Skip Nav Destination
Issues
1 March 2022
-
Cover Image
Cover Image
The cover image shows infiltrating immune cells in a papillomavirus (HPV)-positive human head and neck squamous carcinoma section. Immunohistochemical staining reveals the presence of major leukocyte lineages, including CD68+ myeloid cells (green), CD3+ T cells (blue), and CD20+ B cells (yellow) that are in close proximity to cytokeratin+ malignant epithelial cells (red). For details, see article by Taylor and colleague's on page 903 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
Review
Perspectives
From Basic Science to Clinical Translation in Kidney Cancer: A Report from the Second Kidney Cancer Research Summit
Toni K. Choueiri; Laurence Albiges; Michael B. Atkins; Ziad Bakouny; Gennady Bratslavsky; David A. Braun; Naomi B. Haas; John B.A.G. Haanen; A. Ari Hakimi; Michael A.S. Jewett; Eric Jonasch; William G. Kaelin, Jr; Payal Kapur; Chris Labaki; Bryan Lewis; David F. McDermott; Sumanta K. Pal; Kevin Pels; Susan Poteat; Thomas Powles; W. Kimryn Rathmell; Brian I. Rini; Sabina Signoretti; Nizar M. Tannir; Robert G. Uzzo; Hans J. Hammers
Clinical Trials: Targeted Therapy
Safety, Activity, and Long-term Outcomes of Pomalidomide in the Treatment of Kaposi Sarcoma among Individuals with or without HIV Infection
Ramya Ramaswami; Mark N. Polizzotto; Kathryn Lurain; Kathleen M. Wyvill; Anaida Widell; Jomy George; Priscila Goncalves; Seth M. Steinberg; Denise Whitby; Thomas S. Uldrick; Robert Yarchoan
Updated Overall Survival of Ribociclib plus Endocrine Therapy versus Endocrine Therapy Alone in Pre- and Perimenopausal Patients with HR+/HER2− Advanced Breast Cancer in MONALEESA-7: A Phase III Randomized Clinical Trial
Yen-Shen Lu; Seock-Ah Im; Marco Colleoni; Fabio Franke; Aditya Bardia; Fatima Cardoso; Nadia Harbeck; Sara Hurvitz; Louis Chow; Joohyuk Sohn; Keun Seok Lee; Saul Campos-Gomez; Rafael Villanueva Vazquez; Kyung Hae Jung; K. Govind Babu; Paul Wheatley-Price; Michelino De Laurentiis; Young-Hyuck Im; Sherko Kuemmel; Nagi El-Saghir; Ruth O'Regan; Claudia Gasch; Nadia Solovieff; Craig Wang; Yongyu Wang; Arunava Chakravartty; Yan Ji; Debu Tripathy
The Effect of Corticosteroids on Prostate Cancer Outcome Following Treatment with Enzalutamide: A Multivariate Analysis of the Phase III AFFIRM Trial
Jimmy L. Zhao; Karim Fizazi; Fred Saad; Kim N. Chi; Mary-Ellen Taplin; Cora N. Sternberg; Andrew J. Armstrong; Johann S. de Bono; William T. Duggan; Howard I. Scher
Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type TP53 Solid Tumors and Acute Leukemia
Eytan M. Stein; Daniel J. DeAngelo; Jörg Chromik; Manik Chatterjee; Sebastian Bauer; Chia-Chi Lin; Cristina Suarez; Filip de Vos; Neeltje Steeghs; Philippe A. Cassier; David Tai; Jean-Jacques Kiladjian; Noboru Yamamoto; Rogier Mous; Jordi Esteve; Hironobu Minami; Stephane Ferretti; Nelson Guerreiro; Christophe Meille; Rajkumar Radhakrishnan; Bernard Pereira; Luisa Mariconti; Ensar Halilovic; Claire Fabre; Cecilia Carpio
Clinical Trials: Immunotherapy
A Phase 1a/b Open-Label, Dose-Escalation Study of Etigilimab Alone or in Combination with Nivolumab in Patients with Locally Advanced or Metastatic Solid Tumors
Niharika B. Mettu; Susanna V. Ulahannan; Johanna C. Bendell; Ignacio Garrido-Laguna; John H. Strickler; Kathleen N. Moore; Robert Stagg; Ann M. Kapoun; Leonardo Faoro; Sunil Sharma
