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1 August 2021
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Pseudofluorescent image of the tumor microenvironment of a muscle-invasive bladder cancer specimen using multiplex immunohistochemistry on a single slide. The image depicts CD3 staining in red, CD8 staining in yellow, CD68 staining in green, PD-L1 staining in magenta, pancytokeratin staining in blue, and nuclei stained in gray. For details, see the article by Wang and colleagues on page 4287 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Selumetinib for Plexiform Neurofibroma
Denise Casey; Suzanne Demko; Arup Sinha; Pallavi S. Mishra-Kalyani; Yuan-li Shen; Sachia Khasar; M. Anwar Goheer; Whitney S. Helms; Lili Pan; Yuan Xu; Jianghong Fan; Ruby Leong; Jiang Liu; Yuching Yang; Katherine Windsor; Mei Ou; Olen Stephens; Byeongtaek Oh; Gregory H. Reaman; Abhilasha Nair; Stacy S. Shord; Vishal Bhatnagar; Selena R. Daniels; Sharon Sickafuse; Kirsten B. Goldberg; Marc R. Theoret; Richard Pazdur; Harpreet Singh
Review
Clinical Trials: Targeted Therapy
Intracranial Efficacy of Selpercatinib in RET Fusion-Positive Non–Small Cell Lung Cancers on the LIBRETTO-001 Trial
Vivek Subbiah; Justin F. Gainor; Geoffrey R. Oxnard; Daniel S.W. Tan; Dwight H. Owen; Byoung Chul Cho; Herbert H. Loong; Caroline E. McCoach; Jared Weiss; Yu Jung Kim; Lyudmila Bazhenova; Keunchil Park; Haruko Daga; Benjamin Besse; Oliver Gautschi; Christian Rolfo; Edward Y. Zhu; Jennifer F. Kherani; Xin Huang; Suhyun Kang; Alexander Drilon
First-Line Afatinib plus Cetuximab for EGFR-Mutant Non–Small Cell Lung Cancer: Results from the Randomized Phase II IFCT-1503 ACE-Lung Study
Alexis B. Cortot; Anne Madroszyk; Etienne Giroux-Leprieur; Olivier Molinier; Elisabeth Quoix; Henri Bérard; Josiane Otto; Isabelle Rault; Denis Moro-Sibilot; Judith Raimbourg; Elodie Amour; Franck Morin; José Hureaux; Lionel Moreau; Didier Debieuvre; Hugues Morel; Aldo Renault; Eric Pichon; Benjamin Huret; Sandrine Charpentier; Marc G. Denis; Jacques Cadranel
Author Choice
Phase I/II Trial of Exemestane, Ribociclib, and Everolimus in Women with HR+/HER2− Advanced Breast Cancer after Progression on CDK4/6 Inhibitors (TRINITI-1)
Aditya Bardia; Sara A. Hurvitz; Angela DeMichele; Amy S. Clark; Amelia Zelnak; Denise A. Yardley; Meghan Karuturi; Tara Sanft; Sibel Blau; Lowell Hart; Cynthia Ma; Hope S. Rugo; Das Purkayastha; Stacy Moulder
A Randomized Controlled Trial Comparing Two Different Schedules for Cisplatin Treatment in Patients with Locoregionally Advanced Nasopharyngeal Cancer
Wei-Xiong Xia; Xing Lv; Hu Liang; Guo-Ying Liu; Rui Sun; Qi Zeng; Si-Wei Li; Hao-Yuan Mo; Fei Han; Dong-Hua Luo; Qing Liu; Meng-Yun Shi; Yan-Fang Ye; Jing Yang; Liang-Ru Ke; Meng-Yun Qiang; Wen-Ze Qiu; Ya-Hui Yu; Kui-Yuan Liu; Xin-Jun Huang; Wang-Zhong Li; Shu-Hui Lv; Zhuo-Chen Cai; Jing-Jing Miao; Ling Guo; Ming-Yuan Chen; Ka-Jia Cao; Lin Wang; Chong Zhao; Pei-Yu Huang; Qiu-Yan Chen; Yi-Jun Hua; Lin-Quan Tang; Chao-Nan Qian; Hai-Qiang Mai; Xiang Guo; Yan-Qun Xiang
Clinical Trials: Immunotherapy
Neoadjuvant Pembrolizumab and High-Dose IFNα-2b in Resectable Regionally Advanced Melanoma
