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15 November 2022
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Cover Image
Cover Image
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The cover shows an FFPE section of pancreatic ductal adenocarcinoma (PDAC, tumor cells in cyan). Opal multiplex immunofluorescence staining shows expression of the chemokine receptor CXCR4 (yellow) on tumor-infiltrating lymphocytes together with CD8+ T cells (green) and macrophages (CD68, red). For details, see the article by Kocher and colleagues on page 4957 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Belzutifan for von Hippel-Lindau Disease–Associated Tumors
Jaleh Fallah; Michael H. Brave; Chana Weinstock; Gautam U. Mehta; Diana Bradford; Haley Gittleman; Erik W. Bloomquist; Rosane Charlab; Salaheldin S. Hamed; Claudia P. Miller; Sarah E. Dorff; Wiley A. Chambers; Bronwyn D. Mixter; Jeannette Dinin; William F. Pierce; Tiffany K. Ricks; Shenghui Tang; Martha Donoghue; Richard Pazdur; Laleh Amiri-Kordestani; Amna Ibrahim; Julia A. Beaver
Review
Special Report
Electronic Nicotine Delivery Systems: An Updated Policy Statement from the American Association for Cancer Research and the American Society of Clinical Oncology
Roy S. Herbst; Dorothy Hatsukami; Dana Acton; Meredith Giuliani; Allyn Moushey; Jonathan Phillips; Shimere Sherwood; Benjamin A. Toll; Kasisomayajula Viswanath; Nicholas J.H. Warren; Graham W. Warren; Anthony J. Alberg
Clinical Trials: Targeted Therapy
Phase Ia/b, Open-Label, Multicenter Study of AZD4635 (an Adenosine A2A Receptor Antagonist) as Monotherapy or Combined with Durvalumab, in Patients with Solid Tumors
Emerson A. Lim; Johanna C. Bendell; Gerald S. Falchook; Todd M. Bauer; Charles G. Drake; Jennifer H. Choe; Daniel J. George; Janet L. Karlix; Susanna Ulahannan; Kris F. Sachsenmeier; Deanna L. Russell; Ganesh Moorthy; Ben S. Sidders; Elizabeth A. Pilling; Huifang Chen; Maureen M. Hattersley; Mayukh Das; Rakesh Kumar; Gayle P. Pouliot; Manish R. Patel
Clinical Trials: Immunotherapy
A Therapeutic Antigen-Presenting Cell-Targeting DNA Vaccine VB10.16 in HPV16-Positive High-Grade Cervical Intraepithelial Neoplasia: Results from a Phase I/IIa Trial
Peter Hillemanns; Agnieszka Denecke; Linn Woelber; Gerd Böhmer; Matthias Jentschke; Karoline W. Schjetne; Karsten M.H. Bruins Slot; Agnete B. Fredriksen
Precision Medicine and Imaging
PD-1T TILs as a Predictive Biomarker for Clinical Benefit to PD-1 Blockade in Patients with Advanced NSCLC
Karlijn Hummelink; Vincent van der Noort; Mirte Muller; Robert D. Schouten; Ferry Lalezari; Dennis Peters; Willemijn S.M.E. Theelen; Viktor H. Koelzer; Kirsten D. Mertz; Alfred Zippelius; Michel M. van den Heuvel; Annegien Broeks; John B.A.G. Haanen; Ton N. Schumacher; Gerrit A. Meijer; Egbert F. Smit; Kim Monkhorst; Daniela S. Thommen
ImmunoPET Imaging with 89Zr-Labeled Atezolizumab Enables In Vivo Evaluation of PD-L1 in Tumorgraft Models of Renal Cell Carcinoma
Aditi Mulgaonkar; Roy Elias; Layton Woolford; Bing Guan; Kien Nham; Payal Kapur; Alana Christie; Vanina T. Tcheuyap; Nirmish Singla; I. Alex Bowman; Christina Stevens; Guiyang Hao; James Brugarolas; Xiankai Sun
SPOP Mutations as a Predictive Biomarker for Androgen Receptor Axis–Targeted Therapy in De Novo Metastatic Castration-Sensitive Prostate Cancer
Umang Swami; Ryon P. Graf; Roberto H. Nussenzveig; Virginia Fisher; Hanna Tukachinsky; Alexa B. Schrock; Gerald Li; Jeffrey S. Ross; Nicolas Sayegh; Nishita Tripathi; Vinay Mathew Thomas; Geoffrey R. Oxnard; Emmanuel S. Antonarakis; Neeraj Agarwal
