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1 March 2023
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Cover Image
Cover Image
The cover shows a section of a breast cancer biopsy. Immunohistochemical staining for estrogen receptor alpha (ER) in a sample used as a positive control to evaluate ER expression in patients treated with mifepristone. For details, see the article by Elía and colleagues on page 866 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Pemigatinib for Previously Treated, Unresectable Locally Advanced or Metastatic Cholangiocarcinoma with FGFR2 Fusion or Other Rearrangement
Timil H. Patel; Leigh Marcus; M. Naomi Horiba; Martha Donoghue; Somak Chatterjee; Pallavi S. Mishra-Kalyani; Robert N. Schuck; Yangbing Li; Xinyuan Zhang; Jeanne Fourie Zirkelbach; Rosane Charlab; Jiang Liu; Yuching Yang; Steven J. Lemery; Richard Pazdur; Marc R. Theoret; Lola A. Fashoyin-Aje
Review
Research Briefs: Clinical Trial Brief Reports
Clinical Trials: Targeted Therapy
Beneficial Effects of Mifepristone Treatment in Patients with Breast Cancer Selected by the Progesterone Receptor Isoform Ratio: Results from the MIPRA Trial
Andrés Elía; Leo Saldain; Silvia I. Vanzulli; Luisa A. Helguero; Caroline A. Lamb; Victoria Fabris; Gabriela Pataccini; Paula Martínez-Vazquez; Javier Burruchaga; Ines Caillet-Bois; Eunice Spengler; Gabriela Acosta Haab; Marcos Liguori; Alejandra Castets; Silvia Lovisi; María F. Abascal; Virginia Novaro; Jana Sánchez; Javier Muñoz; José M. Belizán; Martín C. Abba; Hugo Gass; Paola Rojas; Claudia Lanari
Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates
Evan C. Chen; Helen Gandler; Isidora Tošić; Geoffrey G. Fell; Ashlee Fiore; Olga Pozdnyakova; Daniel J. DeAngelo; Ilene Galinsky; Marlise R. Luskin; Martha Wadleigh; Eric S. Winer; Rebecca Leonard; Kelsey O'Day; Adrienne de Jonge; Donna Neuberg; A. Thomas Look; Richard M. Stone; David A. Frank; Jacqueline S. Garcia
Clinical Trials: Immunotherapy
A Phase 1 First-in-Human Study of FS118, a Tetravalent Bispecific Antibody Targeting LAG-3 and PD-L1 in Patients with Advanced Cancer and PD-L1 Resistance
Timothy A. Yap; Patricia M. LoRusso; Deborah J. Wong; Siwen Hu-Lieskovan; Kyriakos P. Papadopoulos; Josefin-Beate Holz; Urszula Grabowska; Cristian Gradinaru; Kin-Mei Leung; Sylwia Marshall; Claire S. Reader; Roslin Russell; Richard C.A. Sainson; Claire J. Seal; Christopher J. Shepherd; Fiona Germaschewski; Daniel Gliddon; Omer Stern; Lesley Young; Neil Brewis; Louis Kayitalire; Michelle Morrow
Precision Medicine and Imaging
Metastatic Colorectal Cancer Treatment Response Evaluation by Ultra-Deep Sequencing of Cell-Free DNA and Matched White Blood Cells
Iris van 't Erve; Jamie E. Medina; Alessandro Leal; Eniko Papp; Jillian Phallen; Vilmos Adleff; Elaine Jiayuee Chiao; Adith S. Arun; Karen Bolhuis; John K. Simmons; Aanavi Karandikar; Kenneth C. Valkenburg; Mark Sausen; Samuel V. Angiuoli; Robert B. Scharpf; Cornelis J.A. Punt; Gerrit A. Meijer; Victor E. Velculescu; Remond J.A. Fijneman
Translational Cancer Mechanisms and Therapy
Mesenchymal Stem Cell–mediated Image-guided Sodium Iodide Symporter (NIS) Gene Therapy Improves Survival of Glioblastoma-bearing Mice
Carolin Kitzberger; Rebekka Spellerberg; Yang Han; Kathrin A. Schmohl; Christina Stauss; Christian Zach; Roland E. Kälin; Gabriele Multhoff; Matthias Eiber; Franz Schilling; Rainer Glass; Wolfgang A. Weber; Ernst Wagner; Peter J. Nelson; Christine Spitzweg
Crizotinib Has Preclinical Efficacy in Philadelphia-Negative Myeloproliferative Neoplasms
Lindsay M. Gurska; Rachel Okabe; Alexandra Schurer; Meng Maxine Tong; Mark Soto; Daniel Choi; Kristina Ames; Shira Glushakow-Smith; Allison Montoya; Ellen Tein; Linde A. Miles; Haiying Cheng; Pamela Hankey-Giblin; Ross L. Levine; Swati Goel; Balazs Halmos; Kira Gritsman
Molecular Clusters and Tumor-Immune Drivers of IgM Monoclonal Gammopathies
Patrizia Mondello; Jonas Paludo; Joseph P. Novak; Kerstin Wenzl; Zhi-Zhang Yang; Shahrzad Jalali; Jordan E. Krull; Esteban Braggio; Surendra Dasari; Michelle K. Manske; Jithma A. Abeykoon; Vivekananda Sarangi; Prashant Kapoor; Aneel Paulus; Craig B. Reeder; Sikander Ailawadhi; Asher A. Chanan-Khan; Robert A. Kyle; Morie A. Gertz; Anne J. Novak; Stephen M. Ansell
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