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15 March 2022
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Cover Image
Cover Image
The cover image shows immunohistochemical staining of a human dysplastic Barrett's esophagus biopsy, demonstrating the basement membrane protein collagen IV. In this study, the authors highlight extracellular matrix protein changes during BE progression to neoplasia and identified that loss of the basement membrane protein, agrin, is a novel diagnostic biomarker that can identify NDBE patients at increased risk of developing advanced neoplasia. For details, see article by Rickelt and colleagues on page 1167 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
U.S. FDA Drug Approvals for Gynecological Malignancies: A Decade in Review
Shaily Arora; Preeti Narayan; Gwynn Ison; Tara Berman; Daniel L. Suzman; Suparna Wedam; Tatiana M. Prowell; Soma Ghosh; Reena Philip; Christy L. Osgood; Jennifer J. Gao; Mirat Shah; Danielle Krol; Sakar Wahby; Melanie Royce; Christina Brus; Erik W. Bloomquist; Mallorie H. Fiero; Shenghui Tang; Richard Pazdur; Amna Ibrahim; Laleh Amiri-Kordestani; Julia A. Beaver
U.S. FDA Drug Approvals for Breast Cancer: A Decade in Review
Shaily Arora; Preeti Narayan; Christy L. Osgood; Suparna Wedam; Tatiana M. Prowell; Jennifer J. Gao; Mirat Shah; Danielle Krol; Sakar Wahby; Melanie Royce; Soma Ghosh; Reena Philip; Gwynn Ison; Tara Berman; Christina Brus; Erik W. Bloomquist; Mallorie H. Fiero; Shenghui Tang; Richard Pazdur; Amna Ibrahim; Laleh Amiri-Kordestani; Julia A. Beaver
Clinical Trials: Targeted Therapy
Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma: Results from a Proof-of-Concept, Phase Ib Study
Albiruni R. Abdul Razak; Sebastian Bauer; Cristina Suarez; Chia-Chi Lin; Richard Quek; Marie Luise Hütter-Krönke; Ricardo Cubedo; Stephane Ferretti; Nelson Guerreiro; Astrid Jullion; Elena J. Orlando; Giorgia Clementi; Janna Sand Dejmek; Ensar Halilovic; Claire Fabre; Jean-Yves Blay; Antoine Italiano
BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600-mutant Melanoma
Janice M. Mehnert; Tara C. Mitchell; Alexander C. Huang; Tomas S. Aleman; Benjamin J. Kim; Lynn M. Schuchter; Gerald P. Linette; Giorgos C. Karakousis; Sheryl Mitnick; Lydia Giles; Mary Carberry; Noelle Frey; Andrew Kossenkov; Roman Groisberg; Leonel F. Hernandez-Aya; George Ansstas; Ann W. Silk; Sunandana Chandra; Jeffrey A. Sosman; Phyllis A. Gimotty; Rosemarie Mick; Ravi K. Amaravadi
Sapanisertib plus Fulvestrant in Postmenopausal Women with Estrogen Receptor–Positive/HER2-Negative Advanced Breast Cancer after Progression on Aromatase Inhibitor
José Á. García-Sáenz; Noelia Martínez-Jáñez; Ricardo Cubedo; Yolanda Jerez; Ainhara Lahuerta; Santiago González-Santiago; Nieves Ferrer; Manuel Ramos; Jose L. Alonso-Romero; Antonio Antón; Eva Carrasco; Jingjing Chen; Rachel Neuwirth; Kevin Galinsky; Sylvie Vincent; E. Jane Leonard; Dennis Slamon
Tepotinib Efficacy and Safety in Patients with MET Exon 14 Skipping NSCLC: Outcomes in Patient Subgroups from the VISION Study with Relevance for Clinical Practice
Xiuning Le; Hiroshi Sakai; Enriqueta Felip; Remi Veillon; Marina Chiara Garassino; Jo Raskin; Alexis B. Cortot; Santiago Viteri; Julien Mazieres; Egbert F. Smit; Michael Thomas; Wade T. Iams; Byoung Chul Cho; Hye Ryun Kim; James Chih-Hsin Yang; Yuh-Min Chen; Jyoti D. Patel; Christine M. Bestvina; Keunchil Park; Frank Griesinger; Melissa Johnson; Maya Gottfried; Christian Britschgi; John Heymach; Elif Sikoglu; Karin Berghoff; Karl-Maria Schumacher; Rolf Bruns; Gordon Otto; Paul K. Paik
A Novel Third-generation EGFR Tyrosine Kinase Inhibitor Abivertinib for EGFR T790M-mutant Non–Small Cell Lung Cancer: a Multicenter Phase I/II Study
Qing Zhou; Lin Wu; Pei Hu; Tongtong An; Jianying Zhou; Li Zhang; Xiao-Qing Liu; Feng Luo; Xin Zheng; Ying Cheng; Nong Yang; Junling Li; Jifeng Feng; Baohui Han; Yong Song; Kai Wang; Li Zhang; Jian Fang; Hong Zhao; Yongqian Shu; Xiao-Yan Lin; Zhihong Chen; Bin Gan; Wan-Hong Xu; Wei Tang; Xiaoying Zhang; Jin-Ji Yang; Xiao Xu; Yi-Long Wu
