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15 September 2023
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Cover Image
Cover Image
The cover shows the section of a breast tumor biopsy from a postpartum breast cancer patient. Multiplex immunohistochemical staining shows the simultaneous density and clustering of the CD20, CD8, CD3 and CD138 markers. For details, see the article by Lefrère and colleagues on page 3729 of this issue. (Image produced by coauthor Iris M. Seignette on a Ventana Discovery Ultra automated stainer [Ventana Medical Systems] using the Opal Polaris 7-Color Manual IHC Kit.) - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
Driving Diversity and Inclusion in Cancer Drug Development – Industry and Regulatory Perspectives, Current Practices, Opportunities, and Challenges
Lola A. Fashoyin-Aje; Craig Tendler; Bea Lavery; Serban Ghiorghiu; Brittany Gerald; Chitkala Kalidas; Nicole Richie; Kathleen Winson; Nicholas J.H. Warren; Tristen V. Tellman; Jon Retzlaff; Margaret Foti; Richard Pazdur
CCR Drug Updates
FDA Approval Summary: Selpercatinib for the Treatment of Advanced RET Fusion-Positive Solid Tumors
Elizabeth S. Duke; Diana Bradford; Michelle Marcovitz; Anup K. Amatya; Pallavi S. Mishra-Kalyani; Emily Nguyen; Lauren S.L. Price; Jeanne Fourie Zirkelbach; Yangbing Li; Youwei Bi; Jeffrey Kraft; Sarah E. Dorff; Barbara Scepura; Maritsa Stephenson; Idara Ojofeitimi; Abhilasha Nair; Yu Han; Zivana Tezak; Steven J. Lemery; Richard Pazdur; Erin Larkins; Harpreet Singh
Review
Clinical Trials: Targeted Therapy
Phase 1 Study of JNJ-64619178, a Protein Arginine Methyltransferase 5 Inhibitor, in Advanced Solid Tumors
Maria Vieito; Victor Moreno; Anna Spreafico; Irene Brana; Judy S. Wang; Meir Preis; Tatiana Hernández; Sofia Genta; Aaron R. Hansen; Bernard Doger; Vladimir Galvao; Laurie Lenox; Regina J. Brown; Anna Kalota; Jaydeep Mehta; Friederike Pastore; Bharvin Patel; Pankaj Mistry; Junchen Gu; Josh Lauring; Manish R. Patel
Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial
Melissa L. Abel; Nobuyuki Takahashi; Cody Peer; Christophe E. Redon; Samantha Nichols; Rasa Vilimas; Min-Jung Lee; Sunmin Lee; Meenakshi Shelat; Robbie Kattappuram; Linda Sciuto; Danielle Pinkiert; Chante Graham; Donna Butcher; Baktiar Karim; Ajit Kumar Sharma; Justin Malin; Rajesh Kumar; Christopher W. Schultz; Shubhank Goyal; Jaydira del Rivero; Manan Krishnamurthy; Deep Upadhyay; Brett Schroeder; Tristan Sissung; Manoj Tyagi; Jung Kim; Yves Pommier; Mirit Aladjem; Mark Raffeld; William Douglas Figg; Jane Trepel; Liqiang Xi; Parth Desai; Anish Thomas
CD49d Expression Identifies a Biologically Distinct Subtype of Chronic Lymphocytic Leukemia with Inferior Progression-Free Survival on BTK Inhibitor Therapy
Anfal Alsadhan; Jonathan Chen; Erika M. Gaglione; Chingiz Underbayev; Pamela L. Tuma; Xin Tian; Lita A. Freeman; Sivasubramanian Baskar; Pia Nierman; Susan Soto; Andy Itsara; Inhye E. Ahn; Clare Sun; Elena Bibikova; Tanja Nicole Hartmann; Maissa Mhibik; Adrian Wiestner
A Phase Ib Trial of AVID200, a TGFβ 1/3 Trap, in Patients with Myelofibrosis
John Mascarenhas; Anna Rita Migliaccio; Heidi Kosiorek; Rupali Bhave; Jeanne Palmer; Andrew Kuykendall; Ruben Mesa; Raajit K. Rampal; Aaron T. Gerds; Abdulraheem Yacoub; Kristen Pettit; Moshe Talpaz; Rami Komrokji; Marina Kremyanskaya; Agapito Gonzalez; Frank Fabris; Kathryn Johnson; Mikaela Dougherty; Erin McGovern; Juan Arango Ossa; Dylan Domenico; Noushin Farnoud; Rona Singer Weinberg; Amy Kong; Vesna Najfeld; Alessandro Maria Vannucchi; Francesca Arciprete; Maria Zingariello; Mario Falchi; Mohamed E. Salama; Carolyn Mead-Harvey; Amylou Dueck; Lilian Varricchio; Ronald Hoffman
Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Steven B. Maron; Walid Chatila; Henry Walch; Joanne F. Chou; Nicholas Ceglia; Ryan Ptashkin; Richard Kinh Gian Do; Viktoriya Paroder; Neeta Pandit-Taskar; Jason S. Lewis; Tiago Biachi De Castria; Shalom Sabwa; Fiona Socolow; Lara Feder; Jasmine Thomas; Isabell Schulze; Kwanghee Kim; Arijh Elzein; Viktoria Bojilova; Matthew Zatzman; Umesh Bhanot; Rebecca J. Nagy; Jeeyun Lee; Marc Simmons; Michal Segal; Geoffrey Yuyat Ku; David H. Ilson; Marinela Capanu; Jaclyn F. Hechtman; Taha Merghoub; Sohrab Shah; Nikolaus Schultz; David B. Solit; Yelena Y. Janjigian
Phase II Study of Docetaxel and Trametinib in Patients with KRAS Mutation Positive Recurrent Non–Small Cell Lung Cancer (NSCLC; SWOG S1507, NCT-02642042)
Shirish M. Gadgeel; Jieling Miao; Jonathan W. Riess; James Moon; Philip C. Mack; Gregory J. Gerstner; Timothy F. Burns; Asma Taj; Wallace L. Akerley, III; Konstantin H. Dragnev; Noel Laudi; Mary W. Redman; Jhanelle E. Gray; David R. Gandara; Karen Kelly
Clinical Trials: Immunotherapy
A Phase I, Multicenter, Open-Label, First-in-Human Study of DS-6157a in Patients with Advanced Gastrointestinal Stromal Tumor
Suzanne George; Michael C. Heinrich; Neeta Somaiah; Peter Oppelt; Robert McLeod; Satoshi Nishioka; Madan G. Kundu; Xiaozhong Qian; Prasanna Kumar; Abderrahmane Laadem; Yvonne Lau; Brittany P. Tran; Maura Fallon; Ololade Dosunmu; Julia Shi; Yoichi Naito
Precision Medicine and Imaging
Development and Multicenter Case–Control Validation of Urinary Comprehensive Genomic Profiling for Urothelial Carcinoma Diagnosis, Surveillance, and Risk-Prediction
Keyan Salari; Debasish Sundi; Jason J. Lee; Shulin Wu; Chin-Lee Wu; Gabrielle DiFiore; Q. Robert Yan; Andrew Pienkny; Chi K. Lee; Daniel Oberlin; Greg Barme; Joel Piser; Robert Kahn; Edward Collins; Kevin G. Phillips; Vincent M. Caruso; Mahdi Goudarzi; Monica Garcia-Ransom; Peter S. Lentz; Martha E. Evans-Holm; Andrew R. MacBride; Daniel S. Fischer; Iden J. Haddadzadeh; Brian C. Mazzarella; Joe W. Gray; Theresa M. Koppie; Vincent T. Bicocca; Trevor G. Levin; Yair Lotan; Adam S. Feldman
Evaluation of Somatic Mutations in Urine Samples as a Noninvasive Method for the Detection and Molecular Classification of Endometrial Cancer
Laura Costas; Irene Onieva; Beatriz Pelegrina; Fátima Marin; Álvaro Carmona; Marta López-Querol; Jon Frias-Gomez; Paula Peremiquel-Trillas; José Manuel Martínez; Eduard Dorca; Joan Brunet; Marta Pineda; Jordi Ponce; Xavier Matias-Guiu; Silvia de Sanjosé; Francesc Xavier Bosch; Laia Alemany; Sonia Paytubi
Integrated Multimodal Analyses of DNA Damage Response and Immune Markers as Predictors of Response in Metastatic Triple-Negative Breast Cancer in the TNT Trial (NCT00532727)
Holly Tovey; Orsolya Sipos; Joel S. Parker; Katherine A. Hoadley; Jelmar Quist; Sarah Kernaghan; Lucy Kilburn; Roberto Salgado; Sherene Loi; Richard D. Kennedy; Ioannis Roxanis; Patrycja Gazinska; Sarah E. Pinder; Judith Bliss; Charles M. Perou; Syed Haider; Anita Grigoriadis; Andrew Tutt; Maggie Chon U. Cheang
Identifying Mechanisms of Resistance by Circulating Tumor DNA in EVOLVE, a Phase II Trial of Cediranib Plus Olaparib for Ovarian Cancer at Time of PARP Inhibitor Progression
Stephanie Lheureux; Stephenie D. Prokopec; Leslie E. Oldfield; Eduardo Gonzalez-Ochoa; Jeffrey P. Bruce; Derek Wong; Arnavaz Danesh; Dax Torti; Jonathan Torchia; Alexander Fortuna; Sharanjit Singh; Matthew Irving; Kayla Marsh; Bernard Lam; Vanessa Speers; Aleksandra Yosifova; Ana Oaknin; Ainhoa Madariaga; Neesha C. Dhani; Valerie Bowering; Amit M. Oza; Trevor J. Pugh
Translational Cancer Mechanisms and Therapy
Estrogen Therapy Induces Receptor-Dependent DNA Damage Enhanced by PARP Inhibition in ER+ Breast Cancer
