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1 March 2021
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Cover Image
Cover Image
The cover shows a section of an invasive breast carcinoma with RET amplification. RET structural variant was not detected. RET immunohistochemistry shows a heterogenous staining pattern. For details, see the article by Yang and colleagues on page 1316 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Tucatinib for the Treatment of Patients with Advanced or Metastatic HER2-positive Breast Cancer
Mirat Shah; Suparna Wedam; Joyce Cheng; Mallorie H. Fiero; Huiming Xia; Fang Li; Jianghong Fan; Xinyuan Zhang; Jingyu Yu; Pengfei Song; Wei Chen; Tiffany K. Ricks; Xiao Hong Chen; Kirsten B. Goldberg; Yutao Gong; William F. Pierce; Shenghui Tang; Marc R. Theoret; Richard Pazdur; Laleh Amiri-Kordestani; Julia A. Beaver
Review
Perspectives
Clinical Trial Brief Report
Eradication of T-ALL Cells by CD7-targeted Universal CAR-T Cells and Initial Test of Ruxolitinib-based CRS Management
Shiqi Li; Xinxin Wang; Zhongtao Yuan; Lin Liu; Le Luo; Yu Li; Kun Wu; Jia Liu; Chunhui Yang; Zhimin Li; Duanpeng Wang; Lianjun Shen; Xun Ye; Jiaping He; Cong Han; Youcheng Wang; Dingsong Zhang; Yancheng Dong; Lihua Fang; Yingnian Chen; Martina Sersch; Wei William Cao; Sanbin Wang
Clinical Trials: Targeted Therapy
Phase I Study of Everolimus, Letrozole, and Trastuzumab in Patients with Hormone Receptor−positive Metastatic Breast Cancer or Other Solid Tumors
Alexej Ballhausen; Jennifer J. Wheler; Daniel D. Karp; Sarina A. Piha-Paul; Siqing Fu; Shubham Pant; Apostolia M. Tsimberidou; David S. Hong; Vivek Subbiah; Veronica R. Holley; Helen J. Huang; Abenaa M. Brewster; Kimberly B. Koenig; Nuhad K. Ibrahim; Funda Meric-Bernstam; Filip Janku
Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non–Small Cell Lung Cancer
Rosemarie de Haan; Michel M. van den Heuvel; Judi van Diessen; Heike M.U. Peulen; Erik van Werkhoven; Adrianus J. de Langen; Ferry Lalezari; Dick Pluim; Manon Verwijs-Janssen; Conchita Vens; Jan H.M. Schellens; Neeltje Steeghs; Marcel Verheij; Baukelien van Triest
Clinical Trials: Immunotherapy
Safety and Clinical Activity of a New Anti-PD-L1 Antibody as Monotherapy or Combined with Targeted Therapy in Advanced Solid Tumors: The PACT Phase Ia/Ib Trial
Amita Patnaik; Timothy A. Yap; Hyun Cheol Chung; Maria J. de Miguel; Yung-Jue Bang; Chia-Chi Lin; Wu-Chou Su; Antoine Italiano; Kay Hoong Chow; Anna M. Szpurka; Danni Yu; Yumin Zhao; Michelle Carlsen; Shelly Schmidt; Burkhard Vangerow; Leena Gandhi; Xiaojian Xu; Johanna Bendell
Vaccine-Induced Intratumoral Lymphoid Aggregates Correlate with Survival Following Treatment with a Neoadjuvant and Adjuvant Vaccine in Patients with Resectable Pancreatic Adenocarcinoma
Lei Zheng; Ding Ding; Barish H. Edil; Carol Judkins; Jennifer N. Durham; Dwayne L. Thomas, II; Katherine M. Bever; Guanglan Mo; Sara E. Solt; Jessica A. Hoare; Raka Bhattacharya; Qingfeng Zhu; Arsen Osipov; Beth Onner; Katrina A. Purtell; Hongyan Cai; Rose Parkinson; Amy Hacker-Prietz; Joseph M. Herman; Dung T. Le; Nilofer S. Azad; Ana M.C. De Jesus-Acosta; Alex B. Blair; Victoria Kim; Kevin C. Soares; Lindsey Manos; John L. Cameron; Martin A. Makary; Matthew J. Weiss; Richard D. Schulick; Jin He; Christopher L. Wolfgang; Elizabeth D. Thompson; Robert A. Anders; Elizabeth Sugar; Elizabeth M. Jaffee; Daniel A. Laheru
