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1 May 2021
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The cover shows an on-treatment biopsy taken from a patient with metastatic microsatellite stable colorectal cancer treated with combined PD-L1/CTLA-4 inhibition and targeted radiotherapy to a liver metastasis. Multiplex immunofluorescence staining demonstrates increased infiltration of CD8+(white)/PD-1+(green)/Ki-67+(red) cells with treatment. Cytokeratin (purple) highlights malignant cells. For details, see the article by Monjazeb and colleagues on page 2470 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Lurbinectedin for the Treatment of Metastatic Small Cell Lung Cancer
Sonia Singh; Adnan A. Jaigirdar; Flora Mulkey; Joyce Cheng; Salaheldin S. Hamed; Yangbing Li; Jiang Liu; Hong Zhao; Anwar Goheer; Whitney S. Helms; Xing Wang; Rajiv Agarwal; Rajan Pragani; Kwadwo Korsah; Shenghui Tang; John Leighton; Atiqur Rahman; Julia A. Beaver; Richard Pazdur; Marc R. Theoret; Harpreet Singh
Review
Perspectives
Continuing to Broaden Eligibility Criteria to Make Clinical Trials More Representative and Inclusive: ASCO–Friends of Cancer Research Joint Research Statement
Edward S. Kim; Thomas S. Uldrick; Caroline Schenkel; Suanna S. Bruinooge; R. Donald Harvey; Allison Magnuson; Alexander Spira; James L. Wade; Mark D. Stewart; Diana Merino Vega; Julia A. Beaver; Andrea M. Denicoff; Gwynn Ison; S. Percy Ivy; Suzanne George; Raymond P. Perez; Patricia A. Spears; William D. Tap; Richard L. Schilsky
Modernizing Clinical Trial Eligibility Criteria: Recommendations of the ASCO-Friends of Cancer Research Washout Period and Concomitant Medication Work Group
R. Donald Harvey; Kathryn F. Mileham; Vishal Bhatnagar; Jamie R. Brewer; Atiqur Rahman; Cassadie Moravek; Andrew S. Kennedy; Elizabeth A. Ness; E. Claire Dees; S. Percy Ivy; Scot W. Ebbinghaus; Caroline Schenkel; Thomas S. Uldrick
Modernizing Clinical Trial Eligibility Criteria: Recommendations of the ASCO–Friends of Cancer Research Prior Therapies Work Group
Raymond U. Osarogiagbon; Diana Merino Vega; Lola Fashoyin-Aje; Suparna Wedam; Gwynn Ison; Sol Atienza; Peter De Porre; Tithi Biswas; Jamie N. Holloway; David S. Hong; Madison M. Wempe; Richard L. Schilsky; Edward S. Kim; James L. Wade, III
Modernizing Clinical Trial Eligibility Criteria: Recommendations of the ASCO-Friends of Cancer Research Laboratory Reference Ranges and Testing Intervals Work Group
Alexander I. Spira; Mark D. Stewart; Suzanne Jones; Elaine Chang; Anitra Fielding; Nicole Richie; Laura S. Wood; Michael A. Thompson; Lee Jones; Abhilasha Nair; Brandon A. Mahal; David E. Gerber
Modernizing Clinical Trial Eligibility Criteria: Recommendations of the ASCO-Friends of Cancer Research Performance Status Work Group
Allison Magnuson; Suanna S. Bruinooge; Harpreet Singh; Keith D. Wilner; Shadia Jalal; Stuart M. Lichtman; Paul G. Kluetz; Gary H. Lyman; Heidi D. Klepin; Mark E. Fleury; Brad Hirsch; Allen Melemed; Fernanda I. Arnaldez; Upal Basu Roy; Caroline Schenkel; Shimere Sherwood; Elizabeth Garrett-Mayer
Impact of Broadening Trial Eligibility Criteria for Patients with Advanced Non–Small Cell Lung Cancer: Real-World Analysis of Select ASCO-Friends Recommendations
R. Donald Harvey; Suanna S. Bruinooge; Li Chen; Elizabeth Garrett-Mayer; Whitney Rhodes; Edward Stepanski; Thomas S. Uldrick; Gwynn Ison; Sean Khozin; Wendy S. Rubinstein; Caroline Schenkel; Robert S. Miller; George A. Komatsoulis; Richard L. Schilsky; Edward S. Kim
