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15 January 2023
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Cover Image
Cover Image
Subclonal accumulation of ALDH1A1+ cells in relapsing glioblastoma. Shown is an immunofluorescence of ALDH1A1 (red), pAKT (green) and Hoechst-positive nuclei (blue) in surgical human tissue sections. For details, see the article by Kebir and colleagues on page 488 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Research Briefs: Clinical Trial Brief Reports
Posoleucel, an Allogeneic, Off-the-Shelf Multivirus-Specific T-Cell Therapy, for the Treatment of Refractory Viral Infections in the Post-HCT Setting
Thomas Pfeiffer; Ifigeneia Tzannou; Mengfen Wu; Carlos Ramos; Ghadir Sasa; Caridad Martinez; Premal Lulla; Robert A. Krance; Lauren Scherer; Daniel Ruderfer; Swati Naik; Claire Bocchini; Iain P. Fraser; Badrish Patel; Dany Ward; Tao Wang; Helen E. Heslop; Ann M. Leen; Bilal Omer
Clinical Trials: Targeted Therapy
A Phase I/II Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination with Low-Dose Gemcitabine in Patients with Advanced Cancer
Robert Jones; Ruth Plummer; Victor Moreno; Louise Carter; Desamparados Roda; Elena Garralda; Rebecca Kristeleit; Debashis Sarker; Tobias Arkenau; Patricia Roxburgh; Harriet S. Walter; Sarah Blagden; Alan Anthoney; Barbara J. Klencke; Mark M. Kowalski; Udai Banerji
A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma
John A. Ligon; R. Taylor Sundby; Mary F. Wedekind; Fernanda I. Arnaldez; Jaydira Del Rivero; Lori Wiener; Ramaprasad Srinivasan; Melissa Spencer; Amanda Carbonell; Haiyan Lei; John Shern; Seth M. Steinberg; William D. Figg; Cody J. Peer; Sara Zimmerman; Josquin Moraly; Xia Xu; Stephen Fox; King Chan; Michael I. Barbato; Thorkell Andresson; Naomi Taylor; Karel Pacak; J. Keith Killian; Eva Dombi; W. Marston Linehan; Markku Miettinen; Richard Piekarz; Lee J. Helman; Paul Meltzer; Brigitte Widemann; John Glod
Clinical Trials: Immunotherapy
Intraperitoneal Monocytes plus IFNs as a Novel Cellular Immunotherapy for Ovarian Cancer: Mechanistic Characterization and Results from a Phase I Clinical Trial
Daniel S. Green; Franklin Ning; Anna Duemler; Timothy G. Myers; Kathryn Trewhitt; Irene Ekwede; Ann McCoy; Nicole Houston; Jung-min Lee; Stanley Lipkowitz; Alexandra Zimmer; Miroslava Pavelova; Erin N. Villanueva; Leslie Smith; Andrew Blakely; Yovanni Casablanca; Steven L. Highfill; David F. Stroncek; Naoza Collins-Johnson; Sandhya Panch; JoLynn Procter; Chauha Pham; Soumya Korrapati; Steven M. Holland; Lindsey B. Rosen; Ana T. Nunes; Kathryn C. Zoon; Christopher B. Cole; Christina M. Annunziata
Precision Medicine and Imaging
Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients Using Deep Learning of H&E Images: A Report from the Children's Oncology Group
David Milewski; Hyun Jung; G. Thomas Brown; Yanling Liu; Ben Somerville; Curtis Lisle; Marc Ladanyi; Erin R. Rudzinski; Hyoyoung Choo-Wosoba; Donald A. Barkauskas; Tammy Lo; David Hall; Corinne M. Linardic; Jun S. Wei; Hsien-Chao Chou; Stephen X. Skapek; Rajkumar Venkatramani; Peter K. Bode; Seth M. Steinberg; George Zaki; Igor B. Kuznetsov; Douglas S. Hawkins; Jack F. Shern; Jack Collins; Javed Khan
