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15 March 2021
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The cover shows a section of a biopsy from a patient with ARID1A mutant microsatellite-stable colorectal cancer. Immunohistochemical staining shows strong T-cell infiltration in the tumor. For details, see the article by Mehrvarz Sarshekeh and colleagues on page 1663 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
Reviews
Clinical Trials: Targeted Therapy
Phase IB Study of Osimertinib in Combination with Navitoclax in EGFR-mutant NSCLC Following Resistance to Initial EGFR Therapy (ETCTN 9903)
Erin M. Bertino; Ryan D. Gentzler; Sarah Clifford; Jill Kolesar; Alona Muzikansky; Eric B. Haura; Zofia Piotrowska; D. Ross Camidge; Thomas E. Stinchcombe; Christine Hann; Jyoti Malhotra; Liza C. Villaruz; Cloud P. Paweletz; Christie L. Lau; Lynette Sholl; Naoko Takebe; Jeffrey A. Moscow; Geoffrey I. Shapiro; Pasi A. Jänne; Geoffrey R. Oxnard
Neratinib-Plus-Cetuximab in Quadruple-WT (KRAS, NRAS, BRAF, PIK3CA) Metastatic Colorectal Cancer Resistant to Cetuximab or Panitumumab: NSABP FC-7, A Phase Ib Study
Samuel A. Jacobs; James J. Lee; Thomas J. George; James L. Wade, III; Philip J. Stella; Ding Wang; Ashwin R. Sama; Fanny Piette; Katherine L. Pogue-Geile; Rim S. Kim; Patrick G. Gavin; Corey Lipchik; Huichen Feng; Ying Wang; Melanie Finnigan; Brian F. Kiesel; Jan H. Beumer; Norman Wolmark; Peter C. Lucas; Carmen J. Allegra; Ashok Srinivasan
Clinical Trials: Immunotherapy
Randomized Phase II Trial of Sipuleucel-T with or without Radium-223 in Men with Bone-metastatic Castration-resistant Prostate Cancer
Catherine H. Marshall; Wei Fu; Hao Wang; Jong Chul Park; Theodore L. DeWeese; Phuoc T. Tran; Daniel Y. Song; Serina King; Michaella Afful; Julia Hurrelbrink; Charlotte Manogue; Patrick Cotogno; Nancy P. Moldawer; Pedro C. Barata; Charles G. Drake; Edwin M. Posadas; Andrew J. Armstrong; Oliver Sartor; Emmanuel S. Antonarakis
Author Choice
A Blood-based Assay for Assessment of Tumor Mutational Burden in First-line Metastatic NSCLC Treatment: Results from the MYSTIC Study
Han Si; Michael Kuziora; Katie J. Quinn; Elena Helman; Jiabu Ye; Feng Liu; Urban Scheuring; Solange Peters; Naiyer A. Rizvi; Philip Z. Brohawn; Koustubh Ranade; Brandon W. Higgs; Kimberly C. Banks; Vikram K. Chand; Rajiv Raja
Precision Medicine and Imaging
BRCA2, ATM, and CDK12 Defects Differentially Shape Prostate Tumor Driver Genomics and Clinical Aggression
Evan Warner; Cameron Herberts; Simon Fu; Steven Yip; Amanda Wong; Gang Wang; Elie Ritch; Andrew J. Murtha; Gillian Vandekerkhove; Nicolette M. Fonseca; Arkhjamil Angeles; Arshia Beigi; Elena Schönlau; Kevin Beja; Matti Annala; Daniel Khalaf; Kim N. Chi; Alexander W. Wyatt
ARID1A Mutation May Define an Immunologically Active Subgroup in Patients with Microsatellite Stable Colorectal Cancer
Amir Mehrvarz Sarshekeh; Jumanah Alshenaifi; Jason Roszik; Ganiraju C. Manyam; Shailesh M. Advani; Riham Katkhuda; Anuj Verma; Michael Lam; Jason Willis; John Paul Shen; Jeffrey Morris; Jennifer S. Davis; Jonathan M. Loree; Hey Min Lee; Jaffer A. Ajani; Dipen M. Maru; Michael J. Overman; Scott Kopetz
Double-hit Signature with TP53 Abnormalities Predicts Poor Survival in Patients with Germinal Center Type Diffuse Large B-cell Lymphoma Treated with R-CHOP
Joo Y. Song; Anamarija M. Perry; Alex F. Herrera; Lu Chen; Pamela Skrabek; Michel R. Nasr; Rebecca A. Ottesen; Janet Nikowitz; Victoria Bedell; Joyce Murata-Collins; Yuping Li; Christine McCarthy; Raju Pillai; Jinhui Wang; Xiwei Wu; Jasmine Zain; Leslie Popplewell; Larry W. Kwak; Auayporn P. Nademanee; Joyce C. Niland; David W. Scott; Qiang Gong; Wing C. Chan; Dennis D. Weisenburger
Combining Neratinib with CDK4/6, mTOR, and MEK Inhibitors in Models of HER2-positive Cancer
Ming Zhao; Stephen Scott; Kurt W. Evans; Erkan Yuca; Turcin Saridogan; Xiaofeng Zheng; Heping Wang; Anil Korkut; Christian X. Cruz Pico; Mehmet Demirhan; Bryce Kirby; Scott Kopetz; Irmina Diala; Alshad S. Lalani; Sarina Piha-Paul; Funda Meric-Bernstam
Translational Cancer Mechanisms and Therapy
Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase Fusions