Nicole A. Traphagen; Gary N. Schwartz; Steven Tau; Alyssa M. Roberts; Amanda Jiang; Sarah R. Hosford; Jonathan D. Marotti; Abigail E. Goen; Bianca A. Romo; Anneka L. Johnson; Emily-Claire K. Duffy; Eugene Demidenko; Paul Heverly; Yaron Mosesson; Shannon M. Soucy; Fred Kolling; Todd W. Miller
Poor Outcome in Postpartum Breast Cancer Patients Is Associated with Distinct Molecular and Immunologic Features
Hanne Lefrère; Kat Moore; Giuseppe Floris; Joyce Sanders; Iris M. Seignette; Tycho Bismeijer; Dennis Peters; Annegien Broeks; Erik Hooijberg; Kristel Van Calsteren; Patrick Neven; Ellen Warner; Fedro Alessandro Peccatori; Sibylle Loibl; Charlotte Maggen; Sileny N. Han; Katarzyna J. Jerzak; Daniela Annibali; Diether Lambrechts; Karin E. de Visser; Lodewyk Wessels; Liesbeth Lenaerts; Frédéric Amant
Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis
Teresa González-Muñoz; Angela Di Giannatale; Susana García-Silva; Vanesa Santos; Sara Sánchez-Redondo; Claudia Savini; Osvaldo Graña-Castro; Carmen Blanco-Aparicio; Suzanne Fischer; Olivier De Wever; Edgar Creus-Bachiller; Sara Ortega-Bertran; David J. Pisapia; Jose L. Rodríguez-Peralto; Juana Fernández-Rodríguez; Cleofé Romagosa Pérez-Portabella; Rita Alaggio; Maria Serena Benassi; Laura Pazzaglia; Katia Scotlandi; Nancy Ratner; Kaleb Yohay; Charles P. Theuer; Héctor Peinado
Transcriptomic Signatures of MSI-High Metastatic Colorectal Cancer Predict Efficacy of Immune Checkpoint Inhibitors
Claire Gallois; Matteo Landi; Julien Taieb; Marine Sroussi; Bahar Saberzadeh-Ardestani; Antoine Cazelles; Sara Lonardi; Francesca Bergamo; Rossana Intini; Giulia Maddalena; Filippo Pietrantonio; Francesca Corti; Margherita Ambrosini; Antonia Martinetti; Marco Maria Germani; Chiara Boccaccio; Guglielmo Vetere; Sophie Mouillet-Richard; Aurélien de Reynies; Frank A. Sinicrope; Chiara Cremolini; Pierre Laurent-Puig
Dual Role of CXCL8 in Maintaining the Mesenchymal State of Glioblastoma Stem Cells and M2-Like Tumor-Associated Macrophages
Wei Yuan; Qian Zhang; Danling Gu; Chenfei Lu; Deobrat Dixit; Ryan C. Gimple; Yisu Gao; Jiancheng Gao; Daqi Li; Danyang Shan; Lang Hu; Lu Li; Yangqing Li; Shusheng Ci; Hao You; Linping Yan; Kexin Chen; Ningwei Zhao; Chuanhai Xu; Jianyun Lan; Dong Liu; Junxia Zhang; Zhumei Shi; Qiulian Wu; Kailin Yang; Linjie Zhao; Zhixin Qiu; Deguan Lv; Wei Gao; Hui Yang; Fan Lin; Qianghu Wang; Jianghong Man; Chaojun Li; Weiwei Tao; Sameer Agnihotri; Xu Qian; Stephen C. Mack; Nu Zhang; Yongping You; Jeremy N. Rich; Guan Sun; Xiuxing Wang
Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer
Abigail C. Cornwell; Arwen A. Tisdale; Swati Venkat; Kathryn E. Maraszek; Abdulrahman A. Alahmari; Anthony George; Kristopher Attwood; Madison George; Donald Rempinski; Janusz Franco-Barraza; Mukund Seshadri; Mark D. Parker; Eduardo Cortes Gomez; Christos Fountzilas; Edna Cukierman; Nina G. Steele; Michael E. Feigin
Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment
Jonathan M.J. Derry; Connor Burns; Jason P. Frazier; Emily Beirne; Marc Grenley; Christopher C. DuFort; Emily Killingbeck; Michael Leon; Claire Williams; Mark Gregory; Jeffrey Houlton; Daniel Clayburgh; Paul Swiecicki; Dennis Huszar; Allison Berger; Richard A. Klinghoffer
Correction
Correction: ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors Across Tumor Types
Anderly C. Chüeh; Janson W.T. Tse; Michael Dickinson; Paul Ioannidis; Laura Jenkins; Lars Togel; BeeShin Tan; Ian Luk; Mercedes Davalos-Salas; Rebecca Nightingale; Matthew R. Thompson; Bryan R.G. Williams; Guillaume Lessene; Erinna F. Lee; Walter D. Fairlie; Amardeep S. Dhillon; John M. Mariadason
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
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