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1 September 2022
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Cover Image
Cover Image
Potent antitumor cytotoxicity against neuroblastoma is observed with anti-GD2 antibodies conjugated to IL15 and IL21. The cover shows an abstract illustration of an H&E stain that demonstrates the clash between neuroblastoma cells and immune cells. For more information, see the article by Nguyen and colleagues on page 3785 of this issue. (Media and technique: Acrylic pour on canvas. Artist: Rosa Nguyen. Used with permission.) - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Research Briefs: Clinical Trial Brief Reports
Lenalidomide plus R-GDP (R2-GDP) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Final Results of the R2-GDP-GOTEL Trial and Immune Biomarker Subanalysis
Natalia Palazón-Carrión; Alejandro Martín García-Sancho; Esteban Nogales-Fernández; Carlos Jiménez-Cortegana; Fernando Carnicero-González; Eduardo Ríos-Herranz; Fátima de la Cruz-Vicente; Guillermo Rodríguez-García; Rubén Fernández-Álvarez; Natividad Martínez-Banaclocha; Josep Gumà-Padrò; José Gómez-Codina; Antonio Salar-Silvestre; Delvys Rodríguez-Abreu; Laura Gálvez-Carvajal; Jorge Labrador; María Guirado-Risueño; Daniel J. García-Domínguez; Lourdes Hontecillas-Prieto; Pablo Espejo-García; Isabel Fernández-Román; Mariano Provencio-Pulla; Margarita Sánchez-Beato; Marta Navarro; Lejeune Marylene; Tomás Álvaro-Naranjo; Maria Casanova-Espinosa; Victor Sánchez-Margalet; Antonio Rueda-Domínguez; Luis de la Cruz-Merino
Tumor Immune Microenvironment Changes by Multiplex Immunofluorescence Staining in a Pilot Study of Neoadjuvant Talazoparib for Early-Stage Breast Cancer Patients with a Hereditary BRCA Mutation
Tapsi Kumar; Evie Hobbs; Fei Yang; Jeffrey T. Chang; Alejandro Contreras; Edwin Roger Parra Cuentas; Haven Garber; Sanghoon Lee; Yiling Lu; Marion E. Scoggins; Beatriz E. Adrada; Gary J. Whitman; Banu K. Arun; Elizabeth A. Mittendorf; Jennifer K. Litton
Clinical Trials: Targeted Therapy
Randomized, Double-Blind, Placebo-Controlled Phase III Study of Paclitaxel ± Napabucasin in Pretreated Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
Manish A. Shah; Kohei Shitara; Florian Lordick; Yung-Jue Bang; Niall C. Tebbutt; Jean-Phillippe Metges; Kei Muro; Keun-Wook Lee; Lin Shen; Sergei Tjulandin; John L. Hays; Naureen Starling; Rui-Hua Xu; Keren Sturtz; Marilyn Fontaine; Cindy Oh; Emily M. Brooks; Bo Xu; Wei Li; Chiang J. Li; Laura Borodyansky; Eric Van Cutsem
Clinical Trials: Immunotherapy
First-in-Human Phase I/II ICONIC Trial of the ICOS Agonist Vopratelimab Alone and with Nivolumab: ICOS-High CD4 T-Cell Populations and Predictors of Response
Timothy A. Yap; Justin F. Gainor; Margaret K. Callahan; Gerald S. Falchook; Russell K. Pachynski; Patricia LoRusso; Shivaani Kummar; Geoffrey T. Gibney; Howard A. Burris; Scott S. Tykodi; Osama E. Rahma; Tanguy Y. Seiwert; Kyriakos P. Papadopoulos; Mariela Blum Murphy; Haeseong Park; Amanda Hanson; Yasmin Hashambhoy-Ramsay; Lara McGrath; Ellen Hooper; Xiaoying Xiao; Heather Cohen; Martin Fan; Daniel Felitsky; Courtney Hart; Rachel McComb; Karen Brown; Ali Sepahi; Judith Jimenez; Weidong Zhang; Johan Baeck; Haley Laken; Richard Murray; Elizabeth Trehu; Christopher J. Harvey
