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1 January 2022
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Cover Image
Cover Image
The cover shows a section of resected tumor from a patient with pancreatic ductal adenocarcinoma. Masson's trichrome staining shows fibrotic deposition in which areas of dense collagen were annotated using a tissue classifier machine learning algorithm (blue). Importantly, the annotations were used to assess T-cell sequestration by dense fibrosis following stereotactic body radiotherapy. For details, see the article by Mills and colleagues on page 150 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
CCR Perspectives in Regulatory Science and Policy
Perspectives
Real-World Evidence in Support of Oncology Product Registration: A Systematic Review of New Drug Application and Biologics License Application Approvals from 2015–2020
Bhakti Arondekar; Mei Sheng Duh; Rachel H. Bhak; Maral DerSarkissian; Lynn Huynh; Kelsey Wang; John Wojciehowski; Melody Wu; Bryon Wornson; Alexander Niyazov; George D. Demetri
Clinical Trials: Targeted Therapy
Adavosertib with Chemotherapy in Patients with Primary Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer: An Open-Label, Four-Arm, Phase II Study
Kathleen N. Moore; Setsuko K. Chambers; Erika P. Hamilton; Lee-may Chen; Amit M. Oza; Sharad A. Ghamande; Gottfried E. Konecny; Steven C. Plaxe; Daniel L. Spitz; Jill J.J. Geenen; Tiffany A. Troso-Sandoval; Janiel M. Cragun; Esteban Rodrigo Imedio; Sanjeev Kumar; Ganesh M. Mugundu; Zhongwu Lai; Juliann Chmielecki; Suzanne F. Jones; David R. Spigel; Karen A. Cadoo
Phase I/Ib Study of the Efficacy and Safety of Buparlisib and Ibrutinib Therapy in MCL, FL, and DLBCL with Serial Cell-Free DNA Monitoring
Caitlin M. Stewart; Laure Michaud; Karissa Whiting; Reiko Nakajima; Chelsea Nichols; Stephanie De Frank; Paul A. Hamlin, Jr; Matthew J. Matasar; John F. Gerecitano; Pamela Drullinsky; Audrey Hamilton; David Straus; Steven M. Horwitz; Anita Kumar; Craig H. Moskowitz; Alison Moskowitz; Andrew D. Zelenetz; Jurgen Rademaker; Gilles Salles; Venkatraman Seshan; Heiko Schöder; Anas Younes; Dana W.Y. Tsui; Connie Lee Batlevi
Clinical Trials: Immunotherapy
First-in-Class Anti-immunoglobulin–like Transcript 4 Myeloid-Specific Antibody MK-4830 Abrogates a PD-1 Resistance Mechanism in Patients with Advanced Solid Tumors
Lillian L. Siu; Ding Wang; John Hilton; Ravit Geva; Drew Rasco; Ruth Perets; Anson K. Abraham; Douglas C. Wilson; Julia F. Markensohn; Jared Lunceford; Leah Suttner; Shabana Siddiqi; Rachel A. Altura; Corinne Maurice-Dror
A Phase I, Open-Label, Dose-Escalation Study of the OX40 Agonist Ivuxolimab in Patients with Locally Advanced or Metastatic Cancers
Adi Diab; Omid Hamid; John A. Thompson; Willeke Ros; Ferry A.L.M. Eskens; Toshihiko Doi; Siwen Hu-Lieskovan; Samuel J. Klempner; Bishu Ganguly; Catherine Fleener; Xiao Wang; Tenshang Joh; Ken Liao; Shahram Salek-Ardakani; Carrie Turich Taylor; Jeffrey Chou; Anthony B. El-Khoueiry
A Randomized Phase II Study of Nivolumab Monotherapy or Nivolumab Combined with Ipilimumab in Patients with Advanced Gastrointestinal Stromal Tumors
Arun S. Singh; J. Randolph Hecht; Lee Rosen; Zev A. Wainberg; Xiaoyan Wang; Michael Douek; Anahis Hagopian; Rachel Andes; Lauren Sauer; Sandra R. Brackert; Warren Chow; Ronald DeMatteo; Fritz Christian Eilber; John A. Glaspy; Bartosz Chmielowski
Phase I/IIa Trial of BMS-986148, an Anti-mesothelin Antibody–drug Conjugate, Alone or in Combination with Nivolumab in Patients with Advanced Solid Tumors
Sylvie Rottey; Jeffrey Clarke; Kyaw Aung; Jean-Pascal Machiels; Ben Markman; Kimberley M. Heinhuis; Michael Millward; Martijn Lolkema; Sandip Pravin Patel; Paul de Souza; Matteo Duca; Giuseppe Curigliano; Armando Santoro; Takafumi Koyama; Michelle Brown; Heather Vezina; Chunsheng He; Quincy Siu-Chung Chu
A Randomized Phase II Study of Anti-CSF1 Monoclonal Antibody Lacnotuzumab (MCS110) Combined with Gemcitabine and Carboplatin in Advanced Triple-Negative Breast Cancer
Sherko Kuemmel; Mario Campone; Delphine Loirat; Rafael Lopez Lopez; J. Thaddeus Beck; Michelino De Laurentiis; Seock-Ah Im; Sung-Bae Kim; Ava Kwong; Guenther G. Steger; Esther Zamora Adelantado; Francois P. Duhoux; Richard Greil; Irene Kuter; Yen-Shen Lu; Ariadna Tibau; Mustafa Özgüroğlu; Christian W. Scholz; Christian F. Singer; Estela Vega; Pauline Wimberger; Claudio Zamagni; Xuan-Mai Couillebault; Liqiong Fan; Nelson Guerreiro; Jennifer Mataraza; Janna Sand-Dejmek; Arlene Chan
