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1 July 2021
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Cover Image
Cover Image
The cover shows a multiplex fluorescence IHC image of a patient with PTEN mutation in the phosphatase domain (best response: PD). CD204, CD3, and cytokeratin in cells are shown in red, green, and orange, respectively. Tumors with PTEN phosphatase domain mutations had higher levels of intratumoral CD204 macrophages. For details, see the article by Chida and colleagues on page 3714 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Drug Updates
FDA Approval Summary: Gilteritinib for Relapsed or Refractory Acute Myeloid Leukemia with a FLT3 Mutation
E. Dianne Pulte; Kelly J. Norsworthy; Yaping Wang; Qing Xu; Hisham Qosa; Ramadevi Gudi; Donna Przepiorka; Wentao Fu; Olanrewaju O. Okusanya; Kirsten B. Goldberg; R. Angelo De Claro; Ann T. Farrell; Richard Pazdur
FDA Approval Summary: Nivolumab with Ipilimumab and Chemotherapy for Metastatic Non–small Cell Lung Cancer, A Collaborative Project Orbis Review
Paz J. Vellanki; Flora Mulkey; Adnan A. Jaigirdar; Lisa Rodriguez; Yibo Wang; Yuan Xu; Hong Zhao; Jiang Liu; Grant Howe; Jian Wang; Qiuyi Choo; Sarah J. Golding; Victoria Mansell; Kwadwo Korsah; Dianne Spillman; R. Angelo de Claro; Richard Pazdur; Julia A. Beaver; Harpreet Singh
Review
Perspectives
Research Briefs: Clinical Trial Brief Reports
Author Choice
Activity of Crizotinib in Patients with ALK-Aberrant Relapsed/Refractory Neuroblastoma: A Children's Oncology Group Study (ADVL0912)
Jennifer H. Foster; Stephan D. Voss; David C. Hall; Charles G. Minard; Frank M. Balis; Keith Wilner; Stacey L. Berg; Elizabeth Fox; Peter C. Adamson; Susan M. Blaney; Brenda J. Weigel; Yael P. Mossé
Clinical Trials: Targeted Therapy
Author Choice
First-in-Human Phase I Study of ABBV-085, an Antibody–Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors
George D. Demetri; Jason J. Luke; Antoine Hollebecque; John D. Powderly, II; Alexander I. Spira; Vivek Subbiah; Louie Naumovski; Chris Chen; Hua Fang; Dominic W. Lai; Huibin Yue; Akshanth R. Polepally; James W. Purcell; Randy Robinson; Padmanee Sharma; James P. Allison; Anthony Tolcher; Victor M. Villalobos
Author Choice
Anlotinib in Locally Advanced or Metastatic Medullary Thyroid Carcinoma: A Randomized, Double-Blind Phase IIB Trial
Dapeng Li; Yihebali Chi; Xiaohong Chen; Minghua Ge; Yuan Zhang; Zhuming Guo; Jun Wang; Jie Chen; Jiewu Zhang; Ying Cheng; Zhendong Li; Hui Liu; Jianwu Qin; Jingqiang Zhu; Ruochuan Cheng; Zhengang Xu; Xiangqian Zheng; Pingzhang Tang; Ming Gao
Author Choice
Effect Modifiers of Low-Dose Tamoxifen in a Randomized Trial in Breast Noninvasive Disease
Andrea DeCensi; Matteo Puntoni; Harriet Johansson; Aliana Guerrieri-Gonzaga; Silvia Caviglia; Franca Avino; Laura Cortesi; Antonio Ponti; Maria Grazia Pacquola; Fabio Falcini; Marcella Gulisano; Maria Digennaro; Anna Cariello; Katia Cagossi; Graziella Pinotti; Matteo Lazzeroni; Davide Serrano; Irene Maria Briata; Tania Buttiron Webber; Luca Boni; Bernardo Bonanni
Preclinical Development and First-in-Human Study of KA2507, a Selective and Potent Inhibitor of Histone Deacetylase 6, for Patients with Refractory Solid Tumors
