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1 December 2023
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Cover Image
Cover Image
The cover shows a 4-plex fluorescent immunohistochemistry image of a lymph node biopsy from a patient with diffuse large B-cell lymphoma (overall survival duration >103 months at last follow-up). CD20+, cyan; CD3+, blue; CD4+, red; CD68+, green; dual CD4+CD68+, yellow; dual CD3+CD4+, magenta. A germinal center of normal B cells was noticed in the immune landscape. For details, see the article by Xu-Monette and colleagues on page 4808 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
The New NCI Precision Medicine Trials
Lyndsay N. Harris; Charles D. Blanke; Harry P. Erba; James M. Ford; Robert J. Gray; Michael L. LeBlanc; Siwen Hu-Lieskovan; Mark R. Litzow; Selina M. Luger; Funda Meric-Bernstam; Peter J. O'Dwyer; Megan K.D. Othus; Katerina Politi; Lois E. Shepherd; Carmen J. Allegra; Helen X. Chen; S. Percy Ivy; Larissa A. Korde; Richard F. Little; Lisa M. McShane; Jeffrey A. Moscow; David R. Patton; Magdalena Thurin; Laura M. Yee; James H. Doroshow
Research Briefs: Clinical Trial Brief Reports
A Pilot Study of Paricalcitol plus Nanoliposomal Irinotecan and 5-FU/LV in Advanced Pancreatic Cancer Patients after Progression on Gemcitabine-Based Therapy
Patrick M. Grierson; Rama Suresh; Benjamin Tan; Katrina S. Pedersen; Manik Amin; Haeseong Park; Nikolaos A. Trikalinos; Jingxia Liu; Nicholas Boice; Amberly Brown; Sapana Bansod; Andrea Wang-Gillam; Kian-Huat Lim
Clinical Trials: Targeted Therapy
Fibroblast Activation Protein-Targeted Radioligand Therapy with 177Lu-EB-FAPI for Metastatic Radioiodine-Refractory Thyroid Cancer: First-in-Human, Dose-Escalation Study
Hao Fu; Jingxiong Huang; Tianzhi Zhao; Hongjian Wang; Yuhang Chen; Weizhi Xu; Yizhen Pang; Wei Guo; Long Sun; Hua Wu; Pengfei Xu; Bishan Su; Jingjing Zhang; Xiaoyuan Chen; Haojun Chen
Olaparib and Ceralasertib (AZD6738) in Patients with Triple-Negative Advanced Breast Cancer: Results from Cohort E of the plasmaMATCH Trial (CRUK/15/010)
Alistair Ring; Lucy S. Kilburn; Alex Pearson; Laura Moretti; Angelica Afshari-Mehr; Andrew M. Wardley; Bora Gurel; Iain R. Macpherson; Ruth Riisnaes; Richard D. Baird; Sue Martin; Rebecca Roylance; Hannah Johnson; Ana Ferreira; Matthew C. Winter; Kathryn Dunne; Ellen Copson; Tamas Hickish; Russell Burcombe; Kat Randle; Violeta Serra; Alba Llop-Guevara; Judith M. Bliss; Nicolas C. Turner
A Prospective Study Exploring the Safety and Efficacy of Lenvatinib for Patients with Advanced Hepatocellular Carcinoma and High Tumor Burden: The LAUNCH Study
