Skip Nav Destination
Issues
1 January 2023
-
Cover Image
Cover Image
The cover shows a section of a tumor biopsy from a metastatic lesion of a patient with HR+/HER2− advanced breast cancer. Immunohistochemical staining shows nuclear phospho-Rb expression. For details, see the article by Albanell and colleagues on page 67 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Clinical Trials: Targeted Therapy
Preclinical and Clinical Trial Results Using Talazoparib and Low-Dose Chemotherapy
Zev A. Wainberg; Arun S. Singh; Gottfried E. Konecny; Kelly E. McCann; J. Randolph Hecht; Jonathan Goldman; Bartosz Chmielowski; Richard S. Finn; Neil O'Brien; Erika Von Euw; Megan M. Price; Diego Martinez; Lisa Yonemoto; Meghan Brennan; John A. Glaspy; Dennis J. Slamon
Phase I Study of Niraparib in Combination with Radium-223 for the Treatment of Metastatic Castrate-Resistant Prostate Cancer
Zachary Quinn; Benjamin Leiby; Guru Sonpavde; Atish D. Choudhury; Christopher Sweeney; David Einstein; Russell Szmulewitz; Oliver Sartor; Karen Knudsen; Eddy Shih-Hsin Yang; Wm. Kevin Kelly
Lenalidomide and Eltrombopag for Treatment of Low- or Intermediate-Risk Myelodysplastic Syndrome: Result of a Phase II Clinical Trial
Jesus D. Gonzalez-Lugo; Suman Kambhampati; Abdulraheem Yacoub; William B. Donnellan; Jesus Berdeja; Prafulla Bhagat; Karen Fehn; Cassady Remy; Sakshi Jasra; Mohammed Kazemi; Kith Pradhan; Mimi Kim; Ioannis Mantzaris; R. Alejandro Sica; Nishi Shah; Mendel Goldfinger; Noah Kornblum; Kira Gritsman; Ira Braunschweig; Ulrich Steidl; Britta Will; Aditi Shastri; Amit Verma
Palbociclib Rechallenge for Hormone Receptor–Positive/HER-Negative Advanced Breast Cancer: Findings from the Phase II BioPER Trial
Joan Albanell; José Manuel Pérez-García; Miguel Gil-Gil; Giuseppe Curigliano; Manuel Ruíz-Borrego; Laura Comerma; Joan Gibert; Meritxell Bellet; Begoña Bermejo; Lourdes Calvo; Juan de la Haba; Enrique Espinosa; Alessandro Marco Minisini; Vanesa Quiroga; Ana Santaballa Bertran; Leonardo Mina; Beatriz Bellosillo; Federico Rojo; Silvia Menéndez; Miguel Sampayo-Cordero; Crina Popa; Andrea Malfettone; Javier Cortés; Antonio Llombart-Cussac
Detection of BRCA1, BRCA2, and ATM Alterations in Matched Tumor Tissue and Circulating Tumor DNA in Patients with Prostate Cancer Screened in PROfound
Kim N. Chi; Alan Barnicle; Caroline Sibilla; Zhongwu Lai; Claire Corcoran; J. Carl Barrett; Carrie A. Adelman; Ping Qiu; Ashley Easter; Simon Dearden; Geoffrey R. Oxnard; Neeraj Agarwal; Arun Azad; Johann de Bono; Joaquin Mateo; David Olmos; Antoine Thiery-Vuillemin; Elizabeth A. Harrington
Olaparib Efficacy in Patients with Metastatic Castration-resistant Prostate Cancer and BRCA1, BRCA2, or ATM Alterations Identified by Testing Circulating Tumor DNA
Nobuaki Matsubara; Johann de Bono; David Olmos; Giuseppe Procopio; Satoru Kawakami; Yüksel Ürün; Robbert van Alphen; Aude Flechon; Michael A. Carducci; Young Deuk Choi; Sebastien J. Hotte; Ernesto Korbenfeld; Gero Kramer; Neeraj Agarwal; Kim N. Chi; Simon Dearden; Christopher Gresty; Jinyu Kang; Christian Poehlein; Elizabeth A. Harrington; Maha Hussain
Clinical Trials: Immunotherapy
Pilot Study of ONCOS-102 and Pembrolizumab: Remodeling of the Tumor Microenvironment and Clinical Outcomes in Anti–PD-1–Resistant Advanced Melanoma
Alexander N. Shoushtari; Anthony J. Olszanski; Marta Nyakas; Thomas J. Hornyak; Jedd D. Wolchok; Victor Levitsky; Lukasz Kuryk; Thomas B. Hansen; Magnus Jäderberg
