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1 December 2022
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Cover Image
Cover Image
Multiplex immunofluorescence image depicting T-cell populations in a resected, neoadjuvant-treated pancreatic ductal adenocarcinoma. The image shows abundant CD3+CD8+ cytotoxic T cells (green and purple) and fewer CD3+CD4+ helper T cells (green and cyan). In addition, tumor cells are shown in orange, regulatory FOXP3+ cells are marked by yellow nuclei, and CD45RO+ memory T cells are marked by green and red. For details, see the article by Dias Costa and colleagues on page 5167 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Clinical Trials: Targeted Therapy
A Randomized Multi-institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck
Cherie-Ann O. Nathan; D. Neil Hayes; Theodore Karrison; Olivier Harismendy; José M. Flores; Tara Moore-Medlin; Everett E. Vokes; J. Silvio Gutkind; Prakash Neupane; Glenn Mills; Zoukaa Sargi; Tanguy Seiwert; Juneko Grilley-Olson; Terry Day; Maura Gillison; James L. Wade; Lawrence Feldman; Gautam Jha; Mark Kozloff; Miriam O'Leary; Francis P. Worden; Ezra E.W. Cohen
Randomized Phase II Study of Physiologic MRI-Directed Adaptive Radiation Boost in Poor Prognosis Head and Neck Cancer
Michelle L. Mierzwa; Madhava Aryal; Choonik Lee; Matthew Schipper; Monica VanTil; Krystal Morales; Paul L. Swiecicki; Keith A. Casper; Kelly M. Malloy; Matthew E. Spector; Andrew G. Shuman; Steven B. Chinn; Mark E.P. Prince; Chaz L. Stucken; Andrew J. Rosko; Theodore S. Lawrence; J. Chad Brenner; Benjamin Rosen; Caitlin A. Schonewolf; Jennifer Shah; Avraham Eisbruch; Francis P. Worden; Yue Cao
Clinical Efficacy and Whole-Exome Sequencing of Liquid Biopsies in a Phase IB/II Study of Bazedoxifene and Palbociclib in Advanced Hormone Receptor–Positive Breast Cancer
Junko Tsuji; Tianyu Li; Albert Grinshpun; Tim Coorens; Douglas Russo; Leilani Anderson; Rebecca Rees; Agostina Nardone; Candace Patterson; Niall J. Lennon; Carrie Cibulskis; Ignaty Leshchiner; Nabihah Tayob; Sara M. Tolaney; Nadine Tung; Donald P. McDonnell; Ian E. Krop; Eric P. Winer; Chip Stewart; Gad Getz; Rinath Jeselsohn
Clinical Trials: Immunotherapy
Tilsotolimod Exploits the TLR9 Pathway to Promote Antigen Presentation and Type 1 IFN Signaling in Solid Tumors: A Multicenter International Phase I/II Trial (ILLUMINATE-101)
Hani Babiker; Erkut Borazanci; Vivek Subbiah; Sanjiv Agarwala; Alain Algazi; Jacob Schachter; Michael Lotem; Corinne Maurice-Dror; Daniel Hendler; Shah Rahimian; Hans Minderman; Cara Haymaker; Daruka Mahadevan; Chantale Bernatchez; Ravi Murthy; Rolf Hultsch; Nadia Kaplan; Gregory Woodhead; Charles Hennemeyer; Srinivas Chunduru; Peter M. Anderson; Adi Diab; Igor Puzanov
A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412
Kara L. Davis; Elizabeth Fox; Emasenyie Isikwei; Joel M. Reid; Xiaowei Liu; Charles G. Minard; Stephan Voss; Stacey L. Berg; Brenda J. Weigel; Crystal L. Mackall