Kazufumi Kobayashi; Sadahisa Ogasawara; Susumu Maruta; Tomomi Okubo; Norio Itokawa; Yuki Haga; Yuya Seko; Michihisa Moriguchi; Shunji Watanabe; Yuki Shiko; Hirokazu Takatsuka; Hiroaki Kanzaki; Keisuke Koroki; Masanori Inoue; Masato Nakamura; Soichiro Kiyono; Naoya Kanogawa; Takayuki Kondo; Eiichiro Suzuki; Yoshihiko Ooka; Shingo Nakamoto; Yosuke Inaba; Masafumi Ikeda; Shinichiro Okabe; Naoki Morimoto; Yoshito Itoh; Kazuyoshi Nakamura; Kenji Ito; Ryosaku Azemoto; Masanori Atsukawa; Ei Itobayashi; Naoya Kato
Clinical Trials: Immunotherapy
Efficacy of Nivolumab in Pediatric Cancers with High Mutation Burden and Mismatch Repair Deficiency
Anirban Das; Uri Tabori; Lauren C. Sambira Nahum; Natalie B. Collins; Rebecca Deyell; Rina Dvir; Cecile Faure-Conter; Timothy E. Hassall; Jane E. Minturn; Melissa Edwards; Elissa Brookes; Vanessa Bianchi; Adrian Levine; Simone C. Stone; Sumedha Sudhaman; Santiago Sanchez Ramirez; Ayse B. Ercan; Lucie Stengs; Jill Chung; Logine Negm; Gad Getz; Yosef E. Maruvka; Birgit Ertl-Wagner; Pamela S. Ohashi; Trevor Pugh; Cynthia Hawkins; Eric Bouffet; Daniel A. Morgenstern
Randomized Phase II Trial of Dendritic Cell/Myeloma Fusion Vaccine with Lenalidomide Maintenance after Upfront Autologous Hematopoietic Cell Transplantation for Multiple Myeloma: BMT CTN 1401
David J. Chung; Nina Shah; Juan Wu; Brent Logan; Lina Bisharat; Natalie Callander; Giulia Cheloni; Kenneth Anderson; Thinle Chodon; Binod Dhakal; Steve Devine; Poorvi Somaiya Dutt; Yvonne Efebera; Nancy Geller; Haider Ghiasuddin; Peiman Hematti; Leona Holmberg; Alan Howard; Bryon Johnson; Dimitra Karagkouni; Hillard M. Lazarus; Ehsan Malek; Philip McCarthy; David McKenna; Adam Mendizabal; Ajay Nooka; Nikhil Munshi; Lynn O'Donnell; Aaron P. Rapoport; Jane Reese; Jacalyn Rosenblatt; Robert Soiffer; Dina Stroopinsky; Lynne Uhl; Ioannis S. Vlachos; Edmund K. Waller; James W. Young; Marcelo C. Pasquini; David Avigan
Precision Medicine and Imaging
Circulating Tumor DNA Analysis in Advanced Urothelial Carcinoma: Insights from Biological Analysis and Extended Clinical Follow-up
Sia V. Lindskrog; Karin Birkenkamp-Demtröder; Iver Nordentoft; George Laliotis; Philippe Lamy; Emil Christensen; Derrick Renner; Tine G. Andreasen; Naja Lange; Shruti Sharma; Adam C. ElNaggar; Minetta C. Liu; Himanshu Sethi; Alexey Aleshin; Mads Agerbæk; Jørgen B. Jensen; Lars Dyrskjøt
Tumor-Infiltrating Normal B Cells Revealed by Immunoglobulin Repertoire Clonotype Analysis Are Highly Prognostic and Crucial for Antitumor Immune Responses in DLBCL
Zijun Y. Xu-Monette; Yong Li; Thomas Snyder; Tiantian Yu; Tingxun Lu; Alexandar Tzankov; Carlo Visco; Govind Bhagat; Wenbin Qian; Karen Dybkaer; April Chiu; Wayne Tam; Youli Zu; Eric D. Hsi; Fredrick B. Hagemeister; Yingjun Wang; Heounjeong Go; Maurilio Ponzoni; Andrés J.M. Ferreri; Michael B. Møller; Benjamin M. Parsons; Xiangshan Fan; J. Han van Krieken; Miguel A. Piris; Jane N. Winter; Qingyan Au; Ilan Kirsch; Mingzhi Zhang; John Shaughnessy; Bing Xu; Ken H. Young
