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15 June 2021
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Cover Image
Cover Image
The cover shows an image of a mpMRI-visible PCa tumor analyzed using AI-driven analysis. This tumor has glandular structures composed of malignant cells that represent stroma and compact tumor architecture. Macrophage infiltration is pronounced in the malignant zones, whereas T-cell infiltration primarily is observed in the nonmalignant compartment. For details, see the article by Pachynski and colleagues on page 3478 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Clinical Trials: Targeted Therapy
Author Choice
Phase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas
Jing Wu; Ying Yuan; Debra A. Long Priel; Danielle Fink; Cody J. Peer; Tristan M. Sissung; Yu-Ting Su; Ying Pang; Guangyang Yu; Madison K. Butler; Tito R. Mendoza; Elizabeth Vera; Salman Ahmad; Christine Bryla; Matthew Lindsley; Ewa Grajkowska; Kelly Mentges; Lisa Boris; Ramya Antony; Nancy Garren; Christine Siegel; Nicole Lollo; Christine Cordova; Orwa Aboud; Brett J. Theeler; Eric M. Burton; Marta Penas-Prado; Heather Leeper; Javier Gonzales; Terri S. Armstrong; Katherine R. Calvo; William D. Figg; Douglas B. Kuhns; John I. Gallin; Mark R. Gilbert
Selinexor in Combination with R-CHOP for Frontline Treatment of Non-Hodgkin Lymphoma: Results of a Phase I Study
Erlene K. Seymour; Husain Yar Khan; Yiwei Li; Mahmoud Chaker; Irfana Muqbil; Amro Aboukameel; Radhakrishanan Ramchandren; Christiane Houde; Golbon Sterbis; Jay Yang; Divaya Bhutani; Silvana Pregja; Kathy Reichel; Amy Huddlestun; Colleen Neveux; Kelly Corona; Yosef Landesman; Jatin Shah; Michael Kauffman; Sharon Shacham; Ramzi M. Mohammad; Asfar S. Azmi; Jeffrey A. Zonder
Angiokines Associated with Targeted Therapy Outcomes in Patients with Non–Clear Cell Renal Cell Carcinoma
Andrew J. Armstrong; Andrew B. Nixon; Andrea Carmack; Qian Yang; Tim Eisen; Walter M. Stadler; Robert J. Jones; Jorge A. Garcia; Ulka N. Vaishampayan; Joel Picus; Robert E. Hawkins; John D. Hainsworth; Christian K. Kollmannsberger; Theodore F. Logan; Igor Puzanov; Lisa M. Pickering; Christopher W. Ryan; Andrew Protheroe; Daniel J. George; Susan Halabi
Author Choice
Sapanisertib Plus Exemestane or Fulvestrant in Women with Hormone Receptor–Positive/HER2-Negative Advanced or Metastatic Breast Cancer
Bora Lim; David A. Potter; Mohamad A. Salkeni; Paula Silverman; Tufia C. Haddad; Frederic Forget; Ahmad Awada; Jean-Luc Canon; Michael Danso; Alain Lortholary; Hugues Bourgeois; Elizabeth Tan-Chiu; Sylvie Vincent; Brittany Bahamon; Kevin J. Galinsky; Chirag Patel; Rachel Neuwirth; E. Jane Leonard; Jennifer R. Diamond
Clinical Trials: Immunotherapy
Phase I Trial of N-803, an IL15 Receptor Agonist, with Rituximab in Patients with Indolent Non-Hodgkin Lymphoma
Jennifer A. Foltz; Brian T. Hess; Veronika Bachanova; Nancy L. Bartlett; Melissa M. Berrien-Elliott; Ethan McClain; Michelle Becker-Hapak; Mark Foster; Timothy Schappe; Brad Kahl; Neha Mehta-Shah; Amanda F. Cashen; Nancy D. Marin; Kristen McDaniels; Chaz Moreno; Matthew Mosior; Feng Gao; Obi L. Griffith; Malachi Griffith; Julia A. Wagner; Narendranath Epperla; Amy D. Rock; John Lee; Allegra A. Petti; Patrick Soon-Shiong; Todd A. Fehniger
Neoadjuvant Chemoradiotherapy Combined with Atezolizumab for Resectable Esophageal Adenocarcinoma: A Single-arm Phase II Feasibility Trial (PERFECT)
Tom van den Ende; Nicolien C. de Clercq; Mark I. van Berge Henegouwen; Suzanne S. Gisbertz; E.D. Geijsen; R.H.A. Verhoeven; Sybren L. Meijer; Sandor Schokker; M.P.G. Dings; Jacques J.G.H.M. Bergman; Nadia Haj Mohammad; Jelle P. Ruurda; Richard van Hillegersberg; Stella Mook; Max Nieuwdorp; Tanja D. de Gruijl; Tanya T.D. Soeratram; Bauke Ylstra; Nicole C.T. van Grieken; Maarten F. Bijlsma; Maarten C.C.M. Hulshof; H.W.M. van Laarhoven
Author Choice
Safety and Clinical Activity of Atezolizumab in Patients with Metastatic Castration-Resistant Prostate Cancer: A Phase I Study
Daniel P. Petrylak; Yohann Loriot; David R. Shaffer; Fadi Braiteh; John Powderly; Lauren C. Harshman; Paul Conkling; Jean-Pierre Delord; Michael Gordon; Joseph W. Kim; Indrani Sarkar; Kobe Yuen; Edward E. Kadel, III; Sanjeev Mariathasan; Carol O'Hear; Sujata Narayanan; Marcella Fassò; Susheela Carroll; Thomas Powles
