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15 April 2021
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Cover Image
Cover Image
The cover shows a section of a tumor from a patient with pancreatic ductal adenocarcinoma. RNA in situ hybridization shows strong expression of genes associated with short-term patient survival (red) in the cancer cells relative to those associated with long-term survival (blue). For details, see the article by Birnbaum and colleagues on page 2314 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Pertuzumab, Trastuzumab, and Hyaluronidase–zzxf Injection for Subcutaneous Use in Patients with HER2-positive Breast Cancer
Jennifer J. Gao; Christy L. Osgood; Yutao Gong; Hui Zhang; Erik W. Bloomquist; Xiling Jiang; Junshan Qiu; Jingyu Yu; Pengfei Song; Nam Atiqur Rahman; Haw-Jyh Chiu; Tiffany K. Ricks; Fatima Rizvi; Sherry Hou; Willie Wilson; Abde M. Abukhdeir; Jeffrey Seidman; Soma Ghosh; Reena Philip; William F. Pierce; Vishal Bhatnagar; Paul G. Kluetz; Richard Pazdur; Julia A. Beaver; Laleh Amiri-Kordestani
FDA Approval Summary: Selpercatinib for the Treatment of Lung and Thyroid Cancers with RET Gene Mutations or Fusions
Diana Bradford; Erin Larkins; Sirisha L. Mushti; Lisa Rodriguez; Amy M. Skinner; Whitney S. Helms; Lauren S.L. Price; Jeanne Fourie Zirkelbach; Yangbing Li; Jiang Liu; Rosane Charlab; Francisca Reyes Turcu; Dun Liang; Soma Ghosh; Donna Roscoe; Reena Philip; Autumn Zack-Taylor; Shenghui Tang; Paul G. Kluetz; Julia A. Beaver; Richard Pazdur; Marc R. Theoret; Harpreet Singh
Perspectives
How Did We Get a COVID-19 Vaccine in Less Than 1 Year?
E. John Wherry; Elizabeth M. Jaffee; Nicholas Warren; Gypsyamber D'Souza; Antoni Ribas; on behalf of the AACR COVID-19 and Cancer Task Force
Research Briefs: Clinical Trial Brief Reports
Regorafenib-Avelumab Combination in Patients with Microsatellite Stable Colorectal Cancer (REGOMUNE): A Single-arm, Open-label, Phase II Trial
Sophie Cousin; Coralie Cantarel; Jean-Philippe Guegan; Carlos Gomez-Roca; Jean-Philippe Metges; Antoine Adenis; Simon Pernot; Carine Bellera; Michèle Kind; Céline Auzanneau; François Le Loarer; Isabelle Soubeyran; Alban Bessede; Antoine Italiano
Clinical Trials: Targeted Therapy
Gene Expression–Based Prediction of Neoadjuvant Chemotherapy Response in Early Breast Cancer: Results of the Prospective Multicenter EXPRESSION Trial
Karolina Edlund; Katrin Madjar; Antje Lebrecht; Bahriye Aktas; Henryk Pilch; Gerald Hoffmann; Manfred Hofmann; Hans-Christian Kolberg; Daniel Boehm; Marco Battista; Martina Seehase; Kathrin Stewen; Susanne Gebhard; Cristina Cadenas; Rosemarie Marchan; Walburgis Brenner; Annette Hasenburg; Heinz Koelbl; Christine Solbach; Mathias Gehrmann; Berno Tanner; Karsten E. Weber; Sibylle Loibl; Agapios Sachinidis; Jörg Rahnenführer; Marcus Schmidt; Jan G. Hengstler
Dual Antiangiogenesis Agents Bevacizumab Plus Trebananib, without Chemotherapy, in First-line Treatment of Metastatic Colorectal Cancer: Results of a Phase II Study
Jennifer Mooi; Fiona Chionh; Peter Savas; Jessica Da Gama Duarte; Geoffrey Chong; Stephen Brown; Rachel Wong; Timothy J. Price; Alysson Wann; Effie Skrinos; John M. Mariadason; Niall C. Tebbutt
Clinical Trials: Immunotherapy
