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15 November 2023
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Cover Image
Cover Image
The cover shows a section of a liver metastasis biopsy from a patient with KRAS wildtype pancreatic cancer. Immunohistochemical staining shows strong ROS1 expression within epithelial tumor cells, consistent with the SLC4A4-ROS1 oncogenic fusion detected by genomic analysis. For details, see the article by Singh and colleagues on page 4627 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Circulating Tumor DNA to Drive Treatment in Metastatic Colorectal Cancer
Giorgio Patelli; Gianluca Mauri; Federica Tosi; Alessio Amatu; Katia Bencardino; Erica Bonazzina; Elio Gregory Pizzutilo; Federica Villa; Gabriele Calvanese; Alberto Giuseppe Agostara; Stefano Stabile; Silvia Ghezzi; Giovanni Crisafulli; Federica Di Nicolantonio; Silvia Marsoni; Alberto Bardelli; Salvatore Siena; Andrea Sartore-Bianchi
Perspectives
Clinical Trials: Targeted Therapy
A Phase II Trial of Rivoceranib, an Oral Vascular Endothelial Growth Factor Receptor 2 Inhibitor, for Recurrent or Metastatic Adenoid Cystic Carcinoma
Glenn J. Hanna; Myung-Ju Ahn; Jameel Muzaffar; Bhumsuk Keam; Daniel W. Bowles; Deborah J. Wong; Alan L. Ho; Sung-Bae Kim; Francis Worden; Tak Yun; Xianzhang Meng; Jan M. Van Tornout; Maureen G. Conlan; Hyunseok Kang
Clinical Trials: Immunotherapy
Safety, Efficacy, and Biomarker Analyses of Dostarlimab in Patients with Endometrial Cancer: Interim Results of the Phase I GARNET Study
Ana Oaknin; Bhavana Pothuri; Lucy Gilbert; Renaud Sabatier; Jubilee Brown; Sharad Ghamande; Cara Mathews; David M. O'Malley; Rebecca Kristeleit; Valentina Boni; Adriano Gravina; Susana Banerjee; Rowan Miller; Joanna Pikiel; Mansoor R. Mirza; Ninad Dewal; Grace Antony; Yuping Dong; Eleftherios Zografos; Jennifer Veneris; Anna V. Tinker
Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma
Ciara L. Freeman; Reginald Atkins; Indumathy Varadarajan; Meghan Menges; Jeffrey Edelman; Rachid Baz; Jason Brayer; Omar Castaneda Puglianini; Jose Leonel Ochoa-Bayona; Taiga Nishihori; Kenneth H. Shain; Bijal Shah; Dung Tsa Chen; Linda Kelley; Domenico Coppola; Melissa Alsina; Scott Antonia; Claudio Anasetti; Frederick L. Locke
Precision Medicine and Imaging
Clinical and Genomic Landscape of FGFR3-Altered Urothelial Carcinoma and Treatment Outcomes with Erdafitinib: A Real-World Experience
Brendan J. Guercio; Michal Sarfaty; Min Yuen Teo; Neha Ratna; Cihan Duzgol; Samuel A. Funt; Chung-Han Lee; David H. Aggen; Ashley M. Regazzi; Ziyu Chen; Michael Lattanzi; Hikmat A. Al-Ahmadie; A. Rose Brannon; Ronak Shah; Carissa Chu; Andrew T. Lenis; Eugene Pietzak; Bernard H. Bochner; Michael F. Berger; David B. Solit; Jonathan E. Rosenberg; Dean F. Bajorin; Gopa Iyer
Circulating Tumor DNA Monitoring on Chemo-immunotherapy for Risk Stratification in Advanced Non–Small Cell Lung Cancer
Bruna Pellini; Russell W. Madison; Merrida A. Childress; Shoshana T. Miller; Ole Gjoerup; Jason Cheng; Richard S.P. Huang; Michael Krainock; Pratyush Gupta; Wei Zou; David S. Shames; Solomon Moshkevich; Marcus Ballinger; Minetta C. Liu; Amanda Young; Minu K. Srivastava; Geoffrey R. Oxnard; Mark A. Socinski
RANK Expression as an Independent Predictor for Response to Neoadjuvant Chemotherapy in Luminal-Like Breast Cancer: A Translational Insight from the GeparX Trial
