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1 June 2024
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Cover Image
Cover Image
The cover shows a section of a human pancreatic cancer expressing high levels of Keratin 17 (KRT17, red), a cell surface protein and marker of an aggressive subtype. The tumor is infiltrated by myeloid cells, stained for CA11b in green. For details, see the article by Carpenter and colleagues on page 2497 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Issue Sections
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
Considering Functional Outcomes as Efficacy Endpoints in Pediatric Low-Grade Glioma Clinical Trials: An FDA Educational Symposium
Jason Fangusaro; Robert A. Avery; Michael J. Fisher; Roger J. Packer; Karin S. Walsh; Antoinette Schouten-van Meeteren; Dominik Karres; Diana Bradford; Vishal Bhatnagar; Harpreet Singh; Paul G. Kluetz; Martha Donoghue; Elizabeth S. Duke
CCR Drug Updates
Reviews
Update on Cancer Predisposition Syndromes and Surveillance Guidelines for Childhood Brain Tumors
Jordan R. Hansford; Anirban Das; Rose B. McGee; Yoshiko Nakano; Jack Brzezinski; Sarah R. Scollon; Surya P. Rednam; Jaclyn Schienda; Orli Michaeli; Sun Young Kim; Mary-Louise C. Greer; Rosanna Weksberg; Douglas R. Stewart; William D. Foulkes; Uri Tabori; Kristian W. Pajtler; Stefan M. Pfister; Garrett M. Brodeur; Junne Kamihara
Perspective
Research Briefs: Clinical Trial Brief Reports
Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial
Igor Makhlin; Biniyam G. Demissei; Ralph D'Agostino; W. Greg Hundley; Camelia Baleanu-Gogonea; Nicholas S. Wilcox; Anna Chen; Amanda M. Smith; Nathaniel Sean O'Connell; James L. Januzzi; Glenn J. Lesser; Marielle Scherrer-Crosbie; Borja Ibáñez; W.H. Wilson Tang; Bonnie Ky
Clinical Trials: Targeted Therapy
A Signal-Finding Study of Abemaciclib in Heavily Pretreated Patients with Metastatic Castration–Resistant Prostate Cancer: Results from CYCLONE 1
Neeraj Agarwal; Daniel Castellano; Teresa Alonso-Gordoa; Jose Angel Arranz Arija; Emeline Colomba; Gwenaelle Gravis; Loic Mourey; Stephane Oudard; Aude Fléchon; Macarena González; Pablo M. Rey; Michael T. Schweizer; Enrique Gallardo; Erica Johnston; Arjun Balar; Nadine Haddad; Adams K. Appiah; Karim Nacerddine; José M. Piulats
Upfront Neck Dissection for Treatment Selection and Improvement in Quality of Life as a Novel Treatment Paradigm for Deintensification in HPV+ OPSCC
Paul L. Swiecicki; Emily Bellile; Aleksandar F. Dragovic; Jonathan McHugh; Aaron Udager; Michelle Lynn Mierzwa; Jennifer Shah; Molly Heft-Neal; Andrew Rosko; Kelly M. Malloy; Keith Casper; Steven Bennett Chinn; Andrew G. Shuman; Chaz Stucken; Douglas B. Chepeha; Gregory T. Wolf; Carol Rossier Bradford; Avraham Eisbruch; Mark E. Prince; Francis P. Worden; Matthew E. Spector
A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2α in Patients with Advanced Clear Cell Renal Cell Carcinoma
James Brugarolas; Gregory Obara; Kathryn E. Beckermann; Brian Rini; Elaine T. Lam; James Hamilton; Thomas Schluep; Min Yi; So Wong; Zhongping Lily Mao; Erick Gamelin; Nizar M. Tannir
Clinical Trials: Immunotherapy
Phase I Trial of Viral Vector-Based Personalized Vaccination Elicits Robust Neoantigen-Specific Antitumor T-Cell Responses