Clinical Trials: Targeted Therapy
A Randomized Phase II Study of Coexpression Extrapolation (COXEN) with Neoadjuvant Chemotherapy for Bladder Cancer (SWOG S1314; NCT02177695)
Thomas W. Flaig; Catherine M. Tangen; Siamak Daneshmand; Ajjai Alva; Seth P. Lerner; M. Scott Lucia; David J. McConkey; Dan Theodorescu; Amir Goldkorn; Matthew I. Milowsky; Rick Bangs; Gary R. MacVicar; Bruno R. Bastos; Jared S. Fowles; Daniel L. Gustafson; Melissa Plets; Ian M. Thompson, Jr
A Phase I and Surgical Study of Ribociclib and Everolimus in Children with Recurrent or Refractory Malignant Brain Tumors: A Pediatric Brain Tumor Consortium Study
Mariko D. DeWire; Christine Fuller; Olivia Campagne; Tong Lin; Haitao Pan; Tina Young Poussaint; Patricia A. Baxter; Eugene I. Hwang; Andrew Bukowinski; Kathleen Dorris; Lindsey Hoffman; Angela J. Waanders; Matthias A. Karajannis; Clinton F. Stewart; Arzu Onar-Thomas; Maryam Fouladi; Ira J. Dunkel
An Open-label, Multicenter, Single-arm, Phase II Study of Fluzoparib in Patients with Germline BRCA1/2 Mutation and Platinum-sensitive Recurrent Ovarian Cancer
Ning Li; Hualei Bu; Jihong Liu; Jianqing Zhu; Qi Zhou; Li Wang; Rutie Yin; Xiaohua Wu; Shuzhong Yao; Kangsheng Gu; Hui Zhang; Guiling Li; Hongming Pan; Qiang Wu; Ruifang An; Xinfeng Yang; Yaping Zhu; Xiaoping Wan; Wei Duan; Jianping Xiong; Hongyan Guo; Ge Lou; Jing Wang; Wenjing Hu; Xin Zhang; Yuanguang Meng; Ben Zhang; Yuting Wang; Quanren Wang; Lingying Wu
Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non–Small Cell Lung Cancer
Michael Skwarski; Daniel R. McGowan; Elizabeth Belcher; Francesco Di Chiara; Dionisios Stavroulias; Mark McCole; Jennifer L. Derham; Kwun-Ye Chu; Eugene Teoh; Jagat Chauhan; Dawn O’Reilly; Benjamin H.L. Harris; Philip S. Macklin; Joshua A. Bull; Marcus Green; Gonzalo Rodriguez-Berriguete; Remko Prevo; Lisa K. Folkes; Leticia Campo; Petra Ferencz; Paula L. Croal; Helen Flight; Cathy Qi; Jane Holmes; James P.B. O’Connor; Fergus V. Gleeson; W. Gillies McKenna; Adrian L. Harris; Daniel Bulte; Francesca M. Buffa; Ruth E. Macpherson; Geoff S. Higgins
Clinical Trials: Immunotherapy
A Randomized Trial of Combined PD-L1 and CTLA-4 Inhibition with Targeted Low-Dose or Hypofractionated Radiation for Patients with Metastatic Colorectal Cancer
Arta M. Monjazeb; Anita Giobbie-Hurder; Ana Lako; Emily M. Thrash; Ryan C. Brennick; Katrina Z. Kao; Claire Manuszak; Ryan D. Gentzler; Anteneh Tesfaye; Salma K. Jabbour; Olatunji B. Alese; Osama E. Rahma; James M. Cleary; Elad Sharon; Harvey J. Mamon; May Cho; Howard Streicher; Helen X. Chen; Mansoor M. Ahmed; Adrian Mariño-Enríquez; Seunghee Kim-Schulze; Sacha Gnjatic; Emanual Maverakis; Alina I. Marusina; Alexander A. Merleev; Mariano Severgnini; Kathleen L. Pfaff; James Lindsay; Jason L. Weirather; Srinika Ranasinghe; Alexander Spektor; Scott J. Rodig; F. Stephen Hodi; Jonathan D. Schoenfeld
Author Choice
Intratumoral Plasmid IL12 Expands CD8+ T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy
Melinda L. Telli; Hiroshi Nagata; Irene Wapnir; Chaitanya R. Acharya; Kaitlin Zablotsky; Bernard A. Fox; Carlo B. Bifulco; Shawn M. Jensen; Carmen Ballesteros-Merino; Mai Hope Le; Robert H. Pierce; Erica Browning; Reneta Hermiz; Lauren Svenson; Donna Bannavong; Kim Jaffe; Jendy Sell; Kellie Malloy Foerter; David A. Canton; Christopher G. Twitty; Takuya Osada; H. Kim Lyerly; Erika J. Crosby
