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1 May 2022
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Cover Image
Cover Image
Multiplex immunofluorescence image of a resected intraductal papillary mucinous neoplasm with low-grade dysplasia showing infiltration of CD3+ T cells (red), CD8+ T cells (pink), CD68+ macrophages (yellow). Pan-CK staining (cyan) highlights the epithelial dysplastic cells. Nuclei are stained with DAPI (blue). For details, see article by Hernandez and colleagues on page 1938 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Review
CCR Drug Updates
Research Briefs: Clinical Trial Brief Reports
Trabectedin plus Durvalumab in Patients with Advanced Pretreated Soft Tissue Sarcoma and Ovarian Carcinoma (TRAMUNE): An Open-Label, Multicenter Phase Ib Study
Maud Toulmonde; Mehdi Brahmi; Antoine Giraud; Camille Chakiba; Alban Bessede; Michèle Kind; Emilie Toulza; Marina Pulido; Sabrina Albert; Jean-Philippe Guégan; Sophie Cousin; Simone Mathoulin-Pelissier; Raul Perret; Sabrina Croce; Jean-Yves Blay; Isabelle Ray-Coquard; Anne Floquet; Antoine Italiano
Clinical Trials: Targeted Therapy
Phase II Study of ONC201 in Neuroendocrine Tumors including Pheochromocytoma-Paraganglioma and Desmoplastic Small Round Cell Tumor
Peter M. Anderson; Matteo M. Trucco; Rohinton S. Tarapore; Stacey Zahler; Stefanie Thomas; Janette Gortz; Omar Mian; Martin Stoignew; Varun Prabhu; Sara Morrow; Joshua E. Allen
Dose Escalation Data from the Phase 1 Study of the Liposomal Formulation of Eribulin (E7389-LF) in Japanese Patients with Advanced Solid Tumors
Jun Sato; Toshio Shimizu; Takafumi Koyama; Satoru Iwasa; Akihiko Shimomura; Shunsuke Kondo; Shigehisa Kitano; Kan Yonemori; Yutaka Fujiwara; Kenji Tamura; Takuya Suzuki; Takao Takase; Reiko Nagai; Kohei Yamaguchi; Taro Semba; Zi-Ming Zhao; Min Ren; Noboru Yamamoto
A Phase III Multicenter Randomized Clinical Trial of 60 Gy versus 50 Gy Radiation Dose in Concurrent Chemoradiotherapy for Inoperable Esophageal Squamous Cell Carcinoma
Yujin Xu; Baiqiang Dong; Weiguo Zhu; Jiancheng Li; Rong Huang; Zongwen Sun; Xinmei Yang; Liping Liu; Han He; Zhongxing Liao; Ni Guan; Yue Kong; Wanwei Wang; Jianxiang Chen; Huijuan He; Guoqin Qiu; Ming Zeng; Juan Pu; Wangyuan Hu; Yong Bao; Zhigang Liu; Jun Ma; Hao Jiang; Xianghui Du; Jin Hu; Tingting Zhuang; Jing Cai; Jin Huang; Hua Tao; Yuan Liu; Xiaodong Liang; Juying Zhou; Guangzhou Tao; Xiao Zheng; Ming Chen
Circulating Cell-free DNA as a Prognostic Biomarker in Patients with Advanced ALK+ Non–small Cell Lung Cancer in the Global Phase III ALEX Trial
Rafal Dziadziuszko; Solange Peters; Tony Mok; D. Ross Camidge; Shirish M. Gadgeel; Sai-Hong Ignatius Ou; Krzysztof Konopa; Johannes Noé; Malgorzata Nowicka; Walter Bordogna; Peter N. Morcos; Vlatka Smoljanovic; Alice T. Shaw
Precision Medicine and Imaging
Targeted Analysis of Cell-free Circulating Tumor DNA is Suitable for Early Relapse and Actionable Target Detection in Patients with Neuroblastoma
Marco Lodrini; Josefine Graef; Theresa M. Thole-Kliesch; Kathy Astrahantseff; Annika Sprüssel; Maddalena Grimaldi; Constantin Peitz; Rasmus B. Linke; Jan F. Hollander; Erwin Lankes; Annette Künkele; Lena Oevermann; Georg Schwabe; Jörg Fuchs; Annabell Szymansky; Johannes H. Schulte; Patrick Hundsdörfer; Cornelia Eckert; Holger Amthauer; Angelika Eggert; Hedwig E. Deubzer
Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data
Casey W. Williamson; Tyler J. Nelson; Caroline A. Thompson; Lucas K. Vitzthum; Kaveh Zakeri; Paul J. Riviere; Alex K. Bryant; Andrew B. Sharabi; Jingjing Zou; Loren K. Mell
cfTrack: A Method of Exome-Wide Mutation Analysis of Cell-free DNA to Simultaneously Monitor the Full Spectrum of Cancer Treatment Outcomes Including MRD, Recurrence, and Evolution
Shuo Li; Weihua Zeng; Xiaohui Ni; Yonggang Zhou; Mary L. Stackpole; Zorawar S. Noor; Zuyang Yuan; Adam Neal; Sanaz Memarzadeh; Edward B. Garon; Steven M. Dubinett; Wenyuan Li; Xianghong Jasmine Zhou
Genetic Polymorphisms and Correlation with Treatment-Induced Cardiotoxicity and Prognosis in Patients with Breast Cancer
