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15 September 2022
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Cover Image
Cover Image
The cover shows a digital image from a whole colon tumor section stained for epithelium (green, pan-cytokeratin), hematopoietic cells (purple, CD45) and DNA (blue, SYTO13). Regions of interest were selected for spatial transcriptomic profiling, segmented into epithelium and nonepithelium compartments, to measure relative contribution of each region to transcriptional signatures. For details, see the article by Fisher and colleagues on page 4056 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Perspectives
Statistical Considerations for Analyses of Time-To-Event Endpoints in Oncology Clinical Trials: Illustrations with CAR-T Immunotherapy Studies
Yimei Li; Wei-Ting Hwang; Shannon L. Maude; David T. Teachey; Noelle V. Frey; Regina M. Myers; Allison Barz Leahy; Hongyan Liu; David L. Porter; Stephan A. Grupp; Pamela A. Shaw
Clinical Trials: Targeted Therapy
A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma
Giselle Saulnier-Sholler; Dan G. Duda; Genevieve Bergendahl; David Ebb; Matija Snuderl; Theodore W. Laetsch; Jennifer Michlitsch; Derek Hanson; Michael S. Isakoff; Kevin Bielamowicz; Jacqueline M. Kraveka; William Ferguson; Peter Carmeliet; A. De Deene; Lore Gijsen; Rakesh K. Jain
Adding Umbralisib and Ublituximab (U2) to Ibrutinib in Patients with CLL: A Phase II Study of an MRD-Driven Approach
Lindsey E. Roeker; Tatyana A. Feldman; Jacob D. Soumerai; Victoria Falco; Gail Panton; Colleen Dorsey; Andrew D. Zelenetz; Lorenzo Falchi; Jae H. Park; David J. Straus; Camila Pena Velasquez; Sonia Lebowitz; Yehudit Fox; Kristen Battiato; Carissa Laudati; Meghan C. Thompson; Elizabeth McCarthy; Sabrina Kdiry; Rosalba Martignetti; Teja Turpuseema; Michelle Purdom; Dana Paskalis; Hari P. Miskin; Peter Sportelli; Lori A. Leslie; Anthony R. Mato
Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003
Cassie Kline; Payal Jain; Lindsay Kilburn; Erin R. Bonner; Nalin Gupta; John R. Crawford; Anu Banerjee; Roger J. Packer; Javier Villanueva-Meyer; Tracy Luks; Yalan Zhang; Madhuri Kambhampati; Jie Zhang; Sridevi Yadavilli; Bo Zhang; Krutika S. Gaonkar; Jo Lynne Rokita; Adam Kraya; John Kuhn; Winnie Liang; Sara Byron; Michael Berens; Annette Molinaro; Michael Prados; Adam Resnick; Sebastian M. Waszak; Javad Nazarian; Sabine Mueller
Clinical Trials: Immunotherapy
Phase IB Study of GITR Agonist Antibody TRX518 Singly and in Combination with Gemcitabine, Pembrolizumab, or Nivolumab in Patients with Advanced Solid Tumors
Diwakar Davar; Roberta Zappasodi; Hong Wang; Girish S. Naik; Takami Sato; Todd Bauer; David Bajor; Olivier Rixe; Walter Newman; Jingjing Qi; Aliya Holland; Phillip Wong; Lianna Sifferlen; Diane Piper; Cynthia A. Sirard; Taha Merghoub; Jedd D. Wolchok; Jason J. Luke
Improved Efficacy of Tafasitamab plus Lenalidomide versus Systemic Therapies for Relapsed/Refractory DLBCL: RE-MIND2, an Observational Retrospective Matched Cohort Study
Grzegorz S. Nowakowski; Dok Hyun Yoon; Anthea Peters; Patrizia Mondello; Erel Joffe; Isabelle Fleury; Richard Greil; Matthew Ku; Reinhard Marks; Kibum Kim; Pier Luigi Zinzani; Judith Trotman; Dan Huang; Eva E. Waltl; Mark Winderlich; Nuwan C. Kurukulasuriya; Sumeet Ambarkhane; Georg Hess; Gilles Salles
Comprehensive Genome Profiling in Patients With Metastatic Non–Small Cell Lung Cancer: The Precision Medicine Phase II Randomized SAFIR02-Lung/IFCT 1301 Trial
Fabrice Barlesi; Pascale Tomasini; Maryam Karimi; Stefan Michiels; Judith Raimbourg; Catherine Daniel; Henri Janicot; Anne Madroszyk; Clarisse Audigier-Valette; Elisabeth Quoix; Julien Mazieres; Denis Moro-Sibilot; Eric Dansin; Olivier Molinier; Hugues Morel; Eric Pichon; Alexis Cortot; Josiane Otto; François Chomy; Pierre-Jean Souquet; Nicolas Cloarec; Etienne Giroux-Leprieur; Ivan Bieche; Ludovic Lacroix; Sandrine Boyault; Valery Attignon; Isabelle Soubeyran; Alain Morel; Alicia Tran-Dien; Alexandra Jacquet; Filippo Gustavo Dall'Olio; Marta Jimenez; Jean-Charles Soria; Benjamin Besse
Precision Medicine and Imaging
A Prospective Observational Study of Active Surveillance in Primary Desmoid Fibromatosis