Yana G. Najjar; Dustin McCurry; Huang Lin; Yan Lin; Yan Zang; Diwakar Davar; Arivarasan Karunamurthy; Joseph J. Drabick; Rogerio I. Neves; Lisa H. Butterfield; Marc S. Ernstoff; Igor Puzanov; Joseph J. Skitzki; Jennifer Bordeaux; IlaSri B. Summit; Jehovana O. Bender; Ju Young Kim; Beiru Chen; Ghanashyam Sarikonda; Anil Pahuja; Jennifer Tsau; Zeni Alfonso; Christian Laing; James F. Pingpank; Matthew P. Holtzman; Cindy Sander; Amy Rose; Hassane M. Zarour; John M. Kirkwood; Ahmad A. Tarhini
Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial
Reetta Virtakoivu; Jenna H. Rannikko; Miro Viitala; Felix Vaura; Akira Takeda; Tapio Lönnberg; Jussi Koivunen; Panu Jaakkola; Annika Pasanen; Shishir Shetty; Maja J.A. de Jonge; Debbie Robbrecht; Yuk Ting Ma; Tanja Skyttä; Anna Minchom; Sirpa Jalkanen; Matti K. Karvonen; Jami Mandelin; Petri Bono; Maija Hollmén
Precision Medicine and Imaging
Prognostic Significance of Blood-Based Multi-cancer Detection in Plasma Cell-Free DNA
Xiaoji Chen; Zhao Dong; Earl Hubbell; Kathryn N. Kurtzman; Geoffrey R. Oxnard; Oliver Venn; Collin Melton; Christina A. Clarke; Rita Shaknovich; Ting Ma; Gerry Meixiong; Michael V. Seiden; Eric A. Klein; Eric T. Fung; Minetta C. Liu
Tumor-Naïve Multimodal Profiling of Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma
Justin M. Burgener; Jinfeng Zou; Zhen Zhao; Yangqiao Zheng; Shu Yi Shen; Shao Hui Huang; Sareh Keshavarzi; Wei Xu; Fei-Fei Liu; Geoffrey Liu; John N. Waldron; Ilan Weinreb; Anna Spreafico; Lillian L. Siu; John R. de Almeida; David P. Goldstein; Michael M. Hoffman; Daniel D. De Carvalho; Scott V. Bratman
Standardized Uptake Value for 18F-Fluorodeoxyglucose Is a Marker of Inflammatory State and Immune Infiltrate in Cervical Cancer
John M. Floberg; Jin Zhang; Naoshad Muhammad; Todd A. DeWees; Matthew Inkman; Kevin Chen; Alexander J. Lin; Ramachandran Rashmi; Kay Jayachandran; Brian T. Edelson; Barry A. Siegel; Farrokh Dehdashti; Perry W. Grigsby; Stephanie Markovina; Julie K. Schwarz
Oncogenic Mutations in PI3K/AKT/mTOR Pathway Effectors Associate with Worse Prognosis in BRAFV600E-Driven Papillary Thyroid Cancer Patients
Theodora Pappa; Sara Ahmadi; Ellen Marqusee; Hannah L. Johnson; Matthew A. Nehs; Nancy L. Cho; Justine A. Barletta; Jochen H. Lorch; Gerard M. Doherty; Neal I. Lindeman; Erik K. Alexander; Iñigo Landa
Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms
Charles W. Abbott; Sean M. Boyle; Rachel Marty Pyke; Lee D. McDaniel; Eric Levy; Fábio C.P. Navarro; Dattatreya Mellacheruvu; Simo V. Zhang; Mengyao Tan; Rose Santiago; Zeid M. Rusan; Pamela Milani; Gabor Bartha; Jason Harris; Rena McClory; Michael P. Snyder; Sekwon Jang; Richard Chen
Translational Cancer Mechanisms and Therapy
Myeloid Cell–associated Resistance to PD-1/PD-L1 Blockade in Urothelial Cancer Revealed Through Bulk and Single-cell RNA Sequencing
Li Wang; John P. Sfakianos; Kristin G. Beaumont; Guray Akturk; Amir Horowitz; Robert P. Sebra; Adam M. Farkas; Sacha Gnjatic; Austin Hake; Sudeh Izadmehr; Peter Wiklund; William K. Oh; Peter M. Szabo; Megan Wind-Rotolo; Keziban Unsal-Kacmaz; Xin Yao; Eric Schadt; Padmanee Sharma; Nina Bhardwaj; Jun Zhu; Matthew D. Galsky
Regulation of OATP1B1 Function by Tyrosine Kinase–mediated Phosphorylation
Elizabeth R. Hayden; Mingqing Chen; Kyle Z. Pasquariello; Alice A. Gibson; James J. Petti; Shichen Shen; Jun Qu; Su Sien Ong; Taosheng Chen; Yan Jin; Muhammad Erfan Uddin; Kevin M. Huang; Aviv Paz; Alex Sparreboom; Shuiying Hu; Jason A. Sprowl
Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion
Fabio Conforti; Laura Pala; Eleonora Pagan; Vincenzo Bagnardi; Tommaso De Pas; Paola Queirolo; Elisabetta Pennacchioli; Chiara Catania; Emilia Cocorocchio; Pier Francesco Ferrucci; Maristella Saponara; Gianmarco Orsolini; Paola Zagami; Eleonora Nicoló; Filippo De Marinis; Giampaolo Tortora; Emilio Bria; Saverio Minucci; Hadine Joffe; Paolo Veronesi; Jennifer Wargo; Rachel Rosenthal; Charles Swanton; Alberto Mantovani; Richard D. Gelber; Giuseppe Viale; Aron Goldhirsch; Giuseppe Giaccone
Opening of the Blood–Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models
Aria Sabbagh; Kevin Beccaria; Xiaoyang Ling; Anantha Marisetty; Martina Ott; Hillary Caruso; Emily Barton; Ling-Yuan Kong; Dexing Fang; Khatri Latha; Daniel Yang Zhang; Jun Wei; John DeGroot; Michael A. Curran; Ganesh Rao; Jian Hu; Carole Desseaux; Guillaume Bouchoux; Michael Canney; Alexandre Carpentier; Amy B. Heimberger
Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma
Lin Xiao; Klaartje Somers; Jayne Murray; Ruby Pandher; Mawar Karsa; Emma Ronca; Angelika Bongers; Rachael Terry; Anahid Ehteda; Laura D. Gamble; Natalia Issaeva; Katerina I. Leonova; Aisling O'Connor; Chelsea Mayoh; Pooja Venkat; Hazel Quek; Jennifer Brand; Frances K. Kusuma; Jessica A. Pettitt; Erin Mosmann; Adam Kearns; Georgina Eden; Stephanie Alfred; Sophie Allan; Lei Zhai; Alvin Kamili; Andrew J. Gifford; Daniel R. Carter; Michelle J. Henderson; Jamie I. Fletcher; Glenn Marshall; Ricky W. Johnstone; Anthony J. Cesare; David S. Ziegler; Andrei V. Gudkov; Katerina V. Gurova; Murray D. Norris; Michelle Haber
Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control
Kyoko Nakamura; Ankur Karmokar; Paul M. Farrington; Neil H. James; Antonio Ramos-Montoya; Susan J. Bickerton; Gareth D. Hughes; Timothy M. Illidge; Elaine B. Cadogan; Barry R. Davies; Simon J. Dovedi; Viia Valge-Archer
Darolutamide Potentiates the Antitumor Efficacy of a PSMA-targeted Thorium-227 Conjugate by a Dual Mode of Action in Prostate Cancer Models
Stefanie Hammer; Andreas Schlicker; Sabine Zitzmann-Kolbe; Simon Baumgart; Urs B. Hagemann; Arne Scholz; Bernard Haendler; Pascale Lejeune; Jenny Karlsson; Christine Ellingsen; Hartwig Hennekes; Carsten H. Nielsen; Mark U. Juul; Dominik Mumberg; Christoph A. Schatz
Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER+ Breast Cancer
Alberto Servetto; Rahul Kollipara; Luigi Formisano; Chang-Ching Lin; Kyung-Min Lee; Dhivya R. Sudhan; Paula I. Gonzalez-Ericsson; Sumanta Chatterjee; Angel Guerrero-Zotano; Saurabh Mendiratta; Hiroaki Akamatsu; Nicholas James; Roberto Bianco; Ariella B. Hanker; Ralf Kittler; Carlos L. Arteaga
Modeling Clinical Responses to Targeted Therapies by Patient-Derived Organoids of Advanced Lung Adenocarcinoma
Seok-Young Kim; Sang-Min Kim; Sumin Lim; Ji Yeon Lee; Su-Jin Choi; San-Duk Yang; Mi Ran Yun; Chang Gon Kim; Seo Rin Gu; Chaewon Park; A-Young Park; Sun Min Lim; Seong Gu Heo; HyunKi Kim; Byoung Chul Cho
HYAL4-V1/Chondroitinase (Chase) Drives Gemcitabine Resistance and Predicts Chemotherapy Failure in Patients with Bladder Cancer
Sarrah L. Hasanali; Daley S. Morera; Ronny R. Racine; Martin Hennig; Santu Ghosh; Luis E. Lopez; Marie C. Hupe; Diogo O. Escudero; Jiaojiao Wang; Huabin Zhu; Semih Sarcan; Ijeoma Azih; Michael Zhou; Andre R. Jordan; Martha K. Terris; Markus A. Kuczyk; Axel S. Merseburger; Vinata B. Lokeshwar
