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15 October 2023
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Cover Image
Cover Image
The covers shows a section of a tumor biopsy from a patient with metastatic melanoma. Immunofluorescence staining shows infiltration of CD4+ T cells co-expressing CD38 and CD39. For details, see the article by Mitra et al. on page 4242 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Futibatinib for Unresectable Advanced or Metastatic, Chemotherapy Refractory Intrahepatic Cholangiocarcinoma with FGFR2 Fusions or Other Rearrangements
Shruti U. Gandhy; Sandra J. Casak; Sirisha L. Mushti; Joyce Cheng; Sriram Subramaniam; Hong Zhao; Miao Zhao; Youwei Bi; Guansheng Liu; Jianghong Fan; Oluseyi Adeniyi; Rosane Charlab; Dubravka Kufrin; Matthew D. Thompson; Kristin Jarrell; Doris Auth; Steven J. Lemery; Richard Pazdur; Paul G. Kluetz; Lola A. Fashoyin-Aje
Review
Research Briefs: Clinical Trial Brief Reports
Urinary Tumor DNA MRD Analysis to Identify Responders to Neoadjuvant Immunotherapy in Muscle-invasive Bladder Cancer
Ruiyun Zhang; Jingyu Zang; Di Jin; Feng Xie; Akezhouli Shahatiaili; Guangyu Wu; Lu Zhang; Lu Wang; Yue Zhang; Zhixin Zhao; Pan Du; Shidong Jia; Jinhai Fan; Guanglei Zhuang; Haige Chen
Clinical Trials: Targeted Therapy
Anlotinib in Locally Advanced or Metastatic Radioiodine-Refractory Differentiated Thyroid Carcinoma: A Randomized, Double-Blind, Multicenter Phase II Trial
Yihebali Chi; Xiangqian Zheng; Yuan Zhang; Feng Shi; Ying Cheng; Zhuming Guo; Minghua Ge; Jianwu Qin; Jiewu Zhang; Zhendong Li; Xiaohong Zhou; Rui Huang; Xiaohong Chen; Hui Liu; Ruochuan Cheng; Zhengang Xu; Dapeng Li; Pingzhang Tang; Ming Gao
Targeting Hedgehog Signaling with Glasdegib in Patients with Refractory Sclerotic Chronic GVHD: A Report of Two Phase I/II Trials
Eduardo Rodríguez-Arbolí; Catherine J. Lee; Teresa Caballero-Velázquez; Carmen Martínez; Clara García-Calderón; María Reyes Jiménez-León; María Aránzazu Bermúdez-Rodríguez; Lucía López-Corral; Ana Triguero; Lynn Onstad; Mitchell E. Horwitz; Stefanie Sarantopoulos; Stephanie J. Lee; José Antonio Pérez-Simón
Molecular Results and Potential Biomarkers Identified from the Phase 3 MILO/ENGOT-ov11 Study of Binimetinib versus Physician Choice of Chemotherapy in Recurrent Low-Grade Serous Ovarian Cancer
Rachel N. Grisham; Ignace Vergote; Susana Banerjee; Esther Drill; Elsa Kalbacher; Mansoor Raza Mirza; Ignacio Romero; Peter Vuylsteke; Robert L. Coleman; Felix Hilpert; Amit M. Oza; Anneke Westermann; Martin K. Oehler; Sandro Pignata; Carol Aghajanian; Nicoletta Colombo; David Cibula; Kathleen N. Moore; Josep M. del Campo; Regina Berger; Christian Marth; Jalid Sehouli; David M. O'Malley; Cristina Churruca; Gunnar Kristensen; Andrew Clamp; John Farley; Gopa Iyer; Isabelle Ray-Coquard; Bradley J. Monk
Tumor Microenvironment Modifications Induced by Afatinib in Squamous Cell Carcinoma of the Head and Neck: A Window-of-Opportunity Study (EORTC-90111–24111)
