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15 October 2021
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Cover Image
Cover Image
The cover shows a colorized second-generation harmonics microscopy image highlighting the collagen fibers present in the extracellular matrix of a section of normal breast tissue. For details, see the article by Thompson and colleagues on page 5660 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Pralsetinib for the Treatment of Lung and Thyroid Cancers With RET Gene Mutations or Fusions
Janice Kim; Diana Bradford; Erin Larkins; Lee H. Pai-Scherf; Somak Chatterjee; Pallavi S. Mishra-Kalyani; Emily Wearne; Whitney S. Helms; Amal Ayyoub; Youwei Bi; Jielin Sun; Rosane Charlab; Jiang Liu; Hong Zhao; Dun Liang; Soma Ghosh; Reena Philip; Richard Pazdur; Marc R. Theoret; Julia A. Beaver; Harpreet Singh
Review
Perspectives
Special Report
A Grant-Based Experiment to Train Clinical Investigators: The AACR/ASCO Methods in Clinical Cancer Research Workshop
Daniel D. Von Hoff; Gary M. Clark; Charles A. Coltman; Mary L. Disis; S.G. Eckhardt; Lee M. Ellis; Margaret Foti; Elizabeth Garrett-Mayer; Mithat Gönen; Manuel Hidalgo; Susan G. Hilsenbeck; John H. Littlefield; Patricia M. LoRusso; H. Kim Lyerly; Neal J. Meropol; Jyoti D. Patel; Steven Piantadosi; Dean A. Post; Meredith M. Regan; Yu Shyr; Margaret A. Tempero; Joel E. Tepper; Jamie Von Roenn; Louis M. Weiner; Donn C. Young; Nu V. Vu
Clinical Trials: Targeted Therapy
Niraparib for Advanced Breast Cancer with Germline BRCA1 and BRCA2 Mutations: the EORTC 1307-BCG/BIG5–13/TESARO PR-30–50–10-C BRAVO Study
Nicholas C. Turner; Judith Balmaña; Coralie Poncet; Theodora Goulioti; Konstantinos Tryfonidis; Aafke H. Honkoop; Gabriele Zoppoli; Evangelia Razis; Oskar T. Johannsson; Marco Colleoni; Andrew N. Tutt; William Audeh; Michail Ignatiadis; Audrey Mailliez; Olivier Trédan; Antonino Musolino; Peter Vuylsteke; Maria Jose Juan-Fita; Iain R.J. Macpherson; Bella Kaufman; Luis Manso; Lori J. Goldstein; Susan L. Ellard; István Láng; Kai Yu Jen; Virginie Adam; Saskia Litière; John Erban; David A. Cameron; on behalf of the BRAVO Steering Committee and the BRAVO investigators
A Phase II Trial of the Bruton Tyrosine-Kinase Inhibitor Zanubrutinib (BGB-3111) in Patients with Relapsed/Refractory Waldenström Macroglobulinemia
Gang An; Daobin Zhou; Shu Cheng; Keshu Zhou; Jianyong Li; Jianfeng Zhou; Liping Xie; Jie Jin; Liye Zhong; Lingzhi Yan; Haiyi Guo; Chenmu Du; Jinhua Zhong; Yiling Yu; Binghao Wu; Lugui Qiu
A Randomized, Phase III Study of Lenvatinib in Chinese Patients with Radioiodine-Refractory Differentiated Thyroid Cancer
Xiangqian Zheng; Zhengang Xu; Qinghai Ji; Minghua Ge; Feng Shi; Jianwu Qin; Feng Wang; Guang Chen; Yuan Zhang; Rui Huang; Jian Tan; Tao Huang; Sijin Li; Zhongwei Lv; Yansong Lin; Zhuming Guo; Tomoki Kubota; Takuya Suzuki; Hiroki Ikezawa; Ming Gao
Clinical Trials: Immunotherapy
Phase I Study of Stereotactic Body Radiotherapy plus Nivolumab and Urelumab or Cabiralizumab in Advanced Solid Tumors
Corey C. Foster; Gini F. Fleming; Theodore G. Karrison; Chih-Yi Liao; Ami V. Desai; John W. Moroney; Mark J. Ratain; Rita Nanda; Blase N. Polite; Olwen M. Hahn; Peter H. O'Donnell; Everett E. Vokes; Hedy L. Kindler; Robyn Hseu; Linda A. Janisch; Julia Dai; Mark D. Hoffman; Ralph R. Weichselbaum; Sean P. Pitroda; Steven J. Chmura; Jason J. Luke
A Phase I Study of the Combination of Pexidartinib and Sirolimus to Target Tumor-Associated Macrophages in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors
Gulam A. Manji; Brian A. Van Tine; Shing M. Lee; Alexander G. Raufi; Ilenia Pellicciotta; Angela C. Hirbe; Jaya Pradhan; Andrew Chen; Raul Rabadan; Gary K. Schwartz
