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1 April 2021
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Cover Image
Cover Image
The cover shows a section of pancreatic cancer precursor lesions in a mouse model of this disease expressing oncogenic Kras and the Sonic Hedgehog ligand. Gomori trichrome stain shows collagen deposition in blue, cell nuclei in dark purple, and cell cytoplasm in pink. For details, see the article by Steele and colleagues on page 2023 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Atezolizumab Plus Bevacizumab for the Treatment of Patients with Advanced Unresectable or Metastatic Hepatocellular Carcinoma
Sandra J. Casak; Martha Donoghue; Lola Fashoyin-Aje; Xiaoping Jiang; Lisa Rodriguez; Yuan-Li Shen; Yuan Xu; Xiling Jiang; Jiang Liu; Hong Zhao; William F. Pierce; Shubhangi Mehta; Kirsten B. Goldberg; Marc R. Theoret; Paul G. Kluetz; Richard Pazdur; Steven J. Lemery
FDA Approval Summary: Alpelisib Plus Fulvestrant for Patients with HR-positive, HER2-negative, PIK3CA-mutated, Advanced or Metastatic Breast Cancer
Preeti Narayan; Tatiana M. Prowell; Jennifer J. Gao; Laura L. Fernandes; Emily Li; Xiling Jiang; Junshan Qiu; Jianghong Fan; Pengfei Song; Jingyu Yu; Xinyuan Zhang; Bellinda L. King-Kallimanis; Wei Chen; Tiffany K. Ricks; Yutao Gong; Xing Wang; Katherine Windsor; Steve Y. Rhieu; Gerlie Geiser; Anamitro Banerjee; Xiaohong Chen; Francisca Reyes Turcu; Deb K. Chatterjee; Anand Pathak; Jeffrey Seidman; Soma Ghosh; Reena Philip; Kirsten B. Goldberg; Paul G. Kluetz; Shenghui Tang; Laleh Amiri-Kordestani; Marc R. Theoret; Richard Pazdur; Julia A. Beaver
FDA Approval Summary: Accelerated Approval of Sacituzumab Govitecan-hziy for Third-line Treatment of Metastatic Triple-negative Breast Cancer
Sakar Wahby; Lola Fashoyin-Aje; Christy L. Osgood; Joyce Cheng; Mallorie H. Fiero; Lijun Zhang; Shenghui Tang; Salaheldin S. Hamed; Pengfei Song; Rosane Charlab; Sarah E. Dorff; Tiffany K. Ricks; Kimberly Barnett-Ringgold; Jeannette Dinin; Kirsten B. Goldberg; Marc R. Theoret; Richard Pazdur; Laleh Amiri-Kordestani; Julia A. Beaver
Research Briefs: Clinical Trial Brief Reports
Clinical Trials: Targeted Therapy
Preclinical Evaluation and Phase Ib Study of Prexasertib, a CHK1 Inhibitor, and Samotolisib (LY3023414), a Dual PI3K/mTOR Inhibitor
David S. Hong; Kathleen N. Moore; Johanna C. Bendell; Daniel D. Karp; Judy S. Wang; Susanna V. Ulahannan; Suzanne Jones; Wenjuan Wu; Gregory P. Donoho; Yan Ding; Andrew Capen; Xuejing Wang; Aimee Bence Lin; Manish R. Patel
Author Choice
PIPAC-OX: A Phase I Study of Oxaliplatin-Based Pressurized Intraperitoneal Aerosol Chemotherapy in Patients with Peritoneal Metastases
Guowei Kim; Hon Lyn Tan; Raghav Sundar; Bettina Lieske; Cheng Ean Chee; Jingshan Ho; Asim Shabbir; Maria V. Babak; Wee Han Ang; Boon Cher Goh; Wei Peng Yong; Lingzhi Wang; Jimmy B.Y. So
Author Choice
Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE)
Simon J. Crabb; Sarah Danson; James W.F. Catto; Syed Hussain; Danna Chan; Denise Dunkley; Nichola Downs; Ellice Marwood; Laura Day; Geoff Saunders; Michelle Light; Amy Whitehead; Deborah Ellis; Naveed Sarwar; Deborah Enting; Alison Birtle; Bernadette Johnson; Robert Huddart; Gareth Griffiths
Clinical Responsiveness to All-trans Retinoic Acid Is Potentiated by LSD1 Inhibition and Associated with a Quiescent Transcriptome in Myeloid Malignancies
