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1 August 2024
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Cover Image
Cover Image
The cover shows an in vivo fluorescence intensity image of the esophagus with the lumen of the esophagus on the bottom left (blue). The highlighted area (yellow) indicates a cancerous lesion within the esophagus. For details, see the article by Schmidt and colleagues on page 3211 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
CCR Translations
CCR Drug Updates
FDA Approval Summary: Fruquintinib for the Treatment of Refractory Metastatic Colorectal Cancer
Michael J. Fusco; Sandra J. Casak; Sirisha L. Mushti; Joyce Cheng; Brian J. Christmas; Matthew D. Thompson; Wentao Fu; Hezhen Wang; Miyoung Yoon; Yuching Yang; Jason N. Moore; Youwei Bi; Yang Nan; Craig E. Long; Doris Auth; Nam A. Rahman; Shenghui Tang; Richard Pazdur; Lola A. Fashoyin-Aje; Paul G. Kluetz; Steven J. Lemery
Reviews
Perspective
Neuroblastoma Predisposition and Surveillance—An Update from the 2023 AACR Childhood Cancer Predisposition Workshop
Junne Kamihara; Lisa R. Diller; William D. Foulkes; Orli Michaeli; Yoshiko Nakano; Kristian W. Pajtler; Melissa Perrino; Sarah R. Scollon; Douglas R. Stewart; Stephan Voss; Rosanna Weksberg; Jordan R. Hansford; Garrett M. Brodeur
Special Report
Research Briefs: Clinical Trial Brief Reports
Anastrozole Dose Escalation for Optimal Estrogen Suppression in Postmenopausal Early-Stage Breast Cancer: A Prospective Trial
Tufia C. Haddad; Vera J. Suman; Karthik V. Giridhar; Kostandinos Sideras; Donald W. Northfelt; Brenda J. Ernst; Ciara C. O’Sullivan; Ravinder J. Singh; Zeruesenay Desta; Prema P. Peethambaram; Timothy J. Hobday; Saranya Chumsri; Roberto A. Leon-Ferre; Kathryn J. Ruddy; Siddhartha Yadav; Jodi L. Taraba; Barbara Goodnature; Matthew P. Goetz; Liewei Wang; James N. Ingle
Clinical Trials: Targeted Therapy
A Proof-of-Concept Study of Sequential Treatment with the HDAC Inhibitor Vorinostat following BRAF and MEK Inhibitors in BRAFV600-Mutated Melanoma
Alaa Embaby; Sanne C.F.A. Huijberts; Liqin Wang; Rodrigo Leite de Oliveira; Hilde Rosing; Bastiaan Nuijen; Joyce Sanders; Ingrid Hofland; Charlaine van Steenis; Roelof J.C. Kluin; Cor Lieftink; Christopher G. Smith; Christian U. Blank; Johannes V. van Thienen; John B.A.G. Haanen; Neeltje Steeghs; Frans L. Opdam; Jos H. Beijnen; Alwin D.R. Huitema; Rene Bernards; Jan H.M. Schellens; Sofie Wilgenhof
Evaluating the Base Excision Repair Inhibitor TRC102 and Temozolomide for Patients with Recurrent Glioblastoma in the Phase 2 Adult Brain Tumor Consortium Trial BERT
Manmeet S. Ahluwalia; Ahmad Ozair; Jan Drappatz; Xiaobu Ye; Sen Peng; Matthew Lee; Sanhita Rath; Harshil Dhruv; Yue Hao; Michael E. Berens; Tobias Walbert; Matthias Holdhoff; Glenn J. Lesser; Timothy F. Cloughesy; Andrew E. Sloan; Naoko Takebe; Marta Couce; David M. Peereboom; Burt Nabors; Patrick Y. Wen; Stuart A. Grossman; Lisa R. Rogers
Sacituzumab Govitecan Demonstrates Efficacy across Tumor Trop-2 Expression Levels in Patients with Advanced Urothelial Cancer
