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15 October 2022
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Cover Image
Cover Image
The cover shows an H&E-stained section of an ovarian low-grade serous carcinoma. For details, see the article by Manning-Geist and colleagues on page 4456 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Research Briefs: Clinical Trial Brief Reports
Effective Tumor Debulking with Ibrutinib Before Initiation of Venetoclax: Results from the CAPTIVATE Minimal Residual Disease and Fixed-Duration Cohorts
Paul M. Barr; Alessandra Tedeschi; William G. Wierda; John N. Allan; Paolo Ghia; Daniele Vallisa; Ryan Jacobs; Susan O'Brien; Andrew P. Grigg; Patricia Walker; Cathy Zhou; Joi Ninomoto; Gabriel Krigsfeld; Constantine S. Tam
Clinical Trials: Immunotherapy
A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Virus Gene Therapy in Metastatic Triple-Negative Breast Cancer
Kai Sun; Yitian Xu; Licheng Zhang; Polly Niravath; Jorge Darcourt; Tejal Patel; Bin S. Teh; Andrew M. Farach; Carlo Guerrero; Sunil Mathur; Mark A. Sultenfuss; Nakul Gupta; Mary R. Schwartz; Susan L. Haley; Sindhu Nair; Xiaoxian Li; Thi Truc Anh Nguyen; Joseph D. Butner; Joe Ensor; Jaime A. Mejia; Zhuyong Mei; E. Brian Butler; Shu-hsia Chen; Eric H. Bernicker; Jenny C. Chang
A Randomized Comparison of Nivolumab versus Nivolumab + Docetaxel for Previously Treated Advanced or Recurrent ICI-Naïve Non–Small Cell Lung Cancer: TORG1630
Yuri Taniguchi; Tsuneo Shimokawa; Yuichi Takiguchi; Toshihiro Misumi; Yukiko Nakamura; Yosuke Kawashima; Naoki Furuya; Yoshimasa Shiraishi; Toshiyuki Harada; Hisashi Tanaka; Satoru Miura; Ayumi Uchiyama; Yoshiro Nakahara; Takaaki Tokito; Katsuhiko Naoki; Akihiro Bessho; Yasuhiro Goto; Masahiro Seike; Hiroaki Okamoto
Precision Medicine and Imaging
Novel Radiomic Measurements of Tumor-Associated Vasculature Morphology on Clinical Imaging as a Biomarker of Treatment Response in Multiple Cancers
Nathaniel Braman; Prateek Prasanna; Kaustav Bera; Mehdi Alilou; Mohammadhadi Khorrami; Patrick Leo; Maryam Etesami; Manasa Vulchi; Paulette Turk; Amit Gupta; Prantesh Jain; Pingfu Fu; Nathan Pennell; Vamsidhar Velcheti; Jame Abraham; Donna Plecha; Anant Madabhushi
89Zr-panitumumab Combined With 18F-FDG PET Improves Detection and Staging of Head and Neck Squamous Cell Carcinoma
Yu-Jin Lee; Nynke S. van den Berg; Heying Duan; E. Carmen Azevedo; Valentina Ferri; Marisa Hom; Roan C. Raymundo; Alex Valencia; Jessa Castillo; Bin Shen; Quan Zhou; Laura Freeman; Mary Ellen Koran; Michael J. Kaplan; A. Dimitrios Colevas; Fred M. Baik; Frederick T. Chin; Brock A. Martin; Andrei Iagaru; Eben L. Rosenthal
Clinical Validation of EndoPredict in Pre-Menopausal Women with ER-Positive, HER2-Negative Primary Breast Cancer
Anastasia Constantinidou; Yiola Marcou; Michael S. Toss; Timothy Simmons; Ryan Bernhisel; Elisha Hughes; Braden Probst; Stephanie Meek; Eleni Kakouri; Georgios Georgiou; Ioanna Zouvani; Gabriella Savvidou; Vanessa Kuhl; Jennifer Doedt; Susanne Wagner; Alexander Gutin; Thomas P. Slavin; Jerry S. Lanchbury; Ralf Kronenwett; Ian O. Ellis; Emad A. Rakha
Functional Testing to Characterize and Stratify PI3K Inhibitor Responses in Chronic Lymphocytic Leukemia
Yanping Yin; Paschalis Athanasiadis; Linda Karlsen; Aleksandra Urban; Haifeng Xu; Ishwarya Murali; Stacey M. Fernandes; Alberto J. Arribas; Abdul K. Hilli; Kjetil Taskén; Francesco Bertoni; Anthony R. Mato; Emmanuel Normant; Jennifer R. Brown; Geir E. Tjønnfjord; Tero Aittokallio; Sigrid S. Skånland
Translational Cancer Mechanisms and Therapy
MAPK Pathway Genetic Alterations Are Associated with Prolonged Overall Survival in Low-Grade Serous Ovarian Carcinoma
Beryl Manning-Geist; Sushmita Gordhandas; Ying L. Liu; Qin Zhou; Alexia Iasonos; Arnaud Da Cruz Paula; Diana Mandelker; Kara Long Roche; Oliver Zivanovic; Anna Maio; Yelena Kemel; Dennis S. Chi; Roisin E. O'Cearbhaill; Carol Aghajanian; Britta Weigelt; M. Herman Chui; Rachel N. Grisham
