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1 December 2021
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Cover Image
Cover Image
The cover shows a section of a surgical specimen from a patient with diffuse-type gastric cancer. Masson's trichrome staining shows that accumulation of stromal collagen (sky blue) in the deep invasive portion of the primary tumor is more profuse when compared with the superficial portion. For details, see the article by Jeong and colleagues on page 6529 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Research Briefs: Clinical Trial Brief Reports
Integrated Molecular and Immune Phenotype of HER2-Positive Breast Cancer and Response to Neoadjuvant Therapy: A NeoALTTO Exploratory Analysis
Sara Pizzamiglio; Chiara Maura Ciniselli; Tiziana Triulzi; Chiara Gargiuli; Loris De Cecco; Evandro de Azambuja; Debora Fumagalli; Christos Sotiriou; Nadia Harbeck; Miguel Izquierdo; Paolo Nuciforo; Jens Huober; Vera Cappelletti; Saverio Cinieri; Martine Piccart; Maria Grazia Daidone; Giancarlo Pruneri; Mario Paolo Colombo; Elda Tagliabue; Paolo Verderio; Serena Di Cosimo
Clinical Trials: Targeted Therapy
Randomized Phase II Study of PARP Inhibitor ABT-888 (Veliparib) with Modified FOLFIRI versus FOLFIRI as Second-line Treatment of Metastatic Pancreatic Cancer: SWOG S1513
E. Gabriela Chiorean; Katherine A. Guthrie; Philip A. Philip; Elizabeth M. Swisher; Florencia Jalikis; Michael J. Pishvaian; Jordan Berlin; Marcus S. Noel; Jennifer M. Suga; Ignacio Garrido-Laguna; Dana Backlund Cardin; Marc R. Radke; Mai Duong; Shay Bellasea; Andrew M. Lowy; Howard S. Hochster
The MAGNOLIA Trial: Zanubrutinib, a Next-Generation Bruton Tyrosine Kinase Inhibitor, Demonstrates Safety and Efficacy in Relapsed/Refractory Marginal Zone Lymphoma
Stephen Opat; Alessandra Tedeschi; Kim Linton; Pamela McKay; Bei Hu; Henry Chan; Jie Jin; Magdalena Sobieraj-Teague; Pier Luigi Zinzani; Morton Coleman; Catherine Thieblemont; Peter Browett; Xiaoyan Ke; Mingyuan Sun; Robert Marcus; Craig A. Portell; Kirit Ardeshna; Fontanet Bijou; Patricia Walker; Eliza A. Hawkes; Sally Mapp; Shir-Jing Ho; Dipti Talaulikar; Ke-Shu Zhou; Melannie Co; Xiaotong Li; Wenxiao Zhou; Massimo Cappellini; Chris Tankersley; Jane Huang; Judith Trotman
Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study
Sebastian Bauer; Michael C. Heinrich; Suzanne George; John R. Zalcberg; César Serrano; Hans Gelderblom; Robin L. Jones; Steven Attia; Gina D'Amato; Ping Chi; Peter Reichardt; Julie Meade; Ying Su; Rodrigo Ruiz-Soto; Jean-Yves Blay; Margaret von Mehren; Patrick Schöffski
Results and Molecular Correlates from a Pilot Study of Neoadjuvant Induction FOLFIRINOX Followed by Chemoradiation and Surgery for Gastroesophageal Adenocarcinomas
Jennifer Y. Wo; Jeffrey W. Clark; Christine E. Eyler; Mari Mino-Kenudson; Samuel J. Klempner; Jill N. Allen; Florence K. Keane; Aparna R. Parikh; Eric Roeland; Lorraine C. Drapek; David P. Ryan; Ryan B. Corcoran; Emily Van Seventer; Isobel J. Fetter; Heather A. Shahzade; Melin J. Khandekar; Michael Lanuti; Christopher R. Morse; Rebecca S. Heist; Christine A. Ulysse; Benjamin Christopher; Christian Baglini; Beow Y. Yeap; John T. Mullen; Theodore S. Hong
