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15 May 2023
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Cover Image
Cover Image
The cover shows an immunofluorescence staining for phospho γ-H2AX on the tumor treated with the Actinium-225 labeled anti-CD46 antibody, [225Ac]DOTA-YS5. Immunofluorescence staining shows the formation of γ-H2AX foci after treatment. For details, see the article by Bidkar and colleagues on page 1916 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
Reviews
Research Briefs: Clinical Trial Brief Reports
Targeting the Inducible T-cell Costimulator (ICOS) in Patients with Relapsed/Refractory T-follicular Helper Phenotype Peripheral T-cell and Angioimmunoblastic T-cell Lymphoma
Julio C. Chavez; Francine M. Foss; Basem M. William; Jonathan E. Brammer; Sonali M. Smith; Anca Prica; Jasmine M. Zain; Joseph M. Tuscano; Harsh Shah; Neha Mehta-Shah; Praveen Ramakrishnan Geethakumari; Ben X. Wang; Stephanie Zantinge; Lisa Wang; Ling Zhang; Anmarie Boutrin; Weiguang Zhao; Lily Cheng; Nathan Standifer; Lisa Hewitt; Enowmpey Enowtambong; Weiping Shao; Shringi Sharma; Gianluca Carlesso; Jeffrey A. Moscow; Lillian L. Siu
Clinical Trials: Targeted Therapy
Randomized Trial of Tepotinib Plus Gefitinib versus Chemotherapy in EGFR-Mutant NSCLC with EGFR Inhibitor Resistance Due to MET Amplification: INSIGHT Final Analysis
Chong Kin Liam; Azura Rozila Ahmad; Te-Chun Hsia; Jianying Zhou; Dong-Wan Kim; Ross Andrew Soo; Ying Cheng; Shun Lu; Sang Won Shin; James Chih-Hsin Yang; Yiping Zhang; Jun Zhao; Karin Berghoff; Rolf Bruns; Andreas Johne; Yi-Long Wu
Randomized Phase II Cabazitaxel Dose Individualization and Neutropenia Prevention Trial in Patients with Metastatic Castration-Resistant Prostate Cancer
Aurelius Omlin; Richard Cathomas; Gunhild von Amsberg; Christoph Reuter; Susan Feyerabend; Wolfgang Loidl; Martin Boegemann; Anja Lorch; Axel Heidenreich; Igor Tsaur; Julian Larcher-Senn; Stefan A.J. Buck; Ron H.J. Mathijssen; Ulrich Jaehde; Silke Gillessen; Markus Joerger
Clinical Trials: Immunotherapy
Safety and Efficacy of Axicabtagene Ciloleucel versus Standard of Care in Patients 65 Years of Age or Older with Relapsed/Refractory Large B-Cell Lymphoma
Jason R. Westin; Frederick L. Locke; Michael Dickinson; Armin Ghobadi; Mahmoud Elsawy; Tom van Meerten; David B. Miklos; Matthew L. Ulrickson; Miguel-Angel Perales; Umar Farooq; Luciano Wannesson; Lori Leslie; Marie José Kersten; Caron A. Jacobson; John M. Pagel; Gerald Wulf; Patrick Johnston; Aaron P. Rapoport; Linqiu Du; Saran Vardhanabhuti; Simone Filosto; Jina Shah; Julia T. Snider; Paul Cheng; Christina To; Olalekan O. Oluwole; Anna Sureda
Durvalumab plus Cetuximab in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: An Open-label, Nonrandomized, Phase II Clinical Trial
Shuchi Gulati; McKenzie Crist; Muhammed Kashif Riaz; Vinita Takiar; Maria Lehn; Ilaina Monroe; Sarah Palackdharry; Nicky Kurtzweil; Roman Jandarov; Nusrat Harun; Trisha M. Wise-Draper
Precision Medicine and Imaging
Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy
