Dimosthenis Andreou; Fredrik Baecklund; Daniel Baumhoer; Stefan S. Bielack; Rajesh Botchu; Kjetil Boye; Bernadette Brennan; Michael Capra; Lucia Cottone; Uta Dirksen; Franca Fagioli; Natalia Fernandez; Adrienne M. Flanagan; Marco Gambarotti; Nathalie Gaspar; Hans Gelderblom; Craig Gerrand; Anne Gomez-Mascard; Jendrik Hardes; Stefanie Hecker-Nolting; Edita Kabickova; Leo Kager; Jukka Kanerva; Lennart A. Kester; Marieke L. Kuijjer; Valérie Laurence; Cyril Lervat; Antonin Marchais; Perrine Marec-Berard; Cristina Mendes; Johannes H.M. Merks; Benjamin Ory; Emanuela Palmerini; Pan Pantziarka; Evgenia Papakonstantinou; Sophie Piperno-Neumann; Anna Raciborska; Elizabeth A. Roundhill; Vilma Rutkauskaite; Akmal Safwat; Katia Scotlandi; Eric L. Staals; Sandra J. Strauss; Didier Surdez; Gwen M.L. Sys; Marie-Dominique Tabone; Maud Toulmonde; Claudia Valverde; Michiel A.J. van de Sande; Klaus Wörtler; Quentin Campbell-Hewson; Martin G. McCabe; Michaela Nathrath
Research Briefs: Clinical Trial Brief Reports
Early On-Treatment Assessment of T Cells, Cytokines, and Tumor DNA with Adaptively Dosed Nivolumab + Ipilimumab: Final Results from the Phase 2 ADAPT-IT Study
James W. Smithy; Hannah L. Kalvin; Fiona D. Ehrich; Ronak Shah; Matthew Adamow; Vladislav Raber; Collen A. Maher; Jenna Kleman; Deborah A.G. McIntyre; Alexander N. Shoushtari; Allison Betof Warner; Margaret K. Callahan; Parisa Momtaz; Omar Eton; Suresh Nair; Jedd D. Wolchok; Paul B. Chapman; Michael F. Berger; Katherine S. Panageas; Michael A. Postow
Clinical Trials: Targeted Therapy
Apalutamide and Goserelin for Androgen Receptor–Positive Salivary Gland Carcinoma: A Phase II Nonrandomized Clinical Trial, YATAGARASU
Yoshitaka Honma; Nobuya Monden; Keisuke Yamazaki; Satoshi Kano; Hironaga Satake; Shigenori Kadowaki; Yoshitaka Utsumi; Tomohiko Nakatogawa; Ryo Takano; Koji Fujii; Yosuke Koroki; Junya Aoyama; Shohei Ouchi; Tetsuro Ogawa; Sharon McCarthy; Sabine D. Brookman-May; Suneel Mundle; Jinhui Li; Daksh Thaper; Toshitaka Nagao; Yuichiro Tada
Clinical Trials: Immunotherapy
Nivolumab with or without Ipilimumab Combined with Stereotactic Body Radiotherapy in Patients with Metastatic Biliary Tract Cancer: A Randomized Phase 2 Study
Alice Markussen; Julia S. Johansen; Finn O. Larsen; Susann Theile; Jane P. Hasselby; Gro L. Willemoe; Torben Lorentzen; Kasper Madsen; Estrid Høgdall; Tim S. Poulsen; Eva E. Wilken; Poul Geertsen; Claus P. Behrens; Inge M. Svane; Dorte Nielsen; Inna M. Chen
Intraperitoneal Nivolumab after Debulking Surgery and Hyperthermic Intraperitoneal Chemotherapy in Advanced Ovarian Cancer: A Phase I Study with Expansion Cohort
Pauline Corbaux; Gilles Freyer; Olivier Glehen; Benoît You; Naoual Bakrin; Audrey Gelot; David Dayde; Christophe Sajous; Max Piffoux; Julien Péron; Gaelle Lescuyer; Lea Payen; Vahan Kepenekian
Research Briefs: Precision Medicine and Therapeutics
Precision Medicine and Imaging
Tissue-Free Liquid Biopsies Combining Genomic and Methylation Signals for Minimal Residual Disease Detection in Patients with Early Colorectal Cancer from the UK TRACC Part B Study
Susanna Slater; Annette Bryant; Maria Aresu; Ruwaida Begum; Hsiang-Chi Chen; Clare Peckitt; Retchel Lazaro-Alcausi; Paul Carter; Gayathri Anandappa; Shelize Khakoo; Lucinda Melcher; Vanessa Potter; Francisca M. Marti; Joesph Huang; Graham Branagan; Nicol George; Muti Abulafi; Sarah Duff; Ashraf Raja; Ashish Gupta; Nicholas West; Leslie Bucheit; Thereasa Rich; Ian Chau; David Cunningham; Naureen Starling; for the TRACC Part B trial investigators
