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1 October 2023
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Cover Image
Cover Image
The cover depicts a GFP+ metastatic melanoma tumor cell line in coculture with autologous CD4+ tumor-infiltrating lymphocytes (TILs). The eTox red reagent was used to stain the nuclei of dead cells and to detect cytotoxicity. For details, see the article by Draghi and colleagues on page 3937 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Mirvetuximab Soravtansine-Gynx for FRα-Positive, Platinum-Resistant Ovarian Cancer
Asma Dilawari; Mirat Shah; Gwynn Ison; Haley Gittleman; Mallorie H. Fiero; Ankit Shah; Salaheldin S. Hamed; Junshan Qiu; Jingyu Yu; Wimolnut Manheng; Tiffany K. Ricks; Rajan Pragani; Arulvathani Arudchandran; Paresma Patel; Shadia Zaman; Arpita Roy; Shyam Kalavar; Soma Ghosh; William F. Pierce; Nam Atiqur Rahman; Shenghui Tang; Bronwyn D. Mixter; Paul G. Kluetz; Richard Pazdur; Laleh Amiri-Kordestani
Review
Special Report
Clinical Trials: Targeted Therapy
A Phase II Study of Optimized Individualized Adaptive Radiotherapy for Hepatocellular Carcinoma
Daniel J. Herr; Chang Wang; Mishal Mendiratta-Lala; Martha Matuszak; Charles S. Mayo; Yue Cao; Neehar D. Parikh; Randy Ten Haken; Dawn Owen; Joseph R. Evans; Teodor Stanescu; Michael Yan; Laura A. Dawson; Matthew Schipper; Theodore S. Lawrence; Kyle C. Cuneo
Neoadjuvant Cabazitaxel plus Abiraterone/Leuprolide Acetate in Patients with High-Risk Prostate Cancer: ACDC-RP Phase II Trial
Neil E. Fleshner; Rashid K. Sayyid; Aaron R. Hansen; Joseph L.K. Chin; Ricardo Fernandes; Eric Winquist; Theodorus van der Kwast; Joan Sweet; Katherine Lajkosz; Miran Kenk; Karen Hersey; Rosette Veloso; Doron Berlin; Jaime O. Herrera-Caceres; Srikala Sridhar; Madeleine Moussa; Antonio Finelli; Robert J. Hamilton; Girish S. Kulkarni; Alexandre R. Zlotta; Anthony M. Joshua
Clinical Trials: Immunotherapy
A Phase II Study of Durvalumab for Bacillus Calmette-Guerin (BCG) Unresponsive Urothelial Carcinoma In Situ of the Bladder
Roger Li; Wade J. Sexton; Jasreman Dhillon; Anders Berglund; Shreyas Naidu; Gustavo Borjas; Kyle Rose; Youngchul Kim; Xuefeng Wang; Jose R. Conejo-Garcia; Rohit K. Jain; Michael A. Poch; Philippe E. Spiess; Julio Pow-Sang; Scott M. Gilbert; Jingsong Zhang
ILUSTRO: Phase II Multicohort Trial of Zolbetuximab in Patients with Advanced or Metastatic Claudin 18.2–Positive Gastric or Gastroesophageal Junction Adenocarcinoma
Samuel J. Klempner; Keun-Wook Lee; Kohei Shitara; Jean-Phillippe Metges; Sara Lonardi; David H. Ilson; Nicola Fazio; Tae Yong Kim; Li-Yuan Bai; Diarmuid Moran; Jianning Yang; Ahsan Arozullah; Jung Wook Park; Jeffrey J. Raizer; Yung-Jue Bang; Manish A. Shah
Precision Medicine and Imaging
Prognostic Markers of DNA Methylation and Next-Generation Sequencing in Progressive Glioblastoma from the EORTC-26101 Trial
Tobias Kessler; Daniel Schrimpf; Laura Doerner; Ling Hai; Leon D. Kaulen; Jakob Ito; Martin van den Bent; Martin Taphoorn; Alba A. Brandes; Ahmed Idbaih; Julien Dômont; Paul M. Clement; Mario Campone; Martin Bendszus; Andreas von Deimling; Felix Sahm; Michael Platten; Wolfgang Wick; Antje Wick
Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma
Eileen M. Boyle; Patrick Blaney; James H. Stoeckle; Yubao Wang; Hussein Ghamlouch; Dylan Gagler; Marc Braunstein; Louis Williams; Avital Tenenbaum; Ariel Siegel; Xiaoyi Chen; Gaurav Varma; Jason Avigan; Alexander Li; Monica Jinsi; David Kaminetzsky; Arnaldo Arbini; Lydia Montes; Jill Corre; Even H. Rustad; Ola Landgren; Francesco Maura; Brian A. Walker; Michael Bauer; Benedetto Bruno; Aristotelis Tsirigos; Faith E. Davies; Gareth J. Morgan
Translational Cancer Mechanisms and Therapy
Unique Spectrum of Activating BRAF Alterations in Prostate Cancer
Alex Chehrazi-Raffle; Hanna Tukachinsky; Eamon Toye; Smruthy Sivakumar; Alexa B. Schrock; Hannah E. Bergom; Hedyeh Ebrahimi; Sumanta Pal; Tanya Dorff; Neeraj Agarwal; Brandon A. Mahal; Geoffrey R. Oxnard; Justin Hwang; Emmanuel S. Antonarakis
Autocrine 17-β-Estradiol/Estrogen Receptor-α Loop Determines the Response to Immune Checkpoint Inhibitors in Non–Small Cell Lung Cancer
Dario P. Anobile; Iris C. Salaroglio; Fabrizio Tabbò; Sofia La Vecchia; Muhlis Akman; Francesca Napoli; Maristella Bungaro; Federica Benso; Elisabetta Aldieri; Paolo Bironzo; Joanna Kopecka; Francesco Passiglia; Luisella Righi; Silvia Novello; Giorgio V. Scagliotti; Chiara Riganti
SETD2 Loss and ATR Inhibition Synergize to Promote cGAS Signaling and Immunotherapy Response in Renal Cell Carcinoma
Xian-De Liu; Yan-Ting Zhang; Daniel J. McGrail; Xuesong Zhang; Truong Lam; Anh Hoang; Elshad Hasanov; Ganiraju Manyam; Christine B. Peterson; Haifeng Zhu; Shwetha V. Kumar; Rehan Akbani; Patrick G. Pilie; Nizar M. Tannir; Guang Peng; Eric Jonasch
Letters to the Editor
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
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