EWS::FLI1 and HOXD13 Control Tumor Cell Plasticity in Ewing Sarcoma
April A. Apfelbaum; Feinan Wu; Allegra G. Hawkins; Brian Magnuson; Jennifer A. Jiménez; Sean D. Taylor; Emma D. Wrenn; Olivia Waltner; Elise R. Pfaltzgraff; Jane Y. Song; Cody Hall; Deneen M. Wellik; Mats Ljungman; Scott N. Furlan; Russell J.H. Ryan; Jay F. Sarthy; Elizabeth R. Lawlor
Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy–Resistant Early Breast Cancers
Patrycja Gazinska; Charlotte Milton; Jacopo Iacovacci; Joseph Ward; Richard Buus; Thanussuyah Alaguthurai; Rosalind Graham; Ayse Akarca; Esther Lips; Kalnisha Naidoo; Jelle Wesseling; Teresa Marafioti; Maggie Cheang; Cheryl Gillett; Yin Wu; Aadil Khan; Alan Melcher; Roberto Salgado; Mitch Dowsett; Andrew Tutt; Ioannis Roxanis; Syed Haider; Sheeba Irshad
Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Laura Torrens; Marc Puigvehí; Miguel Torres-Martín; Huan Wang; Miho Maeda; Philipp K. Haber; Thais Leonel; Mireia García-López; Roger Esteban-Fabró; Wei Qiang Leow; Carla Montironi; Sara Torrecilla; Ajay Ramakrishnan Varadarajan; Patricia Taik; Genís Campreciós; Chinbold Enkhbold; Erdenebileg Taivanbaatar; Amankyeldi Yerbolat; Augusto Villanueva; Sofía Pérez-del-Pulgar; Swan Thung; Jigjidsuren Chinburen; Eric Letouzé; Jessica Zucman-Rossi; Andrew Uzilov; Jaclyn Neely; Xavier Forns; Sasan Roayaie; Daniela Sia; Josep M. Llovet
Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance
Violeta Serra; Anderson T. Wang; Marta Castroviejo-Bermejo; Urszula M. Polanska; Marta Palafox; Andrea Herencia-Ropero; Gemma N. Jones; Zhongwu Lai; Joshua Armenia; Filippos Michopoulos; Alba Llop-Guevara; Rachel Brough; Aditi Gulati; Stephen J. Pettitt; Krishna C. Bulusu; Jenni Nikkilä; Zena Wilson; Adina Hughes; Paul W.G. Wijnhoven; Ambar Ahmed; Alejandra Bruna; Albert Gris-Oliver; Marta Guzman; Olga Rodríguez; Judit Grueso; Joaquin Arribas; Javier Cortés; Cristina Saura; Alan Lau; Susan Critchlow; Brian Dougherty; Carlos Caldas; Gordon B. Mills; J. Carl Barrett; Josep V. Forment; Elaine Cadogan; Christopher J. Lord; Cristina Cruz; Judith Balmaña; Mark J. O'Connor
Inhibition of LSD1 with Bomedemstat Sensitizes Small Cell Lung Cancer to Immune Checkpoint Blockade and T-Cell Killing
Joseph B. Hiatt; Holly Sandborg; Sarah M. Garrison; Henry U. Arnold; Sheng-You Liao; Justin P. Norton; Travis J. Friesen; Feinan Wu; Kate D. Sutherland; Hugh Y. Rienhoff, Jr; Renato Martins; A. McGarry Houghton; Shivani Srivastava; David MacPherson
Early Postoperative Treatment versus Initial Observation in CNS WHO Grade 2 and 3 Oligodendroglioma: Clinical Outcomes and DNA Methylation Patterns
Maximilian J. Mair; Annette Leibetseder; Gerwin Heller; Rainer Puhr; Erwin Tomasich; Sebastian Goldberger; Teresa Hatziioannou; Adelheid Wöhrer; Georg Widhalm; Karin Dieckmann; Martin Aichholzer; Serge Weis; Tim von Oertzen; Julia Furtner; Josef Pichler; Matthias Preusser; Anna S. Berghoff
Corrections
Correction: Clinical Significance of PIK3CA and ESR1 Mutations in Circulating Tumor DNA: Analysis from the MONARCH 2 Study of Abemaciclib plus Fulvestrant
Sara M. Tolaney; Masakazu Toi; Patrick Neven; Joohyuk Sohn; Eva-Maria Grischke; Antonio Llombart-Cussac; Hatem Soliman; Hong Wang; Sameera Wijayawardana; Valerie M. Jansen; Lacey M. Litchfield; George W. Sledge, Jr
Correction: Functional Categorization of BRCA1 Variants of Uncertain Clinical Significance in Homologous Recombination Repair Complementation Assays
Peter Bouwman; Ingrid van der Heijden; Hanneke van der Gulden; Roebi de Bruijn; Merel E. Braspenning; Setareh Moghadasi; Lodewyk F.A. Wessels; the Dutch-Belgian VUS workgroup; Maaike P.G. Vreeswijk; Jos Jonkers
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