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Issues

Volume 29, Issue 13
1 July 2023
Clinical Cancer Research Cover Image for Volume 29, Issue 13
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    Multiplexed immunofluorescence of a lung adenocarcinoma harboring concurrent loss-of-function mutations in ATM and TP53, showing high CD8+ T-cells infiltration and high PD-L1 expression levels on tumor and nontumor cells. For details, see the article by Ricciuti and colleagues on page 2540 of this issue.
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ISSN 1078-0432
EISSN 1557-3265

Highlights

Selected Articles from This Issue
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CCR Translations

Direct-to-Patient Clinical Trials: One Small Step or a Giant Leap?
Aakash Desai; Vivek Subbiah
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Time to Introduce Nerve Density in Cancer Histopathologic Assessment
Hubert Hondermarck; Chen Chen Jiang
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CD16+ Macrophages: An Emerging Biomarker for Combined CTLA-4 and PD-1 Blockade
James W. Smithy; Jason J. Luke
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Heparin Prowess: Favorable Vascular–Immune Reprogramming in Pancreatic Cancer
Murray Korc
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Reviews

Molecular Pathways and Mechanisms of HER2 in Cancer Therapy
Kanwal P.S. Raghav; Mark M. Moasser
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Facts and Hopes in Immunotherapy for Early-Stage Triple-Negative Breast Cancer
Iris Nederlof; Leonie Voorwerk; Marleen Kok
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Perspectives

Breakthrough Therapy Designation Criteria Identify Drugs that Improve Clinical Outcomes for Patients: A Case for More Streamlined Coverage of Promising Therapies
Grace Collins; Mark Stewart; Brittany McKelvey; Hillary Stires; Jeff Allen
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Clinical Trials: Targeted Therapy

PI3K Inhibition Restores and Amplifies Response to Ruxolitinib in Patients with Myelofibrosis
Tamara K. Moyo; Ashwin Kishtagari; Matthew T. Villaume; Brandon McMahon; Sanjay R. Mohan; Tess Stopczynski; Sheau-Chiann Chen; Run Fan; Yuankai Huo; Hyeonsoo Moon; Yucheng Tang; Cosmin A. Bejan; Merrida Childress; Ingrid Anderson; Kyle Rawling; Rhea M. Simons; Ashley Moncrief; Rebekah Caza; Laura Dugger; Aunshka Collins; Channing V. Dudley; P. Brent Ferrell; Michael Byrne; Stephen A. Strickland; Gregory D. Ayers; Bennett A. Landman; Emily F. Mason; Ruben A. Mesa; Jeanne M. Palmer; Laura C. Michaelis; Michael R. Savona
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Novel BCL-2 Inhibitor Lisaftoclax in Relapsed or Refractory Chronic Lymphocytic Leukemia and Other Hematologic Malignancies: First-in-Human Open-Label Trial
Sikander Ailawadhi; Zi Chen; Bo Huang; Aneel Paulus; Mary C. Collins; Lei (Tommy) Fu; Mingyu Li; Mohammad Ahmad; Lichuang Men; Hengbang Wang; Matthew S. Davids; Eric Liang; Divya J. Mekala; Zhicong He; Masa Lasica; Costas K. Yannakou; Ricardo Parrondo; Laura Glass; Dajun Yang; Asher Chanan-Khan; Yifan Zhai
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Devimistat in Combination with Gemcitabine and Cisplatin in Biliary Tract Cancer: Preclinical Evaluation and Phase Ib Multicenter Clinical Trial (BilT-04)
Arathi Mohan; Kent A. Griffith; Fulei Wuchu; David B. Zhen; Chandan Kumar-Sinha; Oxana Crysler; David Hsiehchen; Thomas Enzler; Dominique Dippman; Valerie Gunchick; Abhinav Achreja; Olamide Animasahun; Srinadh Choppara; Minal Nenwani; Arul M. Chinnaiyan; Deepak Nagrath; Mark M. Zalupski; Vaibhav Sahai
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A Phase II Redifferentiation Trial with Dabrafenib-Trametinib and 131I in Metastatic Radioactive Iodine Refractory BRAF p.V600E-Mutated Differentiated Thyroid Cancer
Sophie Leboulleux; Christine Do Cao; Slimane Zerdoud; Marie Attard; Claire Bournaud; Ludovic Lacroix; Danielle Benisvy; David Taïeb; Stéphane Bardet; Marie Terroir-Cassou-Mounat; Nadège Anizan; Emilie Bouvier-Morel; Livia Lamartina; Georges Lion; Sarah Betrian; Christophe Sajous; Aurélie Schiazza; Marie-Eve Garcia; Renaud Ciappuccini; Martin Schlumberger; Abir Al Ghuzlan; Yann Godbert; Isabelle Borget
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Intravenous N-Acetylcysteine to Prevent Cisplatin-Induced Hearing Loss in Children: A Nonrandomized Controlled Phase I Trial
Etan Orgel; Kristin R. Knight; Yueh-Yun Chi; Jemily Malvar; Teresa Rushing; Victoria Mena; Laurie S. Eisenberg; Shahrad R. Rassekh; Colin J.D. Ross; Erika N. Scott; Michael Neely; Edward A. Neuwelt; Leslie L. Muldoon; David R. Freyer
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Phase II Investigation of TVB-2640 (Denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma
William Kelly; Adolfo Enrique Diaz Duque; Joel Michalek; Brandon Konkel; Laura Caflisch; Yidong Chen; Sarath Chand Pathuri; Vinu Madhusudanannair-Kunnuparampil; John Floyd, II; Andrew Brenner
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Clinical Trials: Immunotherapy