Efficacy and Safety of the Anti–PD-L1 mAb Socazolimab for Recurrent or Metastatic Cervical Cancer: a Phase I Dose-Escalation and Expansion Study
Jusheng An; Jie Tang; Benjamin X. Li; Huihua Xiong; Hui Qiu; Lin Luo; Li Wang; Danbo Wang; Qi Zhou; Qin Xu; Honglin Song; Yunyan Zhang; Hongping Zhang; Yujie Li; Xiaohui Yu; Jing Zhang; Rachel Ng; Wayne Zhao; Michael Wong; Xiangrong Dai; Guiling Li; Lingying Wu
Neoadjuvant Pembrolizumab and Radical Cystectomy in Patients with Muscle-Invasive Urothelial Bladder Cancer: 3-Year Median Follow-Up Update of PURE-01 Trial
Giuseppe Basile; Marco Bandini; Ewan A. Gibb; Jeffrey S. Ross; Daniele Raggi; Laura Marandino; Tiago Costa de Padua; Emanuele Crupi; Renzo Colombo; Maurizio Colecchia; Roberta Lucianò; Luigi Nocera; Marco Moschini; Alberto Briganti; Francesco Montorsi; Andrea Necchi
Precision Medicine and Imaging
hENT1 Expression Predicts Response to Gemcitabine and Nab-Paclitaxel in Advanced Pancreatic Ductal Adenocarcinoma
Sheron Perera; Gun Ho Jang; Yifan Wang; Deirdre Kelly; Michael Allen; Amy Zhang; Robert E. Denroche; Anna Dodd; Stephanie Ramotar; Shawn Hutchinson; Mustapha Tehfe; Ravi Ramjeesingh; James Biagi; Bernard Lam; Julie Wilson; Sandra E. Fischer; George Zogopoulos; Faiyaz Notta; Steven Gallinger; Robert C. Grant; Jennifer J. Knox; Grainne M. O'Kane
Translational Cancer Mechanisms and Therapy
Activation of Adaptive and Innate Immune Cells via Localized IL2 Cytokine Factories Eradicates Mesothelioma Tumors
Amanda M. Nash; Samira Aghlara-Fotovat; Bertha Castillio; Andrea Hernandez; Aarthi Pugazenthi; Hyun-Sung Lee; Hee-Jin Jang; Annie Nguyen; Alexander Lu; Bryan M. Burt; Ravi K. Ghanta; Omid Veiseh
Mass Cytometry Reveals Classical Monocytes, NK Cells, and ICOS+ CD4+ T Cells Associated with Pembrolizumab Efficacy in Patients with Lung Cancer
Philippe Rochigneux; Aaron Lisberg; Alejandro Garcia; Samuel Granjeaud; Anne Madroszyk; Stéphane Fattori; Anthony Gonçalves; Raynier Devillier; Pauline Maby; Nassim Salem; Laurent Gorvel; Brice Chanez; Jaklin Gukasyan; James Carroll; Jonathan Goldman; Anne Sophie Chretien; Daniel Olive; Edward B. Garon
Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets
Urvi A. Shah; Kylee H. Maclachlan; Andriy Derkach; Meghan Salcedo; Kelly Barnett; Julia Caple; Jenna Blaslov; Linh Tran; Amanda Ciardiello; Miranda Burge; Tala Shekarkhand; Peter Adintori; Justin Cross; Matthew J. Pianko; Kinga Hosszu; Devin McAvoy; Sham Mailankody; Neha Korde; Malin Hultcrantz; Hani Hassoun; Carlyn R. Tan; Sydney X. Lu; Dhwani Patel; Benjamin Diamond; Gunjan Shah; Michael Scordo; Oscar Lahoud; David J. Chung; Heather Landau; Saad Z. Usmani; Sergio Giralt; Ying Taur; C. Ola Landgren; Gladys Block; Torin Block; Jonathan U. Peled; Marcel R.M. van den Brink; Alexander M. Lesokhin
Feasibility of a Novel Academic BCMA-CART (HBI0101) for the Treatment of Relapsed and Refractory AL Amyloidosis