Precision Medicine and Imaging
Clinically Tractable Outcome Prediction of Non-WNT/Non-SHH Medulloblastoma Based on TPD52 IHC in a Multicohort Study
Alberto Delaidelli; Christopher Dunham; Mariarita Santi; Gian Luca Negri; Joanna Triscott; Olga Zheludkova; Andrey Golanov; Marina Ryzhova; Konstantin Okonechnikov; Daniel Schrimpf; Damian Stichel; David W. Ellison; Andreas von Deimling; Marcel Kool; Stefan M. Pfister; Vijay Ramaswamy; Andrey Korshunov; Michael D. Taylor; Poul H. Sorensen
Temporal Muscle Thickness as a Prognostic Marker in Patients with Newly Diagnosed Glioblastoma: Translational Imaging Analysis of the CENTRIC EORTC 26071–22072 and CORE Trials
Julia Furtner; Michael Weller; Michael Weber; Thierry Gorlia; Burt Nabors; David A. Reardon; Joerg C. Tonn; Roger Stupp; Matthias Preusser; for the EORTC Brain Tumor Group
High FGFR1–4 mRNA Expression Levels Correlate with Response to Selective FGFR Inhibitors in Breast Cancer
Mònica Sánchez-Guixé; Cinta Hierro; José Jiménez; Cristina Viaplana; Guillermo Villacampa; Erika Monelli; Fara Brasó-Maristany; Zighereda Ogbah; Mireia Parés; Marta Guzmán; Judit Grueso; Olga Rodríguez; Mafalda Oliveira; Analía Azaro; Elena Garralda; Josep Tabernero; Oriol Casanovas; Maurizio Scaltriti; Aleix Prat; Rodrigo Dienstmann; Paolo Nuciforo; Cristina Saura; Mariona Graupera; Ana Vivancos; Jordi Rodon; Violeta Serra
Translational Cancer Mechanisms and Therapy
Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy
Bradley N. Mills; Haoming Qiu; Michael G. Drage; Chunmo Chen; Jocelyn S. Mathew; Jesse Garrett-Larsen; Jian Ye; Taylor P. Uccello; Joseph D. Murphy; Brian A. Belt; Edith M. Lord; Alan W. Katz; David C. Linehan; Scott A. Gerber
Biomarkers of Response and Resistance to Palbociclib Plus Letrozole in Patients With ER+/HER2− Breast Cancer
Mitch Dowsett; Lucy Kilburn; Mothaffar F. Rimawi; C. Kent Osborne; Katherine Pogue-Geile; Yuan Liu; Samuel A. Jacobs; Melanie Finnigan; Shannon Puhalla; Andrew Dodson; Vera Martins; Maggie Cheang; Sophie Perry; Chris Holcombe; Nick Turner; Claire Swift; Judith M. Bliss; Stephen Johnston; on behalf of the PALLET trialists
A High-Content Screen for C/EBPα Expression Identifies Novel Therapeutic Agents in Dedifferentiated Liposarcoma
Christina V. Angeles; Ana Velez; Jordan Rios; Bernadette Laxa; David Shum; Penelope D. Ruiz; Yawei Shen; Irina Ostrovnaya; Rodrigo Gularte-Mérida; Benjamin A. Nacev; Mark A. Dickson; Hakim Djaballah; Tomoyo Okada; Samuel Singer
Establishment of Patient-Derived Succinate Dehydrogenase–Deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response
Mayra Yebra; Shruti Bhargava; Avi Kumar; Adam M. Burgoyne; Chih-Min Tang; Hyunho Yoon; Sudeep Banerjee; Joseph Aguilera; Thekla Cordes; Vipul Sheth; Sangkyu Noh; Rowan Ustoy; Sam Li; Sunil J. Advani; Christopher L. Corless; Michael C. Heinrich; Razelle Kurzrock; Scott M. Lippman; Paul T. Fanta; Olivier Harismendy; Christian Metallo; Jason K. Sicklick
Targeting Fc Receptor-Mediated Effects and the “Don't Eat Me” Signal with an Oncolytic Virus Expressing an Anti-CD47 Antibody to Treat Metastatic Ovarian Cancer
Lei Tian; Bo Xu; Kun-Yu Teng; Mihae Song; Zheng Zhu; Yuqing Chen; Jing Wang; Jianying Zhang; Mingye Feng; Balveen Kaur; Lorna Rodriguez; Michael A. Caligiuri; Jianhua Yu
Anti–PD-1 Efficacy in Patients with Metastatic Urothelial Cancer Associates with Intratumoral Juxtaposition of T Helper-Type 1 and CD8+ T cells
Maud Rijnders; Hayri E. Balcioglu; Debbie G.J. Robbrecht; Astrid A.M. Oostvogels; Rebecca Wijers; Maureen J.B. Aarts; Paul Hamberg; Geert J.L.H. van Leenders; J. Alberto Nakauma-González; Jens Voortman; Hans M. Westgeest; Joost L. Boormans; Ronald de Wit; Martijn P. Lolkema; Astrid A.M. van der Veldt; Reno Debets
Inactivation of AMPK Leads to Attenuation of Antigen Presentation and Immune Evasion in Lung Adenocarcinoma
Yajing Gao; Pekka Päivinen; Sushil Tripathi; Eva Domènech-Moreno; Iris P.L. Wong; Kari Vaahtomeri; Ashwini S. Nagaraj; Sarang S. Talwelkar; Marc Foretz; Emmy W. Verschuren; Benoit Viollet; Yan Yan; Tomi P. Mäkelä
Acknowledgment to Reviewers
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