Liquid Biopsy Detects Early Molecular Response and Predicts Benefit to First-Line Chemotherapy plus Cetuximab in Metastatic Colorectal Cancer: PLATFORM-B Study
Joana Vidal; Maria Concepción Fernández-Rodríguez; David Casadevall; Pilar García-Alfonso; David Páez; Marta Guix; Vicente Alonso; Maria Teresa Cano; Cristina Santos; Gema Durán; Elena Elez; José Luís Manzano; Rocío Garcia-Carbonero; Reyes Ferreiro; Ferran Losa; Estela Pineda; Javier Sastre; Fernando Rivera; Beatriz Bellosillo; Josep Tabernero; Enrique Aranda; Ramon Salazar; Clara Montagut; on behalf of the Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Triple-Negative PAM50 Non-Basal Breast Cancer Subtype Predicts Benefit from Extended Adjuvant Capecitabine
Karama Asleh; Ana Lluch; Angela Goytain; Carlos Barrios; Xue Q. Wang; Laura Torrecillas; Dongxia Gao; Manuel Ruiz-Borrego; Samuel Leung; José Bines; Ángel Guerrero-Zotano; Jose Ángel García-Sáenz; Juan Miguel Cejalvo; Jesus Herranz; Roberto Torres; Juan de la Haba-Rodriguez; Francisco Ayala; Henry Gómez; Federico Rojo; Torsten O. Nielsen; Miguel Martin
Examining Stripes on a Herd of Zebras: Impact of Genomic Matching for Ultrarare Sarcomas in Phase 1 Clinical Trials (SAMBA 102)
Justin T. Moyers; Roberto Carmagnani Pestana; Jason Roszik; David S. Hong; Aung Naing; Siqing Fu; Sarina Piha-Paul; Timothy A. Yap; Daniel Karp; Jordi Rodon; Andy Livingston; Maria Alejandra Zarzour; Vinod Ravi; Shreyaskumar Patel; Robert S. Benjamin; Joseph Ludwig; Cynthia Herzog; Ravin Ratan; Neeta Somaiah; Anthony Conley; Richard Gorlick; Funda Meric-Bernstam; Vivek Subbiah
Translational Cancer Mechanisms and Therapy
High-Sensitivity Mutation Analysis of Cell-Free DNA for Disease Monitoring in Endometrial Cancer
Charles W. Ashley; Pier Selenica; Juber Patel; Michelle Wu; Josip Nincevic; Yulia Lakhman; Qin Zhou; Ronak H. Shah; Michael F. Berger; Arnaud Da Cruz Paula; David N. Brown; Antonio Marra; Alexia Iasonos; Amir Momeni-Boroujeni; Kaled M. Alektiar; Kara Long Roche; Oliver Zivanovic; Jennifer J. Mueller; Dmitriy Zamarin; Vance A. Broach; Yukio Sonoda; Mario M. Leitao, Jr; Claire F. Friedman; Elizabeth Jewell; Jorge S. Reis-Filho; Lora H. Ellenson; Carol Aghajanian; Nadeem R. Abu-Rustum; Karen Cadoo; Britta Weigelt
NBN Pathogenic Germline Variants are Associated with Pan-Cancer Susceptibility and In Vitro DNA Damage Response Defects
Sami Belhadj; Aliya Khurram; Chaitanya Bandlamudi; Guillermo Palou-Márquez; Vignesh Ravichandran; Zoe Steinsnyder; Temima Wildman; Amanda Catchings; Yelena Kemel; Semanti Mukherjee; Benjamin Fesko; Kanika Arora; Miika Mehine; Sita Dandiker; Aalin Izhar; John Petrini; Susan Domchek; Katherine L. Nathanson; Jamie Brower; Fergus Couch; Zsofia Stadler; Mark Robson; Michael Walsh; Joseph Vijai; Michael Berger; Fran Supek; Rachid Karam; Sabine Topka; Kenneth Offit
