Issues

The cover shows a section of resected tumor from a patient with pancreatic ductal adenocarcinoma. Masson's trichrome staining shows fibrotic deposition in which areas of dense collagen were annotated using a tissue classifier machine learning algorithm (blue). Importantly, the annotations were used to assess T-cell sequestration by dense fibrosis following stereotactic body radiotherapy. For details, see the article by Mills and colleagues on page 150 of this issue.