Blocking TIM-3 in Treatment-refractory Advanced Solid Tumors: A Phase Ia/b Study of LY3321367 with or without an Anti-PD-L1 Antibody
James J. Harding; Victor Moreno; Yung-Jue Bang; Min Hee Hong; Amita Patnaik; José Trigo; Anna M. Szpurka; Noboru Yamamoto; Toshihiko Doi; Siqing Fu; Boris Calderon; Nieves Velez de Mendizabal; Emiliano Calvo; Danni Yu; Leena Gandhi; Zhuqing Tina Liu; Violeta Regnier Galvao; Ching Ching Leow; Maria J. de Miguel
Long-Term Follow-up of a Phase III Study of ch14.18 (Dinutuximab) + Cytokine Immunotherapy in Children with High-Risk Neuroblastoma: COG Study ANBL0032
Alice L. Yu; Andrew L. Gilman; M. Fevzi Ozkaynak; Arlene Naranjo; Mitchell B. Diccianni; Jacek Gan; Jacquelyn A. Hank; Ayse Batova; Wendy B. London; Sheena C. Tenney; Malcolm Smith; Barry L. Shulkin; Marguerite Parisi; Katherine K. Matthay; Susan L. Cohn; John M. Maris; Rochelle Bagatell; Julie R. Park; Paul M. Sondel
Author Choice
Phase I Study of the CD47 Blocker TTI-621 in Patients with Relapsed or Refractory Hematologic Malignancies
Stephen M. Ansell; Michael B. Maris; Alexander M. Lesokhin; Robert W. Chen; Ian W. Flinn; Ahmed Sawas; Mark D. Minden; Diego Villa; Mary-Elizabeth M. Percival; Anjali S. Advani; James M. Foran; Steven M. Horwitz; Matthew G. Mei; Jasmine Zain; Kerry J. Savage; Christiane Querfeld; Oleg E. Akilov; Lisa D.S. Johnson; Tina Catalano; Penka S. Petrova; Robert A. Uger; Eric L. Sievers; Anca Milea; Kathleen Roberge; Yaping Shou; Owen A. O'Connor
Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair–proficient Metastatic Colorectal Cancer
Neil H. Segal; Andrea Cercek; Geoffrey Ku; Abraham J. Wu; Andreas Rimner; Danny N. Khalil; Diane Reidy-Lagunes; John Cuaron; T. Jonathan Yang; Martin R. Weiser; Paul B. Romesser; Zsofia K. Stadler; Anna M. Varghese; Karuna Ganesh; Rona Yaeger; Louise C. Connell; David Faleck; Ghassan K. Abou-Alfa; Kathleen C. Mcauliffe; Pamela Vaiskauskas; Mark L. Solter; Martinique Ogle; Matthew J. Adamow; Aliya Holland; Pallavi Vedantam; Phillip Wong; Taha Merghoub; Efsevia Vakiani; Travis J. Hollmann; Krishna Juluru; Joanne F. Chou; Marinela Capanu; Joseph Erinjeri; Stephen Solomon; Yoshiya Yamada; Nancy Kemeny; Christopher H. Crane; Leonard B. Saltz
Precision Medicine and Imaging
Treatment Outcomes and Clinical Characteristics of Patients with KRAS-G12C–Mutant Non–Small Cell Lung Cancer
Kathryn C. Arbour; Hira Rizvi; Andrew J. Plodkowski; Matthew D. Hellmann; Andrea Knezevic; Glenn Heller; Helena A. Yu; Marc Ladanyi; Mark G. Kris; Maria E. Arcila; Charles M. Rudin; Piro Lito; Gregory J. Riely
Therapeutic Implications of Detecting MAPK-Activating Alterations in Cutaneous and Unknown Primary Melanomas
Alexander N. Shoushtari; Walid K. Chatila; Arshi Arora; Francisco Sanchez-Vega; Havish S. Kantheti; Jorge A. Rojas Zamalloa; Penina Krieger; Margaret K. Callahan; Allison Betof Warner; Michael A. Postow; Parisa Momtaz; Suresh Nair; Charlotte E. Ariyan; Christopher A. Barker; Mary Susan Brady; Daniel G. Coit; Neal Rosen; Paul B. Chapman; Klaus J. Busam; David B. Solit; Katherine S. Panageas; Jedd D. Wolchok; Nikolaus Schultz
Microbiome Analysis of More Than 2,000 NHS Bowel Cancer Screening Programme Samples Shows the Potential to Improve Screening Accuracy
