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15 September 2021
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Cover Image
Cover Image
The cover shows early epithelial-to-mesenchymal transition (EMT) events in HER2-positive breast cancer cells. Immunfluorescence staining shows E-cadherin membrane delocalization (green) and F-actin stress fibers formation (magenta). For details, see the article by Guardia and colleagues on page 5096 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Clinical Trials: Targeted Therapy
Relevance of Platinum-free Interval and BRCA Reversion Mutations for Veliparib Monotherapy after Progression on Carboplatin/Paclitaxel for gBRCA Advanced Breast Cancer (BROCADE3 Crossover)
Shannon L. Puhalla; Véronique Diéras; Banu K. Arun; Bella Kaufman; Hans Wildiers; Hyo S. Han; Jean-Pierre Ayoub; Vered Stearns; Yuan Yuan; Teresa Helsten; Bridget Riley-Gillis; Erin Murphy; Madan G. Kundu; Meijing Wu; David Maag; Christine K. Ratajczak; Cyril Y. Ramathal; Michael Friedlander
A Phase I Dose-Escalation and Expansion Study of Telaglenastat in Patients with Advanced or Metastatic Solid Tumors
James J. Harding; Melinda Telli; Pamela Munster; Martin H. Voss; Jeffrey R. Infante; Angela DeMichele; Mark Dunphy; Mai H. Le; Chris Molineaux; Keith Orford; Frank Parlati; Sam H. Whiting; Mark K. Bennett; Nizar M. Tannir; Funda Meric-Bernstam
Phase I Dose-Escalation Study of the Dual PI3K-mTORC1/2 Inhibitor Gedatolisib in Combination with Paclitaxel and Carboplatin in Patients with Advanced Solid Tumors
Ilaria Colombo; Sofia Genta; Federica Martorana; Monia Guidi; Milo Frattini; Eleftherios Pierre Samartzis; Simone Brandt; Sheila Gaggetta; Laura Moser; Mariarosa Pascale; Tatiana Terrot; Cristiana Sessa; Anastasios Stathis
Clinical Trials: Immunotherapy
Motixafortide and Pembrolizumab Combined to Nanoliposomal Irinotecan, Fluorouracil, and Folinic Acid in Metastatic Pancreatic Cancer: The COMBAT/KEYNOTE-202 Trial
Bruno Bockorny; Teresa Macarulla; Valerya Semenisty; Erkut Borazanci; Jaime Feliu; Mariano Ponz-Sarvise; David Gutierrez Abad; Paul Oberstein; Angela Alistar; Andres Muñoz; Ravit Geva; Carmen Guillén-Ponce; Mercedes Salgado Fernandez; Amnon Peled; Marya Chaney; Irit Gliko-Kabir; Liron Shemesh-Darvish; Debby Ickowicz; Ella Sorani; Shaul Kadosh; Abi Vainstein-Haras; Manuel Hidalgo
Precision Medicine and Imaging
Author Choice
Network for Biomarker Immunoprofiling for Cancer Immunotherapy: Cancer Immune Monitoring and Analysis Centers and Cancer Immunologic Data Commons (CIMAC-CIDC)
Helen X. Chen; Minkyung Song; Holden T. Maecker; Sacha Gnjatic; David Patton; J. Jack Lee; Stacey J. Adam; Radim Moravec; Xiaole Shirley Liu; Ethan Cerami; James Lindsay; Ming Tang; F. Stephen Hodi; Catherine J. Wu; Ignacio I. Wistuba; Gheath Al-Atrash; Chantale Bernatchez; Sean C. Bendall; Stephen M. Hewitt; Elad Sharon; Howard Streicher; Rebecca A. Enos; Melissa D. Bowman; Valerie M. Tatard-Leitman; Beatriz Sanchez-Espiridion; Srinika Ranasinghe; Mina Pichavant; Diane M. Del Valle; Joyce Yu; Sylvie Janssens; Jenny Peterson-Klaus; Cathy Rowe; Gerold Bongers; Robert R. Jenq; Chia-Chi Chang; Jeffrey S. Abrams; Margaret Mooney; James H. Doroshow; Lyndsay N. Harris; Magdalena Thurin
Author Choice
Cross-Site Concordance Evaluation of Tumor DNA and RNA Sequencing Platforms for the CIMAC-CIDC Network
Zexian Zeng; Jingxin Fu; Carrie Cibulskis; Aashna Jhaveri; Curtis Gumbs; Biswajit Das; Beatriz Sanchez-Espiridion; Sylvie Janssens; Len Taing; Jin Wang; James Lindsay; Tomas Vilimas; Jianhua Zhang; Collin Tokheim; Avinash Sahu; Peng Jiang; Chunhua Yan; Dzifa Yawa Duose; Ethan Cerami; Li Chen; David Cohen; Qingrong Chen; Rebecca Enos; Xin Huang; Jack J. Lee; Yang Liu; Donna S. Neuberg; Cu Nguyen; Candace Patterson; Sharmistha Sarkar; Sachet Shukla; Ming Tang; Junko Tsuji; Mohamed Uduman; Xiaoman Wang; Jason L. Weirather; Jijun Yu; Joyce Yu; Jianjun Zhang; Jiexin Zhang; Daoud Meerzaman; Magdalena Thurin; Andrew Futreal; Chris Karlovich; Stacey B. Gabriel; Ignacio Ivan Wistuba; X. Shirley Liu; Catherine J. Wu
