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1 April 2023
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Cover Image
Cover Image
The cover shows an aggressive primary bladder cancer with strong immunohistochemical staining of CUB domain–containing protein 1 (CDCP1) on the tumor cell surface. CDCP1 is an emerging therapeutic target for multiple subtypes of bladder cancer. For details, see the article by Chopra and colleagues on page 1232 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Perspectives
Clinical Trials: Targeted Therapy
Randomized Phase II Trial of Sunitinib or Cediranib in Alveolar Soft Part Sarcoma
James Nguyen; Naoko Takebe; Shivaani Kummar; Albiruni Razak; Sant P. Chawla; Suzanne George; Shreyaskumar R. Patel; Mary Louise Keohan; Sujana Movva; Geraldine O'Sullivan Coyne; Khanh Do; Lamin Juwara; Brooke Augustine; Seth M. Steinberg; Laura Kuhlmann; S. Percy Ivy; James H. Doroshow; Alice P. Chen
Clinical Trials: Immunotherapy
Targeting MDSC Differentiation Using ATRA: A Phase I/II Clinical Trial Combining Pembrolizumab and All-Trans Retinoic Acid for Metastatic Melanoma
Richard P. Tobin; Dasha T. Cogswell; Victoria M. Cates; Dana M. Davis; Jessica S.W. Borgers; Robert J. Van Gulick; Elizabeth Katsnelson; Kasey L. Couts; Kimberly R. Jordan; Dexiang Gao; Eduardo Davila; Theresa M. Medina; Karl D. Lewis; Rene Gonzalez; Ross W. McFarland; William A. Robinson; Martin D. McCarter
Precision Medicine and Imaging
Application of Genomic Sequencing to Refine Patient Stratification for Adjuvant Therapy in Renal Cell Carcinoma
Naveen S. Vasudev; Ghislaine Scelo; Kate I. Glennon; Michelle Wilson; Louis Letourneau; Robert Eveleigh; Nazanin Nourbehesht; Madeleine Arseneault; Antoine Paccard; Lars Egevad; Juris Viksna; Edgars Celms; Sharon M. Jackson; Behnoush Abedi-Ardekani; Anne Y. Warren; Peter J. Selby; Sebastian Trainor; Michael Kimuli; Jon Cartledge; Naeem Soomro; Adebanji Adeyoju; Poulam M. Patel; Magdalena B. Wozniak; Ivana Holcatova; Antonin Brisuda; Vladimir Janout; Estelle Chanudet; David Zaridze; Anush Moukeria; Oxana Shangina; Lenka Foretova; Marie Navratilova; Dana Mates; Viorel Jinga; Ljiljana Bogdanovic; Bozidar Kovacevic; Anne Cambon-Thomsen; Guillaume Bourque; Alvis Brazma; Jörg Tost; Paul Brennan; Mark Lathrop; Yasser Riazalhosseini; Rosamonde E. Banks
Theranostic Targeting of CUB Domain–Containing Protein 1 (CDCP1) in Multiple Subtypes of Bladder Cancer
Shalini Chopra; Kai Trepka; Sasank Sakhamuri; Alberto Carretero-González; Jun Zhu; Emily Egusa; Jie Zhou; Kevin Leung; Ning Zhao; Nima Hooshdaran; Felix Y. Feng; James A. Wells; Jonathan Chou; Michael J. Evans
Pathogenic Variants in Adult-Onset Cancer Predisposition Genes in Pediatric Cancer: Prevalence and Impact on Tumor Molecular Features and Clinical Management
Rose B. McGee; Ninad Oak; Lynn Harrison; Ke Xu; Regina Nuccio; Alise K. Blake; Roya Mostafavi; Sara Lewis; Leslie M. Taylor; Manish Kubal; Annastasia Ouma; Stacy J. Hines-Dowell; Cheng Cheng; Larissa V. Furtado; Kim E. Nichols
Liquid Biopsy of Cerebrospinal Fluid Enables Selective Profiling of Glioma Molecular Subtypes at First Clinical Presentation