Aging and CNS Myeloid Cell Depletion Attenuate Breast Cancer Brain Metastasis
Alex Man Lai Wu; Selamawit Gossa; Ramakrishna Samala; Monika A. Chung; Brunilde Gril; Howard H. Yang; Helen R. Thorsheim; Andy D. Tran; Debbie Wei; Esra Taner; Kristine Isanogle; Yuan Yang; Emma L. Dolan; Christina Robinson; Simone Difilippantonio; Maxwell P. Lee; Imran Khan; Quentin R. Smith; Dorian B. McGavern; Lalage M. Wakefield; Patricia S. Steeg
Neutralization of PD-L2 is Essential for Overcoming Immune Checkpoint Blockade Resistance in Ovarian Cancer
Yu Rebecca Miao; Kaushik N. Thakkar; Jin Qian; Mihalis S. Kariolis; Wei Huang; Saravanan Nandagopal; Teddy Tat Chi Yang; Anh N. Diep; Gerald Maxwell Cherf; Yu Xu; Eui Jung Moon; Yiren Xiao; Haizea Alemany; Tiane Li; Wenhua Yu; Bo Wei; Erinn B. Rankin; Amato J. Giaccia
Editor’s Notes
Editor's Note: Biologic Effects of Platelet-Derived Growth Factor Receptor α Blockade in Uterine Cancer
Ju-Won Roh; Jie Huang; Wei Hu; XiaoYun Yang; Nicholas B. Jennings; Vasudha Sehgal; Bo Hwa Sohn; Hee Dong Han; Sun Joo Lee; Duangmani Thanapprapasr; Justin Bottsford-Miller; Behrouz Zand; Heather J. Dalton; Rebecca A. Previs; Ashley N. Davis; Koji Matsuo; Ju-Seog Lee; Prahlad Ram; Robert L. Coleman; Anil K. Sood
Editor's Note: Targeting Src in Mucinous Ovarian Carcinoma
Koji Matsuo; Masato Nishimura; Justin N. Bottsford-Miller; Jie Huang; Kakajan Komurov; Guillermo N. Armaiz-Pena; Mian M.K. Shahzad; Rebecca L. Stone; Ju Won Roh; Angela M. Sanguino; Chunhua Lu; Dwight D. Im; Neil B. Rosenshien; Atsuko Sakakibara; Tadayoshi Nagano; Masato Yamasaki; Takayuki Enomoto; Tadashi Kimura; Prahlad T. Ram; Kathleen M. Schmeler; Gary E. Gallick; Kwong K. Wong; Michael Frumovitz; Anil K. Sood
Editor's Note: Dopamine Blocks Stress-mediated Ovarian Carcinoma Growth
Myrthala Moreno-Smith; Chunhua Lu; Mian M.K. Shahzad; Guillermo N. Armaiz Pena; Julie K. Allen; Rebecca L. Stone; Lingegowda S. Mangala; Hee Dong Han; Hye Sun Kim; Donna Farley; Gabriel Lopez Berestein; Steve W. Cole; Susan K. Lutgendorf; Anil K. Sood
Editor's Note: Functional Roles of Src and Fgr in Ovarian Carcinoma
Hye-Sun Kim; Hee Dong Han; Guillermo N. Armaiz-Pena; Rebecca L. Stone; Eun Ji Nam; Jeong-Won Lee; Mian M.K. Shahzad; Alpa M. Nick; Sun Joo Lee; Ju-Won Roh; Masato Nishimura; Lingegowda S. Mangala; Justin Bottsford-Miller; Gary E. Gallick; Gabriel Lopez-Berestein; Anil K. Sood
Editor's Note: Targeted Gene Silencing Using RGD-Labeled Chitosan Nanoparticles
Hee Dong Han; Lingegowda S. Mangala; Jeong Won Lee; Mian M.K. Shahzad; Hye Sun Kim; Deyu Shen; Eun Ji Nam; Edna M. Mora; Rebecca L. Stone; Chunhua Lu; Sun Joo Lee; Ju Won Roh; Alpa M. Nick; Gabriel Lopez-Berestein; Anil K. Sood
Editor's Note: Therapeutic Targeting of ATP7B in Ovarian Carcinoma
Lingegowda S. Mangala; Vesna Zuzel; Rosemarie Schmandt; Erik S. Leshane; Jyotsna B. Halder; Guillermo N. Armaiz-Pena; Whitney A. Spannuth; Takemi Tanaka; Mian M.K. Shahzad; Yvonne G. Lin; Alpa M. Nick; Christopher G. Danes; Jeong-Won Lee; Nicholas B. Jennings; Pablo E. Vivas-Mejia; Judith K. Wolf; Robert L. Coleman; Zahid H. Siddik; Gabriel Lopez-Berestein; Svetlana Lutsenko; Anil K. Sood
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