Phase Ib Dose Expansion and Translational Analyses of Olaparib in Combination with Capivasertib in Recurrent Endometrial, Triple-Negative Breast, and Ovarian Cancer
Shannon N. Westin; Marilyne Labrie; Jennifer K. Litton; Aurora Blucher; Yong Fang; Christopher P. Vellano; Joseph R. Marszalek; Ningping Feng; XiaoYan Ma; Allison Creason; Bryan Fellman; Ying Yuan; Sanghoon Lee; Tae-Beom Kim; Jinsong Liu; Anca Chelariu-Raicu; Tsun Hsuan Chen; Nashwa Kabil; Pamela T. Soliman; Michael Frumovitz; Katheleen M. Schmeler; Amir Jazaeri; Karen H. Lu; Rashmi Murthy; Larissa A. Meyer; Charlotte C. Sun; Anil K. Sood; Robert L. Coleman; Gordon B. Mills
A Phase I Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation
Florence Atrafi; Oliver Boix; Vivek Subbiah; Jennifer R. Diamond; Sant P. Chawla; Anthony W. Tolcher; Patricia M. LoRusso; Joseph P. Eder; Martin Gutierrez; Kumar Sankhala; Prabhu Rajagopalan; Isabelle Genvresse; Simon Langer; Ron H.J. Mathijssen; Jaap Verweij; Ingmar Bruns; Martijn P. Lolkema
Phase II Evaluation of Stereotactic Ablative Radiotherapy (SABR) and Immunity in 11C-Choline-PET/CT–Identified Oligometastatic Castration-Resistant Prostate Cancer
Henan Zhang; Jacob J. Orme; Feven Abraha; B.J. Stish; Val J. Lowe; Fabrice Lucien; Erik J. Tryggestad; Michael S. Bold; Lance C. Pagliaro; C. Richard Choo; Debra H. Brinkmann; Matthew J. Iott; Brian J. Davis; J. Fernando Quevedo; William S. Harmsen; Brian A. Costello; Geoffrey B. Johnson; Mark A. Nathan; Kenneth R. Olivier; Thomas M. Pisansky; Eugene D. Kwon; Haidong Dong; Sean S. Park
Clinical Trials: Immunotherapy
Risk Factors Associated with Durable Progression-Free Survival in Patients with Relapsed or Refractory Multiple Myeloma Treated with Anti-BCMA CAR T-cell Therapy
Mingming Zhang; Linghui Zhou; Houli Zhao; Yanlei Zhang; Guoqing Wei; Ruimin Hong; Wenjun Wu; Huijun Xu; Linqin Wang; Fang Ni; Jiazhen Cui; Shuixiu Peng; Chih-Hua Huang; Alex H. Chang; Yongxian Hu; He Huang
Safety and Antitumor Activity of α-PD-L1 Antibody as Monotherapy or in Combination with α-TIM-3 Antibody in Patients with Microsatellite Instability–High/Mismatch Repair–Deficient Tumors
Antoine Hollebecque; Hyun C. Chung; Maria J. de Miguel; Antoine Italiano; Jean-Pascal Machiels; Chia-Chi Lin; Neesha C. Dhani; Marc Peeters; Victor Moreno; Wu-Chou Su; Kay Hoong Chow; Violeta R. Galvao; Michelle Carlsen; Danni Yu; Anna M. Szpurka; Yumin Zhao; Shelly L. Schmidt; Leena Gandhi; Xiaojian Xu; Yung-Jue Bang
Immunization with a Plasmid DNA Vaccine Encoding the N-Terminus of Insulin-like Growth Factor Binding Protein-2 in Advanced Ovarian Cancer Leads to High-level Type I Immune Responses
Denise L. Cecil; John B. Liao; Yushe Dang; Andrew L. Coveler; Angela Kask; Yi Yang; Jennifer S. Childs; Doreen M. Higgins; Mary L. Disis
Phase II, Randomized Study of Spartalizumab (PDR001), an Anti–PD-1 Antibody, versus Chemotherapy in Patients with Recurrent/Metastatic Nasopharyngeal Cancer