Safety and Tolerability of MEDI0562, an OX40 Agonist mAb, in Combination with Durvalumab or Tremelimumab in Adult Patients with Advanced Solid Tumors
Jonathan W. Goldman; Sarina A. Piha-Paul; Brendan Curti; Katrina S. Pedersen; Todd M. Bauer; Stefanie L. Groenland; Richard D. Carvajal; Vaishali Chhaya; Gray Kirby; Kelly McGlinchey; Scott A. Hammond; Katie Streicher; Danielle M. Townsley; Young Kwang Chae; Jens Voortman; Aurelien Marabelle; John Powderly
Clinical Outcomes and Immune Markers by Race in a Phase I/II Clinical Trial of Durvalumab Concomitant with Neoadjuvant Chemotherapy in Early-Stage TNBC
Julia Foldi; Adriana Kahn; Andrea Silber; Tao Qing; Emily Reisenbichler; Neal Fischbach; Justin Persico; Kerin Adelson; Anamika Katoch; Anees Chagpar; Tristen Park; Adam Blanchard; Kim Blenman; David L. Rimm; Lajos Pusztai
Precision Medicine and Imaging
A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
Gregory T. Kennedy; David E. Holt; Feredun S. Azari; Elizabeth Bernstein; Bilal Nadeem; Ashley Chang; Neil T. Sullivan; Alix Segil; Charuhas Desphande; Eric Bensen; John T. Santini, Jr; John C. Kucharczuk; Edward J. Delikatny; Matthew Bogyo; A.J. Matthew Egan; Charles W. Bradley; Evgeniy Eruslanov; Jason D. Lickliter; Gavin Wright; Sunil Singhal
Classification of BRCA2 Variants of Uncertain Significance (VUS) Using an ACMG/AMP Model Incorporating a Homology-Directed Repair (HDR) Functional Assay
Chunling Hu; Lisa R. Susswein; Maegan E. Roberts; Hana Yang; Megan L. Marshall; Susan Hiraki; Windy Berkofsky-Fessler; Sounak Gupta; Wei Shen; Carolyn A. Dunn; Huaizhi Huang; Jie Na; Susan M. Domchek; Siddhartha Yadav; Alvaro N.A. Monteiro; Eric C. Polley; Steven N. Hart; Kathleen S. Hruska; Fergus J. Couch
Circulating Tumor DNA Kinetics Predict Progression-Free and Overall Survival in EGFR TKI–Treated Patients with EGFR-Mutant NSCLC (SWOG S1403)
Philip C. Mack; Jieling Miao; Mary W. Redman; James Moon; Sarah B. Goldberg; Roy S. Herbst; Mary Ann Melnick; Zenta Walther; Fred R. Hirsch; Katerina Politi; Karen Kelly; David R. Gandara
Novel DNA Methylation Biomarker Panel for Detection of Esophageal Adenocarcinoma and High-Grade Dysplasia
Ming Yu; Helen R. Moinova; Amber Willbanks; Victoria K. Cannon; Ting Wang; Kelly Carter; Andrew Kaz; Deepti Reddi; John Inadomi; Georg Luebeck; Prasad G. Iyer; Marcia I. Canto; Jean S. Wang; Nicholas J. Shaheen; Prashanti N. Thota; Joseph E. Willis; Thomas LaFramboise; Amitabh Chak; Sanford D. Markowitz; William M. Grady
FOXM1 Variant Contributes to Gefitinib Resistance via Activating Wnt/β-Catenin Signal Pathway in Patients with Non–Small Cell Lung Cancer
Shaoxing Guan; Xi Chen; Youhao Chen; Wen Xie; Heng Liang; Xia Zhu; Yunpeng Yang; Wenfeng Fang; Yan Huang; Hongyun Zhao; Wei Zhuang; Shu Liu; Min Huang; Xueding Wang; Li Zhang