Near-Infrared Spectral Tomography for Predicting Residual Cancer Burden during Early-Stage Neoadjuvant Chemotherapy for Breast Cancer
Xu Cao; Kristen E. Muller; Mary D. Chamberlin; Jiang Gui; Peter A. Kaufman; Gary N. Schwartz; Roberta M. diFlorio-Alexander; Brian W. Pogue; Keith D. Paulsen; Shudong Jiang
HLA-I Evolutionary Divergence Confers Response to PD-1 Blockade plus Chemotherapy in Untreated Advanced Non–Small Cell Lung Cancer
Tao Jiang; Qiqi Jin; Jiahao Wang; Fengying Wu; Jian Chen; Gongyan Chen; Yunchao Huang; Jianhua Chen; Ying Cheng; QiMing Wang; Yueyin Pan; Jianying Zhou; Jianhua Shi; Xingxiang Xu; LiZhu Lin; Wei Zhang; Yiping Zhang; Yunpeng Liu; Yong Fang; Jifeng Feng; Zhehai Wang; Sheng Hu; Jian Fang; Yongqian Shu; Jiuwei Cui; Yi Hu; Wenxiu Yao; Xingya Li; Xiaoyan Lin; Rui Wang; Yongsheng Wang; Wei Shi; Gaohua Feng; Jun Ni; Beibei Mao; Dandan Ren; Huaibo Sun; Henghui Zhang; Luonan Chen; Caicun Zhou; Shengxiang Ren
Clinico-Genomic Profiling of Conventional and Dedifferentiated Chondrosarcomas Reveals TP53 Mutation to Be Associated with Worse Outcomes
Ryan A. Denu; Richard K. Yang; Alexander J. Lazar; Shalin S. Patel; Valerae O. Lewis; Jason Roszik; J. Andrew Livingston; Wei-Lien Wang; Kenna R. Shaw; Ravin Ratan; Maria A. Zarzour; Justin Bird; Shaan Raza; Kadir C. Akdemir; Jordi Rodon Ahnert; Vivek Subbiah; Shreyaskumar Patel; Anthony P. Conley
Comparative Genomic Analysis and Clinical Outcomes of BRAF-mutated Advanced Biliary Tract Cancers
Tin-Yun Tang; Federico Nichetti; Ben Kaplan; Sara Lonardi; Filippo Pietrantonio; Lisa Salvatore; Caterina Vivaldi; Lorenza Rimassa; Filippo de Braud; Mario Domenico Rizzato; Dean Pavlick; Randy Chu; Anaemy Danner De Armas; Radwa Sharaf; Ethan Sokol; Jordi Rodon Ahnert; Jeffrey S. Ross; Milind Javle; Monica Niger
Translational Cancer Mechanisms and Therapy
PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors
Michael E. Stokes; Veronica Calvo; Sho Fujisawa; Crissy Dudgeon; Sharon Huang; Nupur Ballal; Leyi Shen; Jennifer Gasparek; Matthew Betzenhauser; Simon J. Taylor; Kirk A. Staschke; Alan C. Rigby; Mark J. Mulvihill; Nandita Bose; Eric S. Lightcap; David Surguladze
Upregulation of Indoleamine 2,3-Dioxygenase 1 in Tumor Cells and Tertiary Lymphoid Structures is a Hallmark of Inflamed Non–Small Cell Lung Cancer
Alban Bessede; Florent Peyraud; Sylvestre Le Moulec; Sophie Cousin; Mathilde Cabart; François Chomy; Christophe Rey; Oren Lara; Ophélie Odin; Imane Nafia; Jean-Philippe Guegan; Antoine Italiano
Differential Benefit of Metronomic Chemotherapy Among Triple-Negative Breast Cancer Subtypes Treated in the IBCSG Trial 22–00