Harshabad Singh; Yvonne Y. Li; Liam F. Spurr; Atul B. Shinagare; Ritika Abhyankar; Emma Reilly; Lauren K. Brais; Anwesha Nag; Matthew D. Ducar; Aaron R. Thorner; Geoffrey I. Shapiro; Rachel B. Keller; Cheta Siletti; Jeffrey W. Clark; Anna F. Farago; Jessica J. Lin; George D. Demetri; Rahul Gujrathi; Matthew H. Kulke; Laura E. MacConaill; Azra H. Ligon; Ewa Sicinska; Matthew L. Meyerson; Jeffrey A. Meyerhardt; Andrew D. Cherniack; Brian M. Wolpin; Kimmie Ng; Marios Giannakis; Jason L. Hornick; James M. Cleary
HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor
Matthew L. Hemming; Shannon Coy; Jia-Ren Lin; Jessica L. Andersen; Joanna Przybyl; Emanuele Mazzola; Amr H. Abdelhamid Ahmed; Matt van de Rijn; Peter K. Sorger; Scott A. Armstrong; George D. Demetri; Sandro Santagata
STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition
Piyada Sitthideatphaiboon; Ana Galan-Cobo; Marcelo V. Negrao; Xiao Qu; Alissa Poteete; Fahao Zhang; Diane D. Liu; Whitney E. Lewis; Haley N. Kemp; Jeff Lewis; Waree Rinsurongkawong; Uma Giri; J. Jack Lee; Jianjun Zhang; Jack A. Roth; Stephen Swisher; John V. Heymach
Author Choice
Integrated Molecular Characterization of Fumarate Hydratase–deficient Renal Cell Carcinoma
Guangxi Sun; Xingming Zhang; Jiayu Liang; Xiuyi Pan; Sha Zhu; Zhenhua Liu; Cameron M. Armstrong; Jianhui Chen; Wei Lin; Banghua Liao; Tianhai Lin; Rui Huang; Mengni Zhang; Linmao Zheng; Xiaoxue Yin; Ling Nie; Pengfei Shen; Jinge Zhao; Haoran Zhang; Jindong Dai; Yali Shen; Zhiping Li; Jiyan Liu; Junru Chen; Jiandong Liu; Zhipeng Wang; Xudong Zhu; Yuchao Ni; Dan Qin; Ling Yang; Yuntian Chen; Qiang Wei; Xiang Li; Qiao Zhou; Haojie Huang; Jin Yao; Ni Chen; Hao Zeng
Author Choice
A Bispecific Single-Domain Antibody Boosts Autologous Vγ9Vδ2-T Cell Responses Toward CD1d in Chronic Lymphocytic Leukemia
Iris de Weerdt; Roeland Lameris; Jurjen M. Ruben; Renate de Boer; Jan Kloosterman; Lisa A. King; Mark-David Levin; Paul W.H.I. Parren; Tanja D. de Gruijl; Arnon P. Kater; Hans J. van der Vliet
Unbiased Detection of Driver Mutations in Extramammary Paget Disease
Yoshihiro Ishida; Nobuyuki Kakiuchi; Kenichi Yoshida; Yoshikage Inoue; Hiroyuki Irie; Tatsuki R. Kataoka; Masahiro Hirata; Takeru Funakoshi; Shigeto Matsushita; Hiroo Hata; Hiroshi Uchi; Yuki Yamamoto; Yasuhiro Fujisawa; Taku Fujimura; Ryunosuke Saiki; Kengo Takeuchi; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Atsushi Otsuka; Satoru Miyano; Kenji Kabashima; Seishi Ogawa
Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma
Michael I. Chastkofsky; Katarzyna C. Pituch; Hiroaki Katagi; Markella Zannikou; Liliana Ilut; Ting Xiao; Yu Han; Adam M. Sonabend; David T. Curiel; Erin R. Bonner; Javad Nazarian; Craig M. Horbinski; C. David James; Amanda M. Saratsis; Rintaro Hashizume; Maciej S. Lesniak; Irina V. Balyasnikova
Attenuation of SRC Kinase Activity Augments PARP Inhibitor–mediated Synthetic Lethality in BRCA2-altered Prostate Tumors
Goutam Chakraborty; Nabeela Khan Patail; Rahim Hirani; Subhiksha Nandakumar; Ying Z. Mazzu; Yuki Yoshikawa; Mohammad Atiq; Lina E. Jehane; Konrad H. Stopsack; Gwo-Shu Mary Lee; Wassim Abida; Michael J. Morris; Lorelei A. Mucci; Daniel Danila; Philip W. Kantoff
Delta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET
Marc Garcia-Moure; Marisol Gonzalez-Huarriz; Sara Labiano; Elizabeth Guruceaga; Eva Bandres; Marta Zalacain; Lucia Marrodan; Carlos de Andrea; Maria Villalba; Naiara Martinez-Velez; Virginia Laspidea; Montse Puigdelloses; Jaime Gallego Perez-Larraya; Ignacio Iñigo-Marco; Renata Stripecke; Jennifer A. Chan; Eric H. Raabe; Marcel Kool; Candelaria Gomez-Manzano; Juan Fueyo; Ana Patiño-García; Marta M. Alonso
Obituary
Correction
Correction: A Randomized Controlled Trial of a 6-Month Low-Carbohydrate Intervention on Disease Progression in Men with Recurrent Prostate Cancer: Carbohydrate and Prostate Study 2 (CAPS2)
Stephen J. Freedland; Jenifer Allen; Aubrey Jarman; Taofik Oyekunle; Andrew J. Armstrong; Judd W. Moul; Howard M. Sandler; Edwin Posadas; Dana Levin; Emily Wiggins; Lauren E. Howard; Yuan Wu; Pao-Hwa Lin
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