GEN-1 in Combination with Neoadjuvant Chemotherapy for Patients with Advanced Epithelial Ovarian Cancer: A Phase I Dose-escalation Study
Premal H. Thaker; William H. Bradley; Charles A. Leath, III; Camille Gunderson Jackson; Nicholas Borys; Khursheed Anwer; Lauren Musso; Junko Matsuzaki; Wiam Bshara; Kunle Odunsi; Ronald D. Alvarez
Phase 2 Trial of Oncolytic H-1 Parvovirus Therapy Shows Safety and Signs of Immune System Activation in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
Jacek Hajda; Barbara Leuchs; Assia L. Angelova; Veronika Frehtman; Jean Rommelaere; Mieke Mertens; Maximilian Pilz; Meinhard Kieser; Ottheinz Krebs; Michael Dahm; Bernard Huber; Christine E. Engeland; Athanasios Mavratzas; Nicolas Hohmann; Jutta Schreiber; Dirk Jäger; Niels Halama; Oliver Sedlaczek; Matthias M. Gaida; Volker Daniel; Christoph Springfeld; Guy Ungerechts
Precision Medicine and Imaging
TP53 Mutations with Low Variant Allele Frequency Predict Short Survival in Chronic Lymphocytic Leukemia
Riccardo Bomben; Francesca Maria Rossi; Filippo Vit; Tamara Bittolo; Tiziana D'Agaro; Antonella Zucchetto; Erika Tissino; Federico Pozzo; Elena Vendramini; Massimo Degan; Eva Zaina; Ilaria Cattarossi; Paola Varaschin; Paola Nanni; Michele Berton; Alessandra Braida; Jerry Polesel; Jared A. Cohen; Enrico Santinelli; Annalisa Biagi; Massimo Gentile; Fortunato Morabito; Gilberto Fronza; Gabriele Pozzato; Giovanni D'Arena; Jacopo Olivieri; Pietro Bulian; Chris Pepper; Anna Hockaday; Anna Schuh; Peter Hillmen; Davide Rossi; Annalisa Chiarenza; Francesco Zaja; Francesco Di Raimondo; Giovanni Del Poeta; Valter Gattei
Improving Risk Stratification for Pediatric Patients with Rhabdomyosarcoma by Molecular Detection of Disseminated Disease
Nathalie S.M. Lak; Timon L. Voormanns; Lily Zappeij-Kannegieter; Lieke M.J. van Zogchel; Marta Fiocco; Max M. van Noesel; Johannes H.M. Merks; C. Ellen van der Schoot; Godelieve A.M. Tytgat; Janine Stutterheim
Author Choice
Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer
Aparna R. Parikh; Emily E. Van Seventer; Giulia Siravegna; Anna V. Hartwig; Ariel Jaimovich; Yupeng He; Katie Kanter; Madeleine G. Fish; Kathryn D. Fosbenner; Benchun Miao; Susannah Phillips; John H. Carmichael; Nihaarika Sharma; Joy Jarnagin; Islam Baiev; Yojan S. Shah; Isobel J. Fetter; Heather A. Shahzade; Jill N. Allen; Lawrence S. Blaszkowsky; Jeffrey W. Clark; Jon S. Dubois; Joseph W. Franses; Bruce J. Giantonio; Lipika Goyal; Samuel J. Klempner; Ryan D. Nipp; Eric J. Roeland; David P. Ryan; Colin D. Weekes; Jennifer Y. Wo; Theodore S. Hong; Liliana Bordeianou; Cristina R. Ferrone; Motaz Qadan; Hiroko Kunitake; David Berger; Rocco Ricciardi; James C. Cusack; Victoria M. Raymond; AmirAli Talasaz; Genevieve M. Boland; Ryan B. Corcoran
Prevalence and Landscape of Actionable Genomic Alterations in Renal Cell Carcinoma
Kyrollis Attalla; Renzo G. DiNatale; Phillip M. Rappold; Christopher J. Fong; Francisco Sanchez-Vega; Andrew W. Silagy; Stanley Weng; Jonathan Coleman; Chung-Han Lee; Maria I. Carlo; Jeremy C. Durack; Stephen B. Solomon; Victor E. Reuter; Paul Russo; Timothy A. Chan; Robert J. Motzer; Nikolaus D. Schultz; Ed Reznik; Martin H. Voss; A. Ari Hakimi
Translational Cancer Mechanisms and Therapy
Copy Number Aberration Analysis to Predict Response to Neoadjuvant Anti-HER2 Therapy: Results from the NeoALTTO Phase III Clinical Trial
David Venet; Mattia Rediti; Marion Maetens; Debora Fumagalli; David N. Brown; Samira Majjaj; Roberto Salgado; Lajos Pusztai; Nadia Harbeck; Sarra El-Abed; Yingbo Wang; Cristina Saura; Henry Gomez; Vladimir Fedorovich Semiglazov; Evandro de Azambuja; Jens Huober; Paolo Nuciforo; Serena Di Cosimo; Martine Piccart; Sherene Loi; Françoise Rothé; Christos Sotiriou