Shlomit Kfir-Erenfeld; Nathalie Asherie; Sigal Grisariu; Batia Avni; Eran Zimran; Miri Assayag; Tatyana Dubnikov Sharon; Marjorie Pick; Eyal Lebel; Adir Shaulov; Yael C. Cohen; Irit Avivi; Cyrille J. Cohen; Polina Stepensky; Moshe E. Gatt
Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer
Andressa Dias Costa; Sara A. Väyrynen; Akhil Chawla; Jinming Zhang; Juha P. Väyrynen; Mai Chan Lau; Hannah L. Williams; Chen Yuan; Vicente Morales-Oyarvide; Dalia Elganainy; Harshabad Singh; James M. Cleary; Kimberly Perez; Kimmie Ng; William Freed-Pastor; Joseph D. Mancias; Stephanie K. Dougan; Jiping Wang; Douglas A. Rubinson; Richard F. Dunne; Margaret M. Kozak; Lauren Brais; Emma Reilly; Thomas Clancy; David C. Linehan; Daniel T. Chang; Aram F. Hezel; Albert C. Koong; Andrew J. Aguirre; Brian M. Wolpin; Jonathan A. Nowak
Associations between Pretreatment Body Composition Features and Clinical Outcomes among Patients with Metastatic Clear Cell Renal Cell Carcinoma Treated with Immune Checkpoint Blockade
Yasser Ged; Alejandro Sanchez; Sujata Patil; Andrea Knezevic; Emily Stein; Stacey Petruzella; Kate Weiss; Cihan Duzgol; Joshua Chaim; Oguz Akin; Marina Mourtzakis; Michael T. Paris; Jessica Scott; Fengshen Kuo; Ritesh Kotecha; A. Ari Hakimi; Chung-Han Lee; Robert J. Motzer; Martin H. Voss; Helena Furberg
A Novel B7-H6–Targeted IgG-Like T Cell–Engaging Antibody for the Treatment of Gastrointestinal Tumors
Wei Zhang; Aurélie Auguste; Xiaoyun Liao; Christian Walterskirchen; Kathrin Bauer; Yu-Hsi Lin; Ling Yang; Farzaneh Sayedian; Markus Fabits; Michael Bergmann; Carina Binder; Leticia Corrales; Anne B. Vogt; Lindsey J. Hudson; Martin P. Barnes; Arnima Bisht; Craig Giragossian; Vladimir Voynov; Paul J. Adam; Susanne Hipp
Therapy-related Myeloid Neoplasms Following PARP Inhibitors: Real-life Experience
Vincent Marmouset; Justine Decroocq; Sylvain Garciaz; Gabriel Etienne; Amine Belhabri; Sarah Bertoli; Lauris Gastaud; Célestine Simand; Sylvain Chantepie; Madalina Uzunov; Alexis Genthon; Céline Berthon; Edmond Chiche; Pierre-Yves Dumas; Jacques Vargaftig; Géraldine Salmeron; Emilie Lemasle; Emmanuelle Tavernier; Jérémy Delage; Marion Loirat; Nadine Morineau; Félix Blanc-Durand; Patricia Pautier; Véronique Vergé; Nathalie Auger; Myrtille Thomas; Laetitia Stefani; Marion Lepelley; Thomas Boyer; Sylvain Thepot; Marie-Pierre Gourin; Pascal Bourquard; Matthieu Duchmann; Pierre-Marie Morice; Mauricette Michallet; Lionel Adès; Pierre Fenaux; Christian Récher; Hervé Dombret; Arnaud Pagès; Christophe Marzac; Alexandra Leary; Jean-Baptiste Micol; on behalf of UNIHEM, French Network of Pharmacovigilance Centers, ALFA, FILO, and GFM
Serologic Profiling Using an Epstein-Barr Virus Mammalian Expression Library Identifies EBNA1 IgA as a Prediagnostic Marker for Nasopharyngeal Carcinoma
Sarita Paudel; Benjamin E. Warner; Renwei Wang; Jennifer Adams-Haduch; Alex S. Reznik; Jason Dou; Yufei Huang; Yu-Tang Gao; Woon-Puay Koh; Alan Bäckerholm; Jian-Min Yuan; Kathy H.Y. Shair
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