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15 August 2023
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Cover Image
Cover Image
The cover shows a multiplexed imaging mass cytometry of the immune-excluded environment and high B7-H4 expression in adenoid cystic carcinoma. For more information, see the article by Sousa and colleagues on page 3162 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
FDA Oncology Center of Excellence Crowdsourcing Initiative: Outreach to the Scientific Community to Identify Research Questions for Pooled Analyses of Oncology Clinical Trial Data
Julie A. Schneider; Julia Eckstein; Kirsten B. Goldberg; Mark C. Ascione; Thamar Bailey; Kimberly Taylor; Aisha M. Coffey; Darshini Satchi; Howard Philips; Rajeshwari Sridhara; Abhilasha Nair; Richard Pazdur; Marc R. Theoret
CCR Drug Updates
FDA Approval Summary: Atezolizumab as Adjuvant Treatment following Surgical Resection and Platinum-Based Chemotherapy for Stage II to IIIA NSCLC
Luckson N. Mathieu; Erin Larkins; Arup K. Sinha; Pallavi S. Mishra-Kalyani; Samina Jafri; Shyam Kalavar; Soma Ghosh; Kirsten B. Goldberg; Richard Pazdur; Julia A. Beaver; Harpreet Singh
Clinical Trials: Targeted Therapy
Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers
Julia Rotow; Jyoti D. Patel; Matthew P. Hanley; Helena Yu; Mark Awad; Jonathan W. Goldman; Hovav Nechushtan; Matthias Scheffler; Chih-Hsi S. Kuo; Senthil Rajappa; Guilherme Harada; Sarah Clifford; Alison Santucci; Laura Silva; Rebecca Tupper; Geoffrey R. Oxnard; Jennifer Kherani; Alexander Drilon
Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma
Vivek Subbiah; Sant P. Chawla; Anthony P. Conley; Breelyn A. Wilky; Anthony Tolcher; Nehal J. Lakhani; David Berz; Vasily Andrianov; William Crago; Monica Holcomb; Abrahim Hussain; Carson Veldstra; James Kalabus; Brianne O’Neill; Lane Senne; Emily Rowell; Analeah B. Heidt; Katelyn M. Willis; Brendan P. Eckelman
Clinical Trials: Immunotherapy
Bavituximab Decreases Immunosuppressive Myeloid-Derived Suppressor Cells in Newly Diagnosed Glioblastoma Patients
K. Ina Ly; Leland G. Richardson; Mofei Liu; Alona Muzikansky; Jonathan Cardona; Kevin Lou; Andrew L. Beers; Ken Chang; James M. Brown; Xiaoyue Ma; David A. Reardon; Isabel C. Arrillaga-Romany; Deborah A. Forst; Justin T. Jordan; Eudocia Q. Lee; Jorg Dietrich; Lakshmi Nayak; Patrick Y. Wen; Ugonma Chukwueke; Anita Giobbie-Hurder; Bryan D. Choi; Tracy T. Batchelor; Jayashree Kalpathy-Cramer; William T. Curry; Elizabeth R. Gerstner
Precision Medicine and Imaging
ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk
Lenka Stolarova; Petra Kleiblova; Petra Zemankova; Barbora Stastna; Marketa Janatova; Jana Soukupova; Maria Isabel Achatz; Christine Ambrosone; Paraskevi Apostolou; Banu K. Arun; Paul Auer; Mollie Barnard; Birgitte Bertelsen; Biobank Japan; Marinus J. Blok; Nicholas Boddicker; Joan Brunet; Elizabeth S. Burnside; Mariarosaria Calvello; Ian Campbell; Sock Hoai Chan; Fei Chen; Jian Bang Chiang; Anna Coppa; Laura Cortesi; Ana Crujeiras-González; Consortium CZECANCA; Kim De Leeneer; Robin De Putter; Allison DePersia; Lisa Devereux; Susan Domchek; Anna Efremidis; Christoph Engel; Corinna Ernst; D. Gareth R. Evans; Lidia Feliubadaló; Florentia Fostira; Olivia Fuentes-Ríos; Encarna B. Gómez-García; Sara González; Christopher Haiman; Thomas van Overeem Hansen; Jan Hauke; James Hodge; Chunling Hu; Hongyan Huang; Nur Diana Binte Ishak; Yusuke Iwasaki; Irene Konstantopoulou; Peter Kraft; James Lacey; Conxi Lázaro; Na Li; Weng Khong Lim; Sara Lindstrom; Adriana Lori; Elana Martinez; Alexandra Martins; Koichi Matsuda; Giuseppe Matullo; Simone McInerny; Kyriaki Michailidou; Marco Montagna; Alvaro N.A. Monteiro; Luigi Mori; Katherine Nathanson; Susan L. Neuhausen; Heli Nevanlinna; Janet E. Olson; Julie Palmer; Barbara Pasini; Alpa Patel; Maria Piane; Bruce Poppe; Paolo Radice; Alessandra Renieri; Nicoletta Resta; Marcy E. Richardson; Toon Rosseel; Kathryn J. Ruddy; Marta Santamariña; Elizabeth Santana Dos Santos; Lauren Teras; Amanda E. Toland; Amy Trentham-Dietz; Celine M. Vachon; Alexander E. Volk; Nana Weber-Lassalle; Jeffrey N. Weitzel; Lisa Wiesmuller; Stacey Winham; Siddhartha Yadav; Drakoulis Yannoukakos; Song Yao; Valentina Zampiga; Magnus Zethoven; Ze Wen Zhang; Tomas Zima; Amanda B. Spurdle; Ana Vega; Maria Rossing; Jesús Del Valle; Arcangela De Nicolo; Eric Hahnen; Kathleen B.M. Claes; Joanne Ngeow; Yukihide Momozawa; Paul A. James; Fergus J. Couch; Libor Macurek; Zdenek Kleibl
DNA-Methylome–Based Tumor Hypoxia Classifier Identifies HPV-Negative Head and Neck Cancer Patients at Risk for Locoregional Recurrence after Primary Radiochemotherapy
Bouchra Tawk; Katrin Rein; Christian Schwager; Maximilian Knoll; Ute Wirkner; Juliane Hörner-Rieber; Jakob Liermann; Ina Kurth; Panagiotis Balermpas; Claus Rödel; Annett Linge; Steffen Löck; Fabian Lohaus; Ingeborg Tinhofer; Mechtild Krause; Martin Stuschke; Anca Ligia Grosu; Daniel Zips; Stephanie E. Combs; Claus Belka; Albrecht Stenzinger; Christel Herold-Mende; Michael Baumann; Peter Schirmacher; Jürgen Debus; Amir Abdollahi
B-cell Receptor Pathway Mutations Are Infrequent in Patients with Chronic Lymphocytic Leukemia on Continuous Ibrutinib Therapy
Jennifer A. Woyach; Paolo Ghia; John C. Byrd; Inhye E. Ahn; Carol Moreno; Susan M. O'Brien; Daniel Jones; Leo W.K. Cheung; Elizabeth Chong; Kevin Kwei; James P. Dean; Danelle F. James; Adrian Wiestner
Early Changes in Circulating Cell-Free KRAS G12C Predict Response to Adagrasib in KRAS Mutant Non–Small Cell Lung Cancer Patients
Cloud P. Paweletz; Grace A. Heavey; Yanan Kuang; Emily Durlacher; Thian Kheoh; Richard C. Chao; Alexander I. Spira; Konstantinos Leventakos; Melissa L. Johnson; Sai-Hong Ignatius Ou; Gregory J. Riely; Kenna Anderes; Wenjing Yang; James G. Christensen; Pasi A. Jänne