Circulating Tumor DNA Analysis Detects FGFR2 Amplification and Concurrent Genomic Alterations Associated with FGFR Inhibitor Efficacy in Advanced Gastric Cancer
Tomoko Jogo; Yoshiaki Nakamura; Kohei Shitara; Hideaki Bando; Hisateru Yasui; Taito Esaki; Tetsuji Terazawa; Taroh Satoh; Eiji Shinozaki; Tomohiro Nishina; Yu Sunakawa; Yoshito Komatsu; Hiroki Hara; Eiji Oki; Nobuhisa Matsuhashi; Takashi Ohta; Takeshi Kato; Koushiro Ohtsubo; Takeshi Kawakami; Naohiro Okano; Yoshiyuki Yamamoto; Takanobu Yamada; Akihito Tsuji; Justin I. Odegaard; Hiroya Taniguchi; Toshihiko Doi; Satoshi Fujii; Takayuki Yoshino
Characteristics and Spatially Defined Immune (micro)landscapes of Early-stage PD-L1–positive Triple-negative Breast Cancer
Jodi M. Carter; Mei-Yin C. Polley; Roberto A. Leon-Ferre; Jason Sinnwell; Kevin J. Thompson; Xue Wang; Yaohua Ma; David Zahrieh; Jennifer M. Kachergus; Malvika Solanki; Judy C. Boughey; Minetta C. Liu; James N. Ingle; Krishna R. Kalari; Fergus J. Couch; E. Aubrey Thompson; Matthew P. Goetz
Prognostic Value and Relation with Adjuvant Treatment Duration of ctDNA in Stage III Colon Cancer: a Post Hoc Analysis of the PRODIGE-GERCOR IDEA-France Trial
Julien Taieb; Valérie Taly; Julie Henriques; Camille Bourreau; Laurent Mineur; Jaafar Bennouna; Jérôme Desrame; Christophe Louvet; Céline Lepere; May Mabro; Joëlle Egreteau; Olivier Bouche; Claire Mulot; Katia Hormigos; Kariman Chaba; Thibault Mazard; Aimery de Gramont; Dewi Vernerey; Thierry André; Pierre Laurent-Puig
Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells
Adam J. Linley; Laura I. Karydis; Anil K. Mondru; Annalisa D'Avola; Humood Al Shmrany; Silvia Cicconi; Rebecca Griffin; Francesco Forconi; Andrew R. Pettitt; Nagesh Kalakonda; Andrew C. Rawstron; Peter Hillmen; Andrew J. Steele; David J. MacEwan; Graham Packham; Ian A. Prior; Joseph R. Slupsky
Sulindac, a Nonselective NSAID, Reduces Breast Density in Postmenopausal Women with Breast Cancer Treated with Aromatase Inhibitors
Patricia A. Thompson; Chuan Huang; Jie Yang; Betsy C. Wertheim; Denise Roe; Xiaoyue Zhang; Jie Ding; Pavani Chalasani; Christina Preece; Jessica Martinez; H.-H. Sherry Chow; Alison T. Stopeck
TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas
Edgar Gonzalez-Buendia; Junfei Zhao; Lu Wang; Subhas Mukherjee; Daniel Zhang; Víctor A. Arrieta; Eric Feldstein; J. Robert Kane; Seong Jae Kang; Catalina Lee-Chang; Aayushi Mahajan; Li Chen; Ronald Realubit; Charles Karan; Lisa Magnuson; Craig Horbinski; Stacy A. Marshall; Jann N. Sarkaria; Ahmed Mohyeldin; Ichiro Nakano; Mukesh Bansal; Charles D. James; Daniel J. Brat; Atique Ahmed; Peter Canoll; Raul Rabadan; Ali Shilatifard; Adam M. Sonabend
Prognostic Utility of Breast Cancer Index to Stratify Distant Recurrence Risk in Invasive Lobular Carcinoma
Raquel Nunes; Tal Sella; Kai Treuner; Jennifer M. Atkinson; Jenna Wong; Yi Zhang; Pedro Exman; David Dabbs; Andrea L. Richardson; Catherine A. Schnabel; Dennis C. Sgroi; Steffi Oesterreich; Ashley Cimino-Mathews; Otto Metzger
KRAS Inhibitor Resistance in MET-Amplified KRASG12C Non–Small Cell Lung Cancer Induced By RAS- and Non–RAS-Mediated Cell Signaling Mechanisms
Shinichiro Suzuki; Kimio Yonesaka; Takeshi Teramura; Toshiyuki Takehara; Ryoji Kato; Hitomi Sakai; Koji Haratani; Junko Tanizaki; Hisato Kawakami; Hidetoshi Hayashi; Kazuko Sakai; Kazuto Nishio; Kazuhiko Nakagawa
Therapeutic Targeting of Mesothelin with Chimeric Antigen Receptor T Cells in Acute Myeloid Leukemia
Quy Le; Sommer Castro; Thao Tang; Anisha M. Loeb; Tiffany Hylkema; Cyd Nourigat McKay; LaKeisha Perkins; Shivani Srivastava; Lindsey Call; Jenny Smith; Amanda Leonti; Rhonda Ries; Laura Pardo; Michael R. Loken; Colin Correnti; Salvatore Fiorenza; Cameron J. Turtle; Stanley Riddell; Katherine Tarlock; Soheil Meshinchi
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