Ipilimumab and Radiation in Patients with High-risk Resected or Regionally Advanced Melanoma
April K.S. Salama; Manisha Palta; Christel N. Rushing; M. Angelica Selim; Kristen N. Linney; Brian G. Czito; David S. Yoo; Brent A. Hanks; Georgia M. Beasley; Paul J. Mosca; Chelsae Dumbauld; Katelyn N. Steadman; John S. Yi; Kent J. Weinhold; Douglas S. Tyler; Walter T. Lee; David M. Brizel
Efficacy and Biomarker Analysis of Camrelizumab in Combination with Apatinib in Patients with Advanced Nonsquamous NSCLC Previously Treated with Chemotherapy
Caicun Zhou; Yina Wang; Jun Zhao; Gongyan Chen; Zhihua Liu; Kangsheng Gu; Meijuan Huang; Jianxing He; Jianhua Chen; Zhiyong Ma; Jifeng Feng; Jianhua Shi; Xinmin Yu; Ying Cheng; Yu Yao; Yuan Chen; Renhua Guo; Xiaoyan Lin; Zhehai Wang; Guanghui Gao; Quanren Wang; Weixia Li; Xinfeng Yang; Lihong Wu; Jun Zhang; Shengxiang Ren
Precision Medicine and Imaging
Molecular Imaging of Prostate Cancer Targeting CD46 Using ImmunoPET
Sinan Wang; Jun Li; Jun Hua; Yang Su; Denis R. Beckford-Vera; Walter Zhao; Mayuri Jayaraman; Tony L. Huynh; Ning Zhao; Yung-hua Wang; Yangjie Huang; Fujun Qin; Sui Shen; Daniel Gioeli; Robert Dreicer; Renuka Sriram; Emily A. Egusa; Jonathan Chou; Felix Y. Feng; Rahul Aggarwal; Michael J. Evans; Youngho Seo; Bin Liu; Robert R. Flavell; Jiang He
A Performance Comparison of Commonly Used Assays to Detect RET Fusions
Soo-Ryum Yang; Umut Aypar; Ezra Y. Rosen; Douglas A. Mata; Ryma Benayed; Kerry Mullaney; Gowtham Jayakumaran; Yanming Zhang; Denise Frosina; Alexander Drilon; Marc Ladanyi; Achim A. Jungbluth; Natasha Rekhtman; Jaclyn F. Hechtman
Gut Microbiome Components Predict Response to Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer: A Prospective, Longitudinal Study
Yuxi Yi; Lijun Shen; Wei Shi; Fan Xia; Hui Zhang; Yan Wang; Jing Zhang; Yaqi Wang; Xiaoyang Sun; Zhiyuan Zhang; Wei Zou; Wang Yang; Lingyi Zhang; Ji Zhu; Ajay Goel; Yanlei Ma; Zhen Zhang
Final Results of the Prospective Biomarker Trial PETra: [11C]-MET-Accumulation in Postoperative PET/MRI Predicts Outcome after Radiochemotherapy in Glioblastoma
Annekatrin Seidlitz; Bettina Beuthien-Baumann; Steffen Löck; Christina Jentsch; Ivan Platzek; Klaus Zöphel; Annett Linge; Jörg Kotzerke; Jan Petr; Jörg van den Hoff; Jörg Steinbach; Dietmar Krex; Gabriele Schmitz-Schackert; Monique Falk; Michael Baumann; Mechthild Krause
Author Choice
The Use of Serial Circulating Tumor DNA to Detect Resistance Alterations in Progressive Metastatic Breast Cancer
Saya Jacob; Andrew A. Davis; Lorenzo Gerratana; Marko Velimirovic; Ami N. Shah; Firas Wehbe; Neelima Katam; Qiang Zhang; Lisa Flaum; Kalliopi P. Siziopikou; Leonidas C. Platanias; William J. Gradishar; Amir Behdad; Aditya Bardia; Massimo Cristofanilli
Expression of T-Cell Exhaustion Molecules and Human Endogenous Retroviruses as Predictive Biomarkers for Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma
Miriam Ficial; Opeyemi A. Jegede; Miriam Sant'Angelo; Yue Hou; Abdallah Flaifel; Jean-Christophe Pignon; David A. Braun; Megan Wind-Rotolo; Maura A. Sticco-Ivins; Paul J. Catalano; Gordon J. Freeman; Arlene H. Sharpe; F. Stephen Hodi; Robert J. Motzer; Catherine J. Wu; Michael B. Atkins; David F. McDermott; Sachet A. Shukla; Toni K. Choueiri; Sabina Signoretti
