Skip Nav Destination
Issues
1 February 2022
-
Cover Image
Cover Image
![issue cover]()
The cover shows a pathologic section of invasive, keratinizing squamous cell carcinoma from a patient with recurrent oral cavity or tongue cancer prior to neoadjuvant immunotherapy before salvage surgery. For details, see the article by Hanna and colleagues on page 468 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Tivozanib for Relapsed or Refractory Renal Cell Carcinoma
Elaine Chang; Chana Weinstock; Lijun Zhang; Mallorie H. Fiero; Miao Zhao; Eias Zahalka; Tiffany K. Ricks; Jeanne Fourie Zirkelbach; Junshan Qiu; Jingyu Yu; Xiao Hong Chen; Vishal Bhatnagar; Kirsten B. Goldberg; Shenghui Tang; Paul G. Kluetz; Richard Pazdur; Amna Ibrahim; Julia A. Beaver; Laleh Amiri-Kordestani
FDA Approval Summary: Nivolumab in Combination with Ipilimumab for the Treatment of Unresectable Malignant Pleural Mesothelioma
Erica C. Nakajima; Paz J. Vellanki; Erin Larkins; Somak Chatterjee; Pallavi S. Mishra-Kalyani; Youwei Bi; Hisham Qosa; Jiang Liu; Hong Zhao; Missiratch Biable; Lauren Tesh Hotaki; Yuan-Li Shen; Richard Pazdur; Julia A. Beaver; Harpreet Singh; Martha Donoghue
Clinical Trials: Targeted Therapy
A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma
Andrew B. Lassman; Patrick Y. Wen; Martin J. van den Bent; Scott R. Plotkin; Annemiek M.E. Walenkamp; Adam L. Green; Kai Li; Christopher J. Walker; Hua Chang; Sharon Tamir; Leah Henegar; Yao Shen; Mariano J. Alvarez; Andrea Califano; Yosef Landesman; Michael G. Kauffman; Sharon Shacham; Morten Mau-Sørensen
Pyrotinib in Patients with HER2-Amplified Advanced Non–Small Cell Lung Cancer: A Prospective, Multicenter, Single-Arm Trial
Zhengbo Song; Dongqing Lv; Shi-Qing Chen; Jianjin Huang; Yuping Li; Shenpeng Ying; Xiaoyu Wu; Feng Hua; Wenxian Wang; Chunwei Xu; Ting Bei; Chan Gao; Zhijian Sun; Yiping Zhang; Shun Lu
Clinical Trials: Immunotherapy
Neoadjuvant and Adjuvant Nivolumab and Lirilumab in Patients with Recurrent, Resectable Squamous Cell Carcinoma of the Head and Neck
Glenn J. Hanna; Anne O'Neill; Kee-Young Shin; Kristine Wong; Vickie Y. Jo; Charles T. Quinn; Jennifer M. Cutler; Michelle Flynn; Patrick H. Lizotte; Donald J. Annino, Jr; Laura A. Goguen; Jason I. Kass; Eleni M. Rettig; Rosh K.V. Sethi; Jochen H. Lorch; Jonathan D. Schoenfeld; Danielle N. Margalit; Roy B. Tishler; Peter C. Everett; Anupam M. Desai; Megan E. Cavanaugh; Cloud P. Paweletz; Ann Marie Egloff; Ravindra Uppaluri; Robert I. Haddad
Mogamulizumab in Combination with Nivolumab in a Phase I/II Study of Patients with Locally Advanced or Metastatic Solid Tumors
David S. Hong; Olivier Rixe; Vi K. Chiu; Patrick M. Forde; Tomislav Dragovich; Yanyan Lou; Asha Nayak-Kapoor; Rom Leidner; James N. Atkins; Agron Collaku; Floyd E. Fox; Margaret A. Marshall; Anthony J. Olszanski
Safety, Efficacy, and Biomarker Analysis of Toripalimab in Patients with Previously Treated Advanced Urothelial Carcinoma: Results from a Multicenter Phase II Trial POLARIS-03
Xinan Sheng; Haige Chen; Bin Hu; Xudong Yao; Ziling Liu; Xin Yao; Hongqian Guo; Yi Hu; Zhigang Ji; Hong Luo; Benkang Shi; Jiyan Liu; Jin Wu; FangJian Zhou; Zhisong He; Jinhai Fan; Weifeng Wang; Hui Feng; Sheng Yao; Patricia Keegan; Yiran Huang; Jun Guo
