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15 March 2023
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Cover Image
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The cover shows a section of gastric adenocarcinoma from a patient treated with an immune checkpoint inhibitor. Spatial transcriptomics were performed and included immunofluorescent staining for tumor cells (green), cancer-associated fibroblasts (yellow), and immune cells (pink). For details, see the article by Park and colleagues on page 1077 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Clinical Trials: Targeted Therapy
A Phase Ib/II Trial of Combined BRAF and EGFR Inhibition in BRAF V600E Positive Metastatic Colorectal Cancer and Other Cancers: The EVICT (Erlotinib and Vemurafenib In Combination Trial) Study
Lavinia Tan; Ben Tran; Jeanne Tie; Ben Markman; Sumi Ananda; Niall C. Tebbutt; Michael Michael; Emma Link; Stephen Q. Wong; Sushma Chandrashekar; Jerick Guinto; David Ritchie; Rachel Koldej; Benjamin J. Solomon; Grant A. McArthur; Rodney J. Hicks; Peter Gibbs; Sarah-Jane Dawson; Jayesh Desai
A Single-Arm Phase II Trial of Sitravatinib in Advanced Well-Differentiated/Dedifferentiated Liposarcoma
Matthew Ingham; Shing Lee; Brian A. Van Tine; Edwin Choy; Jay Oza; Sahil Doshi; Liner Ge; Peter Oppelt; Gregory Cote; Brian Corgiat; Naomi Sender; Sarah Sta Ana; Lavan Panchalingam; Emmanuel Petricoin; Gary K. Schwartz
Clinical Trials: Immunotherapy
Tumor Dynamic Model-Based Decision Support for Phase Ib/II Combination Studies: A Retrospective Assessment Based on Resampling of the Phase III Study IMpower150
René Bruno; Mathilde Marchand; Kenta Yoshida; Phyllis Chan; Haocheng Li; Wei Zou; Francois Mercier; Pascal Chanu; Benjamin Wu; Anthony Lee; Chunze Li; Jin Y. Jin; Michael L. Maitland; Martin Reck; Mark A. Socinski
Precision Medicine and Imaging
Bolus versus Continuous Intravenous Delivery of Doxorubicin in Soft-Tissue Sarcomas: Post Hoc Analysis of a Prospective Randomized Trial (SARC021/TH CR-406)
Lee D. Cranmer; Yao Lu; Rachel S. Heise; Karla V. Ballman; Elizabeth T. Loggers; Seth M. Pollack; Michael J. Wagner; Denise K. Reinke; Patrick Schöffski; William D. Tap
Translational Cancer Mechanisms and Therapy
Design and Preclinical Evaluation of a Novel B7-H4–Directed Antibody–Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305
Krista Kinneer; Philipp Wortmann; Zachary A. Cooper; Niall J. Dickinson; Luke Masterson; Thais Cailleau; Ian Hutchinson; Balakumar Vijayakrishnan; Mary McFarlane; Kathryn Ball; Michael Davies; Arthur Lewis; Yue Huang; Anton I. Rosenbaum; Jiaqi Yuan; Jon Chesebrough; Judith Anderton; Noel Monks; Steven Novick; Jixin Wang; Nazzareno Dimasi; R. James Christie; Darrin Sabol; Frances Anne Tosto; Yann Wallez; Elisabetta Leo; Mark R. Albertella; Anna D. Staniszewska; David A. Tice; Philip W. Howard; Nadia Luheshi; Puja Sapra
Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer
Simonetta M. Leto; Martina Ferri; Francesco Sassi; Eugenia R. Zanella; Francesca Cottino; Valentina Vurchio; Irene Catalano; Alessandro Ferrero; Caterina C. Zingaretti; Caterina Marchiò; Elena Grassi; Livio Trusolino; Andrea Bertotti
Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality
Shernan G. Holtan; Constanza Savid-Frontera; Kelly Walton; Anne A. Eaton; Connor Demorest; Andrea Hoeschen; Ling Zhang; Kayla Reid; Tony Kurian; Zena Sayegh; Estefania Julia; Joseph Maakaron; Veronika Bachanova; Najla El Jurdi; Margaret L. MacMillan; Daniel J. Weisdorf; Martin Felices; Jeffrey S. Miller; Bruce R. Blazar; Marco L. Davila; Brian C. Betts
LAMC2 Regulates Key Transcriptional and Targetable Effectors to Support Pancreatic Cancer Growth
Oihane Erice; Shruthi Narayanan; Iker Feliu; Rodrigo Entrialgo-Cadierno; Antonia Malinova; Caterina Vicentini; Elizabeth Guruceaga; Pietro Delfino; Marija Trajkovic-Arsic; Haritz Moreno; Karmele Valencia; Ester Blanco; Irati Macaya; Daniel Öhlund; Purvesh Khatri; Fernando Lecanda; Aldo Scarpa; Jens T. Siveke; Vincenzo Corbo; Mariano Ponz-Sarvise; Silve Vicent
Letters to the Editor
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