Early Evaluation of Risk Stratification and Clinical Outcomes for Patients with Advanced Breast Cancer through Combined Monitoring of Baseline Circulating Tumor Cells and DNA
Qiang Zhang; Zheng Cai; Lorenzo Gerratana; Andrew A. Davis; Paolo D’Amico; Akhil Chawla; Saya Jacob; Youbin Zhang; Jianhua Jiao; Weijun Qin; Carolina Reduzzi; Lisa Flaum; Ami Shah; William J. Gradishar
Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma
Flurina A.M. Saner; Kazuaki Takahashi; Timothy Budden; Ahwan Pandey; Dinuka Ariyaratne; Tibor A. Zwimpfer; Nicola S. Meagher; Sian Fereday; Laura Twomey; Kathleen I. Pishas; Therese Hoang; Adelyn Bolithon; Nadia Traficante; for the Australian Ovarian Cancer Study Group; Kathryn Alsop; Elizabeth L. Christie; Eun-Young Kang; Gregg S. Nelson; Prafull Ghatage; Cheng-Han Lee; Marjorie J. Riggan; Jennifer Alsop; Matthias W. Beckmann; Jessica Boros; Alison H. Brand; Angela Brooks-Wilson; Michael E. Carney; Penny Coulson; Madeleine Courtney-Brooks; Kara L. Cushing-Haugen; Cezary Cybulski; Mona A. El-Bahrawy; Esther Elishaev; Ramona Erber; Simon A. Gayther; Aleksandra Gentry-Maharaj; C. Blake Gilks; Paul R. Harnett; Holly R. Harris; Arndt Hartmann; Alexander Hein; Joy Hendley; Brenda Y. Hernandez; Anna Jakubowska; Mercedes Jimenez-Linan; Michael E. Jones; Scott H. Kaufmann; Catherine J. Kennedy; Tomasz Kluz; Jennifer M. Koziak; Björg Kristjansdottir; Nhu D. Le; Marcin Lener; Jenny Lester; Jan Lubiński; Constantina Mateoiu; Sandra Orsulic; Matthias Ruebner; Minouk J. Schoemaker; Mitul Shah; Raghwa Sharma; Mark E. Sherman; Yurii B. Shvetsov; T. Rinda Soong; Helen Steed; Paniti Sukumvanich; Aline Talhouk; Sarah E. Taylor; Robert A. Vierkant; Chen Wang; Martin Widschwendter; Lynne R. Wilkens; Stacey J. Winham; Michael S. Anglesio; Andrew Berchuck; James D. Brenton; Ian Campbell; Linda S. Cook; Jennifer A. Doherty; Peter A. Fasching; Renée T. Fortner; Marc T. Goodman; Jacek Gronwald; David G. Huntsman; Beth Y. Karlan; Linda E. Kelemen; Usha Menon; Francesmary Modugno; Paul D.P. Pharoah; Joellen M. Schildkraut; Karin Sundfeldt; Anthony J. Swerdlow; Ellen L. Goode; Anna DeFazio; Martin Köbel; Susan J. Ramus; David D.L. Bowtell; Dale W. Garsed
A Novel Approach to Quantify Heterogeneity of Intrahepatic Cholangiocarcinoma: The Hidden-Genome Classifier
Yi Song; Thomas Boerner; Esther Drill; Paul Shin; Sandeep Kumar; Carlie Sigel; Andrea Cercek; Nancy Kemeny; Ghassan Abou-Alfa; Christine Iacobuzio-Donahue; Darren Cowzer; Nikolaus Schultz; Henry Walch; Vinod Balachandran; Bas Groot Koerkamp; Peter Kingham; Kevin Soares; Alice Wei; Michael D’Angelica; Jeffrey Drebin; Rohit Chandwani; James J. Harding; William Jarnagin
T2-FLAIR Mismatch Sign Predicts DNA Methylation Subclass and CDKN2A/B Status in IDH-Mutant Astrocytomas
Matthew D. Lee; Rajan Jain; Kristyn Galbraith; Anna Chen; Evan Lieberman; Sohil H. Patel; Dimitris G. Placantonakis; David Zagzag; Marissa Barbaro; Maria del Pilar Guillermo Prieto Eibl; John G. Golfinos; Daniel A. Orringer; Matija Snuderl
Translational Cancer Mechanisms and Therapy
Cell Context Is the Third Axis of Synergy for the Combination of ATR Inhibition and Cisplatin in Ewing Sarcoma