Chiara Colombo; Marco Fiore; Giovanni Grignani; Francesco Tolomeo; Alessandra Merlini; Elena Palassini; Paola Collini; Silvia Stacchiotti; Paolo Giovanni Casali; Federica Perrone; Luigi Mariani; Alessandro Gronchi
Large-Scale In Vitro and In Vivo CRISPR-Cas9 Knockout Screens Identify a 16-Gene Fitness Score for Improved Risk Assessment in Acute Myeloid Leukemia
Peng Jin; Qiqi Jin; Xiaoling Wang; Ming Zhao; Fangyi Dong; Ge Jiang; Zeyi Li; Jie Shen; Wei Zhang; Shishuang Wu; Ran Li; Yunxiang Zhang; Xiaoyang Li; Junmin Li
Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma
Thomas Denize; Yue Hou; Jean-Christophe Pignon; Emily Walton; Destiny J. West; Gordon J. Freeman; David A. Braun; Catherine J. Wu; Saurabh Gupta; Robert J. Motzer; Michael B. Atkins; David McDermott; Toni K. Choueiri; Sachet A. Shukla; Sabina Signoretti
Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data
Natalie C. Fisher; Ryan M. Byrne; Holly Leslie; Colin Wood; Assya Legrini; Andrew J. Cameron; Baharak Ahmaderaghi; Shania M. Corry; Sudhir B. Malla; Raheleh Amirkhah; Aoife J. McCooey; Emily Rogan; Keara L. Redmond; Svetlana Sakhnevych; Enric Domingo; James Jackson; Maurice B. Loughrey; Simon Leedham; Tim Maughan; Mark Lawler; Owen J. Sansom; Felicity Lamrock; Viktor H. Koelzer; Nigel B. Jamieson; Philip D. Dunne
Clinico-Genomic Characterization of Patients with Metastatic Urothelial Carcinoma in Real-World Practice Identifies a Novel Bladder Immune Performance Index (BIPI)
Bernadett Szabados; Mariano Ponz-Sarvisé; Robson Machado; Diego Saldana; Edward E. Kadel; Romain Banchereau; Fanny Bouquet; Marius Garmhausen; Thomas Powles; Carsten Schröder; On Behalf of the imCORE Working Group of Early Career Investigators (imFLAME)
Translational Cancer Mechanisms and Therapy
Systemic Chemotherapies Retain Antitumor Activity in Desmoid Tumors Independent of Specific Mutations in CTNNB1 or APC: A Multi-institutional Retrospective Study
Michael J. Nathenson; Junxiao Hu; Ravin Ratan; Neeta Somaiah; Robert Hsu; Peter J. DeMaria; Heath W. Catoe; Angela Pang; Ty K. Subhawong; Behrang Amini; Kevin Sweet; Katharina Feister; Karan Malik; Jyothi Jagannathan; Marta Braschi-Amirfarzan; Jamie Sheren; Yupanqui Caldas; Cristiam Moreno Tellez; Andrew E. Rosenberg; Alexander J. Lazar; Robert G. Maki; Pasquale Benedetto; Jonathan Cohen; Jonathan C. Trent; Vinod Ravi; Shreyaskumar Patel; Breelyn A. Wilky
Lack of Prognostic Value of CTNNB1 Mutation Profile in Desmoid-Type Fibromatosis
Nicolas Penel; Sylvie Bonvalot; André-Michel Bimbai; Alexandra Meurgey; François Le Loarer; Sébastien Salas; Sophie Piperno-Neumann; Christine Chevreau; Pascaline Boudou-Rouquette; Pascale Dubray-Longeras; Jean-Emmanuel Kurtz; Cécile Guillemet; Emmanuelle Bompas; Antoine Italiano; Axel Le Cesne; Daniel Orbach; Julien Thery; Marie-Cécile Le Deley; Jean-Yves Blay; Olivier Mir
Estrogen Receptor Alpha Gene Amplification Is an Independent Predictor of Long-Term Outcome in Postmenopausal Patients with Endocrine-Responsive Early Breast Cancer
Christian F. Singer; for the ABCSG; Frederik Holst; Stefan Steurer; Eike C. Burandt; Sigurd F. Lax; Raimund Jakesz; Margaretha Rudas; Herbert Stöger; Richard Greil; for the ABCSG; Guido Sauter; Martin Filipits; for the ABCSG; Ronald Simon; Michael Gnant; for the ABCSG
Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer
Duy T. Nguyen; Wei Yang; Arun Renganathan; Cody Weimholt; Duminduni H. Angappulige; Thanh Nguyen; Robert W. Sprung; Gerald L. Andriole; Eric H. Kim; Nupam P. Mahajan; Kiran Mahajan
Preclinical Development of [211At]meta- astatobenzylguanidine ([211At]MABG) as an Alpha Particle Radiopharmaceutical Therapy for Neuroblastoma
Vandana Batra; Minu Samanta; Mehran Makvandi; David Groff; Paul Martorano; Jimmy Elias; Pietro Ranieri; Matthew Tsang; Catherine Hou; Yimei Li; Bruce Pawel; Daniel Martinez; Ganesan Vaidyanathan; Sean Carlin; Daniel A. Pryma; John M. Maris
Correction
Correction: First-in-Class Anti-immunoglobulin–like Transcript 4 Myeloid-Specific Antibody MK-4830 Abrogates a PD-1 Resistance Mechanism in Patients with Advanced Solid Tumors
Lillian L. Siu; Ding Wang; John Hilton; Ravit Geva; Drew Rasco; Ruth Perets; Anson K. Abraham; Douglas C. Wilson; Julia F. Markensohn; Jared Lunceford; Leah Suttner; Shabana Siddiqi; Rachel A. Altura; Corinne Maurice-Dror
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