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15 August 2021
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Cover Image
Cover Image
The cover shows a section of a pretherapeutic tumor sample from a patient with metastatic melanoma. Immunohistochemical staining shows T- and B-lymphocyte interactions in the stroma compartment by dual CD3/CD19 staining. Connected bands represent spatial proximity distribution. For details, see the article by Brase and colleagues on page 4500 of this issue. - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Review
CCR Drug Updates
FDA Approval Summary: Fam-Trastuzumab Deruxtecan-Nxki for the Treatment of Unresectable or Metastatic HER2-Positive Breast Cancer
Preeti Narayan; Christy L. Osgood; Harpreet Singh; Haw-Jyh Chiu; Tiffany K. Ricks; Edwin Chiu Yuen Chow; Junshan Qiu; Pengfei Song; Jingyu Yu; Frances Namuswe; Maria Guiterrez-Lugo; Sherry Hou; William F. Pierce; Kirsten B. Goldberg; Shenghui Tang; Laleh Amiri-Kordestani; Marc R. Theoret; Richard Pazdur; Julia A. Beaver
Perspectives
Clinical Trials: Targeted Therapy
Vorasidenib, a Dual Inhibitor of Mutant IDH1/2, in Recurrent or Progressive Glioma; Results of a First-in-Human Phase I Trial
Ingo K. Mellinghoff; Marta Penas-Prado; Katherine B. Peters; Howard A. Burris, III; Elizabeth A. Maher; Filip Janku; Gregory M. Cote; Macarena I. de la Fuente; Jennifer L. Clarke; Benjamin M. Ellingson; Saewon Chun; Robert J. Young; Hua Liu; Sung Choe; Min Lu; Kha Le; Islam Hassan; Lori Steelman; Shuchi S. Pandya; Timothy F. Cloughesy; Patrick Y. Wen
Role of Tumor-Infiltrating B Cells in Clinical Outcome of Patients with Melanoma Treated With Dabrafenib Plus Trametinib
Jan C. Brase; Robert F.H. Walter; Alexander Savchenko; Daniel Gusenleitner; James Garrett; Tobias Schimming; Renata Varaljai; Deborah Castelletti; Ju Kim; Naveen Dakappagari; Ken Schultz; Caroline Robert; Georgina V. Long; Paul D. Nathan; Antoni Ribas; Keith T. Flaherty; Boguslawa Karaszewska; Jacob Schachter; Antje Sucker; Kurt W. Schmid; Lisa Zimmer; Elisabeth Livingstone; Eduard Gasal; Dirk Schadendorf; Alexander Roesch
First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody–Drug Conjugate Targeting Protein Tyrosine Kinase 7, in Advanced Solid Tumors
Michael L. Maitland; Jasgit C. Sachdev; Manish R. Sharma; Victor Moreno; Valentina Boni; Shivaani Kummar; Erica Stringer-Reasor; Nehal Lakhani; Allison R. Moreau; Dawei Xuan; Ray Li; Eric L. Powell; Amy Jackson-Fisher; Michelle Bowers; Shilpa Alekar; Xiaohua Xin; Anthony W. Tolcher; Emiliano Calvo
Author Choice
Phase I, First-in-Human Study of the Probody Therapeutic CX-2029 in Adults with Advanced Solid Tumor Malignancies
Melissa Johnson; Anthony El-Khoueiry; Navid Hafez; Nehal Lakhani; Hirva Mamdani; Jordi Rodon; Rachel E. Sanborn; Javier Garcia-Corbacho; Valentina Boni; Mark Stroh; Alison L. Hannah; Song Wang; Henry Castro; Alexander Spira
Blood Biomarker Landscape in Patients with High-risk Nonmetastatic Castration-Resistant Prostate Cancer Treated with Apalutamide and Androgen-Deprivation Therapy as They Progress to Metastatic Disease
Matthew R. Smith; Shibu Thomas; Michael Gormley; Simon Chowdhury; David Olmos; Stéphane Oudard; Felix Y. Feng; Yashoda Rajpurohit; Karen Urtishak; Deborah S. Ricci; Brendan Rooney; Angela Lopez-Gitlitz; Margaret Yu; Alexander W. Wyatt; Mark Li; Gerhardt Attard; Eric J. Small
Toxicity and Efficacy of Concurrent Androgen Deprivation Therapy, Pelvic Radiotherapy, and Radium-223 in Patients with De Novo Metastatic Hormone-Sensitive Prostate Cancer
Philip G. Turner; Suneil Jain; Aidan Cole; Arthur Grey; Darren Mitchell; Kevin M. Prise; Alan R. Hounsell; Conor K. McGarry; Sandra Biggart; Joe M. O'Sullivan
Clinical Trials: Immunotherapy
Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck
Renata Ferrarotto; Moran Amit; Priyadharsini Nagarajan; M. Laura Rubin; Ying Yuan; Diana Bell; Adel K. El-Naggar; Jason M. Johnson; William H. Morrison; David I. Rosenthal; Bonnie S. Glisson; Faye M. Johnson; Charles Lu; Frank E. Mott; Bita Esmaeli; Eduardo M. Diaz, Jr; Paul W. Gidley; Ryan P. Goepfert; Carol M. Lewis; Randal S. Weber; Jennifer A. Wargo; Sreyashi Basu; Fei Duan; Shalini S. Yadav; Padmanee Sharma; James P. Allison; Jeffrey N. Myers; Neil D. Gross