Jennifer Jess; Katie M. Sorensen; Elissa A. Boguslawski; Matthew C. Stout; Zachary B. Madaj; Benjamin P. Caiello; Monica Pomaville; Elizabeth R. Wilson; Seneca S. Kinn-Gurzo; Curtis C. Parker; Sridhar M. Veluvolu; Taylor V. Brysgel; Rebecca Kaufman; Susan M. Kitchen-Goosen; Jenna M. Gedminas; Patrick J. Grohar
Oral Estrogen Receptor PROTAC Vepdegestrant (ARV-471) Is Highly Efficacious as Monotherapy and in Combination with CDK4/6 or PI3K/mTOR Pathway Inhibitors in Preclinical ER+ Breast Cancer Models
Sheryl M. Gough; John J. Flanagan; Jessica Teh; Monica Andreoli; Emma Rousseau; Melissa Pannone; Mark Bookbinder; Ryan Willard; Kim Davenport; Elizabeth Bortolon; Gregory Cadelina; Debbie Gordon; Jennifer Pizzano; Jennifer Macaluso; Leofal Soto; John Corradi; Katherine Digianantonio; Ieva Drulyte; Alicia Morgan; Connor Quinn; Miklós Békés; Caterina Ferraro; Xin Chen; Gan Wang; Hanqing Dong; Jing Wang; David R. Langley; John Houston; Richard Gedrich; Ian C. Taylor
Preclinical Development of CAR T Cells with Antigen-Inducible IL18 Enforcement to Treat GD2-Positive Solid Cancers
Lena Fischer-Riepe; Sareetha Kailayangiri; Katharina Zimmermann; Rita Pfeifer; Michael Aigner; Bianca Altvater; Sascha Kretschmann; Simon Völkl; Jordan Hartley; Celine Dreger; Katja Petry; Andreas Bosio; Angelika von Döllen; Wolfgang Hartmann; Holger Lode; Dennis Görlich; Andreas Mackensen; Melanie Jungblut; Axel Schambach; Hinrich Abken; Claudia Rossig
Targeting GPC2 on Intraocular and CNS Metastatic Retinoblastomas with Local and Systemic Delivery of CAR T Cells
Guillem Pascual-Pasto; Brendan McIntyre; Anna M. Giudice; Fatemeh Alikarami; Amanda Morrissey; Stephanie Matlaga; Ted J. Hofmann; Victor Burgueño; Kyra Harvey; Daniel Martinez; Amish C. Shah; Jessica B. Foster; Jennifer Pogoriler; Ralph C. Eagle; Angel M. Carcaboso; Carol L. Shields; Ann-Marie Leahey; Kristopher R. Bosse
Urinary Metabolite Diagnostic and Prognostic Liquid Biopsy Biomarkers of Lung Cancer in Nonsmokers and Tobacco Smokers
Bhavik Dalal; Takeshi Tada; Daxesh P. Patel; Sharon R. Pine; Mohammed Khan; Takahiro Oike; Yasuyuki Kanke; Amelia L. Parker; Majda Haznadar; Leila Toulabi; Kristopher W. Krausz; Ana I. Robles; Elise D. Bowman; Frank J. Gonzalez; Curtis C. Harris
A PDE3A-SLFN12 Molecular Glue Exhibits Significant Antitumor Activity in TKI-Resistant Gastrointestinal Stromal Tumors
Emiri O. Takaki; Kunihiko Kiyono; Yutaka Obuchi; Takeshi Yamauchi; Takashi Watanabe; Hideki Matsumoto; Miho Karimine; Yuki Kuniyoshi; Shingo Nishikori; Fumiharu Yokoyama; Hikaru Nishimori; Hiroshi Nabeshima; Kazuhide Nakamura
Missense Mutations in Myc Box I Influence Nucleocytoplasmic Transport to Promote Leukemogenesis
Nancy B.J. Arthur; Keegan A. Christensen; Kathleen Mannino; Marianna B. Ruzinova; Ashutosh Kumar; Agata Gruszczynska; Ryan B. Day; Petra Erdmann-Gilmore; Yiling Mi; Robert Sprung; Conner R. York; Robert R. Townsend; David H. Spencer; Stephen M. Sykes; Francesca Ferraro
Correction
Editor’s Notes
Editor’s Note: Detection of Wilms’ Tumor Antigen–Specific CTL in Tumor-Draining Lymph Nodes of Patients with Early Breast Cancer
Roopinder Gillmore; Shao-An Xue; Angelika Holler; Jaspal Kaeda; Dimitri Hadjiminas; Vourneen Healy; Roberto Dina; Suzanne C. Parry; Ilaria Bellantuono; Yasmeen Ghani; R. Charles Coombes; Jonathan Waxman; Hans J. Stauss
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