Immune Profiling Mass Cytometry Assay Harmonization: Multicenter Experience from CIMAC-CIDC
Bita Sahaf; Mina Pichavant; Brian H. Lee; Caroline Duault; Emily M. Thrash; Melanie Davila; Nicolas Fernandez; Karen Millerchip; Salah-Eddine Bentebibel; Cara Haymaker; Natalia Sigal; Diane M. Del Valle; Srinika Ranasinghe; Sarah Fayle; Beatriz Sanchez-Espiridion; Jiexin Zhang; Chantale Bernatchez; Catherine J. Wu; Ignacio I. Wistuba; Seunghee Kim-Schulze; Sacha Gnjatic; Sean C. Bendall; Minkyung Song; Magdalena Thurin; J. Jack Lee; Holden T. Maecker; Adeeb Rahman
Multiplex Tissue Imaging Harmonization: A Multicenter Experience from CIMAC-CIDC Immuno-Oncology Biomarkers Network
Guray Akturk; Edwin R. Parra; Evisa Gjini; Ana Lako; J. Jack Lee; Donna Neuberg; Jiexin Zhang; Shen Yao; Ilaria Laface; Anita Rogic; Pei-Hsuan Chen; Beatriz Sanchez-Espiridion; Diane M. Del Valle; Radim Moravec; Robert Kinders; Courtney Hudgens; Catherine Wu; Ignacio I. Wistuba; Magdalena Thurin; Stephen M. Hewitt; Scott Rodig; Sacha Gnjatic; Michael T. Tetzlaff
Translational Cancer Mechanisms and Therapy
Identification and Validation of T-cell Receptors Targeting RAS Hotspot Mutations in Human Cancers for Use in Cell-based Immunotherapy
Noam Levin; Biman C. Paria; Nolan R. Vale; Rami Yossef; Frank J. Lowery; Maria R. Parkhurst; Zhiya Yu; Maria Florentin; Gal Cafri; Jared J. Gartner; Mackenzie L. Shindorf; Lien T. Ngo; Satyajit Ray; Sanghyun P. Kim; Amy R. Copeland; Paul F. Robbins; Steven A. Rosenberg
Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer
Cristina Guardia; Giampaolo Bianchini; Oriol Arpí-LLucià; Silvia Menendez; David Casadevall; Barbara Galbardi; Matteo Dugo; Sonia Servitja; Juan Carlos Montero; Luis Soria-Jiménez; MohammadA Sabbaghi; Raul Peña; Juan Madoz-Gúrpide; Belen Lloveras; Ana Lluch; Pilar Eroles; Joaquin Arribas; Atanasio Pandiella; Luca Gianni; Federico Rojo; Ana Rovira; Joan Albanell
Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome–Like Acute Lymphoblastic Leukemia
Yang-Yang Ding; Hannah Kim; Kellyn Madden; Joseph P. Loftus; Gregory M. Chen; David Hottman Allen; Ruitao Zhang; Jason Xu; Chia-Hui Chen; Yuxuan Hu; Sarah K. Tasian; Kai Tan
Heterogeneity in NECTIN4 Expression Across Molecular Subtypes of Urothelial Cancer Mediates Sensitivity to Enfortumab Vedotin
Carissa E. Chu; Martin Sjöström; Emily A. Egusa; Ewan A. Gibb; Michelle L. Badura; Jun Zhu; Vadim S. Koshkin; Bradley A. Stohr; Maxwell V. Meng; Raj S. Pruthi; Terence W. Friedlander; Yair Lotan; Peter C. Black; Sima P. Porten; Felix Y. Feng; Jonathan Chou
Immunotherapy-Mediated Thyroid Dysfunction: Genetic Risk and Impact on Outcomes with PD-1 Blockade in Non–Small Cell Lung Cancer
Jia Luo; Victoria L. Martucci; Zoe Quandt; Stefan Groha; Megan H. Murray; Christine M. Lovly; Hira Rizvi; Jacklynn V. Egger; Andrew J. Plodkowski; Mohsen Abu-Akeel; Isabell Schulze; Taha Merghoub; Eduardo Cardenas; Scott Huntsman; Min Li; Donglei Hu; Matthew A. Gubens; Alexander Gusev; Melinda C. Aldrich; Matthew D. Hellmann; Elad Ziv
Organoid Platform in Preclinical Investigation of Personalized Immunotherapy Efficacy in Appendiceal Cancer: Feasibility Study
Steven D. Forsythe; Richard A. Erali; Shyama Sasikumar; Preston Laney; Ethan Shelkey; Ralph D'Agostino, Jr; Lance D. Miller; Perry Shen; Edward A. Levine; Shay Soker; Konstantinos I. Votanopoulos
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