Combination of the STING Agonist MIW815 (ADU-S100) and PD-1 Inhibitor Spartalizumab in Advanced/Metastatic Solid Tumors or Lymphomas: An Open-Label, Multicenter, Phase Ib Study
Funda Meric-Bernstam; Randy F. Sweis; Stefan Kasper; Omid Hamid; Shailender Bhatia; Reinhard Dummer; Agostina Stradella; Georgina V. Long; Anna Spreafico; Toshio Shimizu; Neeltje Steeghs; Jason J. Luke; Sarah M. McWhirter; Thomas Müller; Nitya Nair; Nancy Lewis; Xinhui Chen; Andrew Bean; Lisa Kattenhorn; Marc Pelletier; Shahneen Sandhu
Phase II Trial of Pembrolizumab and Anti-CD3 x Anti-HER2 Bispecific Antibody-Armed Activated T Cells in Metastatic Castration-Resistant Prostate Cancer
Ulka N. Vaishampayan; Archana Thakur; Wei Chen; Abhinav Deol; Meera Patel; Kimberlee Dobson; Brenda Dickow; Dana Schalk; Amy Schienschang; Sarah Whitaker; Amanda Polend; Joseph A. Fontana; Elisabeth I. Heath; Lawrence G. Lum
Precision Medicine and Imaging
Prognostic Impact of Unsupervised Early Assessment of Bulk and Leukemic Stem Cell Measurable Residual Disease in Acute Myeloid Leukemia
Alban Canali; Inès Vergnolle; Sarah Bertoli; Laetitia Largeaud; Marie-Laure Nicolau; Jean-Baptiste Rieu; Suzanne Tavitian; Françoise Huguet; Muriel Picard; Pierre Bories; Jean Philippe Vial; Nicolas Lechevalier; Marie Christine Béné; Isabelle Luquet; Véronique Mansat-De Mas; Eric Delabesse; Christian Récher; François Vergez
Meta-Analysis of the Test–Retest Repeatability of [18F]-Fluorodeoxyglucose Standardized Uptake Values: Implications for Assessment of Tumor Response
Lalitha K. Shankar; Erich Huang; Saskia Litiere; Otto S. Hoekstra; Larry Schwartz; Sandra Collette; Ronald Boellaard; Jan Bogaerts; Lesley Seymour; Elisabeth G.E. deVries
Translational Cancer Mechanisms and Therapy
Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
Andrew W. Hahn; Ashley V. Menk; Dayana B. Rivadeneira; Ryan C. Augustin; Mingchu Xu; Jun Li; Xiaogang Wu; Aditya K. Mishra; Tuba N. Gide; Camelia Quek; Yan Zang; Christine N. Spencer; Alexander M. Menzies; Carrie R. Daniel; Courtney W. Hudgens; Theodore Nowicki; Lauren E. Haydu; M.A. Wadud Khan; Vancheswaran Gopalakrishnan; Elizabeth M. Burton; Jared Malke; Julie M. Simon; Chantale Bernatchez; Nagireddy Putluri; Scott E. Woodman; Y.N. Vashisht Gopal; Renato Guerrieri; Grant M. Fischer; Jian Wang; Khalida M. Wani; John F. Thompson; Jeffrey E. Lee; Patrick Hwu; Nadim Ajami; Jeffrey E. Gershenwald; Georgina V. Long; Richard A. Scolyer; Michael T. Tetzlaff; Alexander J. Lazar; Dirk Schadendorf; Jennifer A. Wargo; John M. Kirkwood; Ralph J. DeBerardinis; Han Liang; Andrew Futreal; Jianhua Zhang; James S. Wilmott; Weiyi Peng; Michael A. Davies; Greg M. Delgoffe; Yana G. Najjar; Jennifer L. McQuade
Conditioning Regimens are Associated with Distinct Patterns of Microbiota Injury in Allogeneic Hematopoietic Cell Transplantation
Roni Shouval; Nicholas R. Waters; Antonio L. C. Gomes; Corrado Zuanelli Brambilla; Teng Fei; Sean M. Devlin; Chi L. Nguyen; Kate A. Markey; Anqi Dai; John B. Slingerland; Annelie G. Clurman; Emily Fontana; Luigi A. Amoretti; Roberta J. Wright; Tobias M. Hohl; Ying Taur; Anthony D. Sung; Daniela Weber; Daigo Hashimoto; Takanori Teshima; Nelson J. Chao; Ernst Holler; Michael Scordo; Sergio A. Giralt; Miguel-Angel Perales; Jonathan U. Peled; Marcel R.M. van den Brink
Preclinical and Clinical Efficacy of Trastuzumab Deruxtecan in Breast Cancer Brain Metastases