Anna Morena D'Alise; Guido Leoni; Gabriella Cotugno; Loredana Siani; Rosa Vitale; Valentino Ruzza; Irene Garzia; Laura Antonucci; Elisa Micarelli; Veronica Venafra; Sven Gogov; Alessia Capone; Sarah Runswick; Juan Martin‐Liberal; Emiliano Calvo; Victor Moreno; Stefan N. Symeonides; Elisa Scarselli; Oliver Bechter
Maintenance Pembrolizumab Therapy in Patients with Metastatic HER2-negative Breast Cancer with Prior Response to Chemotherapy
Toshiaki Iwase; Evan N. Cohen; Hui Gao; Angela Alexander; Megumi Kai; Vivian Chiv; Xiaoping Wang; Savitri Krishnamurthy; Diane Liu; Yu Shen; Kumiko Kida; Alexandre Reuben; Rachel M. Layman; David L. Ramirez; Debasish Tripathy; Stacy L. Moulder; Clinton Yam; Vicente Valero; Bora Lim; James M. Reuben; Naoto T. Ueno
Safety and Preliminary Efficacy of Pembrolizumab Following Transarterial Chemoembolization for Hepatocellular Carcinoma: The PETAL Phase Ib Study
David J. Pinato; Antonio D'Alessio; Claudia Angela Maria Fulgenzi; Alexandra Emilia Schlaak; Ciro Celsa; Saskia Killmer; Jesus Miguens Blanco; Caroline Ward; Charalampos-Vlasios Stikas; Mark R. Openshaw; Nicole Acuti; Georgios Nteliopoulos; Cristina Balcells; Hector C. Keun; Robert D. Goldin; Paul J. Ross; Alessio Cortellini; Robert Thomas; Anna-Mary Young; Nathan Danckert; Paul Tait; Julian R. Marchesi; Bertram Bengsch; Rohini Sharma
Research Briefs: Precision Medicine and Therapeutics
Cell-free DNA Concentration as a Biomarker of Response and Recurrence in HER2-Negative Breast Cancer Receiving Neoadjuvant Chemotherapy
Mark Jesus M. Magbanua; Ziad Ahmed; Rosalyn W. Sayaman; Lamorna Brown Swigart; Gillian L. Hirst; Christina Yau; Denise M. Wolf; Wen Li; Amy L. Delson; Jane Perlmutter; Paula Pohlmann; W. Fraser Symmans; Douglas Yee; Nola M. Hylton; Laura J. Esserman; Angela M. DeMichele; Hope S. Rugo; Laura J. van 't Veer
Precision Medicine and Imaging
Targeted and Shallow Whole-Genome Sequencing Identifies Therapeutic Opportunities in p53abn Endometrial Cancers
Amy Jamieson; Juliana Sobral de Barros; Dawn R. Cochrane; J. Maxwell Douglas; Sameer Shankar; Branden J. Lynch; Samuel Leung; Spencer Martin; Janine Senz; Amy Lum; Yvette Drew; C. Blake Gilks; David G. Huntsman; Jessica N. McAlpine
A Prospective Double-Blinded Comparison of Reflectance Confocal Microscopy with Conventional Histopathology for In Vivo Assessment in Oral Cancer
Daniella K. Zanoni; Paula Demétrio De Souza França; Cristina Valero; Gary Peterson; Marco Ardigo; Ronald Ghossein; Stephen W. Dusza; Danielli Matsuura; Daniel W. Scholfield; Dauren Adilbay; Pablo H. Montero; Jocelyn Migliacci; Naga Vara Kishore Pillarsetty; Kivanc Kose; Ian Ganly; Milind Rajadhyaksha; Snehal G. Patel
Translational Cancer Mechanisms and Therapy
KRT17high/CXCL8+ Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment
Eileen S. Carpenter; Padma Kadiyala; Ahmed M. Elhossiny; Samantha B. Kemp; Jay Li; Nina G. Steele; Rémy Nicolle; Zeribe C. Nwosu; Julia Freeman; Henry Dai; Daniel Paglia; Wenting Du; Katelyn Donahue; Jacqueline Morales; Paola I. Medina-Cabrera; Monica E. Bonilla; Lindsey Harris; Stephanie The; Valerie Gunchick; Nicole Peterson; Kristee Brown; Michael Mattea; Carlos E. Espinoza; Jake McGue; Sarah M. Kabala; Rachel K. Baliira; Nur M. Renollet; Ayden G. Mooney; Jianhua Liu; Sean Bhalla; Jeremy P. Farida; Christopher Ko; Jorge D. Machicado; Richard S. Kwon; Erik-Jan Wamsteker; Allison Schulman; Michelle A. Anderson; Ryan Law; Anoop Prabhu; Pierre A. Coulombe; Arvind Rao; Timothy L. Frankel; Filip Bednar; Jiaqi Shi; Vaibhav Sahai; Marina Pasca Di Magliano