Human Metastatic Cholangiocarcinoma Patient-Derived Xenografts and Tumoroids for Preclinical Drug Evaluation
Queralt Serra-Camprubí; Helena Verdaguer; Winona Oliveros; Núria Lupión-Garcia; Alba Llop-Guevara; Cristina Molina; Maria Vila-Casadesús; Anthony Turpin; Cindy Neuzillet; Joan Frigola; Jessica Querol; Mariana Yáñez-Bartolomé; Florian Castet; Carles Fabregat-Franco; Carmen Escudero-Iriarte; Marta Escorihuela; Enrique J. Arenas; Cristina Bernadó-Morales; Noemí Haro; Francis J. Giles; Óscar J. Pozo; Josep M. Miquel; Paolo G. Nuciforo; Ana Vivancos; Marta Melé; Violeta Serra; Joaquín Arribas; Josep Tabernero; Sandra Peiró; Teresa Macarulla; Tian V. Tian
The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models
Katie E. Hebron; Xiaolin Wan; Jacob S. Roth; David J. Liewehr; Nancy E. Sealover; William J.E. Frye; Angela Kim; Stacey Stauffer; Olivia L. Perkins; Wenyue Sun; Kristine A. Isanogle; Christina M. Robinson; Amy James; Parirokh Awasthi; Priya Shankarappa; Xiaoling Luo; Haiyan Lei; Donna Butcher; Roberta Smith; Elijah F. Edmondson; Jin-Qiu Chen; Noemi Kedei; Cody J. Peer; Jack F. Shern; W. Douglas Figg; Lu Chen; Matthew D. Hall; Simone Difilippantonio; Frederic G. Barr; Robert L. Kortum; Robert W. Robey; Angelina V. Vaseva; Javed Khan; Marielle E. Yohe
A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
Sied Kebir; Vivien Ullrich; Pia Berger; Celia Dobersalske; Sarah Langer; Laurèl Rauschenbach; Daniel Trageser; Andreas Till; Franziska K. Lorbeer; Anja Wieland; Timo Wilhelm-Buchstab; Ashar Ahmad; Holger Fröhlich; Igor Cima; Shruthi Prasad; Johann Matschke; Verena Jendrossek; Marc Remke; Barbara M. Grüner; Alexander Roesch; Jens T. Siveke; Christel Herold-Mende; Tobias Blau; Kathy Keyvani; Frank K.H. van Landeghem; Torsten Pietsch; Jörg Felsberg; Guido Reifenberger; Michael Weller; Ulrich Sure; Oliver Brüstle; Matthias Simon; Martin Glas; Björn Scheffler
Corrections
Correction: Intraperitoneal Monocytes plus IFNs as a Novel Cellular Immunotherapy for Ovarian Cancer: Mechanistic Characterization and Results from a Phase I Clinical Trial
Daniel S. Green; Franklin Ning; Anna Duemler; Timothy G. Myers; Kathryn Trewhitt; Irene Ekwede; Ann McCoy; Nicole Houston; Jung-min Lee; Stanley Lipkowitz; Alexandra Zimmer; Miroslava Pavelova; Erin N. Villanueva; Leslie Smith; Andrew Blakely; Yovanni Casablanca; Steven L. Highfill; David F. Stroncek; Naoza Collins-Johnson; Sandhya Panch; JoLynn Procter; Chauha Pham; Soumya Korrapati; Steven M. Holland; Lindsey B. Rosen; Ana T. Nunes; Kathryn C. Zoon; Christopher B. Cole; Christina M. Annunziata
Correction: Macrophage Exclusion after Radiation Therapy (MERT): A First-in-Human Phase I/II Trial using a CXCR4 Inhibitor in Glioblastoma
Reena P. Thomas; Seema Nagpal; Michael Iv; Scott G. Soltys; Sophie Bertrand; Judith S. Pelpola; Robyn Ball; Jaden Yang; Vandana Sundaram; Sophia B. Chernikova; Jonathan Lavezo; Donald Born; Hannes Vogel; J. Martin Brown; Lawrence D. Recht
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