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15 January 2022
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The cover shows a section of a pretreatment biopsy from a patient with Luminal B-like breast cancer who achieved a pathologic complete response after neoadjuvant chemotherapy and immunotherapy. Multiplex fluorescence immunohistochemistry depicts CD3 in magenta, PD-1 in yellow, CD68 in white, CD163 in green, PD-L1 in red, pan-cytokeratin in cyan, and nuclei in blue. For details, see the article by Dieci and colleagues on page 308 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Drug Updates
FDA Approval Summary: Capmatinib and Tepotinib for the Treatment of Metastatic NSCLC Harboring MET Exon 14 Skipping Mutations or Alterations
Luckson N. Mathieu; Erin Larkins; Oladimeji Akinboro; Pourab Roy; Anup K. Amatya; Mallorie H. Fiero; Pallavi S. Mishra-Kalyani; Whitney S. Helms; Claire E. Myers; Amy M. Skinner; Stephanie Aungst; Runyan Jin; Hong Zhao; Huiming Xia; Jeanne Fourie Zirkelbach; Youwei Bi; Yangbing Li; Jiang Liu; Manuela Grimstein; Xinyuan Zhang; Stacie Woods; Kelie Reece; Abdelrahmman M. Abukhdeir; Soma Ghosh; Reena Philip; Shenghui Tang; Kirsten B. Goldberg; Richard Pazdur; Julia A. Beaver; Harpreet Singh
Review
Perspective
Research Briefs: Clinical Trial Brief Reports
A Multicenter Phase II Trial of Ipilimumab and Nivolumab in Unresectable or Metastatic Metaplastic Breast Cancer: Cohort 36 of Dual Anti–CTLA-4 and Anti–PD-1 Blockade in Rare Tumors (DART, SWOG S1609)
Sylvia Adams; Megan Othus; Sandip Pravin Patel; Kathy D. Miller; Rashmi Chugh; Scott M. Schuetze; Mary D. Chamberlin; Barbara J. Haley; Anna Maria V. Storniolo; Mridula P. Reddy; Scott A. Anderson; Collin T. Zimmerman; Anne P. O'Dea; Hamid R. Mirshahidi; Jordi Rodon Ahnert; Frank J. Brescia; Olwen Hahn; Jane M. Raymond; David D. Biggs; Roisin M. Connolly; Elad Sharon; Larissa A. Korde; Robert J. Gray; Edward Mayerson; Melissa Plets; Charles D. Blanke; Young Kwang Chae; Razelle Kurzrock
Clinical Trials: Targeted Therapy
Clinical Activity of Single-Agent Cabozantinib (XL184), a Multi-receptor Tyrosine Kinase Inhibitor, in Patients with Refractory Soft-Tissue Sarcomas
Geraldine O'Sullivan Coyne; Shivaani Kummar; James Hu; Kristen Ganjoo; Warren A. Chow; Khanh T. Do; Jennifer Zlott; Ashley Bruns; Lawrence Rubinstein; Jared C. Foster; Lamin Juwara; Robert Meehan; Richard Piekarz; Howard Streicher; Elad Sharon; Naoko Takebe; Andrea Regier Voth; Donald Bottaro; Rene Costello; John J. Wright; James H. Doroshow; Alice P. Chen
Results from Phase I Extension Study Assessing Pexidartinib Treatment in Six Cohorts with Solid Tumors including TGCT, and Abnormal CSF1 Transcripts in TGCT
William D. Tap; Arun S. Singh; Stephen Patrick Anthony; Mike Sterba; Chao Zhang; John H. Healey; Bartosz Chmielowski; Allen Lee Cohn; Geoffrey I. Shapiro; Vicki L. Keedy; Zev A. Wainberg; Igor Puzanov; Gregory M. Cote; Andrew J. Wagner; Fadi Braiteh; Eric Sherman; Henry H. Hsu; Charles Peterfy; Heather L. Gelhorn; Xin Ye; Paul Severson; Brian L. West; Paul S. Lin; Sandra Tong-Starksen
Clinical Trials: Immunotherapy
Neoadjuvant Chemotherapy and Immunotherapy in Luminal B-like Breast Cancer: Results of the Phase II GIADA Trial
Maria Vittoria Dieci; Valentina Guarneri; Anna Tosi; Giancarlo Bisagni; Antonino Musolino; Simon Spazzapan; Gabriella Moretti; Grazia Maria Vernaci; Gaia Griguolo; Tommaso Giarratano; Loredana Urso; Francesca Schiavi; Claudia Pinato; Giovanna Magni; Marcello Lo Mele; Gian Luca De Salvo; Antonio Rosato; Pierfranco Conte
Precision Medicine and Imaging
Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors
Konrad H. Stopsack; Subhiksha Nandakumar; Kanika Arora; Bastien Nguyen; Samantha E. Vasselman; Barbara Nweji; Sean M. McBride; Michael J. Morris; Dana E. Rathkopf; Susan F. Slovin; Daniel C. Danila; Karen A. Autio; Howard I. Scher; Lorelei A. Mucci; David B. Solit; Mithat Gönen; Yu Chen; Michael F. Berger; Nikolaus Schultz; Wassim Abida; Philip W. Kantoff
18F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition
Kirsten M. Reeves; Patrick N. Song; Allyson Angermeier; Deborah Della Manna; Yufeng Li; Jianbo Wang; Eddy S. Yang; Anna G. Sorace; Benjamin M. Larimer
Longitudinal Copy-Number Alteration Analysis in Plasma Cell-Free DNA of Neuroendocrine Neoplasms is a Novel Specific Biomarker for Diagnosis, Prognosis, and Follow-up
Gitta Boons; Timon Vandamme; Laura Mariën; Willem Lybaert; Geert Roeyen; Tim Rondou; Konstantinos Papadimitriou; Katrien Janssens; Bart Op de Beeck; Marc Simoens; Wim Demey; Isabel Dero; Guy Van Camp; Marc Peeters; Ken Op de Beeck
Early HPV ctDNA Kinetics and Imaging Biomarkers Predict Therapeutic Response in p16+ Oropharyngeal Squamous Cell Carcinoma
Yue Cao; Catherine T. Haring; Collin Brummel; Chandan Bhambhani; Madhava Aryal; Choonik Lee; Molly Heft Neal; Apurva Bhangale; Wenjin Gu; Keith Casper; Kelly Malloy; Yilun Sun; Andrew Shuman; Mark E. Prince; Matthew E. Spector; Steven Chinn; Jennifer Shah; Caitlin Schonewolf; Jonathan B. McHugh; Ryan E. Mills; Muneesh Tewari; Francis P. Worden; Paul L. Swiecicki; Michelle Mierzwa; J. Chad Brenner
Translational Cancer Mechanisms and Therapy
T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Michael Kilian; Mirco Friedrich; Khwab Sanghvi; Edward Green; Stefan Pusch; Daisuke Kawauchi; Martin Löwer; Jana K. Sonner; Christopher Krämer; Julia Zaman; Stefanie Jung; Michael O. Breckwoldt; Gerald Willimsky; Stefan B. Eichmüller; Andreas von Deimling; Wolfgang Wick; Felix Sahm; Michael Platten; Lukas Bunse
HER3 Augmentation via Blockade of EGFR/AKT Signaling Enhances Anticancer Activity of HER3-Targeting Patritumab Deruxtecan in EGFR-Mutated Non–Small Cell Lung Cancer
Kimio Yonesaka; Junko Tanizaki; Osamu Maenishi; Koji Haratani; Hisato Kawakami; Kaoru Tanaka; Hidetoshi Hayashi; Kazuko Sakai; Yasutaka Chiba; Asuka Tsuya; Hiroki Goto; Eri Otsuka; Hiroaki Okida; Maki Kobayashi; Ryoto Yoshimoto; Masanori Funabashi; Yuuri Hashimoto; Kenji Hirotani; Takashi Kagari; Kazuto Nishio; Kazuhiko Nakagawa
Morphologic and Genomic Characteristics of Breast Cancers Occurring in Individuals with Lynch Syndrome
Christopher J. Schwartz; Edaise M. da Silva; Antonio Marra; Andrea M. Gazzo; Pier Selenica; Vikas K. Rai; Diana Mandelker; Fresia Pareja; Maksym Misyura; Timothy M. D'Alfonso; Edi Brogi; Pamela Drullinsky; Pedram Razavi; Mark E. Robson; Joshua Z. Drago; Hannah Y. Wen; Liying Zhang; Britta Weigelt; Jinru Shia; Jorge S. Reis-Filho; Hong Zhang
Letters to the Editor
Three Distinct Stroma Types in Human Pancreatic Cancer Identified by Image Analysis of Fibroblast Subpopulations and Collagen—Letter
Rachid Bouzid; Amy L. Kessler; Iris J.M. Levink; Thierry P.P. van den Bosch; Sonja I. Buschow; Gwenny M. Fuhler; Maikel P. Peppelenbosch; Jérôme Cros; Philippe Lévy; Marco J. Bruno; Michail Doukas
Corrections
Correction: KRAS Inhibitor Resistance in MET-Amplified KRASG12C Non–Small Cell Lung Cancer Induced By RAS- and Non–RAS-Mediated Cell Signaling Mechanisms
Shinichiro Suzuki; Kimio Yonesaka; Takeshi Teramura; Toshiyuki Takehara; Ryoji Kato; Hitomi Sakai; Koji Haratani; Junko Tanizaki; Hisato Kawakami; Hidetoshi Hayashi; Kazuko Sakai; Kazuto Nishio; Kazuhiko Nakagawa
Correction: Phase I Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-type TP53
Mansoor N. Saleh; Manish R. Patel; Todd M. Bauer; Sanjay Goel; Gerald S. Falchook; Geoffrey I. Shapiro; Ki Y. Chung; Jeffrey R. Infante; Robert M. Conry; Guilherme Rabinowits; David S. Hong; Judy S. Wang; Ulrich Steidl; Loren D. Walensky; Gurudatta Naik; Vincent Guerlavais; Vojislav Vukovic; D. Allen Annis; Manuel Aivado; Funda Meric-Bernstam
Correction: RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma
Yingqin Li; Xiaojing Yang; Xiaojing Du; Yuan Lei; Qingmei He; Xiaohong Hong; Xinran Tang; Xin Wen; Panpan Zhang; Ying Sun; Jian Zhang; Yaqin Wang; Jun Ma; Na Liu
Correction: SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma
Kate Lynn J. Bill; Jeannine Garnett; Isabelle Meaux; XiaoYen Ma; Chad J. Creighton; Svetlana Bolshakov; Cedric Barriere; Laurent Debussche; Alexander J. Lazar; Bethany C. Prudner; Lucia Casadei; Danielle Braggio; Gonzalo Lopez; Abbie Zewdu; Hemant Bid; Lev Dina; Raphael E. Pollock
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