Simon P. Beyaert; Axelle E. Loriot; Nicolas D. Huyghe; Rose-Marie Goebbels; Antonella Mendola; Anne-Sophie Govaerts; Catherine Fortpied; Pamela Baldin; Lisa F. Licitra; Yassine Lalami; Paul M. Clement; Jean-Pascal H. Machiels; Sandra Schmitz
Clinical Trials: Immunotherapy
Efficacy and Safety of Stereotactic Body Radiotherapy Combined with Camrelizumab and Apatinib in Patients with Hepatocellular Carcinoma with Portal Vein Tumor Thrombus
Yue Hu; Min Zhou; Jing Tang; Shuang Li; Hongli Liu; Jianli Hu; Hong Ma; Junli Liu; Tingting Qin; Xiongjie Yu; Yongshun Chen; Jin Peng; Yanmei Zou; Tao Zhang; Jun Xue
Safety and Tolerability of Low-Dose Radiation and Stereotactic Body Radiotherapy + Sintilimab for Treatment-Naïve Stage IV PD-L1+ Non–Small Cell Lung Cancer Patients
Xiaojuan Zhou; Laiyan Zhou; Zhuoran Yao; Meijuan Huang; Youling Gong; Bingwen Zou; Jiang Zhu; Yongmei Liu; Feng Peng; Yan Zhang; Min Yu; Yanying Li; Feifei Na; Yijun Wu; Kai Kang; Weigang Xiu; Xuanwei Zhang; Lin Zhou; Yong Xu; Jin Wang; Yan Wang; Xue Yang; Yuanjun Wu; Rui Li; Yu Zhang; Zhenzhou Yang; Zhipeng Zhou; Jing Bai; Xin Yi; Ruizhan Tong; Limei Yin; Chong Chen; Gabriele Niedermann; You Lu; Jianxin Xue
Therapeutic Vaccination against Human Papillomavirus Type 16 for the Treatment of High-Grade Anal Intraepithelial Neoplasia in HIV+ Men
Karien C.M. Gosens; Sjoerd H. van der Burg; Marij J.P. Welters; Sanne Boekestijn; Nikki M. Loof; Wim G.V. Quint; Carel J.M. van Noesel; Allard C. van der Wal; Olivier Richel; Wilhelmus J.T.A. Krebber; Cornelis J.M. Melief; Henry J.C. de Vries; Jan M. Prins
Axicabtagene Ciloleucel in Combination with the 4–1BB Agonist Utomilumab in Patients with Relapsed/Refractory Large B-Cell Lymphoma: Phase 1 Results from ZUMA-11
Michael D. Jain; David B. Miklos; Caron A. Jacobson; John M. Timmerman; Jennifer Sun; Jenny Nater; Xiang Fang; Ankit Patel; Madison Davis; Darren Heeke; Tan Trinh; Mike Mattie; Frank Neumann; Jenny J. Kim; Christina To; Simone Filosto; Ran Reshef
Safety, Immunologic, and Clinical Activity of Durvalumab in Combination with Olaparib or Cediranib in Advanced Leiomyosarcoma: Results of the DAPPER Clinical Trial.
Abdulazeez Salawu; Ben X. Wang; Ming Han; Caryn Geady; Alya Heirali; Hal K. Berman; Thomas D. Pfister; Alberto Hernando-Calvo; Esmail Mutahar Al-Ezzi; Lee-Anne Stayner; Abha A. Gupta; Olubukola Ayodele; Bernard Lam; Aaron R. Hansen; Anna Spreafico; Philippe L. Bedard; Marcus O. Butler; Lisa Avery; Bryan Coburn; Benjamin Haibe-Kains; Lillian L. Siu; Albiruni R. Abdul Razak
Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
Tina Sarén; Mohanraj Ramachandran; Gustav Gammelgård; Tanja Lövgren; Claudio Mirabello; Åsa K. Björklund; Kristina Wikström; Jamileh Hashemi; Eva Freyhult; Håkan Ahlström; Rose-Marie Amini; Hans Hagberg; Angelica Loskog; Gunilla Enblad; Magnus Essand
Precision Medicine and Imaging
Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer
Christopher J.M. Williams; Faye Elliott; Nancy Sapanara; Faranak Aghaei; Liping Zhang; Andrea Muranyi; Dongyao Yan; Isaac Bai; Zuo Zhao; Michael Shires; Henry M. Wood; Susan D. Richman; Gemma Hemmings; Michael Hale; Daniel Bottomley; Leanne Galvin; Caroline Cartlidge; Sarah Dance; Chris M. Bacon; Laura Mansfield; Kathe Young-Zvandasara; Ajay Sudan; Katy Lambert; Irena Bibby; Sarah E. Coupland; Amir Montazeri; Natalie Kipling; Kathryn Hughes; Simon S. Cross; Alice Dewdney; Leanne Pheasey; Cathryn Leng; Tatenda Gochera; D. Chas Mangham; Mark Saunders; Martin Pritchard; Helen Stott; Abhik Mukherjee; Mohammad Ilyas; Rafael Silverman; Georgina Hyland; Declan Sculthorpe; Kirsty Thornton; Imogen Gould; Ann O'Callaghan; Nicholas Brown; Samantha Turnbull; Lisa Shaw; Matthew T. Seymour; Nicholas P. West; Jenny F. Seligmann; Shalini Singh; Kandavel Shanmugam; Philip Quirke
Baseline Mutations and ctDNA Dynamics as Prognostic and Predictive Factors in ER-Positive/HER2-Negative Metastatic Breast Cancer Patients
Javier Pascual; Miguel Gil-Gil; Paula Proszek; Christoph Zielinski; Alistair Reay; Manuel Ruiz-Borrego; Rosalind Cutts; Eva M. Ciruelos Gil; Andrew Feber; Montserrat Muñoz-Mateu; Claire Swift; Begoña Bermejo; Jesus Herranz; Mireia Margeli Vila; Antonio Antón; Zsuzsanna Kahan; Tibor Csöszi; Yuan Liu; Daniel Fernandez-Garcia; Isaac Garcia-Murillas; Michael Hubank; Nicholas C. Turner; Miguel Martín
Diagnostic Performance of a Tumor Marker Gene Test to Personalize Serum CA19–9 Reference Ranges
Mohamad Dbouk; Toshiya Abe; Chiho Koi; Yohei Ando; Helena Saba; Elizabeth Abou Diwan; Anne MacGregor-Das; Amanda L. Blackford; Evelina Mocci; Katie Beierl; Ali Dbouk; Jin He; Richard Burkhart; Anne Marie Lennon; Lori Sokoll; Marcia Irene Canto; James R. Eshleman; Michael Goggins
Depth of Radiographic Response and Time to Tumor Regrowth Predicts Overall Survival Following Anti-VEGF Therapy in Recurrent Glioblastoma
Benjamin M. Ellingson; Akifumi Hagiwara; Connor J. Morris; Nicholas S. Cho; Sonoko Oshima; Francesco Sanvito; Talia C. Oughourlian; Donatello Telesca; Catalina Raymond; Lauren E. Abrey; Josep Garcia; Dana T. Aftab; Colin Hessel; Tamar Rachmilewitz Minei; Dror Harats; David A. Nathanson; Patrick Y. Wen; Timothy F. Cloughesy
Translational Cancer Mechanisms and Therapy
Memory-like Differentiation, Tumor-Targeting mAbs, and Chimeric Antigen Receptors Enhance Natural Killer Cell Responses to Head and Neck Cancer
Miriam T. Jacobs; Pamela Wong; Alice Y. Zhou; Michelle Becker-Hapak; Nancy D. Marin; Lynne Marsala; Mark Foster; Jennifer A. Foltz; Celia C. Cubitt; Jennifer Tran; David A. Russler-Germain; Carly Neal; Samantha Kersting-Schadek; Lily Chang; Timothy Schappe; Patrick Pence; Ethan McClain; Jose P. Zevallos; Jason T. Rich; Randal C. Paniello; Ryan S. Jackson; Patrik Pipkorn; Douglas R. Adkins; Carl J. DeSelm; Melissa M. Berrien-Elliott; Sidharth V. Puram; Todd A. Fehniger
Specific Targeting of Multiple Myeloma by Dual Split-signaling Chimeric Antigen Receptor T cells Directed against CD38 and CD138
Jort J. van der Schans; Ziyu Wang; Jennemiek van Arkel; Thijs van Schaik; Afroditi Katsarou; Ruud Ruiter; Thomas Baardemans; Huipin Yuan; Joost de Bruijn; Sonja Zweegman; Niels W.C.J. van de Donk; Richard W.J. Groen; Maria Themeli; Tuna Mutis