Combination Treatment with Sipuleucel-T and Abiraterone Acetate or Enzalutamide for Metastatic Castration-Resistant Prostate Cancer: STAMP and STRIDE Trials
Emmanuel S. Antonarakis; Sumit K. Subudhi; Christopher M. Pieczonka; Lawrence I. Karsh; David I. Quinn; Jason M. Hafron; Helen M. Wilfehrt; Matthew Harmon; Nadeem A. Sheikh; Neal D. Shore; Daniel P. Petrylak
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Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies
Jason J. Luke; Sarina A. Piha-Paul; Theresa Medina; Claire F. Verschraegen; Mary Varterasian; Aoife M. Brennan; Richard J. Riese; Anna Sokolovska; James Strauss; David L. Hava; Filip Janku
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Precision Medicine and Imaging

Overcoming Barriers to Tumor Genomic Profiling through Direct-to-Patient Outreach
Seyram A. Doe-Tetteh; Sabrina Y. Camp; Dalicia Reales; Jett Crowdis; Anne Marie Noronha; Bernadette Wolff; Tina Alano; Jesse Galle; S. Duygu Selcuklu; Agnes Viale; Nicholas D. Socci; Ying L. Liu; William P. Tew; Carol Aghajanian; Marc Ladanyi; Meng Xiao He; Saud H. AlDubayan; Roei David Mazor; Ofer Shpilberg; Oshrat Hershkovitz-Rokah; Jose A. Riancho; Jose L. Hernandez; M. Carmen Gonzalez-Vela; Justin J. Buthorn; Manda Wilson; Amy E. Webber; Mariko Yabe; Kseniya Petrova-Drus; Marc Rosenblum; Benjamin H. Durham; Omar Abdel-Wahab; Michael F. Berger; Mark T.A. Donoghue; Andrew L. Kung; Julia Glade Bender; Neerav N. Shukla; Samuel A. Funt; Ahmet Dogan; Robert A. Soslow; Hikmat Al-Ahmadie; Darren R. Feldman; Eliezer M. Van Allen; Eli L. Diamond; David B. Solit
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Inferred Immune-Cell Activity Is an Independent Predictor of HER2-Negative Breast Cancer Prognosis and Response to Paclitaxel-Based Therapy in the GeparSepto Trial
Peter A. Fasching; Christopher Szeto; Carsten Denkert; Stephen Benz; Karsten Weber; Patricia Spilman; Jan Budczies; Andreas Schneeweiss; Elmar Stickeler; Sabine Schmatloch; Christian Jackisch; Thomas Karn; Hans Peter Sinn; Mathias Warm; Marion van Mackelenbergh; Shahrooz Rabizadeh; Christian Schem; Ernst Heinmöller; Volkmar Mueller; Frederik Marmé; Patrick Soon-Shiong; Valentina Nekljudova; Michael Untch; Sibylle Loibl
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RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer
Amanda J. Compadre; Lillian N. van Biljon; Mark C. Valentine; Alba Llop-Guevara; Emily Graham; Bisiayo Fashemi; Andrea Herencia-Ropero; Emilee N. Kotnik; Isaac Cooper; Shariska P. Harrington; Lindsay M. Kuroki; Carolyn K. McCourt; Andrea R. Hagemann; Premal H. Thaker; David G. Mutch; Matthew A. Powell; Lulu Sun; Nima Mosammaparast; Violeta Serra; Peinan Zhao; Elena Lomonosova; Dineo Khabele; Mary M. Mullen
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Translational Cancer Mechanisms and Therapy