CamGFR v2: A New Model for Estimating the Glomerular Filtration Rate from Standardized or Non-standardized Creatinine in Patients with Cancer
Edward H. Williams; Thomas R. Flint; Claire M. Connell; Daniel Giglio; Hassal Lee; Taehoon Ha; Eva Gablenz; Nicholas J. Bird; James M.J. Weaver; Harry Potts; Cameron T. Whitley; Michael A. Bookman; Andy G. Lynch; Hannah V. Meyer; Simon Tavaré; Tobias Janowitz
Author Choice
Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Patients with Metastatic Genitourinary Cancer
Heather J. Chalfin; Tiziano Pramparo; Amir Mortazavi; Scot A. Niglio; Joseph D. Schonhoft; Adam Jendrisak; Yen-Lin Chu; Robin Richardson; Rachel Krupa; Amanda K.L. Anderson; Yipeng Wang; Ryan Dittamore; Sumanta K. Pal; Primo N. Lara; Mark N. Stein; David I. Quinn; Seth M. Steinberg; Lisa M. Cordes; Lisa Ley; Marissa Mallek; Olena Sierra Ortiz; Rene Costello; Jacqueline Cadena; Carlos Diaz; James L. Gulley; William L. Dahut; Howard Streicher; John J. Wright; Jane B. Trepel; Donald P. Bottaro; Andrea B. Apolo
Author Choice
177Lu-DOTA-EB-TATE, a Radiolabeled Analogue of Somatostatin Receptor Type 2, for the Imaging and Treatment of Thyroid Cancer
Shilpa Thakur; Brianna Daley; Corina Millo; Craig Cochran; Orit Jacobson; Huiyan Lu; Zhantong Wang; Dale Kiesewetter; Xiaoyuan Chen; Vasyl Vasko; Joanna Klubo-Gwiezdzinska
Translational Cancer Mechanisms and Therapy
Author Choice
Proteasome Inhibition Overcomes ALK-TKI Resistance in ALK-Rearranged/TP53-Mutant NSCLC via Noxa Expression
Azusa Tanimoto; Shingo Matsumoto; Shinji Takeuchi; Sachiko Arai; Koji Fukuda; Akihiro Nishiyama; Kiyotaka Yoh; Takaya Ikeda; Naoki Furuya; Kazumi Nishino; Yuichiro Ohe; Koichi Goto; Seiji Yano
Early Discontinuation of Endocrine Therapy and Recurrence of Breast Cancer among Premenopausal Women
Lindsay J. Collin; Deirdre P. Cronin-Fenton; Thomas P. Ahern; Michael Goodman; Lauren E. McCullough; Lance A. Waller; Anders Kjærsgaard; Per Damkier; Peer M. Christiansen; Bent Ejlertsen; Maj-Britt Jensen; Henrik Toft Sørensen; Timothy L. Lash
Characterization and Clinical Outcomes of DNA Mismatch Repair–deficient Small Bowel Adenocarcinoma
Alicia Latham; Jinru Shia; Zalak Patel; Diane L. Reidy-Lagunes; Neil H. Segal; Rona Yaeger; Karuna Ganesh; Louise Connell; Nancy E. Kemeny; David P. Kelsen; Jaclyn F. Hechtman; Garrett M. Nash; Philip B. Paty; Ahmet Zehir; Kaitlin A. Tkachuk; Rania Sheikh; Arnold J. Markowitz; Diana Mandelker; Kenneth Offit; Michael F. Berger; Andrea Cercek; Julio Garcia-Aguilar; Leonard B. Saltz; Martin R. Weiser; Zsofia K. Stadler
Targeted Therapy of TERT-Rearranged Neuroblastoma with BET Bromodomain Inhibitor and Proteasome Inhibitor Combination Therapy
Jingwei Chen; Christopher Nelson; Matthew Wong; Andrew E. Tee; Pei Y. Liu; Ting La; Jamie I. Fletcher; Alvin Kamili; Chelsea Mayoh; Christoph Bartenhagen; Toby N. Trahair; Ning Xu; Nisitha Jayatilleke; Marie Wong; Hui Peng; Bernard Atmadibrata; Belamy B. Cheung; Qing Lan; Tracy M. Bryan; Pieter Mestdagh; Jo Vandesompele; Valerie Combaret; Valentina Boeva; Jenny Y. Wang; Isabelle Janoueix-Lerosey; Mark J. Cowley; Karen L. MacKenzie; Alla Dolnikov; Jinyan Li; Patsie Polly; Glenn M. Marshall; Roger R. Reddel; Murray D. Norris; Michelle Haber; Matthias Fischer; Xu D. Zhang; Hilda A. Pickett; Tao Liu