Yohann Loriot; Arjun V. Balar; Daniel P. Petrylak; Arash R. Kalebasty; Petros Grivas; Aude Fléchon; Rohit K. Jain; Umang Swami; Manojkumar Bupathi; Philippe Barthélémy; Philippe Beuzeboc; Phillip Palmbos; Christos E. Kyriakopoulos; Damien Pouessel; Cora N. Sternberg; Julia Tonelli; Mitch Sierecki; Marianna Zavodovskaya; Emon Elboudwarej; Lauri Diehl; Juliane M. Jürgensmeier; Scott T. Tagawa
Clinical Trials: Immunotherapy
Plasma versus Tissue Tumor Mutational Burden as Biomarkers of Durvalumab plus Tremelimumab Response in Patients with Metastatic Colorectal Cancer in the CO.26 Trial
Jonathan M. Loree; Emma Titmuss; James T. Topham; Hagen F. Kennecke; Harriet Feilotter; Shakeel Virk; Young S. Lee; Kimberly Banks; Katie Quinn; Aly Karsan; Daniel J. Renouf; Derek J. Jonker; Dongsheng Tu; Chris J. O’Callaghan; Eric X. Chen
Evaluating Immune Checkpoint Blockade in Metastatic Castration-Resistant Prostate Cancers with Deleterious CDK12 Alterations in the Phase 2 IMPACT Trial
Charles B. Nguyen; Melissa A. Reimers; Chamila Perera; Wassim Abida; Jonathan Chou; Felix Y. Feng; Emmanuel S. Antonarakis; Rana R. McKay; Russell K. Pachynski; Jingsong Zhang; Zachery R. Reichert; Phillip L. Palmbos; Megan E.V. Caram; Ulka N. Vaishampayan; Elisabeth I. Heath; Alexander C. Hopkins; Marcin P. Cieslik; Yi-Mi Wu; Dan R. Robinson; Veerabhadran Baladandayuthapani; Arul M. Chinnaiyan; Ajjai S. Alva
Precision Medicine and Imaging
Ultrasound-Guided Quantitative Fluorescence Molecular Endoscopy for Monitoring Response in Patients with Esophageal Cancer Following Neoadjuvant Chemoradiotherapy
Iris Schmidt; Xiaojuan Zhao; Anne M. van der Waaij; Gert Jan Meersma; Frederieke A. Dijkstra; Jan Willem Haveman; Boudewijn van Etten; Dominic J. Robinson; Gursah Kats-Ugurlu; Wouter B. Nagengast
Plasma Proteomic Signature Predicts Myeloid Neoplasm Risk
Duc Tran; J. Scott Beeler; Jie Liu; Brian Wiley; Irenaeus C.C. Chan; Zilan Xin; Michael H. Kramer; Armel L. Batchi-Bouyou; Xiaoyu Zong; Matthew J. Walter; Giulia E.M. Petrone; Sarantis Chlamydas; Francesca Ferraro; Stephen T. Oh; Daniel C. Link; Ben Busby; Yin Cao; Kelly L. Bolton
Clinical Implications and Molecular Features of Extracellular Matrix Networks in Soft Tissue Sarcomas
Valeriya Pankova; Lukas Krasny; William Kerrison; Yuen B. Tam; Madhumeeta Chadha; Jessica Burns; Christopher P. Wilding; Liang Chen; Avirup Chowdhury; Emma Perkins; Alexander T.J. Lee; Louise Howell; Nafia Guljar; Karen Sisley; Cyril Fisher; Priya Chudasama; Khin Thway; Robin L. Jones; Paul H. Huang
Translational Cancer Mechanisms and Therapy
Chimeric Antigen Receptor T Cell with an Inducible Caspase-9 Suicide Gene Eradicates Uveal Melanoma Liver Metastases via B7-H3 Targeting
Marco Ventin; Giulia Cattaneo; Shahrzad Arya; Jingyu Jia; Maria C. Gelmi; Yi Sun; Luke Maggs; Bruce R. Ksander; Robert M. Verdijk; Genevieve M. Boland; Russell W. Jenkins; Rizwan Haq; Martine J. Jager; Xinhui Wang; Sandra Ryeom; Cristina R. Ferrone
Mapping the Single-Cell Differentiation Landscape of Osteosarcoma
Danh D. Truong; Corey Weistuch; Kevin A. Murgas; Prasad Admane; Bridgette L. King; Jes Chauviere Lee; Salah-E. Lamhamedi-Cherradi; Jyothishmathi Swaminathan; Najat C. Daw; Nancy Gordon; Vidya Gopalakrishnan; Richard G. Gorlick; Neeta Somaiah; Joseph O. Deasy; Antonios G. Mikos; Allen Tannenbaum; Joseph Ludwig
