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1 August 2022
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The cover shows a section of a lymph node biopsy from a patient with diffuse large B-cell lymphoma. Immunoflourescence staining using proximity ligation shows a complex formation between Aiolos and HDAC1 in CD20-positive DLBCL cells. For details, see the article by Hagner and colleagues on page 3367 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Research Briefs: Clinical Trial Brief Reports
Nivolumab Retreatment in Non–Small Cell Lung Cancer Patients Who Responded to Prior Immune Checkpoint Inhibitors and Had ICI-Free Intervals (WJOG9616L)
Hiroaki Akamatsu; Shunsuke Teraoka; Shinkichi Takamori; Satoru Miura; Hidetoshi Hayashi; Akito Hata; Yukihiro Toi; Yoshimasa Shiraishi; Nobuaki Mamesaya; Yuki Sato; Naoki Furuya; Jun Oyanagi; Yasuhiro Koh; Toshihiro Misumi; Nobuyuki Yamamoto; Kazuhiko Nakagawa
Clinical Trials: Targeted Therapy
Overcoming Taxane Resistance: Preclinical and Phase 1 Studies of Relacorilant, a Selective Glucocorticoid Receptor Modulator, with Nab-Paclitaxel in Solid Tumors
Pamela N. Munster; Andrew E. Greenstein; Gini F. Fleming; Erkut Borazanci; Manish R. Sharma; Joseph M. Custodio; Iulia Cristina Tudor; Hristina I. Pashova; Stacie Peacock Shepherd; Andreas Grauer; Jasgit C. Sachdev
Phase II Clinical Trial of Eribulin–Gemcitabine Combination Therapy in Previously Treated Patients With Advanced Liposarcoma or Leiomyosarcoma
Chang Gon Kim; Nam Suk Sim; Jeong Eun Kim; Kum-Hee Yun; Young Han Lee; Seung Hyun Kim; Wooyeol Baek; Yoon Dae Han; Sang Kyum Kim; Jee Hung Kim; Yoon Woo Koh; Inkyung Jung; Su-Jin Shin; Sun Young Rha; Jin-Hee Ahn; Hyo Song Kim
Initial Phase I Safety Study of Gedatolisib plus Cofetuzumab Pelidotin for Patients with Metastatic Triple-Negative Breast Cancer
Milan Radovich; Jeffrey P. Solzak; Chao J. Wang; Bradley A. Hancock; Sunil Badve; Sandra K. Althouse; Steven M. Bray; Anna Maria V. Storniolo; Tarah J. Ballinger; Bryan P. Schneider; Kathy D. Miller
Selinexor Combined with Ibrutinib Demonstrates Tolerability and Safety in Advanced B-Cell Malignancies: A Phase I Study
Deborah M. Stephens; Ying Huang; Amy S. Ruppert; Janek S. Walker; Daniel Canfield; Casey B. Cempre; Qiang Fu; Sharyn Baker; Boyu Hu; Harsh Shah; Renee Vadeboncoeur; Kerry A. Rogers; Seema Bhat; Samantha M. Jaglowski; Hank Lockman; Rosa Lapalombella; John C. Byrd; Jennifer A. Woyach
Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial
Chung-Han Lee; Robert Motzer; Hamid Emamekhoo; Marc Matrana; Ivor Percent; James J. Hsieh; Arif Hussain; Ulka Vaishampayan; Sandy Liu; Steven McCune; Vijay Patel; Montaser Shaheen; Johanna Bendell; Alice C. Fan; Benjamin A. Gartrell; Oscar B. Goodman, Jr; Petros G. Nikolinakos; Arash Rezazadeh Kalebasty; Yousef Zakharia; Zhentao Zhang; Hema Parmar; Lalith Akella; Keith Orford; Nizar M. Tannir
VERONICA: Randomized Phase II Study of Fulvestrant and Venetoclax in ER-Positive Metastatic Breast Cancer Post-CDK4/6 Inhibitors – Efficacy, Safety, and Biomarker Results
Geoffrey J. Lindeman; Tharu M. Fernando; Rebecca Bowen; Katarzyna J. Jerzak; Xinni Song; Thomas Decker; Frances Boyle; Steve McCune; Anne Armstrong; Catherine Shannon; Gianfilippo Bertelli; Ching-Wei Chang; Rupal Desai; Kushagra Gupta; Timothy R. Wilson; Aulde Flechais; Aditya Bardia
Clinical Trials: Immunotherapy
Neoadjuvant Chemoimmunotherapy for the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma: A Single-Arm Phase 2 Clinical Trial
Zhanjie Zhang; Bian Wu; Gang Peng; Guixiang Xiao; Jing Huang; Qian Ding; Chengzhang Yang; Xingao Xiong; Hui Ma; Liangliang Shi; Jinsong Yang; Xiaohua Hong; Jielin Wei; You Qin; Chao Wan; Yi Zhong; Yan Zhou; Xueyan Zhao; Yangming Leng; Tao Zhang; Gang Wu; Min Yao; Xiaomeng Zhang; Kunyu Yang
Three-Year Follow-Up and Response–Survival Relationship of Nivolumab in Previously Treated Patients with Advanced Esophageal Squamous Cell Carcinoma (ATTRACTION-3)