Family History of Prostate and Breast Cancer Integrated with a Polygenic Risk Score Identifies Men at Highest Risk of Dying from Prostate Cancer before Age 75 Years
Anna Plym; Yiwen Zhang; Konrad H. Stopsack; Yon Ho Jee; Fredrik Wiklund; Adam S. Kibel; Peter Kraft; Edward Giovannucci; Kathryn L. Penney; Lorelei A. Mucci
Translational Cancer Mechanisms and Therapy
Interactions in CSF1-Driven Tenosynovial Giant Cell Tumors
David G.P. van IJzendoorn; Magdalena Matusiak; Gregory W. Charville; Geert Spierenburg; Sushama Varma; Deana R.C. Colburg; Michiel A.J. van de Sande; Kirsten van Langevelde; David G. Mohler; Kristen N. Ganjoo; Nam Q. Bui; Raffi S. Avedian; Judith V.M.G. Bovée; Robert Steffner; Robert B. West; Matt van de Rijn
Molecular Subclasses of Clear Cell Ovarian Carcinoma and Their Impact on Disease Behavior and Outcomes
Kelly L. Bolton; Denise Chen; Rosario Corona de la Fuente; Zhuxuan Fu; Rajmohan Murali; Martin Köbel; Yanis Tazi; Julie M. Cunningham; Irenaeus C.C. Chan; Brian J. Wiley; Lea A. Moukarzel; Stacey J. Winham; Sebastian M. Armasu; Jenny Lester; Esther Elishaev; Angela Laslavic; Catherine J. Kennedy; Anna Piskorz; Magdalena Sekowska; Alison H. Brand; Yoke-Eng Chiew; Paul Pharoah; Kevin M. Elias; Ronny Drapkin; Michael Churchman; Charlie Gourley; Anna DeFazio; Beth Karlan; James D. Brenton; Britta Weigelt; Michael S. Anglesio; David Huntsman; Simon Gayther; Jason Konner; Francesmary Modugno; Kate Lawrenson; Ellen L. Goode; Elli Papaemmanuil
Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets
Florian Kocher; Alberto Puccini; Gerold Untergasser; Agnieszka Martowicz; Kai Zimmer; Andreas Pircher; Yasmine Baca; Joanne Xiu; Johannes Haybaeck; Piotr Tymoszuk; Richard M. Goldberg; Angelica Petrillo; Anthony F. Shields; Mohamed E. Salem; John L. Marshall; Michael Hall; W. Michael Korn; Chadi Nabhan; Francesca Battaglin; Heinz-Josef Lenz; Emil Lou; Su-Pin Choo; Chee-Keong Toh; Silvia Gasteiger; Renate Pichler; Dominik Wolf; Andreas Seeber
Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks
Anthony R. Cillo; Elina Mukherjee; Nathanael G. Bailey; Sayali Onkar; Jessica Daley; Claudia Salgado; Xiang Li; Dongyan Liu; Sarangarajan Ranganathan; Melissa Burgess; John Sembrat; Kurt Weiss; Rebecca Watters; Tullia C. Bruno; Dario A.A. Vignali; Kelly M. Bailey
Plasma CD27, a Surrogate of the Intratumoral CD27–CD70 Interaction, Correlates with Immunotherapy Resistance in Renal Cell Carcinoma
Nadine Benhamouda; Ikuan Sam; Nicolas Epaillard; Alain Gey; Letuan Phan; Hang Phuong Pham; Nadège Gruel; Antonin Saldmann; Joséphine Pineau; Milena Hasan; Valentin Quiniou; Camille Nevoret; Virginie Verkarre; Valentina Libri; Sebastien Mella; Clémence Granier; Chloe Broudin; Patrice Ravel; Eléonore De Guillebon; Laetitia Mauge; Dominique Helley; Bernd Jabla; Nathalie Chaput; Laurence Albiges; Sandrine Katsahian; Julien Adam; Arnaud Mejean; Olivier Adotevi; Yann A. Vano; Stéphane Oudard; Eric Tartour
De-escalated Neoadjuvant Chemotherapy in Early Triple-Negative Breast Cancer (TNBC): Impact of Molecular Markers and Final Survival Analysis of the WSG-ADAPT-TN Trial
Oleg Gluz; Ulrike Nitz; Cornelia Kolberg-Liedtke; Aleix Prat; Matthias Christgen; Sherko Kuemmel; Mohammad Parsa Mohammadian; Daniel Gebauer; Ronald Kates; Laia Paré; Eva-Maria Grischke; Helmut Forstbauer; Michael Braun; Mathias Warm; John Hackmann; Christoph Uleer; Bahriye Aktas; Claudia Schumacher; Rachel Wuerstlein; Monika Graeser; Enrico Pelz; Katarzyna Jóźwiak; Christine zu Eulenburg; Hans Heinrich Kreipe; Nadia Harbeck; on behalf of the ADAPT TN investigators
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