Mina M. Tayari; Helena G. Dos Santos; Deukwoo Kwon; Terrence J. Bradley; Amber Thomassen; Charles Chen; Yvonne Dinh; Aymee Perez; Arthur Zelent; Lluis Morey; Luisa Cimmino; Ramin Shiekhattar; Ronan T. Swords; Justin M. Watts
Clinical Trials: Immunotherapy
Author Choice
Phase Ib Clinical Trial of IGV-001 for Patients with Newly Diagnosed Glioblastoma
David W. Andrews; Kevin D. Judy; Charles B. Scott; Samantha Garcia; Larry A. Harshyne; Lawrence Kenyon; Kiran Talekar; Adam Flanders; Kofi-Buaku Atsina; Lyndon Kim; Nina Martinez; Wenyin Shi; Maria Werner-Wasik; Haisong Liu; Mikhail Prosniak; Mark Curtis; Rhonda Kean; Donald Y. Ye; Emily Bongiorno; Sami Sauma; Mark A. Exley; Kara Pigott; D. Craig Hooper
Author Choice
Efficacy of Pembrolizumab Monotherapy for Advanced Gastric/Gastroesophageal Junction Cancer with Programmed Death Ligand 1 Combined Positive Score ≥10
Zev A. Wainberg; Charles S. Fuchs; Josep Tabernero; Kohei Shitara; Kei Muro; Eric Van Cutsem; Yung-Jue Bang; Hyun Cheol Chung; Kensei Yamaguchi; Eniko Varga; Jen-Shi Chen; Daniel Hochhauser; Peter Thuss-Patience; Salah-Eddin Al-Batran; Marcelo Garrido; Uma Kher; Chie-Schin Shih; Sukrut Shah; Pooja Bhagia; Joseph Chao
Precision Medicine and Imaging
Diffusion-weighted Imaging Allows for Downgrading MR BI-RADS 4 Lesions in Contrast-enhanced MRI of the Breast to Avoid Unnecessary Biopsy
Paola Clauser; Barbara Krug; Hubert Bickel; Matthias Dietzel; Katja Pinker; Victor-Frederic Neuhaus; Maria Adele Marino; Marco Moschetta; Nicoletta Troiano; Thomas H. Helbich; Pascal A.T. Baltzer
Changes in Diffuse Optical Tomography Images During Early Stages of Neoadjuvant Chemotherapy Correlate with Tumor Response in Different Breast Cancer Subtypes
Mirella L. Altoe; Kevin Kalinsky; Alessandro Marone; Hyun K. Kim; Hua Guo; Hanina Hibshoosh; Mariella Tejada; Katherine D. Crew; Melissa K. Accordino; Meghna S. Trivedi; Dawn L. Hershman; Andreas H. Hielscher
Baseline Circulating Tumor Cell Count as a Prognostic Marker of PSA Response and Disease Progression in Metastatic Castrate-Sensitive Prostate Cancer (SWOG S1216)
Amir Goldkorn; Catherine Tangen; Melissa Plets; Gareth J. Morrison; Alexander Cunha; Tong Xu; Jacek K. Pinski; Sue A. Ingles; Timothy Triche; Andrea L. Harzstark; Manish Kohli; Gary R. MacVicar; Daniel A. Vaena; Anthony W. Crispino; David J. McConkey; Primo N. Lara, Jr; Maha H.A. Hussain; David I. Quinn; Nicholas J. Vogelzang; Ian Murchie Thompson, Jr; Neeraj Agarwal
Author Choice
VLA4-Targeted Nanoparticles Hijack Cell Adhesion–Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong Survival
Francesca Fontana; Michael J. Scott; John S. Allen; Xiaoxia Yang; Grace Cui; Dipanjan Pan; Noriko Yanaba; Mark A. Fiala; Julie O'Neal; Anne H. Schmieder-Atteberry; Julie Ritchey; Michael Rettig; Kathleen Simons; Steven Fletcher; Ravi Vij; John F. DiPersio; Gregory M. Lanza
Translational Cancer Mechanisms and Therapy
Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer
Sabine Topka; Zoe Steinsnyder; Vignesh Ravichandran; Kaitlyn Tkachuk; Yelena Kemel; Chaitanya Bandlamudi; Mogens Winkel Madsen; Helena Furberg; Ouathek Ouerfelli; Charles M. Rudin; Gopa Iyer; Steven M. Lipkin; Semanti Mukherjee; David B. Solit; Michael F. Berger; Dean F. Bajorin; Jonathan E. Rosenberg; Barry S. Taylor; Elisa de Stanchina; Joseph Vijai; Kenneth Offit
Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer
Judit Börcsök; Zsofia Sztupinszki; Raie Bekele; Sizhi P. Gao; Miklos Diossy; Amruta S. Samant; Kasia M. Dillon; Viktoria Tisza; Sándor Spisák; Orsolya Rusz; Istvan Csabai; Helle Pappot; Zoë J. Frazier; David J. Konieczkowski; David Liu; Naresh Vasani; James A. Rodrigues; David B. Solit; Jean H. Hoffman-Censits; Elizabeth R. Plimack; Jonathan E. Rosenberg; Jean-Bernard Lazaro; Mary-Ellen Taplin; Gopa Iyer; Søren Brunak; Rita Lozsa; Eliezer M. Van Allen; Dávid Szüts; Kent W. Mouw; Zoltan Szallasi
Author Choice
Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer
Nina G. Steele; Giulia Biffi; Samantha B. Kemp; Yaqing Zhang; Donovan Drouillard; LiJyun Syu; Yuan Hao; Tobiloba E. Oni; Erin Brosnan; Ela Elyada; Abhishek Doshi; Christa Hansma; Carlos Espinoza; Ahmed Abbas; Stephanie The; Valerie Irizarry-Negron; Christopher J. Halbrook; Nicole E. Franks; Megan T. Hoffman; Kristee Brown; Eileen S. Carpenter; Zeribe C. Nwosu; Craig Johnson; Fatima Lima; Michelle A. Anderson; Youngkyu Park; Howard C. Crawford; Costas A. Lyssiotis; Timothy L. Frankel; Arvind Rao; Filip Bednar; Andrzej A. Dlugosz; Jonathan B. Preall; David A. Tuveson; Benjamin L. Allen; Marina Pasca di Magliano
Author Choice
Preclinical Modeling of Surgery and Steroid Therapy for Glioblastoma Reveals Changes in Immunophenotype that are Associated with Tumor Growth and Outcome
Balint Otvos; Tyler J. Alban; Matthew M. Grabowski; Defne Bayik; Erin E. Mulkearns-Hubert; Tomas Radivoyevitch; Anja Rabljenovic; Sarah Johnson; Charlie Androjna; Alireza M. Mohammadi; Gene H. Barnett; Manmeet S. Ahluwalia; Michael A. Vogelbaum; Peter E. Fecci; Justin D. Lathia
Author Choice
PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates
Darren R. Veach; Claire M. Storey; Katharina Lückerath; Katharina Braun; Christian von Bodman; Urpo Lamminmäki; Teja Kalidindi; Sven-Erik Strand; Joanna Strand; Mohamed Altai; Robert Damoiseaux; Pat Zanzonico; Nadia Benabdallah; Dmitry Pankov; Howard I. Scher; Peter Scardino; Steven M. Larson; Hans Lilja; Michael R. McDevitt; Daniel L.J. Thorek; David Ulmert
Author Choice
LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors
Kelli-Ann Monaco; Scott Delach; Jing Yuan; Yuji Mishina; Paul Fordjour; Emma Labrot; Daniel McKay; Ribo Guo; Stacy Higgins; Hui Qin Wang; Jinsheng Liang; Karen Bui; John Green; Peter Aspesi; Jessi Ambrose; Felipa Mapa; Lesley Griner; Mariela Jaskelioff; John Fuller; Kenneth Crawford; Gwynn Pardee; Stephania Widger; Peter S. Hammerman; Jeffrey A. Engelman; Darrin D. Stuart; Vesselina G. Cooke; Giordano Caponigro
Initial Whole-Genome Sequencing of Plasma Cell Neoplasms in First Responders and Recovery Workers Exposed to the World Trade Center Attack of September 11, 2001
Francesco Maura; Benjamin Diamond; Kylee H. Maclachlan; Andriy Derkach; Venkata D. Yellapantula; Even H. Rustad; Malin Hultcrantz; Urvi A. Shah; Jessica Hong; Heather J. Landau; Christine A. Iacobuzio-Donahue; Elli Papaemmanuil; Shani Irby; Laura Crowley; Michael Crane; Mayris P. Webber; David G. Goldfarb; Rachel Zeig-Owens; Orsi Giricz; Amit Verma; David J. Prezant; Ahmet Dogan; Sohrab P. Shah; Yanming Zhang; Ola Landgren
Letters to the Editor
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