Sheheryar Kabraji; Jing Ni; Sarah Sammons; Tianyu Li; Amanda E.D. Van Swearingen; Yanzhi Wang; Alyssa Pereslete; Liangge Hsu; Pamela J. DiPiro; Chris Lascola; Heather Moore; Melissa Hughes; Akshara S. Raghavendra; Maria Gule-Monroe; Rashmi K. Murthy; Eric P. Winer; Carey K. Anders; Jean J. Zhao; Nancy U. Lin
Lisaftoclax in Combination with Alrizomadlin Overcomes Venetoclax Resistance in Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia: Preclinical Studies
Yifan Zhai; Qiuqiong Tang; Douglas D. Fang; Jing Deng; Kaixiang Zhang; Qixin Wang; Yan Yin; Chengcheng Fu; Sheng-Li Xue; Na Li; Feng Zhou; Dajun Yang
Monitoring of Circulating Tumor DNA Predicts Response to Treatment and Early Progression in Follicular Lymphoma: Results of a Prospective Pilot Study
Ismael Fernández-Miranda; Lucía Pedrosa; Marta Llanos; Fernando F. Franco; Sagrario Gómez; Paloma Martín-Acosta; Francisco R. García-Arroyo; Josep Gumá; Beatriz Horcajo; Ana K. Ballesteros; Laura Gálvez; Natividad Martínez; Miguel Marín; Silvia Sequero; Marta Navarro; Natalia Yanguas-Casás; Virginia Calvo; Antonio Rueda-Domínguez; Mariano Provencio; Margarita Sánchez-Beato
Preclinical Study of a Biparatopic METxMET Antibody–Drug Conjugate, REGN5093-M114, Overcomes MET-driven Acquired Resistance to EGFR TKIs in EGFR-mutant NSCLC
Seung Yeon Oh; You Won Lee; Eun Ji Lee; Jae Hwan Kim; YoungJoon Park; Seong Gu Heo; Mi Ra Yu; Min Hee Hong; John DaSilva; Christopher Daly; Byoung Chul Cho; Sun Min Lim; Mi Ran Yun
Pharmacological Landscape of FDA-Approved Anticancer Drugs Reveals Sensitivities to Ixabepilone, Romidepsin, Omacetaxine, and Carfilzomib in Aggressive Meningiomas
Gerhard Jungwirth; Tao Yu; Fang Liu; Junguo Cao; Montadar Alaa Eddine; Mahmoud Moustafa; Amir Abdollahi; Rolf Warta; Andreas Unterberg; Christel Herold-Mende
Colorectal Cancer Metastases in the Liver Establish Immunosuppressive Spatial Networking between Tumor-Associated SPP1+ Macrophages and Fibroblasts
Anuja Sathe; Kaishu Mason; Susan M. Grimes; Zilu Zhou; Billy T. Lau; Xiangqi Bai; Andrew Su; Xiao Tan; HoJoon Lee; Carlos J. Suarez; Quan Nguyen; George Poultsides; Nancy R. Zhang; Hanlee P. Ji
Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes
Jiwei Bai; Jianxin Shi; Yazhuo Zhang; Chuzhong Li; Yujia Xiong; Hela Koka; Difei Wang; Tongwu Zhang; Lei Song; Wen Luo; Bin Zhu; Belynda Hicks; Amy Hutchinson; Erin Kirk; Melissa A. Troester; Mingxuan Li; Yutao Shen; Tianshun Ma; Junmei Wang; Xing Liu; Shuai Wang; Songbai Gui; Mary L. McMaster; Stephen J. Chanock; Dilys M. Parry; Alisa M. Goldstein; Xiaohong R. Yang
Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma
Larissa Haertle; Santiago Barrio; Umair Munawar; Seungbin Han; Xiang Zhou; Michal Simicek; Cornelia Vogt; Marietta Truger; Rafael Alonso Fernandez; Maximilian Steinhardt; Julia Weingart; Renata Snaurova; Silvia Nerreter; Eva Teufel; Andoni Garitano-Trojaola; Matteo Da Viá; Yanira Ruiz-Heredia; Andreas Rosenwald; Niccolò Bolli; Roman Hajek; Peter Raab; Marc S. Raab; Niels Weinhold; Claudia Haferlach; Thomas Haaf; Joaquin Martinez-Lopez; Hermann Einsele; Leo Rasche; K. Martin Kortüm
Acknowledgment to Reviewers
Advertisement
Email alerts
NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale within the United States of Bavencio® (avelumab), a pharmaceutical owned by Merck. If any resulting funds are received, they would not be used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.
RSS Feeds