Andrea Joaquin Garcia; Mattia Rediti; David Venet; Samira Majjaj; Roswitha Kammler; Elisabetta Munzone; Lorenzo Gianni; Beat Thürlimann; István Laáng; Marco Colleoni; Sherene Loi; Giuseppe Viale; Meredith M. Regan; Laurence Buisseret; Françoise Rothé; Christos Sotiriou
Potential of Fecal Microbiota Transplantation to Prevent Acute GVHD: Analysis from a Phase II Trial
Armin Rashidi; Maryam Ebadi; Tauseef Ur Rehman; Heba Elhusseini; David Kazadi; Hossam Halaweish; Mohammad H. Khan; Andrea Hoeschen; Qing Cao; Xianghua Luo; Amanda J. Kabage; Sharon Lopez; Shernan G. Holtan; Daniel J. Weisdorf; Alexander Khoruts; Christopher Staley
Suppression of Tumor Cell Lactate-generating Signaling Pathways Eradicates Murine PTEN/p53-deficient Aggressive-variant Prostate Cancer via Macrophage Phagocytosis
Kiranj Chaudagar; Hanna M. Hieromnimon; Anne Kelley; Brian Labadie; Jordan Shafran; Srikrishnan Rameshbabu; Catherine Drovetsky; Kaela Bynoe; Ani Solanki; Erica Markiewicz; Xiaobing Fan; Massimo Loda; Akash Patnaik
Genetic Predictors of Ibrutinib-related Cardiovascular Side Effects in Patients with Chronic Lymphocytic Leukemia
Issam S. Hamadeh; Jai N. Patel; Ryan Jacobs; Hang Zeng; Jiaxian He; Bei Hu; Tamara Kay Moyo; Amy Soni; Steven Park; Ed Copelan; Belinda Avalos; Alicia Hamilton; Nury Steuerwald; Nilanjan Ghosh
Clinical Behavior and Molecular Landscape of Stage I p53-Abnormal Low-Grade Endometrioid Endometrial Carcinomas
Amy Jamieson; Lisa Vermij; Claire J.H. Kramer; Jan J. Jobsen; Ina Jürgemlienk-Schulz; Ludy Lutgens; Jan Willem Mens; Marie A.D. Haverkort; Annerie Slot; Remi A. Nout; Jan Oosting; Joseph Carlson; Brooke E. Howitt; Philip P.C. Ip; Sigurd F. Lax; W. Glenn McCluggage; Naveena Singh; Jessica N. McAlpine; Carien L. Creutzberg; Nanda Horeweg; C. Blake Gilks; Tjalling Bosse
ATM Mutations Associate with Distinct Co-Mutational Patterns and Therapeutic Vulnerabilities in NSCLC
Natalie I. Vokes; Ana Galan Cobo; Margarita Fernandez-Chas; David Molkentine; Santiago Treviño, III; Vitaly Druker; Yu Qian; Sonia Patel; Stephanie Schmidt; Lingzhi Hong; Jeff Lewis; Waree Rinsurongkawong; Vadeerat Rinsurongkawong; J. Jack Lee; Marcelo V. Negrao; Don L. Gibbons; Ara Vaporciyan; Xiuning Le; Jia Wu; Jianjun Zhang; Una Rigney; Sonia Iyer; Emma Dean; John V. Heymach
Advanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence
Margaret Johnson; April Bell; Kristen L. Lauing; Erik Ladomersky; Lijie Zhai; Manon Penco-Campillo; Yajas Shah; Elizabeth Mauer; Joanne Xiu; Theodore Nicolaides; Michael Drumm; Kathleen McCortney; Olivier Elemento; Miri Kim; Prashant Bommi; Justin T. Low; Ruba Memon; Jennifer Wu; Junfei Zhao; Xinlei Mi; Michael J. Glantz; Soma Sengupta; Brandyn Castro; Bakhtiar Yamini; Craig Horbinski; Darren J. Baker; Theresa L. Walunas; Gary E. Schiltz; Rimas V. Lukas; Derek A. Wainwright
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