Functional Genetic Variants in TGFβ1 and TGFβR1 in miRNA-Binding Sites Predict Outcomes in Patients with HPV-positive Oropharyngeal Squamous Cell Carcinoma
Zihao Niu; Peng Sun; Hongliang Liu; Peng Wei; Jia Wu; Zhigang Huang; Neil D. Gross; Sanjay Shete; Qingyi Wei; Mark E. Zafereo; George A. Calin; Guojun Li
Genetic Alterations Detected by Circulating Tumor DNA in HER2-Low Metastatic Breast Cancer
Whitney L. Hensing; Lorenzo Gerratana; Katherine Clifton; Arielle J. Medford; Marko Velimirovic; Ami N. Shah; Paolo D'Amico; Carolina Reduzzi; Qiang Zhang; Charles S. Dai; Elyssa N. Denault; Nusayba A. Bagegni; Mateusz Opyrchal; Foluso O. Ademuyiwa; Ron Bose; Amir Behdad; Cynthia X. Ma; Aditya Bardia; Massimo Cristofanilli; Andrew A. Davis
A Multiparameter Molecular Classifier to Predict Response to Neoadjuvant Lapatinib plus Trastuzumab without Chemotherapy in HER2+ Breast Cancer
Jamunarani Veeraraghavan; Carolina Gutierrez; Carmine De Angelis; Robert Davis; Tao Wang; Tomas Pascual; Pier Selenica; Katherine Sanchez; Hiroaki Nitta; Monesh Kapadia; Anne C. Pavlick; Patricia Galvan; Brent Rexer; Andres Forero-Torres; Rita Nanda; Anna M. Storniolo; Ian E. Krop; Matthew P. Goetz; Julie R. Nangia; Antonio C. Wolff; Britta Weigelt; Jorge S. Reis-Filho; Susan G. Hilsenbeck; Aleix Prat; C. Kent Osborne; Rachel Schiff; Mothaffar F. Rimawi
Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes
Sanna Pikkusaari; Manuela Tumiati; Anni Virtanen; Jaana Oikkonen; Yilin Li; Fernando Perez-Villatoro; Taru Muranen; Matilda Salko; Kaisa Huhtinen; Anna Kanerva; Heidi Koskela; Johanna Tapper; Riitta Koivisto-Korander; Titta Joutsiniemi; Ulla-Maija Haltia; Heini Lassus; Sampsa Hautaniemi; Anniina Färkkilä; Johanna Hynninen; Sakari Hietanen; Olli Carpén; Liisa Kauppi
Clinical Relevance of BRCA1 Promoter Methylation Testing in Patients with Ovarian Cancer
Félix Blanc-Durand; Roseline Tang; Margaux Pommier; Marzieh Nashvi; Sophie Cotteret; Catherine Genestie; Audrey Le Formal; Patricia Pautier; Judith Michels; Maria Kfoury; Robert Hervé; Sylvie Mengue; Estelle Wafo; Antoine Elies; Gregoire Miailhe; Jennifer Uzan; Etienne Rouleau; Alexandra Leary
Translational Cancer Mechanisms and Therapy
MEK Inhibition Sensitizes Pancreatic Cancer to STING Agonism by Tumor Cell–intrinsic Amplification of Type I IFN Signaling
Razmik Ghukasyan; Keke Liang; Kevin Chau; Luyi Li; Charlotte Chan; Evan R. Abt; Thuc Le; Joon Y. Park; Nanping Wu; Alykhan Premji; Robert Damoiseaux; Tony Luu; Amanda Labora; Khalid Rashid; Jason M. Link; Caius G. Radu; Timothy R. Donahue
Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia
Caner Saygin; Giorgia Giordano; Kathryn Shimamoto; Bart Eisfelder; Anika Thomas-Toth; Girish Venkataraman; Vijayalakshmi Ananthanarayanan; Tiffaney L. Vincent; Adam DuVall; Anand A. Patel; Yi Chen; Fenlai Tan; Stephen P. Anthony; Yu Chen; Yue Shen; Olatoyosi Odenike; David T. Teachey; Barbara L. Kee; James LaBelle; Wendy Stock
Spatial Immunoprofiling of Adenoid Cystic Carcinoma Reveals B7-H4 Is a Therapeutic Target for Aggressive Tumors
Luana Guimaraes Sousa; Daniel J. McGrail; Felippe Lazar Neto; Kaiyi Li; Mario L. Marques-Piubelli; Sammy Ferri-Borgogno; Hui Dai; Yoshitsugu Mitani; Nicole Spardy Burr; Zachary A. Cooper; Krista Kinneer; Maria Angelica Cortez; Shiaw-Yih Lin; Diana Bell; Adel El Naggar; Jared Burks; Renata Ferrarotto
The DRD2 Antagonist Haloperidol Mediates Autophagy-Induced Ferroptosis to Increase Temozolomide Sensitivity by Promoting Endoplasmic Reticulum Stress in Glioblastoma
Linyong Shi; Hanning Chen; Kunxiang Chen; Chengzong Zhong; Chong Song; Yifeng Huang; Tong Wang; Lei Chen; Chiyang Li; Annie Huang; Songtao Qi; Hong Li; Yuntao Lu
Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment
Leonard C. Rogers; Jeff C. Kremer; Caitlyn B. Brashears; Zongtao Lin; Zhixian Hu; Alliny C.S. Bastos; Adriana Baker; Nicole Fettig; Dong Zhou; Kooresh I. Shoghi; Carina A. Dehner; John S.A. Chrisinger; John S. Bomalaski; Benjamin A. Garcia; Toshinao Oyama; Eileen P. White; Brian A. Van Tine
Association of Antifolate Response Signature Status and Clinical Activity of Pemetrexed-Platinum Chemotherapy in Non–Small Cell Lung Cancer: The Piedmont Study
Joel R. Eisner; Gregory M. Mayhew; James M. Davison; Kirk D. Beebe; Yoichiro Shibata; Yuelong Guo; Carol Farhangfar; Farhang Farhangfar; Joshua M. Uronis; Jeffrey M. Conroy; Michael V. Milburn; David Neil Hayes; Kathryn F. Mileham
Gold Nanostars Obviate Limitations to Laser Interstitial Thermal Therapy (LITT) for the Treatment of Intracranial Tumors
Ethan S. Srinivasan; Yang Liu; Ren A. Odion; Pakawat Chongsathidkiet; Lucas P. Wachsmuth; Aden P. Haskell-Mendoza; Ryan M. Edwards; Aidan J. Canning; Gavin Willoughby; Joseph Hinton; Stephen J. Norton; Christopher D. Lascola; Paolo F. Maccarini; Christopher L. Mariani; Tuan Vo-Dinh; Peter E. Fecci
Frequent Overexpression of HER3 in Brain Metastases from Breast and Lung Cancer
Erwin Tomasich; Ariane Steindl; Christina Paiato; Teresa Hatziioannou; Markus Kleinberger; Luzia Berchtold; Rainer Puhr; Johannes A. Hainfellner; Leonhard Müllauer; Georg Widhalm; Franziska Eckert; Rupert Bartsch; Gerwin Heller; Matthias Preusser; Anna Sophie Berghoff
Targeting BCL2 Overcomes Resistance and Augments Response to Aurora Kinase B Inhibition by AZD2811 in Small Cell Lung Cancer
Kavya Ramkumar; Azusa Tanimoto; Carminia M. Della Corte; C. Allison Stewart; Qi Wang; Li Shen; Robert J. Cardnell; Jing Wang; Urszula M. Polanska; Courtney Andersen; Jamal Saeh; J. Elizabeth Pease; Jon Travers; Giulia Fabbri; Carl M. Gay; Jelena Urosevic; Lauren A. Byers
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