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15 June 2023
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Cover Image
Cover Image
The cover shows a section of a cerebellar hemangioblastoma from a patient with germline missense von Hippel Lindau (VHL) disease. Multiplexed immunohistochemistry staining demonstrates a heavily vascularized tumor and a strong VHL protein expression following treatment with vorinostat. For details, see the article by Chittiboina and colleagues on page 2199 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
Project Confirm: Accelerated Drug Approvals for Chronic Myeloid Leukemia
Kendra L. Sweet; Jorge E. Cortes; Jane F. Apperley; Mel Mann; Michael J. Mauro; Vivian G. Oehler; Cristina Ruiz; Charles A. Schiffer; Lori A. Ehrlich; Gulsum E. Pamuk; Joseph Wynne; Gautam U. Mehta; R. Angelo de Claro; Marc R. Theoret; B. Douglas Smith; Kelly J. Norsworthy
Review
Perspective
Clinical Trials: Targeted Therapy
Proteostasis Modulation in Germline Missense von Hippel Lindau Disease
Prashant Chittiboina; Debjani Mandal; Alejandro Bugarini; David T. Asuzu; Dustin Mullaney; Panagiotis Mastorakos; Stefan Stoica; Reinier Alvarez; Gretchen Scott; Dragan Maric; Abdel Elkahloun; Zhengping Zhuang; Emily Y. Chew; Chunzhang Yang; Marston Linehan; Russell R. Lonser
Clinical Trials: Immunotherapy
Eganelisib, a First-in-Class PI3Kγ Inhibitor, in Patients with Advanced Solid Tumors: Results of the Phase 1/1b MARIO-1 Trial
David S. Hong; Michael Postow; Bartosz Chmielowski; Ryan Sullivan; Amita Patnaik; Ezra E.W. Cohen; Geoffrey Shapiro; Conor Steuer; Martin Gutierrez; Heather Yeckes-Rodin; Robert Ilaria, Jr; Brenda O'Connell; Joanna Peng; Guangbin Peng; Nora Zizlsperger; Anthony Tolcher; Jedd D. Wolchok
SALVO: Single-Arm Trial of Ipilimumab and Nivolumab as Adjuvant Therapy for Resected Mucosal Melanoma
Lisa A. Kottschade; Gregory Russell Pond; Anthony J. Olszanski; Yousef Zakharia; Evidio Domingo-Musibay; Ralph J. Hauke; Brendan D. Curti; Sarah Schober; Mohammed M. Milhem; Matthew Stephen Block; Tina Hieken; Robert R. McWilliams
Precision Medicine and Imaging
Co-Clinical Study of [fam-] Trastuzumab Deruxtecan (DS8201a) in Patient-Derived Xenograft Models of Uterine Carcinosarcoma and Its Association with Clinical Efficacy
Shigehiro Yagishita; Tadaaki Nishikawa; Hiroshi Yoshida; Daisuke Shintani; Sho Sato; Maiko Miwa; Mikiko Suzuki; Masanori Yasuda; Yusuke Ogitani; Takahiro Jikoh; Kan Yonemori; Kosei Hasegawa; Akinobu Hamada
Translational Cancer Mechanisms and Therapy
Exploring the Immunogenicity of Noncanonical HLA-I Tumor Ligands Identified through Proteogenomics
Maria Lozano-Rabella; Andrea Garcia-Garijo; Jara Palomero; Anna Yuste-Estevanez; Florian Erhard; Roc Farriol-Duran; Juan Martín-Liberal; Maria Ochoa-de-Olza; Ignacio Matos; Jared J. Gartner; Michael Ghosh; Francesc Canals; August Vidal; Josep Maria Piulats; Xavier Matías-Guiu; Irene Brana; Eva Muñoz-Couselo; Elena Garralda; Andreas Schlosser; Alena Gros
Proinflammatory Macrophage Activation by the Polysialic Acid-Siglec-16 Axis Is Linked to Increased Survival of Patients with Glioblastoma