Anil P. Bidkar; Sinan Wang; Kondapa Naidu Bobba; Emily Chan; Scott Bidlingmaier; Emily A. Egusa; Robin Peter; Umama Ali; Niranjan Meher; Anju Wadhwa; Suchi Dhrona; Chandrashekhar Dasari; Denis Beckford-Vera; Yang Su; Ryan Tang; Li Zhang; Jiang He; David M. Wilson; Rahul Aggarwal; Henry F. VanBrocklin; Youngho Seo; Jonathan Chou; Bin Liu; Robert R. Flavell
Translational Cancer Mechanisms and Therapy
PSMA-positive Circulating Tumor Cell Detection and Outcomes with Abiraterone or Enzalutamide Treatment in Men with Metastatic Castrate-resistant Prostate Cancer
Santosh Gupta; Susan Halabi; Qian Yang; Akash Roy; Alisa Tubbs; Yamini Gore; Daniel J. George; David M. Nanus; Emmanuel S. Antonarakis; Daniel C. Danila; Russell Z. Szmulewitz; Richard Wenstrup; Andrew J. Armstrong
Immunologic Predictors for Clinical Responses during Immune Checkpoint Blockade in Patients with Myelodysplastic Syndromes
Sung-Eun Lee; Feng Wang; Maison Grefe; Abel Trujillo-Ocampo; Wilfredo Ruiz-Vasquez; Koichi Takahashi; Hussein A. Abbas; Pamella Borges; Dinler Amaral Antunes; Gheath Al-Atrash; Naval Daver; Jeffrey J. Molldrem; Andrew Futreal; Guillermo Garcia-Manero; Jin S. Im
Reversal of Lactate and PD-1–mediated Macrophage Immunosuppression Controls Growth of PTEN/p53-deficient Prostate Cancer
Kiranj Chaudagar; Hanna M. Hieromnimon; Rimpi Khurana; Brian Labadie; Taghreed Hirz; Shenglin Mei; Raisa Hasan; Jordan Shafran; Anne Kelley; Eva Apostolov; Ghamdan Al-Eryani; Kate Harvey; Srikrishnan Rameshbabu; Mayme Loyd; Kaela Bynoe; Catherine Drovetsky; Ani Solanki; Erica Markiewicz; Marta Zamora; Xiaobing Fan; Stephan Schürer; Alex Swarbrick; David B. Sykes; Akash Patnaik
Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy
Alexander J. Cole; Santiago Panesso-Gómez; Jaynish S. Shah; Tonge Ebai; Qi Jiang; Ece Gumusoglu-Acar; Maya G. Bello; Anda Vlad; Francesmary Modugno; Robert P. Edwards; Ronald J. Buckanovich
Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Xenograft Model
Shih-Shih Chen; Jacqueline C. Barrientos; Gerardo Ferrer; Morgan King-Richards; Yu-Ju Chen; Priyadarshini Ravichandran; Michael Ibrahim; Yasmine Kieso; Sheila Waters; Jeffery L. Kutok; Marisa Peluso; Sujata Sharma; David T. Weaver; Jonathan A. Pachter; Kanti R. Rai; Nicholas Chiorazzi
The Oncolytic Adenovirus XVir-N-31 Joins Forces with CDK4/6 Inhibition Augmenting Innate and Adaptive Antitumor Immunity in Ewing Sarcoma
Sebastian Johannes Schober; Caroline Schoening; Jennifer Eck; Charlotte Middendorf; Julia Lutsch; Pia Knoch; Anna Josefine von Ofen; Hendrik Gassmann; Melanie Thiede; Julia Hauer; Andreas Kolk; Klaus Mantwill; Jürgen E. Gschwend; Stefan E.G. Burdach; Roman Nawroth; Uwe Thiel; Per Sonne Holm
Correction
Correction: sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients
Mitchell E. Fane; Brett L. Ecker; Amanpreet Kaur; Gloria E. Marino; Gretchen M. Alicea; Stephen M. Douglass; Yash Chhabra; Marie R. Webster; Andrea Marshall; Richard Colling; Olivia Espinosa; Nicholas Coupe; Neera Maroo; Leticia Campo; Mark R. Middleton; Pippa Corrie; Xiaowei Xu; Giorgos C. Karakousis; Ashani T. Weeraratna
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