Translational Cancer Mechanisms and Therapy
Systemic and Oligo-Acquired Resistance to PD-(L)1 Blockade in Lung Cancer
Adam J. Schoenfeld; Hira A. Rizvi; Danish Memon; Narek Shaverdian; Matthew J. Bott; Jennifer L. Sauter; C. Jillian Tsai; Jayon Lihm; David Hoyos; Andrew J. Plodkowski; Rocio Perez-Johnston; Peter Sawan; Jacklynn V. Egger; Benjamin D. Greenbaum; Andreas Rimner; Gregory J. Riely; Charles M. Rudin; Valerie W. Rusch; Daniel R. Gomez; Matthew D. Hellmann
Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell–Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19
Caroline Diorio; Rawan Shraim; Regina Myers; Edward M. Behrens; Scott Canna; Hamid Bassiri; Richard Aplenc; Chakkapong Burudpakdee; Fang Chen; Amanda M. DiNofia; Saar Gill; Vanessa Gonzalez; Michele P. Lambert; Allison Barz Leahy; Bruce L. Levine; Robert B. Lindell; Shannon L. Maude; J. Joseph Melenhorst; Haley Newman; Jessica Perazzelli; Alix E. Seif; Simon F. Lacey; Carl H. June; David M. Barrett; Stephan A. Grupp; David T. Teachey
Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
Carla Rohrer Bley; Friederike Wolf; Patrik Gonçalves Jorge; Veljko Grilj; Ioannis Petridis; Benoit Petit; Till T. Böhlen; Raphael Moeckli; Charles Limoli; Jean Bourhis; Valeria Meier; Marie-Catherine Vozenin
DNA Methylation Profiling Identifies Subgroups of Lung Adenocarcinoma with Distinct Immune Cell Composition, DNA Methylation Age, and Clinical Outcome
Kayla Guidry; Varshini Vasudevaraja; Kristen Labbe; Hussein Mohamed; Jonathan Serrano; Brett W. Guidry; Michael DeLorenzo; Hua Zhang; Jiehui Deng; Soumyadip Sahu; Christina Almonte; Andre L. Moreira; Aristotelis Tsirigos; Thales Papagiannakopoulos; Harvey Pass; Matija Snuderl; Kwok-Kin Wong
Regulation of TORC1 by MAPK Signaling Determines Sensitivity and Acquired Resistance to Trametinib in Pediatric BRAFV600E Brain Tumor Models
Fuyang Li; Kathryn M. Bondra; Samson Ghilu; Adam Studebaker; Qianqian Liu; Joel E. Michalek; Mari Kogiso; Xiao-Nan Li; John A. Kalapurakal; C. David James; Sandeep Burma; Raushan T. Kurmasheva; Peter J. Houghton
Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer
Erika Durinikova; Nicole M. Reilly; Kristi Buzo; Elisa Mariella; Rosaria Chilà; Annalisa Lorenzato; João M. L. Dias; Gaia Grasso; Federica Pisati; Simona Lamba; Giorgio Corti; Andrea Degasperi; Carlotta Cancelliere; Gianluca Mauri; Pietro Andrei; Michael Linnebacher; Silvia Marsoni; Salvatore Siena; Andrea Sartore-Bianchi; Serena Nik-Zainal; Federica Di Nicolantonio; Alberto Bardelli; Sabrina Arena
Extracellular Vesicles May Predict Response to Radioembolization and Sorafenib Treatment in Advanced Hepatocellular Carcinoma: An Exploratory Analysis from the SORAMIC Trial
Timothy Wai Ho Shuen; Marianna Alunni-Fabbroni; Elif Öcal; Peter Malfertheiner; Moritz Wildgruber; Regina Schinner; Maciej Pech; Julia Benckert; Bruno Sangro; Christiane Kuhl; Antonio Gasbarrini; Pierce Kah Hoe Chow; Han Chong Toh; Jens Ricke
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