Apostolia M. Tsimberidou; Philip A. Beer; Carrie A. Cartwright; Cara Haymaker; Henry H. Vo; Simin Kiany; Alexander R.L. Cecil; James Dow; Kemal Haque; Franck A. Silva; Lucy Coe; Helen Berryman; Elisabeth A. Bone; Graciela M. Nogueras-Gonzalez; David Vining; Hilary McElwaine-Johnn; Ignacio I. Wistuba
Author Choice
Lutetium-177-PSMA-617 in Low-Volume Hormone-Sensitive Metastatic Prostate Cancer: A Prospective Pilot Study
Bastiaan M. Privé; Steffie M.B. Peters; Constantijn H.J. Muselaers; Inge M. van Oort; Marcel J.R. Janssen; J.P. Michiel Sedelaar; Mark W. Konijnenberg; Patrik Zámecnik; Maike J.M. Uijen; Melline G.M. Schilham; Annemarie Eek; Tom W.J. Scheenen; J. Fred Verzijlbergen; Winald R. Gerritsen; Niven Mehra; Linda G.W. Kerkmeijer; Robert J. Smeenk; Diederik M. Somford; Jean-Paul A. van Basten; Sandra Heskamp; Jelle O. Barentsz; Martin Gotthardt; J. Alfred Witjes; James Nagarajah
Phase I Study of MEDI3726: A Prostate-Specific Membrane Antigen-Targeted Antibody–Drug Conjugate, in Patients with mCRPC after Failure of Abiraterone or Enzalutamide
Johann S. de Bono; Mark T. Fleming; Judy S. Wang; Richard Cathomas; Manuel Selvi Miralles; John Bothos; Mary Jane Hinrichs; Qu Zhang; Peng He; Marna Williams; Anton I. Rosenbaum; Meina Liang; Kapil Vashisht; Song Cho; Pablo Martinez; Daniel P. Petrylak
Phase II Multicenter Study of Enzalutamide in Metastatic Castration-Resistant Prostate Cancer to Identify Mechanisms Driving Resistance
Rana R. McKay; Lucia Kwak; Jett P. Crowdis; Jamie M. Sperger; Shuang G. Zhao; Wanling Xie; Lillian Werner; Rosina T. Lis; Zhenwei Zhang; Xiao X. Wei; Joshua M. Lang; Eliezer M. Van Allen; Rupal S. Bhatt; Evan Y. Yu; Peter S. Nelson; Glenn J. Bubley; R. Bruce Montgomery; Mary-Ellen Taplin
Clinical Trials: Immunotherapy
Phase I/Ib Clinical Trial of Sabatolimab, an Anti–TIM-3 Antibody, Alone and in Combination with Spartalizumab, an Anti–PD-1 Antibody, in Advanced Solid Tumors
Giuseppe Curigliano; Hans Gelderblom; Nicolas Mach; Toshihiko Doi; David Tai; Patrick M. Forde; John Sarantopoulos; Philippe L. Bedard; Chia-Chi Lin; F. Stephen Hodi; Sofie Wilgenhof; Armando Santoro; Catherine A. Sabatos-Peyton; Tyler A. Longmire; Alexandros Xyrafas; Haiying Sun; Sabine Gutzwiller; Luigi Manenti; Aung Naing
Author Choice
A Phase Ib/II Study of Pepinemab in Combination with Avelumab in Advanced Non–Small Cell Lung Cancer
Michael R. Shafique; Terrence L. Fisher; Elizabeth E. Evans; John E. Leonard; Desa Rae E. Pastore; Crystal L. Mallow; Ernest Smith; Vikas Mishra; Andreas Schröder; Kevin M. Chin; Joseph T. Beck; Megan A. Baumgart; Ramaswamy Govindan; Nashat Y. Gabrail; Alexander I. Spira; Nagashree Seetharamu; Yanyan Lou; Aaron S. Mansfield; Rachel E. Sanborn; Jonathan W. Goldman; Maurice Zauderer
ZEBRA: A Multicenter Phase II Study of Pembrolizumab in Patients with Advanced Small-Bowel Adenocarcinoma
Katrina S. Pedersen; Nathan R. Foster; Michael J. Overman; Patrick M. Boland; Sunnie S. Kim; Kathryn A. Arrambide; Brandy L. Jaszewski; Tanios Bekaii-Saab; Rondell P. Graham; Jack Welch; Richard H. Wilson; Robert R. McWilliams
Author Choice