Precision Medicine and Imaging
Virus-positive Merkel Cell Carcinoma Is an Independent Prognostic Group with Distinct Predictive Biomarkers
Kelly L. Harms; Lili Zhao; Bryan Johnson; Xiaoming Wang; Shannon Carskadon; Nallasivam Palanisamy; Daniel R. Rhodes; Rahul Mannan; Josh N. Vo; Jae Eun Choi; May P. Chan; Douglas R. Fullen; Rajiv M. Patel; Javed Siddiqui; Vincent T. Ma; Steven Hrycaj; Scott A. McLean; Tasha M. Hughes; Christopher K. Bichakjian; Scott A. Tomlins; Paul W. Harms
Author Choice
The Added Value of Baseline Circulating Tumor DNA Profiling in Patients with Molecularly Hyperselected, Left-sided Metastatic Colorectal Cancer
Paolo Manca; Salvatore Corallo; Adele Busico; Sara Lonardi; Francesca Corti; Carlotta Antoniotti; Letizia Procaccio; Matteo Clavarezza; Valeria Smiroldo; Gianluca Tomasello; Roberto Murialdo; Andrea Sartore-Bianchi; Patrizia Racca; Filippo Pagani; Giovanni Randon; Antonia Martinetti; Elisa Sottotetti; Federica Palermo; Federica Perrone; Elena Tamborini; Michele Prisciandaro; Alessandra Raimondi; Maria Di Bartolomeo; Federica Morano; Filippo Pietrantonio
Author Choice
Combined Analysis of Concordance between Liquid and Tumor Tissue Biopsies for RAS Mutations in Colorectal Cancer with a Single Metastasis Site: The METABEAM Study
Yoshinori Kagawa; Elena Elez; Jesús García-Foncillas; Hideaki Bando; Hiroya Taniguchi; Ana Vivancos; Kiwamu Akagi; Ariadna García; Tadamichi Denda; Javier Ros; Tomohiro Nishina; Iosune Baraibar; Yoshito Komatsu; Davide Ciardiello; Eiji Oki; Toshihiro Kudo; Takeshi Kato; Takeharu Yamanaka; Josep Tabernero; Takayuki Yoshino
High Detection Rates of Pancreatic Cancer Across Stages by Plasma Assay of Novel Methylated DNA Markers and CA19-9
Shounak Majumder; William R. Taylor; Patrick H. Foote; Calise K. Berger; Chung Wah Wu; Douglas W. Mahoney; William R. Bamlet; Kelli N. Burger; Neil Postier; Jaime de la Fuente; Karen A. Doering; Graham P. Lidgard; Hatim T. Allawi; Gloria M. Petersen; Suresh T. Chari; David A. Ahlquist; John B. Kisiel
Translational Cancer Mechanisms and Therapy
Genome-wide Copy-number Alterations in Circulating Tumor DNA as a Novel Biomarker for Patients with High-grade Serous Ovarian Cancer
Lara Paracchini; Luca Beltrame; Tommaso Grassi; Alessia Inglesi; Robert Fruscio; Fabio Landoni; Davide Ippolito; Martina Delle Marchette; Mariachiara Paderno; Marco Adorni; Marta Jaconi; Chiara Romualdi; Maurizio D'Incalci; Giulia Siravegna; Sergio Marchini
Author Choice
Whole-exome Sequencing in Penile Squamous Cell Carcinoma Uncovers Novel Prognostic Categorization and Drug Targets Similar to Head and Neck Squamous Cell Carcinoma
Jad Chahoud; Frederico O. Gleber-Netto; Barrett Z. McCormick; Priya Rao; Xin Lu; Ming Guo; Maggaret B. Morgan; Randy A. Chu; Magaly Martinez-Ferrer; Agda Karina Eterovic; Curtis R. Pickering; Curtis A. Pettaway
A Uniform Computational Approach Improved on Existing Pipelines to Reveal Microbiome Biomarkers of Nonresponse to Immune Checkpoint Inhibitors
Fyza Y. Shaikh; James R. White; Joell J. Gills; Taiki Hakozaki; Corentin Richard; Bertrand Routy; Yusuke Okuma; Mykhaylo Usyk; Abhishek Pandey; Jeffrey S. Weber; Jiyoung Ahn; Evan J. Lipson; Jarushka Naidoo; Drew M. Pardoll; Cynthia L. Sears
Immune-related Gene Expression Predicts Response to Neoadjuvant Chemotherapy but not Additional Benefit from PD-L1 Inhibition in Women with Early Triple-negative Breast Cancer