Hauke Thiesler; Lina Gretenkort; Leonie Hoffmeister; Iris Albers; Luisa Ohlmeier; Iris Röckle; Andrea Verhagen; Rouzbeh Banan; Nora Köpcke; Nicole Krönke; Friedrich Feuerhake; Felix Behling; Alonso Barrantes-Freer; Dorothee Mielke; Veit Rohde; Bujung Hong; Ajit Varki; Kerstin Schwabe; Joachim K. Krauss; Christine Stadelmann; Christian Hartmann; Herbert Hildebrandt
The Negative Influence of Baseline Cell-free DNA on Long-term Survival in DLBCL Depends on Frontline Treatment Intensity
Fabienne Desmots; Delphine Rossille; Mikael Roussel; Céline Pangault; Laetitia Louarn; Mylène De Saint Jore; Steven Le Gouill; Krimo Bouabdallah; Vincent Delwail; Remy Gressin; Jérôme Cornillon; Gandhi Damaj; Hervé Maisonneuve; Diane Damotte; Françoise Kraeber-Bodere; Thierry Lamy; Marie-Cécile Parrens; Noël Milpied; Thierry Fest
An Immune-Related Gene Expression Signature Predicts Benefit from Adding Atezolizumab to FOLFOXIRI plus Bevacizumab in Metastatic Colorectal Cancer
Carlotta Antoniotti; Alessandra Boccaccino; Robert Seitz; Mirella Giordano; Aurélie Catteau; Daniele Rossini; Filippo Pietrantonio; Lisa Salvatore; Kimberly McGregor; Francesca Bergamo; Veronica Conca; Simone Leonetti; Federica Morano; Giorgio Papiani; Emiliano Tamburini; Maria Bensi; Sabina Murgioni; Douglas Teller Ross; Alessandro Passardi; Isabelle Boquet; Tyler J. Nielsen; Jérôme Galon; Matthew Gordon Varga; Brock L. Schweitzer; Chiara Cremolini
Antitumor Efficacy of Dual Blockade with Encorafenib + Cetuximab in Combination with Chemotherapy in Human BRAFV600E-Mutant Colorectal Cancer
Stefania Napolitano; Melanie Woods; Hey Min Lee; Vincenzo De Falco; Giulia Martini; Carminia Maria Della Corte; Erika Martinelli; Vincenzo Famiglietti; Davide Ciardiello; Amanda Anderson; Natalie Wall Fowlkes; Oscar Eduardo Villareal; Alexey Sorokin; Preeti Kanikarla; Olu Coker; Van Morris; Lucia Altucci; Josep Tabernero; Teresa Troiani; Fortunato Ciardiello; Scott Kopetz
Dynamics of Sequence and Structural Cell-Free DNA Landscapes in Small-Cell Lung Cancer
Lavanya Sivapalan; Wade T. Iams; Zineb Belcaid; Susan C. Scott; Noushin Niknafs; Archana Balan; James R. White; Prasad Kopparapu; Christopher Cann; Blair V. Landon; Gavin Pereira; Victor E. Velculescu; Christine L. Hann; Christine M. Lovly; Valsamo Anagnostou
Expression and Therapeutic Targeting of TROP-2 in Treatment-Resistant Prostate Cancer
Jamie M. Sperger; Kyle T. Helzer; Charlotte N. Stahlfeld; Dawei Jiang; Anupama Singh; Katherine R. Kaufmann; David J. Niles; Erika Heninger; Nicholas R. Rydzewski; Liguo Wang; Liewei Wang; Rendong Yang; Yanan Ren; Jonathan W. Engle; Peng Huang; Christos E. Kyriakopoulos; Susan F. Slovin; Howard R. Soule; Shuang G. Zhao; Manish Kohli; Scott T. Tagawa; Weibo Cai; Scott M. Dehm; Joshua M. Lang
Correction
Correction: Phase I Dose-Escalation Trial of MIW815 (ADU-S100), an Intratumoral STING Agonist, in Patients with Advanced/Metastatic Solid Tumors or Lymphomas
Funda Meric-Bernstam; Randy F. Sweis; F. Stephen Hodi; Wells A. Messersmith; Robert H.I. Andtbacka; Matthew Ingham; Nancy Lewis; Xinhui Chen; Marc Pelletier; Xueying Chen; Jincheng Wu; Thomas W. Dubensky; Sarah M. McWhirter; Thomas Müller; Nitya Nair; Jason J. Luke
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NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck. None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
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