Loss of CDKN2A Cooperates with WWTR1(TAZ)–CAMTA1 Gene Fusion to Promote Tumor Progression in Epithelioid Hemangioendothelioma
Caleb N. Seavey; Andrea Hallett; Shuo Li; Kepeng Che; Ajaybabu V. Pobbati; Shuang Ma; Ashley Burtscher; Ryan Kanai; John M. Lamar; Brian P. Rubin
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Cytochrome P450 Oxidoreductase (POR) Associated with Severe Paclitaxel-Induced Peripheral Neuropathy in Patients of European Ancestry from ECOG-ACRIN E5103
Fei Shen; Guanglong Jiang; Santosh Philips; Laura Gardner; Gloria Xue; Erica Cantor; Reynold C. Ly; Wilberforce Osei; Xi Wu; Chau Dang; Donald Northfelt; Todd Skaar; Kathy D. Miller; George W. Sledge; Bryan P. Schneider
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Increased Nerve Density Adversely Affects Outcome in Oral Cancer
Cindy Perez-Pacheco; Ligia B. Schmitd; Allison Furgal; Emily L. Bellile; Min Liu; Aya Fattah; Laura Gonzalez-Maldonado; Shelby P. Unsworth; Sunny Y. Wong; Laura S. Rozek; Arvind Rao; Gregory T. Wolf; Jeremy M.G. Taylor; Keith Casper; Michelle Mierzwa; Nisha J. D'Silva
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Intratumoral CD16+ Macrophages Are Associated with Clinical Outcomes of Patients with Metastatic Melanoma Treated with Combination Anti-PD-1 and Anti-CTLA-4 Therapy
Hansol Lee; Angela L. Ferguson; Camelia Quek; Ismael A. Vergara; Ines Pires daSilva; Ruth Allen; Tuba Nur Gide; Jordan W. Conway; Lambros T. Koufariotis; Nicholas K. Hayward; Nicola Waddell; Matteo S. Carlino; Alexander M. Menzies; Robyn P.M. Saw; Elena Shklovskaya; Helen Rizos; Serigne Lo; Richard A. Scolyer; Georgina V. Long; Umaimainthan Palendira; James S. Wilmott
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Anticoagulants Enhance Molecular and Cellular Immunotherapy of Cancer by Improving Tumor Microcirculation Structure and Function and Redistributing Tumor Infiltrates
Fang Wei; Yuling Su; Yibo Quan; Xiaojia Li; Qi Zou; Liuxi Zhang; Shu Li; Mengmeng Jiang; Guohuan Lin; Ping Liang; Jie He; Keping Xie
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Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non–Small Cell Lung Cancer
Biagio Ricciuti; Arielle Elkrief; Joao Alessi; Xinan Wang; Yvonne Li; Hersh Gupta; Daniel M. Muldoon; Arrien A. Bertram; Federica Pecci; Giuseppe Lamberti; Alessandro Di Federico; Adriana Barrichello; Victor R. Vaz; Malini Gandhi; Elinton Lee; Geoffrey I. Shapiro; Hyesun Park; Mizuki Nishino; James Lindsay; Kristen D. Felt; Bijaya Sharma; Andrew D. Cherniack; Scott Rodig; Daniel R. Gomez; Narek Shaverdian; Mehrdad Rakaee; Chaitanya Bandlamudi; Marc Ladanyi; Pasi A. Janne; Adam J. Schoenfeld; Lynette M. Sholl; Mark M. Awad; Michael L. Cheng
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Clonal Hematopoiesis in Young Women Treated for Breast Cancer
Christopher J. Gibson; Geoffrey Fell; Tal Sella; Adam S. Sperling; Craig Snow; Shoshana M. Rosenberg; Greg Kirkner; Ashka Patel; Deborah Dillon; Alexander G. Bick; Donna Neuberg; Ann H. Partridge; Peter G. Miller
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