Patient-Specific Targeting of the T-Cell Receptor Variable Region as a Therapeutic Strategy in Clonal T-Cell Diseases
Olivia M. Lucero; Ji-Ann Lee; Jenna Bowman; Kara Johnson; Gopal Sapparapu; John K. Thomas; Guang Fan; Bill H. Chang; Karina Thiel-Klare; Christopher A. Eide; Craig Okada; Mike Palazzolo; Evan Lind; Yoko Kosaka; Brian J. Druker; Nicholas Lydon; Peter M. Bowers
A Population of Tumor-Infiltrating CD4+ T Cells Co-Expressing CD38 and CD39 Is Associated with Checkpoint Inhibitor Resistance
Ankita Mitra; Brian Thompson; Ann Strange; Carol M. Amato; Melinda Vassallo; Igor Dolgalev; Jonathan Hester-McCullough; Tomoaki Muramatsu; Diana Kimono; Amrutesh S. Puranik; Jeffrey S. Weber; David Woods
Integrated Genomic and Transcriptomic Analysis Improves Disease Classification and Risk Stratification of MDS with Ring Sideroblasts
Gabriele Todisco; Maria Creignou; Elsa Bernard; Ann-Charlotte Björklund; Pedro Luis Moura; Bianca Tesi; Teresa Mortera-Blanco; Birgitta Sander; Monika Jansson; Gunilla Walldin; Indira Barbosa; Susanne E. Reinsbach; Isabel Juliana Hofman; Christer Nilsson; Tetsuichi Yoshizato; Marios Dimitriou; David Chang; Svannildur Olafsdottir; Sigita Venckute Larsson; Magnus Tobiasson; Luca Malcovati; Petter Woll; Sten Eirik W. Jacobsen; Elli Papaemmanuil; Eva Hellström-Lindberg
Immune Marker Spatial Distribution and Clinical Outcome after PD-1 Blockade in Mismatch Repair–deficient, Advanced Colorectal Carcinomas
Bahar Saberzadeh-Ardestani; Rondell P. Graham; Sara McMahon; Eze Ahanonu; Qian Shi; Crystal Williams; Antony Hubbard; Wenjun Zhang; Andrea Muranyi; Dongyao Yan; Zhaohui Jin; Kandavel Shanmugam; Frank A. Sinicrope
Neoantigen Targetability in Progressive Advanced Melanoma
Jitske van den Bulk; Els M.E. Verdegaal; Manon van der Ploeg; Marten Visser; Joana B. Nunes; Arnoud H. de Ru; Rayman T.N. Tjokrodirijo; Marieke E. Ijsselsteijn; Natasja I. Janssen; Ruud van der Breggen; Linda de Bruin; Pita de Kok; George M.C. Janssen; Dina Ruano; Ellen H.W. Kapiteijn; Peter A. van Veelen; Noel F.C.C. de Miranda; Sjoerd H. van der Burg
Negative Predictive Value of Circulating Tumor Tissue Modified Viral (TTMV)-HPV DNA for HPV-driven Oropharyngeal Cancer Surveillance
Glenn J. Hanna; Scott A. Roof; Jamie Jabalee; Eleni M. Rettig; Rocco Ferrandino, II; Sida Chen; Marshall R. Posner; Krzysztof J. Misiukiewicz; Eric M. Genden; Raymond L. Chai; John Sims; Elaine Thrash; Scott J. Stern; Noah S. Kalman; Sreenija Yarlagadda; Adam Raben; Lydia Clements; Abie Mendelsohn; John M. Kaczmar; Yadav Pandey; Mihir Bhayani; Piyush Gupta; Charlotte Kuperwasser; Catherine Del Vecchio Fitz; Barry M. Berger
Correction
Correction: Tumor Dynamic Model-Based Decision Support for Phase Ib/II Combination Studies: A Retrospective Assessment Based on Resampling of the Phase III Study IMpower150
René Bruno; Mathilde Marchand; Kenta Yoshida; Phyllis Chan; Haocheng Li; Wei Zou; Francois Mercier; Pascal Chanu; Benjamin Wu; Anthony Lee; Chunze Li; Jin Y. Jin; Michael L. Maitland; Martin Reck; Mark A. Socinski
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
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