Immune Activity and Response Differences of Oncolytic Viral Therapy in Recurrent Glioblastoma: Gene Expression Analyses of a Phase IB Study
Katherine E. Miller; Kevin A. Cassady; Justin C. Roth; Jennifer Clements; Kathleen M. Schieffer; Kristen Leraas; Anthony R. Miller; Nripesh Prasad; Jianmei W. Leavenworth; Inmaculada B. Aban; Richard J. Whitley; G. Yancey Gillespie; Elaine R. Mardis; James M. Markert
Precision Medicine and Imaging
Circulating Tumor DNA in Stage III Colorectal Cancer, beyond Minimal Residual Disease Detection, toward Assessment of Adjuvant Therapy Efficacy and Clinical Behavior of Recurrences
Tenna Vesterman Henriksen; Noelia Tarazona; Amanda Frydendahl; Thomas Reinert; Francisco Gimeno-Valiente; Juan Antonio Carbonell-Asins; Shruti Sharma; Derrick Renner; Dina Hafez; Desamparados Roda; Marisol Huerta; Susana Roselló; Anders Husted Madsen; Uffe S. Løve; Per Vadgaard Andersen; Ole Thorlacius-Ussing; Lene Hjerrild Iversen; Kåre Andersson Gotschalck; Himanshu Sethi; Alexey Aleshin; Andres Cervantes; Claus Lindbjerg Andersen
A PD-1/PD-L1 Proximity Assay as a Theranostic Marker for PD-1 Blockade in Patients with Metastatic Melanoma
Isabelle Girault; Julien Adam; Shensi Shen; Séverine Roy; Caroline Brard; Sara Faouzi; Emilie Routier; Jéremy Lupu; Sarah Warren; Kristina Sorg; SuFey Ong; Pascale Morel; Jean-Yves Scoazec; Stéphan Vagner; Caroline Robert
Translational Cancer Mechanisms and Therapy
Activation of PI3K/AKT Pathway Is a Potential Mechanism of Treatment Resistance in Small Cell Lung Cancer
Ying Jin; Yamei Chen; Huarong Tang; Xiao Hu; Shawna M. Hubert; Qian Li; Dan Su; Haimiao Xu; Yun Fan; Xinmin Yu; Qixun Chen; Jinshi Liu; Wei Hong; Yujin Xu; Huan Deng; Dapeng Zhu; Pansong Li; Yuhua Gong; Xuefeng Xia; Carl M. Gay; Jianjun Zhang; Ming Chen
Immune Profiling of Combined Hepatocellular- Cholangiocarcinoma Reveals Distinct Subtypes and Activation of Gene Signatures Predictive of Response to Immunotherapy
Cong Trung Nguyen; Stefano Caruso; Pascale Maille; Aurélie Beaufrère; Jérémy Augustin; Loetitia Favre; Anaïs Pujals; Camille Boulagnon-Rombi; Rami Rhaiem; Giuliana Amaddeo; Luca di Tommaso; Alain Luciani; Hélène Regnault; Raffaele Brustia; Olivier Scatton; Frédéric Charlotte; Isabelle Brochériou; Daniele Sommacale; Patrick Soussan; Vincent Leroy; Alexis Laurent; Van Ky Le; Van To Ta; Hong Son Trinh; Thi Lan Tran; David Gentien; Audrey Rapinat; Jean Charles Nault; Manon Allaire; Sebastien Mulé; Jessica Zucman-Rossi; Jean-Michel Pawlotsky; Christophe Tournigand; Fouad Lafdil; Valérie Paradis; Julien Calderaro
Single-Cell Analysis Reveals EP4 as a Target for Restoring T-Cell Infiltration and Sensitizing Prostate Cancer to Immunotherapy
Shihong Peng; Pan Hu; Yu-Tian Xiao; Weiqiang Lu; Dandan Guo; Shixiu Hu; Jiayi Xie; Minna Wang; Weiwei Yu; Junjie Yang; Huang Chen; Xiaomin Zhang; Yasheng Zhu; Ye Wang; Yue Yang; Guanghui Zhu; Sujun Chen; Jian Wang; Bo Zhang; Weidong Chen; Huangan Wu; Zhenliang Sun; Tao Ding; Hankun Zhang; Zhengfang Yi; Mingyao Liu; Shancheng Ren
Advertisement