Caroline Young; Henry M. Wood; Alba Fuentes Balaguer; Daniel Bottomley; Niall Gallop; Lyndsay Wilkinson; Sally C. Benton; Martin Brealey; Cerin John; Carole Burtonwood; Kelsey N. Thompson; Yan Yan; Jennifer H. Barrett; Eva J.A. Morris; Curtis Huttenhower; Philip Quirke
Development and Validation of Machine Learning–based Model for the Prediction of Malignancy in Multiple Pulmonary Nodules: Analysis from Multicentric Cohorts
Kezhong Chen; Yuntao Nie; Samina Park; Kai Zhang; Yangming Zhang; Yuan Liu; Bengang Hui; Lixin Zhou; Xun Wang; Qingyi Qi; Hao Li; Guannan Kang; Yuqing Huang; Yingtai Chen; Jiabao Liu; Jian Cui; Mingru Li; In Kyu Park; Chang Hyun Kang; Haifeng Shen; Yingshun Yang; Tian Guan; Yaxiao Zhang; Fan Yang; Young Tae Kim; Jun Wang
Author Choice
A Novel Mouse Model of Radiation-Induced Cardiac Injury Reveals Biological and Radiological Biomarkers of Cardiac Dysfunction with Potential Clinical Relevance
Alexandra D. Dreyfuss; Denisa Goia; Khayrullo Shoniyozov; Swapnil V. Shewale; Anastasia Velalopoulou; Susan Mazzoni; Harris Avgousti; Scott D. Metzler; Paco E. Bravo; Steven J. Feigenberg; Bonnie Ky; Ioannis I. Verginadis; Constantinos Koumenis
Author Choice
Alterations in BAP1 Are Associated with Cisplatin Resistance through Inhibition of Apoptosis in Malignant Pleural Mesothelioma
Kathrin Oehl; Bart Vrugt; Ulrich Wagner; Michaela B. Kirschner; Mayura Meerang; Walter Weder; Emanuela Felley-Bosco; Bernd Wollscheid; Katrin Bankov; Melanie C. Demes; Isabelle Opitz; Peter J. Wild
Translational Cancer Mechanisms and Therapy
Transcriptomic Analysis of Laser Capture Microdissected Tumors Reveals Cancer- and Stromal-Specific Molecular Subtypes of Pancreatic Ductal Adenocarcinoma
David J. Birnbaum; Sebastian K.S. Begg; Pascal Finetti; Charles Vanderburg; Anupriya S. Kulkarni; Azfar Neyaz; Thomas Hank; Eric Tai; Vikram Deshpande; François Bertucci; Daniel Birnbaum; Keith D. Lillemoe; Andrew L. Warshaw; Mari Mino-Kenudson; Carlos Fernandez-Del Castillo; David T. Ting; Andrew S. Liss
Yap1 Mediates Trametinib Resistance in Head and Neck Squamous Cell Carcinomas
Tenny Mudianto; Katie M. Campbell; Jason Webb; Paul Zolkind; Zachary L. Skidmore; Rachel Riley; Erica K. Barnell; Ibrahim Ozgenc; Tusar Giri; Gavin P. Dunn; Douglas R. Adkins; Malachi Griffith; Ann Marie Egloff; Obi L. Griffith; Ravindra Uppaluri
Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies
Yi Liang; Sujeeve Jeganathan; Stefano Marastoni; Adam Sharp; Ines Figueiredo; Richard Marcellus; Amanda Mawson; Zvi Shalev; Aleksandra Pesic; Joan Sweet; Haiyang Guo; David Uehling; Bora Gurel; Antje Neeb; Housheng Hansen He; Bruce Montgomery; Marianne Koritzinsky; Samantha Oakes; Johann S. de Bono; Martin Gleave; Amina Zoubeidi; Bradly G. Wouters; Anthony M. Joshua
Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition
Pu Zhang; Lindsey T. Brinton; Katie Williams; Steven Sher; Shelley Orwick; Lai Tzung-Huei; Alice S. Mims; Christopher C. Coss; Samuel K. Kulp; Youssef Youssef; Wing Keung Chan; Shaneice Mitchell; Allison Mustonen; Matthew Cannon; Hannah Phillips; Amy M. Lehman; Tierney Kauffman; Larry Beaver; Daniel Canfield; Nicole R. Grieselhuber; Lapo Alinari; Deepa Sampath; Pearlly Yan; John C. Byrd; James S. Blachly; Rosa Lapalombella
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