Parvin F. Peddi; Peter A. Fasching; Duan Liu; Emmanuel Quinaux; Nicholas J. Robert; Vicente Valero; John Crown; Carla Falkson; Adam Brufsky; Julie M. Cunningham; Richard M. Weinshilboum; Tadeusz Pienkowski; Wolfgang Eiermann; Miguel Martín; Valerie Bee; Xiaoyan Wang; Liewei Wang; Eric Yang; Dennis J. Slamon; Sara A. Hurvitz
Translational Cancer Mechanisms and Therapy
Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer
Andreas Seeber; Francesca Battaglin; Kai Zimmer; Florian Kocher; Yasmine Baca; Joanne Xiu; Gilbert Spizzo; Veronica Novotny-Diermayr; Dietmar Rieder; Alberto Puccini; Jeff Swensen; Michelle Ellis; Richard M. Goldberg; Axel Grothey; Anthony F. Shields; John L. Marshall; Benjamin A. Weinberg; Paul E. Sackstein; Kiat Hon Lim; Gek San Tan; Chadi Nabhan; W. Michael Korn; Arno Amann; Zlatko Trajanoski; Martin D. Berger; Emil Lou; Dominik Wolf; Heinz-Josef Lenz
Breast Cancer Index Is a Predictive Biomarker of Treatment Benefit and Outcome from Extended Tamoxifen Therapy: Final Analysis of the Trans-aTTom Study
John M.S. Bartlett; Dennis C. Sgroi; Kai Treuner; Yi Zhang; Tammy Piper; Ranelle C. Salunga; Ikhlaaq Ahmed; Lucy Doos; Sarah Thornber; Karen J. Taylor; Elena F. Brachtel; Sarah J. Pirrie; Catherine A. Schnabel; Daniel W. Rea
Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma
Trang T.T. Nguyen; Enyuan Shang; Salveena Schiffgens; Consuelo Torrini; Chang Shu; Hasan Orhan Akman; Varun V. Prabhu; Joshua E. Allen; Mike-Andrew Westhoff; Georg Karpel-Massler; Markus D. Siegelin
Multiomic Analysis Reveals Comprehensive Tumor Heterogeneity and Distinct Immune Subtypes in Multifocal Intrahepatic Cholangiocarcinoma
Shuling Chen; Yubin Xie; Yuhong Cai; Huanjing Hu; Minghui He; Lijuan Liu; Changyi Liao; Yuanqi Wang; Jianping Wang; Xiaoxue Ren; Qianwen Zeng; Hong Peng; Shunli Shen; Shaoqiang Li; Dongming Li; Jiaming Lai; Baogang Peng; Jian Ren; Ming Kuang; Sui Peng
Genomic Correlates of Outcome in Tumor-Infiltrating Lymphocyte Therapy for Metastatic Melanoma
Caitlin A. Creasy; Yuzhong Jeff Meng; Marie-Andrée Forget; Tatiana Karpinets; Katarzyna Tomczak; Chip Stewart; Carlos A. Torres-Cabala; Shari Pilon-Thomas; Amod A. Sarnaik; James J. Mulé; Levi Garraway; Matias Bustos; Jianhua Zhang; Sapna P. Patel; Adi Diab; Isabella C. Glitza; Cassian Yee; Hussein Tawbi; Michael K. Wong; Jennifer McQuade; Dave S.B. Hoon; Michael A. Davies; Patrick Hwu; Rodabe N. Amaria; Cara Haymaker; Rameen Beroukhim; Chantale Bernatchez
Association of TP53 and CDKN2A Mutation Profile with Tumor Mutation Burden in Head and Neck Cancer
Alexander Y. Deneka; Yasmine Baca; Ilya G. Serebriiskii; Emmanuelle Nicolas; Mitchell I. Parker; Theodore T. Nguyen; Joanne Xiu; W. Michael Korn; Michael J. Demeure; Trisha Wise-Draper; Ammar Sukari; Barbara Burtness; Erica A. Golemis
Diminished Immune Surveillance during Histologic Progression of Intraductal Papillary Mucinous Neoplasms Offers a Therapeutic Opportunity for Cancer Interception
Sharia Hernandez; Edwin Roger Parra; Naohiro Uraoka; Ximing Tang; Yu Shen; Wei Qiao; Mei Jiang; Shanyu Zhang; Barbara Mino; Wei Lu; Renganayaki Pandurengan; Cara Haymaker; Kajsa Affolter; Courtney L. Scaife; Michele Yip-Schneider; C. Max Schmidt; Matthew A. Firpo; Sean J. Mulvihill; Eugene J. Koay; Huamin Wang; Ignacio I. Wistuba; Anirban Maitra; Luisa M. Solis; Subrata Sen
Targeting the Ubiquitin–Proteasome System Using the UBA1 Inhibitor TAK-243 is a Potential Therapeutic Strategy for Small-Cell Lung Cancer
Safa Majeed; Mansi K. Aparnathi; Kevin C.J. Nixon; Vidhyasagar Venkatasubramanian; Fariha Rahman; Lifang Song; Jessica Weiss; Ranya Barayan; Vijithan Sugumar; Samir H. Barghout; Joel D. Pearson; Rod Bremner; Aaron D. Schimmer; Ming S. Tsao; Geoffrey Liu; Benjamin H. Lok
Disruption of DNA Repair and Survival Pathways through Heat Shock Protein Inhibition by Onalespib to Sensitize Malignant Gliomas to Chemoradiation Therapy
Jihong Xu; Pei-Jung Wu; Tzung-Huei Lai; Pratibha Sharma; Alessandro Canella; Alessandra M. Welker; Christine E. Beattie; J. Brad Elder; Michelle Easley; Russell Lonser; Naduparambil K. Jacob; Maciej Pietrzak; Cynthia M. Timmers; Frederick Lang; Deepa Sampath; Vinay K. Puduvalli
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