A Phase Ib Open-Label, Multicenter Study of Inhaled DV281, a TLR9 Agonist, in Combination with Nivolumab in Patients with Advanced or Metastatic Non–small Cell Lung Cancer
Edward B. Garon; Alexander I. Spira; Melissa Johnson; Lyudmila Bazhenova; Joseph Leach; Amy L. Cummings; Albert Candia; Robert L. Coffman; Mary J. Janatpour; Robert Janssen; Erick Gamelin; Laura Q.M. Chow
Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer
Katelyn T. Byrne; Courtney B. Betts; Rosemarie Mick; Shamilene Sivagnanam; David L. Bajor; Daniel A. Laheru; E. Gabriela Chiorean; Mark H. O'Hara; Shannon M. Liudahl; Craig Newcomb; Cécile Alanio; Ana P. Ferreira; Byung S. Park; Takuya Ohtani; Austin P. Huffman; Sara A. Väyrynen; Andressa Dias Costa; Judith C. Kaiser; Andreanne M. Lacroix; Colleen Redlinger; Martin Stern; Jonathan A. Nowak; E. John Wherry; Martin A. Cheever; Brian M. Wolpin; Emma E. Furth; Elizabeth M. Jaffee; Lisa M. Coussens; Robert H. Vonderheide
Precision Medicine and Imaging
Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer
Jonathan M. Loree; Yucai Wang; Muddassir A. Syed; Alexey V. Sorokin; Oluwadara Coker; Joanne Xiu; Benjamin A. Weinberg; Ari M. Vanderwalde; Anteneh Tesfaye; Victoria M. Raymond; Benjamin Miron; Gabi Tarcic; Ori Zelichov; Russell R. Broaddus; Patrick Kwok Shing Ng; Kang Jin Jeong; Yiu Huen Tsang; Gordon B. Mills; Michael J. Overman; Axel Grothey; John L. Marshall; Scott Kopetz
Identification of a Novel Inflamed Tumor Microenvironment Signature as a Predictive Biomarker of Bacillus Calmette-Guérin Immunotherapy in Non–Muscle-Invasive Bladder Cancer
Jeffrey S. Damrauer; Kyle R. Roell; Markia A. Smith; Xuezheng Sun; Erin L. Kirk; Katherine A. Hoadley; Halei C. Benefield; Gopakumar Iyer; David B. Solit; Matthew I. Milowsky; William Y. Kim; Matthew E. Nielsen; Sara E. Wobker; Guido Dalbagni; Hikmat A. Al-Ahmadie; Andrew F. Olshan; Bernard H. Bochner; Helena Furberg; Melissa A. Troester; Eugene J. Pietzak
Translational Cancer Mechanisms and Therapy
Evolution of Castration-Resistant Prostate Cancer in ctDNA during Sequential Androgen Receptor Pathway Inhibition
Matti Annala; Sinja Taavitsainen; Daniel J. Khalaf; Gillian Vandekerkhove; Kevin Beja; Joonatan Sipola; Evan W. Warner; Cameron Herberts; Amanda Wong; Simon Fu; Daygen L. Finch; Conrad D. Oja; Joanna Vergidis; Muhammad Zulfiqar; Bernhard J. Eigl; Christian K. Kollmansberger; Matti Nykter; Martin E. Gleave; Kim N. Chi; Alexander W. Wyatt
Pyrotinib Treatment in Patients With HER2-positive Metastatic Breast Cancer and Brain Metastasis: Exploratory Final Analysis of Real-World, Multicenter Data
Munawar Anwar; Qitong Chen; Dengjie Ouyang; Shouman Wang; Ning Xie; Quchang Ouyang; Peizhi Fan; Liyuan Qian; Gannong Chen; Enxiang Zhou; Lei Guo; Xiaowen Gu; Boning Ding; Xiaohong Yang; Liping Liu; Chao Deng; Zhi Xiao; Jing Li; Yunqi Wang; Shan Zeng; Jinhui Hu; Wei Zhou; Bo Qiu; Zhongming Wang; Jie Weng; Mingwen Liu; Yi Li; Tiegang Tang; Jianguo Wang; Hui Zhang; Bin Dai; Wuping Tang; Tao Wu; Maoliang Xiao; Xiantao Li; Hailong Liu; Lai Li; Wenjun Yi
SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma
Shashidhar S. Jatiani; Stephanie Christie; Violetta V. Leshchenko; Rinku Jain; Abhijeet Kapoor; Paola Bisignano; Clement Lee; H. Ümit Kaniskan; Donna Edwards; Fanye Meng; Alessandro Laganà; Youssef Youssef; Adrian Wiestner; Lapo Alinari; Jian Jin; Marta Filizola; Aneel K. Aggarwal; Samir Parekh
Correction
Correction: Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma
Justine S. Paradis; Monica Acosta; Robert Saddawi-Konefka; Ayush Kishore; Simone Lubrano; Frederico Gomes; Nadia Arang; Manoela Tiago; Silvia Coma; Xingyu Wu; Kyle Ford; Chi-Ping Day; Glenn Merlino; Prashant Mali; Jonathan A. Pachter; Takami Sato; Andrew E. Aplin; J. Silvio Gutkind
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