Author Choice
Preclinical Characterization of HPN536, a Trispecific, T-Cell–Activating Protein Construct for the Treatment of Mesothelin-Expressing Solid Tumors
Mary Ellen Molloy; Richard J. Austin; Bryan D. Lemon; Wade H. Aaron; Vaishnavi Ganti; Adrie Jones; Susan D. Jones; Kathryn L. Strobel; Purbasa Patnaik; Kenneth Sexton; Laurie Tatalick; Timothy Z. Yu; Patrick A. Baeuerle; Che-Leung Law; Holger Wesche
Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma
Tyler D. Hitchman; Gabriella Bayshtok; Emilie Ceraudo; Amanda R. Moore; Cindy Lee; Ruobing Jia; Naitao Wang; Mohini R. Pachai; Alexander N. Shoushtari; Jasmine H. Francis; Youxin Guan; Juliet Chen; Matthew T. Chang; Barry S. Taylor; Thomas P. Sakmar; Thomas Huber; Ping Chi; Yu Chen
FGFR Inhibition Overcomes Resistance to EGFR-targeted Therapy in Epithelial-like Cutaneous Carcinoma
Adrià Bernat-Peguera; Juan Navarro-Ventura; Laura Lorenzo-Sanz; Victoria da Silva-Diz; Mattia Bosio; Luis Palomero; Rosa M. Penin; Diana Pérez Sidelnikova; Josep Oriol Bermejo; Miren Taberna; Noelia Vilariño; Josep M. Piulats; Ricard Mesia; Joan Maria Viñals; Eva González-Suárez; Salvador Capella-Gutierrez; Alberto Villanueva; Francesc Viñals; Purificación Muñoz
The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas
Alvin P. Makohon-Moore; Evan J. Lipson; Jody E. Hooper; Amanda Zucker; Jungeui Hong; Craig M. Bielski; Akimasa Hayashi; Collin Tokheim; Priscilla Baez; Rajya Kappagantula; Zachary Kohutek; Vladimir Makarov; Nadeem Riaz; Michael A. Postow; Paul B. Chapman; Rachel Karchin; Nicholas D. Socci; David B. Solit; Timothy A. Chan; Barry S. Taylor; Suzanne L. Topalian; Christine A. Iacobuzio-Donahue
Author Choice
AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer
Michael J. Giffin; Keegan Cooke; Edward K. Lobenhofer; Juan Estrada; Jinghui Zhan; Petra Deegen; Melissa Thomas; Christopher M. Murawsky; Jonathan Werner; Siyuan Liu; Fei Lee; Oliver Homann; Matthias Friedrich; Joshua T. Pearson; Tobias Raum; Yajing Yang; Sean Caenepeel; Jennitte Stevens; Pedro J. Beltran; Jude Canon; Angela Coxon; Julie M. Bailis; Paul E. Hughes
Author Choice
CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma
Deepak Raj; Maria Nikolaidi; Irene Garces; Daniela Lorizio; Natalia M. Castro; Sabrina G. Caiafa; Kate Moore; Nicholas F. Brown; Hemant M. Kocher; Xiaobo Duan; Brad H. Nelson; Nicholas R. Lemoine; John F. Marshall
The Oxford Classic Links Epithelial-to-Mesenchymal Transition to Immunosuppression in Poor Prognosis Ovarian Cancers
Zhiyuan Hu; Paula Cunnea; Zhe Zhong; Haonan Lu; Oloruntoba I. Osagie; Leticia Campo; Mara Artibani; Katherine Nixon; Jennifer Ploski; Laura Santana Gonzalez; Abdulkhaliq Alsaadi; Nina Wietek; Stephen Damato; Sunanda Dhar; Sarah P. Blagden; Christopher Yau; Joanna Hester; Ashwag Albukhari; Eric O. Aboagye; Christina Fotopoulou; Ahmed Ahmed
Letters to the Editor
Correction
Correction: A Phase II Study of Abemaciclib in Patients with Brain Metastases Secondary to Hormone Receptor–positive Breast Cancer
Sara M. Tolaney; Solmaz Sahebjam; Emilie Le Rhun; Thomas Bachelot; Peter Kabos; Ahmad Awada; Denise Yardley; Arlene Chan; Pierfranco Conte; Véronique Diéras; Nancy U. Lin; Melissa Bear; Sonya C. Chapman; Zhengyu Yang; Yanyun Chen; Carey K. Anders
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