Theresa Link; Jens-Uwe Blohmer; Wolfgang D. Schmitt; Jan Dominik Kuhlmann; Marianne Just; Michael Untch; Oliver Stotzer; Peter A. Fasching; Marc Thill; Mattea Reinisch; Andreas Schneeweiss; Pauline Wimberger; Sabine Seiler; Jens Huober; Christian Jackisch; Kerstin Rhiem; Claus Hanusch; Bruno V. Sinn; Valentina Nekljudova; Sibylle Loibl; Carsten Denkert
Translational Cancer Mechanisms and Therapy
Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Jonathan Paolino; Boris Dimitrov; Beth Apsel Winger; Angelica Sandoval-Perez; Amith Vikram Rangarajan; Nicole Ocasio-Martinez; Harrison K. Tsai; Yuting Li; Amanda L. Robichaud; Delan Khalid; Charlie Hatton; Riaz Gillani; Petri Polonen; Anthony Dilig; Giacomo Gotti; Julia Kavanagh; Asmani A. Adhav; Sean Gow; Jonathan Tsai; Yen Der Li; Benjamin L. Ebert; Eliezer M. Van Allen; Jacob Bledsoe; Annette S. Kim; Sarah K. Tasian; Stacy L. Cooper; Todd M. Cooper; Nobuko Hijiya; Maria Luisa Sulis; Neerav N. Shukla; Jeffrey A. Magee; Charles G. Mullighan; Michael J. Burke; Marlise R. Luskin; Brenton G. Mar; Matthew P. Jacobson; Marian H. Harris; Kimberly Stegmaier; Andrew E. Place; Yana Pikman
Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer
Harshabad Singh; Rachel B. Keller; Kevin S. Kapner; Julien Dilly; Srivatsan Raghavan; Chen Yuan; Elizabeth F. Cohen; Michael Tolstorukov; Elizabeth Andrews; Lauren K. Brais; Annacarolina da Silva; Kimberly Perez; Douglas A. Rubinson; Rishi Surana; Marios Giannakis; Kimmie Ng; Thomas E. Clancy; Matthew B. Yurgelun; Benjamin L. Schlechter; Jeffrey W. Clark; Geoffrey I. Shapiro; Michael H. Rosenthal; Jason L. Hornick; Valentina Nardi; Yvonne Y. Li; Hersh Gupta; Andrew D. Cherniack; Matthew Meyerson; James M. Cleary; Jonathan A. Nowak; Brian M. Wolpin; Andrew J. Aguirre
Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair
Anna Solta; Kristiina Boettiger; Ildikó Kovács; Christian Lang; Zsolt Megyesfalvi; Franziska Ferk; Miroslav Mišík; Konrad Hoetzenecker; Clemens Aigner; Christian R. Kowol; Siegfried Knasmueller; Michael Grusch; Beáta Szeitz; Melinda Rezeli; Balazs Dome; Karin Schelch
Assessing the Genomic Landscape of Cervical Cancers: Clinical Opportunities and Therapeutic Targets
Claire F. Friedman; Vignesh Ravichandran; Kathryn Miller; Chad Vanderbilt; Qin Zhou; Alexia Iasonos; Malavika Vivek; Pamela Mishra; Mario M. Leitao, Jr; Vance Broach; Yukio Sonoda; Chrisann Kyi; Dmitriy Zamarin; Roisin E. O'Cearbhaill; Jason Konner; Michael F. Berger; Britta Weigelt; Amir Momeni Boroujeni; Kay J. Park; Carol Aghajanian; David B. Solit; Mark T.A. Donoghue
Effective Reprogramming of Patient-Derived M2-Polarized Glioblastoma-Associated Microglia/Macrophages by Treatment with GW2580
Valentina Fermi; Rolf Warta; Amélie Wöllner; Catharina Lotsch; Lena Jassowicz; Carmen Rapp; Maximilian Knoll; Gerhard Jungwirth; Christine Jungk; Philip Dao Trong; Andreas von Deimling; Amir Abdollahi; Andreas Unterberg; Christel Herold-Mende
Correction
Correction: Defactinib, Pembrolizumab, and Gemcitabine in Patients with Advanced Treatment Refractory Pancreatic Cancer: a Phase I Dose Escalation and Expansion Study
Andrea Wang-Gillam; Kian-Huat Lim; Robert McWilliams; Rama Suresh; Albert C. Lockhart; Amberly Brown; Marcus Breden; Jad I. Belle; John Herndon; Savannah J. Bogner; Katrina Pedersen; Benjamin Tan; Nicholas Boice; Abhi Acharya; Mina Abdiannia; Feng Gao; Harry H. Yoon; Mojun Zhu; Nikolaos A. Trikalinos; Lee Ratner; Olivia Aranha; William G. Hawkins; Brett H. Herzog; David G. DeNardo
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