A Randomized Phase II Study Comparing Nivolumab with Carboplatin–Pemetrexed for EGFR-Mutated NSCLC with Resistance to EGFR Tyrosine Kinase Inhibitors (WJOG8515L)
Hidetoshi Hayashi; Shunichi Sugawara; Yasushi Fukuda; Daichi Fujimoto; Satoru Miura; Keiichi Ota; Yuichi Ozawa; Satoshi Hara; Junko Tanizaki; Koichi Azuma; Shota Omori; Motoko Tachihara; Kazumi Nishino; Akihiro Bessho; Yasutaka Chiba; Koji Haratani; Kazuko Sakai; Kazuto Nishio; Nobuyuki Yamamoto; Kazuhiko Nakagawa
Safety and Efficacy of Pembrolizumab in Combination with Acalabrutinib in Advanced Head and Neck Squamous Cell Carcinoma: Phase 2 Proof-of-Concept Study
Matthew H. Taylor; Courtney B. Betts; Lauren Maloney; Eric Nadler; Alain Algazi; Michael J. Guarino; John Nemunaitis; Antonio Jimeno; Priti Patel; Veerendra Munugalavadla; Lin Tao; Douglas Adkins; Jerome H. Goldschmidt, Jr; Ezra E.W. Cohen; Lisa M. Coussens
Tadalafil Enhances Immune Signatures in Response to Neoadjuvant Nivolumab in Resectable Head and Neck Squamous Cell Carcinoma
Adam J. Luginbuhl; Jennifer M. Johnson; Larry A. Harshyne; Alban J. Linnenbach; Sanket K. Shukla; Angela Alnemri; Gaurav Kumar; David M. Cognetti; Joseph M. Curry; Nikita Kotlov; Zoya Antysheva; Sandrine Degryse; Kyle Mannion; Michael K. Gibson; James Netterville; Brandee Brown; Rita Axelrod; Ralph Zinner; Madalina Tuluc; Stacey Gargano; Benjamin E. Leiby; Ayako Shimada; My G. Mahoney; Ubaldo Martinez-Outschoorn; Ulrich Rodeck; Young J. Kim; Andrew P. South; Athanassios Argiris
Precision Medicine and Imaging
Detecting Neuroendocrine Prostate Cancer Through Tissue-Informed Cell-Free DNA Methylation Analysis
Jacob E. Berchuck; Sylvan C. Baca; Heather M. McClure; Keegan Korthauer; Harrison K. Tsai; Pier Vitale Nuzzo; Kaitlin M. Kelleher; Monica He; John A. Steinharter; Soumya Zacharia; Sandor Spisak; Ji-Heui Seo; Vincenza Conteduca; Olivier Elemento; Joonghoon Auh; Michael Sigouros; Eva Corey; Michelle S. Hirsch; Mary-Ellen Taplin; Toni K. Choueiri; Mark M. Pomerantz; Himisha Beltran; Matthew L. Freedman
Long-term Follow-up and Patterns of Response, Progression, and Hyperprogression in Patients after PD-1 Blockade in Advanced Sarcoma
Nicholas D. Klemen; Sinchun Hwang; Martina Bradic; Evan Rosenbaum; Mark A. Dickson; Mrinal M. Gounder; Ciara M. Kelly; Mary L. Keohan; Sujana Movva; Katherine A. Thornton; Ping Chi; Benjamin A. Nacev; Jason E. Chan; Edmund K. Bartlett; Allison L. Richards; Samuel Singer; Mark T.A. Donoghue; William D. Tap; Sandra P. D'Angelo
ImmunoPET of Ovarian and Pancreatic Cancer with AR9.6, a Novel MUC16-Targeted Therapeutic Antibody
Sai Kiran Sharma; Kyeara N. Mack; Alessandra Piersigilli; Jacob Pourat; Kimberly J. Edwards; Outi Keinänen; Maria S. Jiao; Huiyong Zhao; Brandy White; Cory L. Brooks; Elisa de Stanchina; Madi R. Madiyalakan; Michael A. Hollingsworth; Prakash Radhakrishnan; Jason S. Lewis; Brian M. Zeglis
Differential Survival and Therapy Benefit of Patients with Breast Cancer Are Characterized by Distinct Epithelial and Immune Cell Microenvironments
Lennart Kester; Danielle Seinstra; Annelot G.J. van Rossum; Claire Vennin; Marlous Hoogstraat; Daphne van der Velden; Mark Opdam; Erik van Werkhoven; Kerstin Hahn; Iris Nederlof; Ester H. Lips; Ingrid A.M. Mandjes; A. Elise van Leeuwen-Stok; Sander Canisius; Harm van Tinteren; Alex L.T. Imholz; Johanneke E.A. Portielje; Monique E.M.M. Bos; Sandra D. Bakker; Emiel J. Rutgers; Hugo M. Horlings; Jelle Wesseling; Emile E. Voest; Lodewyk F.A. Wessels; Marleen Kok; Hendrika M. Oosterkamp; Alexander van Oudenaarden; Sabine C. Linn; Jacco van Rheenen