Morihito Okada; Ken Kato; Byoung Chul Cho; Masanobu Takahashi; Chen-Yuan Lin; Keisho Chin; Shigenori Kadowaki; Myung-Ju Ahn; Yasuo Hamamoto; Yuichiro Doki; Chueh-Chuan Yen; Yutaro Kubota; Sung-Bae Kim; Chih-Hung Hsu; Eva Holtved; Ioannis Xynos; Yasuhiro Matsumura; Akira Takazawa; Yuko Kitagawa
Precision Medicine and Imaging
Evaluation of Sensitivity to Endocrine Therapy Index (SET2,3) for Response to Neoadjuvant Endocrine Therapy and Longer-Term Breast Cancer Patient Outcomes (Alliance Z1031)
Vera J. Suman; Lili Du; Tanya Hoskin; Meenakshi Anurag; Cynthia Ma; Isabelle Bedrosian; Kelly K. Hunt; Matthew J. Ellis; W. Fraser Symmans
Precision Medicine in Pancreatic Cancer: Patient-Derived Organoid Pharmacotyping Is a Predictive Biomarker of Clinical Treatment Response
Toni T. Seppälä; Jacquelyn W. Zimmerman; Reecha Suri; Haley Zlomke; Gabriel D. Ivey; Annamaria Szabolcs; Christopher R. Shubert; John L. Cameron; William R. Burns; Kelly J. Lafaro; Jin He; Christopher L. Wolfgang; Ying S. Zou; Lei Zheng; David A. Tuveson; James R. Eshlemann; David P. Ryan; Alec C. Kimmelman; Theodore S. Hong; David T. Ting; Elizabeth M. Jaffee; Richard A. Burkhart
Perioperative ctDNA-Based Molecular Residual Disease Detection for Non–Small Cell Lung Cancer: A Prospective Multicenter Cohort Study (LUNGCA-1)
Liang Xia; Jiandong Mei; Ran Kang; Senyi Deng; Yaohui Chen; Ying Yang; Gang Feng; Yulan Deng; Fanyi Gan; Yidan Lin; Qiang Pu; Lin Ma; Feng Lin; Yong Yuan; Yang Hu; Chenglin Guo; Hu Liao; Chengwu Liu; Yunke Zhu; Wenping Wang; Zheng Liu; Yuyang Xu; Kaidi Li; Chuan Li; Qingyun Li; Ji He; Weizhi Chen; Xiaolong Zhang; Yingli Kou; Yun Wang; Zhu Wu; Guowei Che; Longqi Chen; Lunxu Liu
Translational Cancer Mechanisms and Therapy
Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non–Small Cell Lung Cancer
Joshua K. Sabari; Vamsidhar Velcheti; Kazuhide Shimizu; Matthew R. Strickland; Rebecca S. Heist; Mohini Singh; Naema Nayyar; Anita Giobbie-Hurder; Subba R. Digumarthy; Justin F. Gainor; Anant P. Rajan; Edwin Nieblas-Bedolla; Aaron C. Burns; Jill Hallin; Peter Olson; James G. Christensen; Sylvia C. Kurz; Priscilla K. Brastianos; Hiroaki Wakimoto
Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Patients with Breast Cancer
Peter A. Fasching; Duan Liu; Steve Scully; James N. Ingle; Paulo C. Lyra, Jr.; Brigitte Rack; Alexander Hein; Arif B. Ekici; Andre Reis; Andreas Schneeweiss; Hans Tesch; Tanja N. Fehm; Georg Heinrich; Matthias W. Beckmann; Matthias Ruebner; Hanna Huebner; Diether Lambrechts; Ebony Madden; Jess Shen; Jane Romm; Kim Doheny; Gregory D. Jenkins; Erin E. Carlson; Liang Li; Brooke L. Fridley; Julie M. Cunningham; Wolfgang Janni; Alvaro N.A. Monteiro; Daniel J. Schaid; Lothar Häberle; Richard M. Weinshilboum; Liewei Wang
Improved T-cell Immunity Following Neoadjuvant Chemotherapy in Ovarian Cancer
Min Liu; Nabihah Tayob; Livius Penter; MacLean Sellars; Anna Tarren; Vipheaviny Chea; Isabel Carulli; Teddy Huang; Shuqiang Li; Su-Chun Cheng; Phuong Le; Laura Frackiewicz; Julia Fasse; Courtney Qi; Joyce F. Liu; Elizabeth H. Stover; Jennifer Curtis; Kenneth J. Livak; Donna Neuberg; Guanglan Zhang; Ursula A. Matulonis; Catherine J. Wu; Derin B. Keskin; Panagiotis A. Konstantinopoulos
Phenotypic Composition of Commercial Anti-CD19 CAR T Cells Affects In Vivo Expansion and Disease Response in Patients with Large B-cell Lymphoma
Chiara Monfrini; Federico Stella; Vanessa Aragona; Martina Magni; Silva Ljevar; Cristina Vella; Eugenio Fardella; Annalisa Chiappella; Francesca Nanetti; Martina Pennisi; Anna Dodero; Anna Guidetti; Paolo Corradini; Cristiana Carniti
The PD-L1/4-1BB Bispecific Antibody–Anticalin Fusion Protein PRS-344/S095012 Elicits Strong T-Cell Stimulation in a Tumor-Localized Manner
Janet K. Peper-Gabriel; Marina Pavlidou; Lucia Pattarini; Aizea Morales-Kastresana; Thomas J. Jaquin; Catherine Gallou; Eva-Maria Hansbauer; Marleen Richter; Helene Lelievre; Alix Scholer-Dahirel; Birgit Bossenmaier; Celine Sancerne; Matthieu Riviere; Maximilien Grandclaudon; Markus Zettl; Rachida S. Bel Aiba; Christine Rothe; Veronique Blanc; Shane A. Olwill
Letters to the Editor
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