Caroline Even; Hung-Ming Wang; Shau-Hsuan Li; Roger K-C Ngan; Arunee Dechaphunkul; Li Zhang; Chia-Jui Yen; Po Chung Chan; Somvilai Chakrabandhu; Brigette B.Y. Ma; Suebpong Tanasanvimon; Victor H.F. Lee; Pei-Jen Lou; Zujun Li; Alexander I. Spira; Ammar Sukari; Joël Guigay; Steven McCune; Juan Gonzalez-Maffe; Sebastian Szpakowski; Yao Yao; Hongzi Liang; Jennifer Mataraza; Romain Séchaud; Luigi Manenti; Darren W-T. Lim
Phase II Study of Pembrolizumab in Combination with Doxorubicin in Metastatic and Unresectable Soft-Tissue Sarcoma
Michael B. Livingston; Megan H. Jagosky; Myra M. Robinson; William A. Ahrens; Jennifer H. Benbow; Carol J. Farhangfar; David M. Foureau; Deirdre M. Maxwell; Emily A. Baldrige; Xhevahire Begic; James T. Symanowski; Nury M. Steuerwald; Colin J. Anderson; Joshua C. Patt; Jeffrey S. Kneisl; Edward S. Kim
Precision Medicine and Imaging
Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF-Mutated Multiple Myeloma
Johannes M. Waldschmidt; Jake A. Kloeber; Praveen Anand; Julia Frede; Antonis Kokkalis; Valeriya Dimitrova; Sayalee Potdar; Monica S. Nair; Tushara Vijaykumar; Nam Gyu Im; Amy Guillaumet-Adkins; Nitish Chopra; Hannah Stuart; Lillian Budano; Noori Sotudeh; Guangwu Guo; Clemens Grassberger; Andrew J. Yee; Jacob P. Laubach; Paul G. Richardson; Kenneth C. Anderson; Noopur S. Raje; Birgit Knoechel; Jens G. Lohr
Diagnostic Accuracy of FEC-PET/CT, FDG-PET/CT, and Diffusion-Weighted MRI in Detection of Nodal Metastases in Surgically Treated Endometrial and Cervical Carcinoma
Andrea G. Rockall; Tara D. Barwick; William Wilson; Naveena Singh; Nishat Bharwani; Aslam Sohaib; Marielle Nobbenhuis; Victoria Warbey; Marc Miquel; Dow-Mu Koh; Katja N. De Paepe; Pierre Martin-Hirsch; Sadaf Ghaem-Maghami; Christina Fotopoulou; Helen Stringfellow; Sudha Sundar; Ranjit Manchanda; Anju Sahdev; Allan Hackshaw; Gary J. Cook; MAPPING Study Group
A Clinical PET Imaging Tracer ([18F]DASA-23) to Monitor Pyruvate Kinase M2–Induced Glycolytic Reprogramming in Glioblastoma
Corinne Beinat; Chirag B. Patel; Tom Haywood; Surya Murty; Lewis Naya; Jessa B. Castillo; Samantha T. Reyes; Megan Phillips; Pablo Buccino; Bin Shen; Jun Hyung Park; Mary Ellen I. Koran; Israt S. Alam; Michelle L. James; Dawn Holley; Kim Halbert; Harsh Gandhi; Joy Q. He; Monica Granucci; Eli Johnson; Daniel Dan Liu; Nobuko Uchida; Rahul Sinha; Pauline Chu; Donald E. Born; Geoffrey I. Warnock; Irving Weissman; Melanie Hayden-Gephart; Mehdi Khalighi; Tarik F. Massoud; Andrei Iagaru; Guido Davidzon; Reena Thomas; Seema Nagpal; Lawrence D. Recht; Sanjiv Sam Gambhir
Functional Impact of Genomic Complexity on the Transcriptome of Multiple Myeloma
Bachisio Ziccheddu; Matteo C. Da Vià; Marta Lionetti; Akihiro Maeda; Silvia Morlupi; Matteo Dugo; Katia Todoerti; Stefania Oliva; Mattia D'Agostino; Paolo Corradini; Ola Landgren; Francesco Iorio; Loredana Pettine; Alessandra Pompa; Martina Manzoni; Luca Baldini; Antonino Neri; Francesco Maura; Niccolò Bolli
Translational Cancer Mechanisms and Therapy