Francesca Orzan; Francesca De Bacco; Elisabetta Lazzarini; Giovanni Crisafulli; Alessandra Gasparini; Angelo Dipasquale; Ludovic Barault; Marco Macagno; Pasquale Persico; Federico Pessina; Beatrice Bono; Laura Giordano; Pietro Zeppa; Antonio Melcarne; Paola Cassoni; Diego Garbossa; Armando Santoro; Paolo M. Comoglio; Stefano Indraccolo; Matteo Simonelli; Carla Boccaccio
Translational Cancer Mechanisms and Therapy
An Enhancer Demethylator Phenotype Converged to Immune Dysfunction and Resistance to Immune Checkpoint Inhibitors in Clear-Cell Renal Cell Carcinomas
Xiaofan Lu; Yann Vano; Alexandra Helleux; Xiaoping Su; Véronique Lindner; Guillaume Davidson; Roger Mouawad; Jean-Philippe Spano; Morgan Rouprêt; Reza Elaidi; Eva Compérat; Virginie Verkarre; Chengming Sun; Christine Chevreau; Mostefa Bennamoun; Hervé Lang; Thibault Tricard; Wenxuan Cheng; Li Xu; Irwin Davidson; Fangrong Yan; Wolf Herman Fridman; Catherine Sautes-Fridman; Stéphane Oudard; Gabriel G. Malouf
IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLC
Sonia A. Patel; Monique B. Nilsson; Yan Yang; Xiuning Le; Hai T. Tran; Yasir Y. Elamin; Xiaoxing Yu; Fahao Zhang; Alissa Poteete; Xiaoyang Ren; Li Shen; Jing Wang; Seyed Javad Moghaddam; Tina Cascone; Michael Curran; Don L. Gibbons; John V. Heymach
Combination Therapies Targeting ALK-aberrant Neuroblastoma in Preclinical Models
Elizabeth R. Tucker; Irene Jiménez; Lindi Chen; Angela Bellini; Chiara Gorrini; Elizabeth Calton; Qiong Gao; Harvey Che; Evon Poon; Yann Jamin; Barbara Martins Da Costa; Karen Barker; Sumana Shrestha; J. Ciaran Hutchinson; Simran Dhariwal; Angharad Goodman; Elaine Del Nery; Pierre Gestraud; Jaydutt Bhalshankar; Yasmine Iddir; Elnaz Saberi-Ansari; Alexandra Saint-Charles; Birgit Geoerger; Maria Eugénia Marques Da Costa; Cécile Pierre-Eugène; Isabelle Janoueix-Lerosey; Didier Decaudin; Fariba Nemati; Angel M. Carcaboso; Didier Surdez; Olivier Delattre; Sally L. George; Louis Chesler; Deborah A. Tweddle; Gudrun Schleiermacher
Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma
Abdullah A. Osman; Emre Arslan; Mason Bartels; Chieko Michikawa; Antje Lindemann; Katarzyna Tomczak; Wangjie Yu; Vlad Sandulache; Wencai Ma; Li Shen; Jing Wang; Anand K. Singh; Mitchell J. Frederick; Nakia D. Spencer; Jeffery Kovacs; Timothy Heffernan; William F. Symmans; Kunal Rai; Jeffrey N. Myers
Event-Free Survival as a Surrogate for Overall Survival in Gastric and Gastroesophageal Junction Adenocarcinoma: A Meta-analysis in the Neoadjuvant ± Adjuvant Setting
Zev A. Wainberg; Jipan Xie; Adriana Valderrama; Lei Yin; Shujing Zhang; Chie-Schin Shih; Pooja Bhagia; Qianqian Gu; Kohei Shitara; Yelena Y. Janjigian; Josep Tabernero
Genomic Biomarkers Associated with Response to Induction Chemotherapy in Patients with Localized Pancreatic Ductal Adenocarcinoma
Brett L. Ecker; Alice J. Tao; Quisette P. Janssen; Henry S. Walch; Colin M. Court; Vinod P. Balachandran; Christopher H. Crane; Michael I. D'Angelica; Jeffrey A. Drebin; T. Peter Kingham; Kevin C. Soares; Christine A. Iacobuzio-Donahue; Efsevia Vakiani; Mithat Gonen; Eileen M. O'Reilly; Anna M. Varghese; William R. Jarnagin; Alice C. Wei
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