KLRG1 Cell Depletion as a Novel Therapeutic Strategy in Patients with Mature T-Cell Lymphoma Subtypes
Bimarzhan Assatova; Robert Willim; Christopher Trevisani; Garrett Haskett; Khyati Maulik Kariya; Kusha Chopra; Sung Rye Park; Michael Yevgeniy Tolstorukov; Sean M. McCabe; Jessica Duffy; Abner Louissaint, Jr; Jani Huuhtanen; Dipabarna Bhattacharya; Satu Mustjoki; Min Jung Koh; Foster Powers; Elizabeth A. Morgan; Lei Yang; Brandy Pinckney; Matthew J. Cotton; Andrew Crabbe; Jessica Beth Ziemba; Ian Brain; Tayla B. Heavican-Foral; Javeed Iqbal; Ronald Nemec; Anna Baird Rider; Josie Germain Ford; Min Ji Koh; Nora Scanlan; David J. Feith; Thomas P. Loughran, Jr; Won Seog Kim; Jaehyuk Choi; Juliette Roels; Lena Boehme; Tom Putteman; Tom Taghon; Jeffrey A. Barnes; P. Connor Johnson; Eric D. Jacobsen; Steven A. Greenberg; David M. Weinstock; Salvia Jain
Preclinical Efficacy of a PSMA-Targeted Actinium-225 Conjugate (225Ac-Macropa-Pelgifatamab): A Targeted Alpha Therapy for Prostate Cancer
Christoph A. Schatz; Sabine Zitzmann-Kolbe; Ingrid Moen; Monika Klotz; Shankari Nair; Stefan Stargard; Roger M. Bjerke; Katrine Wickstrøm Biseth; Yuan Zeng Feng; Bård Indrevoll; Veronique Cruciani; Jenny Karlsson; Bernard Haendler; Carsten H. Nielsen; Maria Z. Alfsen; Stefanie Hammer; Hartwig Hennekes; Alan Cuthbertson; Urs B. Hagemann; Åsmund Larsen
GD2-Targeting CAR T-cell Therapy for Patients with GD2+ Medulloblastoma
Roselia Ciccone; Concetta Quintarelli; Antonio Camera; Michele Pezzella; Simona Caruso; Simona Manni; Alessio Ottaviani; Marika Guercio; Francesca Del Bufalo; Maria Cecilia Quadraccia; Domenico Orlando; Stefano Di Cecca; Matilde Sinibaldi; Mariasole Aurigemma; Laura Iaffaldano; Andrea Sarcinelli; Maria Luisa D'Amore; Manuela Ceccarelli; Francesca Nazio; Veronica Marabitti; Ezio Giorda; Marco Pezzullo; Cristiano De Stefanis; Andrea Carai; Sabrina Rossi; Rita Alaggio; Giada Del Baldo; Marco Becilli; Angela Mastronuzzi; Biagio De Angelis; Franco Locatelli
Memory/Active T-Cell Activation Is Associated with Immunotherapeutic Response in Fumarate Hydratase–Deficient Renal Cell Carcinoma
Junru Chen; Xu Hu; Junjie Zhao; Xiaoxue Yin; Linmao Zheng; Jingjing Guo; Jianhui Chen; Yongquan Wang; Xinan Sheng; Haiying Dong; Xiaodong Liu; Xingming Zhang; Jiayu Liang; Haolin Liu; Jin Yao; Jiyan Liu; Yali Shen; Zhibin Chen; Zhengyu He; Yaodong Wang; Ni Chen; Ling Nie; Mengni Zhang; Xiuyi Pan; Yuntian Chen; Haoyang Liu; Yaowen Zhang; Yanfeng Tang; Sha Zhu; Jinge Zhao; Jindong Dai; Zilin Wang; Yuhao Zeng; Zhipeng Wang; Haojie Huang; Zhenhua Liu; Pengfei Shen; Hao Zeng; Guangxi Sun
Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
Myrofora Panagi; Fotios Mpekris; Chrysovalantis Voutouri; Andreas G. Hadjigeorgiou; Chloe Symeonidou; Eleni Porfyriou; Christina Michael; Andreas Stylianou; John D. Martin; Horacio Cabral; Anastasia Constantinidou; Triantafyllos Stylianopoulos
The VEGF-Hypoxia Signature Is Upregulated in Basal-like Breast Tumors from Women of African Ancestry and Associated with Poor Outcomes in Breast Cancer
Yoo Jane Han; Siyao Liu; Ashley Hardeman; Padma Sheila Rajagopal; Jeffrey Mueller; Galina Khramtsova; Ayodele Sanni; Mustapha Ajani; Wendy Clayton; Ian W. Hurley; Toshio F. Yoshimatsu; Yonglan Zheng; Joel Parker; Charles M. Perou; Olufunmilayo I. Olopade
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