Bruno V. Sinn; Sibylle Loibl; Claus A. Hanusch; Dirk-Michael Zahm; Hans-Peter Sinn; Michael Untch; Karsten Weber; Thomas Karn; Clemens Becker; Frederik Marmé; Wolfgang D. Schmitt; Volkmar Müller; Christian Schem; Denise Treue; Elmar Stickeler; Frederik Klauschen; Nicole Burchardi; Jenny Furlanetto; Marion van Mackelenbergh; Peter A. Fasching; Andreas Schneeweiss; Carsten Denkert
Circulating Protein Biomarkers for Use in Pancreatic Ductal Adenocarcinoma Identification
Sidsel C. Lindgaard; Zsófia Sztupinszki; Emil Maag; Inna M. Chen; Astrid Z. Johansen; Benny V. Jensen; Stig E. Bojesen; Dorte L. Nielsen; Carsten P. Hansen; Jane P. Hasselby; Kaspar R. Nielsen; Zoltan Szallasi; Julia S. Johansen
KRASG12C Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma
Gregory D. Jones; Raul Caso; Kay See Tan; Brooke Mastrogiacomo; Francisco Sanchez-Vega; Yuan Liu; James G. Connolly; Yonina R. Murciano-Goroff; Matthew J. Bott; Prasad S. Adusumilli; Daniela Molena; Gaetano Rocco; Valerie W. Rusch; Smita Sihag; Sandra Misale; Rona Yaeger; Alexander Drilon; Kathryn C. Arbour; Gregory J. Riely; Neal Rosen; Piro Lito; Haiying Zhang; David C. Lyden; Charles M. Rudin; David R. Jones; Bob T. Li; James M. Isbell
Clinicopathologic and Genomic Analysis of TP53-Mutated Endometrial Carcinomas
Amir Momeni-Boroujeni; Wissam Dahoud; Chad M. Vanderbilt; Sarah Chiang; Rajmohan Murali; Eric V. Rios-Doria; Kaled M. Alektiar; Carol Aghajanian; Nadeem R. Abu-Rustum; Marc Ladanyi; Lora H. Ellenson; Britta Weigelt; Robert A. Soslow
G9a Inhibition Enhances Checkpoint Inhibitor Blockade Response in Melanoma
Gregory M. Kelly; Fares Al-Ejeh; Robert McCuaig; Francesco Casciello; Nabilah Ahmad Kamal; Blake Ferguson; Antonia L. Pritchard; Sayed Ali; Ines P. Silva; James S. Wilmott; Georgina V. Long; Richard A. Scolyer; Sudha Rao; Nicholas K. Hayward; Frank Gannon; Jason S. Lee
Therapeutic Targeting of Nemo-like Kinase in Primary and Acquired Endocrine-resistant Breast Cancer
Xian Wang; Jamunarani Veeraraghavan; Chia-Chia Liu; Xixi Cao; Lanfang Qin; Jin-Ah Kim; Ying Tan; Suet Kee Loo; Yiheng Hu; Ling Lin; Sanghoon Lee; Martin J. Shea; Tamika Mitchell; Shunqiang Li; Matthew J. Ellis; Susan G. Hilsenbeck; Rachel Schiff; Xiao-Song Wang
Corrections
Correction: A Virus-infected, Reprogrammed Somatic Cell–derived Tumor Cell (VIReST) Vaccination Regime can Prevent Initiation and Progression of Pancreatic Cancer
Shuangshuang Lu; Zhe Zhang; Pan Du; Louisa S. Chard; Wenli Yan; Margueritte El Khouri; Zhizhong Wang; Zhongxian Zhang; Yongchao Chu; Dongling Gao; Qinxian Zhang; Lirong Zhang; Ai Nagano; Jun Wang; Claude Chelala; Jing Liu; Jiekai Chen; Pentao Liu; Yunshu Dong; Shengdian Wang; Xiaozhu Li; Jianzeng Dong; Nick R. Lemoine; Duanqing Pei; Yaohe Wang
Correction: PRMT5 Circular RNA Promotes Metastasis of Urothelial Carcinoma of the Bladder through Sponging miR-30c to Induce Epithelial–Mesenchymal Transition
Xin Chen; Ri-Xin Chen; Wen-Su Wei; Yong-Hong Li; Zi-Hao Feng; Lei Tan; Jie-Wei Chen; Gang-Jun Yuan; Si-Liang Chen; Sheng-Jie Guo; Kang-Hua Xiao; Zhuo-Wei Liu; Jun-Hang Luo; Fang-Jian Zhou; Dan Xie
Editor’s Notes
Editor's Note: Epigenetic Modifications of RASSF1A Gene through Chromatin Remodeling in Prostate Cancer
Ken Kawamoto; Steven T. Okino; Robert F. Place; Shinji Urakami; Hiroshi Hirata; Nobuyuki Kikuno; Toshifumi Kawakami; Yuichiro Tanaka; Deepa Pookot; Zhong Chen; Shahana Majid; Hideki Enokida; Masayuki Nakagawa; Rajvir Dahiya
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