Exposure–Response and Subgroup Analyses to Support Body Weight–Based Dosing of Brentuximab Vedotin in Children and Young Adults with Newly Diagnosed High-risk Classical Hodgkin Lymphoma
Zufei Zhang; Daping Zhang; Wenchuan Guo; Keenan Fenton; Sujata Narayanan; Shweta Jain; Joy Jiang; Sharon M. Castellino; Kara M. Kelly; Peter D. Cole; Frank G. Keller; Amit Garg; Yen Lin Chia
A Pooled Analysis of Treatment-Free Survival in Advanced Renal Cell Carcinoma
Elaine Chang; Jiaxi Zhou; Chi Song; Haley Gittleman; Laura Fernandes; Chana Weinstock; Michael B. Atkins; Sundeep Agrawal; Rajeshwari Sridhara; Nicole Gormley; Shenghui Tang; Daniel L. Suzman; Laleh Amiri-Kordestani; Paul G. Kluetz; Richard Pazdur; Brian I. Rini; David F. McDermott; Meredith M. Regan
Bystander Effects, Pharmacokinetics, and Linker-Payload Stability of EGFR-Targeting Antibody-Drug Conjugates Losatuxizumab Vedotin and Depatux-M in Glioblastoma Models
Sonia Jain; Jessica I. Griffith; Kendra A. Porath; Sneha Rathi; Jiayan Le; Tugce I. Pasa; Paul A. Decker; Shiv K. Gupta; Zeng Hu; Brett L. Carlson; Katrina Bakken; Danielle M. Burgenske; Thomas M. Feldsien; Didier R. Lefebvre; Rachael A. Vaubel; Jeanette E. Eckel-Passow; Edward B. Reilly; William F. Elmquist; Jann N. Sarkaria
Anti-EGFR Antibody–Drug Conjugate Carrying an Inhibitor Targeting CDK Restricts Triple-Negative Breast Cancer Growth
Anthony Cheung; Alicia M. Chenoweth; Annelie Johansson; Roman Laddach; Naomi Guppy; Jennifer Trendell; Benjamina Esapa; Antranik Mavousian; Blanca Navarro-Llinas; Syed Haider; Pablo Romero-Clavijo; Ricarda M. Hoffmann; Paolo Andriollo; Khondaker M. Rahman; Paul Jackson; Sophia Tsoka; Sheeba Irshad; Ioannis Roxanis; Anita Grigoriadis; David E. Thurston; Christopher J. Lord; Andrew N. J. Tutt; Sophia N. Karagiannis
Sequential Analysis of cfDNA Reveals Clonal Evolution in Patients with Neuroblastoma Receiving ALK-Targeted Therapy
Charles Bobin; Yasmine Iddir; Charlotte Butterworth; Julien Masliah-Planchon; Alexandra Saint-Charles; Angela Bellini; Jaydutt Bhalshankar; Gaelle Pierron; Valérie Combaret; Valéry Attignon; Nicolas André; Nadège Corradini; Benoit Dumont; Ludovic Mansuy; Camille Khanfar; Sebastien Klein; Claire Briandet; Dominique Plantaz; Frederic Millot; Sandrine Thouvenin; Isabelle Aerts; Lee Aymar Ndounga-Diakou; Salim Laghouati; Samuel Abbou; Nina Jehanno; Hubert Tissot; Shufang Renault; Sylvain Baulande; Virginie Raynal; Laurence Bozec; Ivan Bieche; Olivier Delattre; Pablo Berlanga; Gudrun Schleiermacher
Personalized ctDNA for Monitoring Disease Status in Head and Neck Squamous Cell Carcinoma
Glenn J. Hanna; Michael J. Dennis; Nicole Scarfo; Michelle S. Mullin; Rosh K.V. Sethi; Kartik Sehgal; Donald J. Annino, Jr; Laura A. Goguen; Robert I. Haddad; Roy B. Tishler; Danielle N. Margalit; Ravindra Uppaluri; Jonathan D. Schoenfeld; Eleni M. Rettig
A 5-Hydroxymethylcytosine-Based Noninvasive Model for Early Detection of Colorectal Carcinomas and Advanced Adenomas: The METHOD-2 Study
Wenju Chang; Zhou Zhang; Baoqing Jia; Kefeng Ding; Zhizhong Pan; Guoqiang Su; Wei Zhang; Tianyu Liu; Yunshi Zhong; Guodong He; Li Ren; Ye Wei; Dongdong Li; Xiaolong Cui; Jun Yang; Yixiang Shi; Marc Bissonnette; Chuan He; Wei Zhang; Jia Fan; Jianmin Xu
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