Clinical and Immunologic Responses to a B-Cell Epitope Vaccine in Patients with HER2/neu-Overexpressing Advanced Gastric Cancer—Results from Phase Ib Trial IMU.ACS.001
Ursula Wiedermann; Erika Garner-Spitzer; Yee Chao; Marina Maglakelidze; Iurie Bulat; Arunee Dechaphunkul; Wichit Arpornwirat; Chaiyut Charoentum; Chia-Jui Yen; Thomas Cheung Yau; Suebpong Tanasanvimon; Jedzada Maneechavakajorn; Aumkhae Sookprasert; Li-Yuan Bai; Wen-Chi Chou; Teerapat Ungtrakul; Mirjana Drinic; Joshua Tobias; Christoph C. Zielinski; Leslie Chong; Nicholas J. Ede; Mark T. Marino; Anthony J. Good
IFNα Augments Clinical Efficacy of Regulatory T-cell Depletion with Denileukin Diftitox in Ovarian Cancer
Suzanne R. Thibodeaux; Brian B. Barnett; Srilakshmi Pandeswara; Shawna R. Wall; Vincent Hurez; Vinh Dao; Lishi Sun; Benjamin J. Daniel; Michael J. Brumlik; Justin Drerup; Álvaro Padrón; Teresa Whiteside; Ilona Kryczek; Weiping Zou; Tyler J. Curiel
Precision Medicine and Imaging
Author Choice
Diagnostic Performance of 18F-DCFPyL-PET/CT in Men with Biochemically Recurrent Prostate Cancer: Results from the CONDOR Phase III, Multicenter Study
Michael J. Morris; Steven P. Rowe; Michael A. Gorin; Lawrence Saperstein; Frédéric Pouliot; David Josephson; Jeffrey Y.C. Wong; Austin R. Pantel; Steve Y. Cho; Kenneth L. Gage; Morand Piert; Andrei Iagaru; Janet H. Pollard; Vivien Wong; Jessica Jensen; Tess Lin; Nancy Stambler; Peter R. Carroll; Barry A. Siegel; CONDOR Study Group
Author Choice
Integration of Genomic and Transcriptomic Markers Improves the Prognosis Prediction of Acute Promyelocytic Leukemia
Xiaojing Lin; Niu Qiao; Yang Shen; Hai Fang; Qing Xue; Bowen Cui; Li Chen; Hongming Zhu; Sujiang Zhang; Yu Chen; Lu Jiang; Shengyue Wang; Junmin Li; Bingshun Wang; Bing Chen; Zhu Chen; Saijuan Chen
Development and Validation of a Simplified Score to Predict Early Relapse in Newly Diagnosed Multiple Myeloma in a Pooled Dataset of 2,190 Patients
Gian Maria Zaccaria; Luca Bertamini; Maria Teresa Petrucci; Massimo Offidani; Paolo Corradini; Andrea Capra; Alessandra Romano; Anna Marina Liberati; Donato Mannina; Paolo de Fabritiis; Nicola Cascavilla; Marina Ruggeri; Roberto Mina; Francesca Patriarca; Giulia Benevolo; Angelo Belotti; Gianluca Gaidano; Arnon Nagler; Roman Hájek; Andrew Spencer; Pieter Sonneveld; Pellegrino Musto; Mario Boccadoro; Francesca Gay
Diagnosis of Pseudoprogression Following Lomustine–Temozolomide Chemoradiation in Newly Diagnosed Glioblastoma Patients Using FET-PET
Jan-Michael Werner; Johannes Weller; Garry Ceccon; Christina Schaub; Caroline Tscherpel; Philipp Lohmann; Elena K. Bauer; Niklas Schäfer; Gabriele Stoffels; Christian Baues; Eren Celik; Simone Marnitz; Christoph Kabbasch; Gerrit H. Gielen; Gereon R. Fink; Karl-Josef Langen; Ulrich Herrlinger; Norbert Galldiks
Translational Cancer Mechanisms and Therapy
Author Choice
A Low Tumor Mutational Burden and PTEN Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors
Keigo Chida; Akihito Kawazoe; Masahito Kawazu; Toshihiro Suzuki; Yoshiaki Nakamura; Tetsuya Nakatsura; Takeshi Kuwata; Toshihide Ueno; Yasutoshi Kuboki; Daisuke Kotani; Takashi Kojima; Hiroya Taniguchi; Hiroyuki Mano; Masafumi Ikeda; Kohei Shitara; Itaru Endo; Takayuki Yoshino