Clinical Trials: Immunotherapy
Preoperative Chemoradiotherapy plus Nivolumab before Surgery in Patients with Microsatellite Stable and Microsatellite Instability–High Locally Advanced Rectal Cancer
Hideaki Bando; Yuichiro Tsukada; Koji Inamori; Yosuke Togashi; Shohei Koyama; Daisuke Kotani; Shota Fukuoka; Satoshi Yuki; Yoshito Komatsu; Shigenori Homma; Akinobu Taketomi; Mamoru Uemura; Takeshi Kato; Makoto Fukui; Masashi Wakabayashi; Naoki Nakamura; Motohiro Kojima; Hiroshi Kawachi; Richard Kirsch; Tsutomu Yoshida; Yutaka Suzuki; Akihiro Sato; Hiroyoshi Nishikawa; Masaaki Ito; Takayuki Yoshino
Tislelizumab for Relapsed/Refractory Classical Hodgkin Lymphoma: 3-Year Follow-up and Correlative Biomarker Analysis
Yuqin Song; Quanli Gao; Huilai Zhang; Lei Fan; Jianfeng Zhou; Dehui Zou; Wei Li; Haiyan Yang; Ting Liu; Quanshun Wang; Fangfang Lv; Haiyi Guo; Xia Zhao; Dan Wang; Pei Zhang; Yidi Wang; Lei Wang; Tengfei Liu; Yun Zhang; Zhirong Shen; Jane Huang; Jun Zhu
Intralesional SD-101 in Combination with Pembrolizumab in Anti-PD-1 Treatment-Naïve Head and Neck Squamous Cell Carcinoma: Results from a Multicenter, Phase II Trial
Ezra E.W. Cohen; Lisle Nabell; Deborah J. Wong; Terry Day; Gregory A. Daniels; Mohammed Milhem; Sanjeev Deva; Michael Jameson; Orlando Guntinas-Lichius; Mohammed Almubarak; Matthew Strother; Eric Whitman; Michael Chisamore; Cynthia Obiozor; Teresa Bagulho; Jose Gomez-Romo; Cristiana Guiducci; Robert Janssen; Erick Gamelin; Alain P. Algazi
Precision Medicine and Imaging
Agrin Loss in Barrett's Esophagus-Related Neoplasia and Its Utility as a Diagnostic and Predictive Biomarker
Steffen Rickelt; Azfar Neyaz; Charlene Condon; Charles A. Whittaker; Ali H. Zaidi; Martin S. Taylor; Genevieve Abbruzzese; Anthony R. Mattia; Lawrence Zukerberg; Stuti G. Shroff; Omer H. Yilmaz; Osman Yilmaz; Elizabeth Y. Wu; Won-Tak Choi; Blair A. Jobe; Robert D. Odze; Deepa T. Patil; Vikram Deshpande; Richard O. Hynes
Assessing CSF ctDNA to Improve Diagnostic Accuracy and Therapeutic Monitoring in Breast Cancer Leptomeningeal Metastasis
Amanda Fitzpatrick; Marjan Iravani; Adam Mills; Lucy Childs; Thanussuyah Alaguthurai; Angela Clifford; Isaac Garcia-Murillas; Steven Van Laere; Luc Dirix; Mark Harries; Alicia Okines; Nicholas C. Turner; Syed Haider; Andrew N.J. Tutt; Clare M. Isacke
Circulating Immune Bioenergetic, Metabolic, and Genetic Signatures Predict Melanoma Patients' Response to Anti–PD-1 Immune Checkpoint Blockade
Pierre L. Triozzi; Elizabeth R. Stirling; Qianqian Song; Brian Westwood; Mitra Kooshki; M. Elizabeth Forbes; Beth C. Holbrook; Katherine L. Cook; Martha A. Alexander-Miller; Lance D. Miller; Wei Zhang; David R. Soto-Pantoja
Translational Cancer Mechanisms and Therapy
Predictive and Therapeutic Implications of a Novel PLCγ1/SHP2-Driven Mechanism of Cetuximab Resistance in Metastatic Colorectal Cancer
Raquel Cruz-Duarte; Cátia Rebelo de Almeida; Magda Negrão; Afonso Fernandes; Paula Borralho; Daniel Sobral; Lina M. Gallego-Paez; Daniel Machado; João Gramaça; José Vílchez; Ana T. Xavier; Miguel Godinho Ferreira; Ana R. Miranda; Helder Mansinho; Maria J. Brito; Teresa R. Pacheco; Catarina Abreu; Ana Lucia-Costa; André Mansinho; Rita Fior; Luís Costa; Marta Martins
Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor–positive Breast Cancers
Milana A. Bergamino; Gabriele Morani; Joel Parker; Eugene F. Schuster; Mariana F. Leal; Elena López-Knowles; Holly Tovey; Judith M. Bliss; John F.R. Robertson; Ian E. Smith; Mitch Dowsett; Maggie C.U. Cheang
Long-Acting Recombinant Human Interleukin-7, NT-I7, Increases Cytotoxic CD8 T Cells and Enhances Survival in Mouse Glioma Models
Jian L. Campian; Subhajit Ghosh; Vaishali Kapoor; Ran Yan; Sukrutha Thotala; Arijita Jash; Tong Hu; Anita Mahadevan; Kasem Rifai; Logan Page; Byung Ha Lee; Sara Ferrando-Martinez; Alexandra A. Wolfarth; Se Hwan Yang; Dennis Hallahan; Milan G. Chheda; Dinesh Thotala
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