The Novel Nucleoside Analogue ProTide NUC-7738 Overcomes Cancer Resistance Mechanisms In Vitro and in a First-In-Human Phase I Clinical Trial
Hagen Schwenzer; Erica De Zan; Mustafa Elshani; Ruud van Stiphout; Mary Kudsy; Josephine Morris; Valentina Ferrari; In Hwa Um; James Chettle; Farasat Kazmi; Leticia Campo; Alistair Easton; Sebastian Nijman; Michaela Serpi; Stefan Symeonides; Ruth Plummer; David J. Harrison; Gareth Bond; Sarah P. Blagden
Tumor Cell IDO Enhances Immune Suppression and Decreases Survival Independent of Tryptophan Metabolism in Glioblastoma
Lijie Zhai; April Bell; Erik Ladomersky; Kristen L. Lauing; Lakshmi Bollu; Brenda Nguyen; Matthew Genet; Miri Kim; Peiwen Chen; Xinlei Mi; Jennifer D. Wu; Matthew J. Schipma; Brian Wray; John Griffiths; Richard D. Unwin; Simon J. Clark; Rajesh Acharya; Riyue Bao; Craig Horbinski; Rimas V. Lukas; Gary E. Schiltz; Derek A. Wainwright
Fresh Tissue Multi-omics Profiling Reveals Immune Classification and Suggests Immunotherapy Candidates for Conventional Chondrosarcoma
Binghao Li; Guoqi Li; Xiaobo Yan; Dan Zhu; Patrick P. Lin; Zenan Wang; Hao Qu; Xuexin He; Yanbiao Fu; Xiuliang Zhu; Peng Lin; Jiangnan Zhang; Xiaoya Li; Hui Dai; Huabiao Chen; Mark C. Poznansky; Nong Lin; Zhaoming Ye
Ovarian Cancer–Specific BRCA-like Copy-Number Aberration Classifiers Detect Mutations Associated with Homologous Recombination Deficiency in the AGO-TR1 Trial
Philip C. Schouten; Lisa Richters; Daniel J. Vis; Stefan Kommoss; Ewald van Dijk; Corinna Ernst; Roelof J.C. Kluin; Frederik Marmé; Esther H. Lips; Sandra Schmidt; Esther Scheerman; Katharina Prieske; Carolien H.M. van Deurzen; Alexander Burges; Patricia C. Ewing-Graham; Dimo Dietrich; Agnes Jager; Nikolaus de Gregorio; Jan Hauke; Andreas du Bois; Petra M. Nederlof; Lodewyk F. Wessels; Eric Hahnen; Philipp Harter; Sabine C. Linn; Rita K. Schmutzler
The Safety of Bridging Radiation with Anti-BCMA CAR T-Cell Therapy for Multiple Myeloma
Shwetha H. Manjunath; Adam D. Cohen; Simon F. Lacey; Megan M. Davis; Alfred L. Garfall; J. Joseph Melenhorst; Russell Maxwell; W. Tristram Arscott; Amit Maity; Joshua A. Jones; John P. Plastaras; Edward A. Stadtmauer; Bruce L. Levine; Carl H. June; Michael C. Milone; Ima Paydar
Antitumor Activity of the Novel BTK Inhibitor TG-1701 Is Associated with Disruption of Ikaros Signaling in Patients with B-cell Non–Hodgkin Lymphoma
Marcelo Lima Ribeiro; Diana Reyes-Garau; Meritxell Vinyoles; Núria Profitós Pelejà; Juliana Carvalho Santos; Marc Armengol; Miranda Fernández-Serrano; Alícia Sedó Mor; Joan J. Bech-Serra; Pedro Blecua; Eva Musulen; Carolina De La Torre; Hari Miskin; Manel Esteller; Francesc Bosch; Pablo Menéndez; Emmanuel Normant; Gaël Roué
Organoids Derived from Neoadjuvant FOLFIRINOX Patients Recapitulate Therapy Resistance in Pancreatic Ductal Adenocarcinoma
Elham Aida Farshadi; Jiang Chang; Bharath Sampadi; Michail Doukas; Freek Van 't Land; Fleur van der Sijde; Eveline E. Vietsch; Joris Pothof; Bas Groot Koerkamp; Casper H.J. van Eijck
Letters to the Editor
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