Genetic Subtyping and Phenotypic Characterization of the Immune Microenvironment and MYC/BCL2 Double Expression Reveal Heterogeneity in Diffuse Large B-cell Lymphoma
Zijun Y. Xu-Monette; Li Wei; Xiaosheng Fang; Qingyan Au; Harry Nunns; Máté Nagy; Alexandar Tzankov; Feng Zhu; Carlo Visco; Govind Bhagat; Karen Dybkaer; April Chiu; Wayne Tam; Youli Zu; Eric D. Hsi; Fredrick B. Hagemeister; Xiaoping Sun; Xin Han; Heounjeong Go; Maurilio Ponzoni; Andrés J.M. Ferreri; Michael B. Møller; Benjamin M. Parsons; J. Han van Krieken; Miguel A. Piris; Jane N. Winter; Yong Li; Bing Xu; Maher Albitar; Hua You; Ken H. Young
Functional Mapping of AKT Signaling and Biomarkers of Response from the FAIRLANE Trial of Neoadjuvant Ipatasertib plus Paclitaxel for Triple-Negative Breast Cancer
Zhen Shi; Julia Wulfkuhle; Malgorzata Nowicka; Rosa I. Gallagher; Cristina Saura; Paolo G. Nuciforo; Isabel Calvo; Jay Andersen; José Luis Passos-Coelho; Miguel J. Gil-Gil; Begoña Bermejo; Debra A. Pratt; Eva M. Ciruelos; Patricia Villagrasa; Matthew J. Wongchenko; Emanuel F. Petricoin; Mafalda Oliveira; Steven J. Isakoff
Translational Cancer Mechanisms and Therapy
20-Year Steady Increase in Survival of Adult Patients with Relapsed Philadelphia-Positive Acute Lymphoblastic Leukemia Post Allogeneic Hematopoietic Cell Transplantation
Ali Bazarbachi; Myriam Labopin; Mahmoud Aljurf; Riitta Niittyvuopio; Marie Balsat; Didier Blaise; Ibrahim Yakoub-Agha; Anna Grassi; Hans Christian Reinhardt; Stig Lenhoff; Pavel Jindra; Jakob Passweg; Iman Abou Dalle; Michael Stadler; Bruno Lioure; Patrice Ceballos; Eolia Brissot; Sebastian Giebel; Arnon Nagler; Christoph Schmid; Mohamad Mohty
Targeting Treg-Expressed STAT3 Enhances NK-Mediated Surveillance of Metastasis and Improves Therapeutic Response in Pancreatic Adenocarcinoma
Miles Piper; Benjamin Van Court; Adam Mueller; Shuichi Watanabe; Thomas Bickett; Shilpa Bhatia; Laurel B. Darragh; Max Mayeda; Diemmy Nguyen; Jacob Gadwa; Michael Knitz; Sophia Corbo; Rustain Morgan; Jung-Jae Lee; Alexander Dent; Karyn Goodman; Wells Messersmith; Richard Schulick; Marco Del Chiaro; Yuwen Zhu; Ross M. Kedl; Laurel Lenz; Sana D. Karam
Circulating CD137+ T Cells Correlate with Improved Response to Anti-PD1 Immunotherapy in Patients with Cancer
Ilaria Grazia Zizzari; Alessandra Di Filippo; Andrea Botticelli; Lidia Strigari; Angelina Pernazza; Emma Rullo; Maria Gemma Pignataro; Alessio Ugolini; Fabio Scirocchi; Francesca Romana Di Pietro; Ernesto Rossi; Alain Gelibter; Giovanni Schinzari; Giulia D'Amati; Aurelia Rughetti; Paolo Marchetti; Marianna Nuti; Chiara Napoletano
Therapy-Related Transcriptional Subtypes in Matched Primary and Recurrent Head and Neck Cancer
Peter Weber; Axel Künstner; Julia Hess; Kristian Unger; Sebastian Marschner; Christian Idel; Julika Ribbat-Idel; Philipp Baumeister; Olivier Gires; Christoph Walz; Sibylle Rietzler; Laura Valeanu; Timm Herkommer; Lisa Kreutzer; Olena Klymenko; Guido Drexler; Thomas Kirchner; Cornelius Maihöfer; Ute Ganswindt; Axel Walch; Michael Sterr; Heiko Lickert; Martin Canis; Dirk Rades; Sven Perner; Mauricio Berriel Diaz; Stefan Herzig; Kirsten Lauber; Barbara Wollenberg; Hauke Busch; Claus Belka; Horst Zitzelsberger
Advertisement