Targeted Deep Sequencing of Bladder Tumors Reveals Novel Associations between Cancer Gene Mutations and Mutational Signatures with Major Risk Factors
Stella Koutros; Nina Rao; Lee E. Moore; Michael L. Nickerson; Donghyuk Lee; Bin Zhu; Larissa A. Pardo; Dalsu Baris; Molly Schwenn; Alison Johnson; Kristine Jones; Montserrat Garcia-Closas; Ludmila Prokunina-Olsson; Debra T. Silverman; Nathaniel Rothman; Michael Dean
Combining AFM13, a Bispecific CD30/CD16 Antibody, with Cytokine-Activated Blood and Cord Blood–Derived NK Cells Facilitates CAR-like Responses Against CD30+ Malignancies
Lucila N. Kerbauy; Nancy D. Marin; Mecit Kaplan; Pinaki P. Banerjee; Melissa M. Berrien-Elliott; Michelle Becker-Hapak; Rafet Basar; Mark Foster; Luciana Garcia Melo; Carly C. Neal; Ethan McClain; May Daher; Ana Karen Nunez Cortes; Sweta Desai; Francesca Wei Inng Lim; Mayela Carolina Mendt; Timothy Schappe; Li Li; Hila Shaim; Mayra Shanley; Emily L. Ensley; Nadima Uprety; Pamela Wong; Enli Liu; Sonny O. Ang; Rong Cai; Vandana Nandivada; Vakul Mohanty; Qi Miao; Yifei Shen; Natalia Baran; Natalie W. Fowlkes; Ken Chen; Luis Muniz-Feliciano; Richard E. Champlin; Yago L. Nieto; Joachim Koch; Martin Treder; Wolfgang Fischer; Oswaldo Keith Okamoto; Elizabeth J. Shpall; Todd A. Fehniger; Katayoun Rezvani
Author Choice
A Pan-Histone Deacetylase Inhibitor Enhances the Antitumor Activity of B7-H3–Specific CAR T Cells in Solid Tumors
Xinyuan Lei; Zhanpeng Ou; Zhaohui Yang; Jianglong Zhong; Yanliang Zhu; Jing Tian; Jiannan Wu; Heran Deng; Xinyu Lin; Yu Peng; Bowen Li; Lile He; Zhiming Tu; Weixiong Chen; Qunxing Li; Niu Liu; Hanqing Zhang; Zhangsong Wang; Zezhen Fang; Teppei Yamada; Xiaobin Lv; Tian Tian; Guokai Pan; Fan Wu; Liping Xiao; Lizao Zhang; Tingting Cai; Xinhui Wang; Bakhos A. Tannous; Jinsong Li; Filippos Kontos; Soldano Ferrone; Song Fan
The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients
Bo Zheng; Xiao-Long Liu; Rong Fan; Jian Bai; Hao Wen; Lu-Tao Du; Guo-Qing Jiang; Chun-Ying Wang; Xiao-Tang Fan; Yi-Nong Ye; Yun-Song Qian; Ying-Chao Wang; Gao-Jing Liu; Guo-Hong Deng; Feng Shen; He-Ping Hu; Hui Wang; Qing-Zheng Zhang; Lan-Lan Ru; Jing Zhang; Yan-Hang Gao; Jie Xia; Hua-Dong Yan; Min-Feng Liang; Yan-Long Yu; Fu-Ming Sun; Yu-Jing Gao; Jian Sun; Chun-Xiu Zhong; Yin Wang; Fei Kong; Jin-Ming Chen; Dan Zheng; Yuan Yang; Chuan-Xin Wang; Lin Wu; Jin-Lin Hou; Jing-Feng Liu; Hong-Yang Wang; Lei Chen
Fecal Microbiota Transplantation from Overweight or Obese Donors in Cachectic Patients with Advanced Gastroesophageal Cancer: A Randomized, Double-blind, Placebo-Controlled, Phase II Study
Nicolien C. de Clercq; Tom van den Ende; Andrei Prodan; Robert Hemke; Mark Davids; Helle K. Pedersen; Henrik B. Nielsen; A.K. Groen; Willem M. de Vos; Hanneke W.M. van Laarhoven; Max Nieuwdorp
Bone Marrow Mesenchymal Stromal Cells Can Render Multiple Myeloma Cells Resistant to Cytotoxic Machinery of CAR T Cells through Inhibition of Apoptosis
Lisa C. Holthof; Jort J. van der Schans; Afroditi Katsarou; Renée Poels; Anne T. Gelderloos; Esther Drent; Susan E. van Hal-van Veen; Fengzhi Li; Sonja Zweegman; Niels W.C.J. van de Donk; Maria Themeli; Richard W.J. Groen; Tuna Mutis
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