Precision Medicine and Imaging
A Clinically Applicable 24-Protein Model for Classifying Risk Subgroups in Pancreatic Ductal Adenocarcinomas using Multiple Reaction Monitoring-Mass Spectrometry
Minsoo Son; Hongbeom Kim; Dohyun Han; Yoseop Kim; Iksoo Huh; Youngmin Han; Seung-Mo Hong; Wooil Kwon; Haeryoung Kim; Jin-Young Jang; Youngsoo Kim
Plasma KIM-1 Is Associated with Recurrence Risk after Nephrectomy for Localized Renal Cell Carcinoma: A Trial of the ECOG-ACRIN Research Group (E2805)
Wenxin Xu; Mäneka Puligandla; Brian Halbert; Naomi B. Haas; Keith T. Flaherty; Robert G. Uzzo; Janice P. Dutcher; Robert S. DiPaola; Venkata Sabbisetti; Rupal S. Bhatt
Tumor Tissue- versus Plasma-based Genotyping for Selection of Matched Therapy and Impact on Clinical Outcomes in Patients with Metastatic Breast Cancer
Neelima Vidula; Andrzej Niemierko; Giuliana Malvarosa; Megan Yuen; Jochen Lennerz; A. John Iafrate; Seth A. Wander; Laura Spring; Dejan Juric; Steven Isakoff; Jerry Younger; Beverly Moy; Leif W. Ellisen; Aditya Bardia
Author Choice
Development and Validation of a Novel Nomogram for Individualized Prediction of Survival in Cancer of Unknown Primary
Kanwal Raghav; Hyunsoo Hwang; Alexandre A. Jácome; Eric Bhang; Anneleis Willett; Ryan W. Huey; Nishat P. Dhillon; Jignesh Modha; Brandon Smaglo; Aurelio Matamoros, Jr; Jeannelyn S. Estrella; Justin Jao; Michael J. Overman; Xuemei Wang; F. Anthony Greco; Jonathan M. Loree; Gauri R. Varadhachary
Author Choice
Artificial Intelligence–Assisted Amphiregulin and Epiregulin IHC Predicts Panitumumab Benefit in RAS Wild-Type Metastatic Colorectal Cancer
Christopher J.M. Williams; Jenny F. Seligmann; Faye Elliott; Michael Shires; Susan D. Richman; Sarah Brown; Liping Zhang; Shalini Singh; Judith Pugh; Xiao-Meng Xu; Andrea Muranyi; Christoph Guetter; Auranuch Lorsakul; Uday Kurkure; Zuo Zhao; Jim Martin; Xingwei Wang; Kien Nguyen; Wen-Wei Liu; Dongyao Yan; Nicholas P. West; Jennifer H. Barrett; Michael Barnes; Isaac Bai; Matthew T. Seymour; Philip Quirke; Kandavel Shanmugam
Translational Cancer Mechanisms and Therapy
Impact of Baseline and On-Treatment Glycemia on Everolimus-Exemestane Efficacy in Patients with Hormone Receptor–Positive Advanced Breast Cancer (EVERMET)
Claudio Vernieri; Federico Nichetti; Luca Lalli; Luca Moscetti; Carlo Alberto Giorgi; Gaia Griguolo; Antonio Marra; Giovanni Randon; Carmen G. Rea; Francesca Ligorio; Simone Scagnoli; Claudia De Angelis; Chiara Molinelli; Agnese Fabbri; Emanuela Ferraro; Dario Trapani; Andrea Milani; Elisa Agostinetto; Ottavia Bernocchi; Giovanna Catania; Amelia Vantaggiato; Michela Palleschi; Anna Moretti; Debora Basile; Marika Cinausero; Arta Ajazi; Lorenzo Castagnoli; Salvatore Lo Vullo; Lorenzo Gerratana; Fabio Puglisi; Nicla La Verde; Grazia Arpino; Andrea Rocca; Mariangela Ciccarese; Rebecca Pedersini; Alessandra Fabi; Daniele Generali; Agnese Losurdo; Filippo Montemurro; Giuseppe Curigliano; Lucia Del Mastro; Andrea Michelotti; Enrico Cortesi; Valentina Guarneri; Giancarlo Pruneri; Luigi Mariani; Filippo de Braud
Therapeutic Efficacy of Combined JAK1/2, Pan-PIM, and CDK4/6 Inhibition in Myeloproliferative Neoplasms
Raajit K. Rampal; Maria Pinzon-Ortiz; Amritha Varshini Hanasoge Somasundara; Benjamin Durham; Richard Koche; Barbara Spitzer; Shoron Mowla; Aishwarya Krishnan; Bing Li; Wenbin An; Andriy Derkach; Sean Devlin; Xianhui Rong; Tyler Longmire; Shira Esther Eisman; Keith Cordner; Justin T. Whitfield; Gary Vanasse; Zhu A. Cao; Ross L. Levine
Single-cell Spatial Proteomic Revelations on the Multiparametric MRI Heterogeneity of Clinically Significant Prostate Cancer
Russell K. Pachynski; Eric H. Kim; Natalia Miheecheva; Nikita Kotlov; Akshaya Ramachandran; Ekaterina Postovalova; Ilia Galkin; Viktor Svekolkin; Yang Lyu; Qiong Zou; Dengfeng Cao; Joseph Gaut; Joseph E. Ippolito; Alexander Bagaev; Maria Bruttan; Olga Gancharova; Krystle Nomie; Maria Tsiper; Gerald L. Andriole; Ravshan Ataullakhanov; James J. Hsieh
Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways
Smita Sihag; Samuel C. Nussenzweig; Henry S. Walch; Meier Hsu; Kay See Tan; Francisco Sanchez-Vega; Walid K. Chatila; Sergio A. De La Torre; Assem Patel; Yelena Y. Janjigian; Steven Maron; Geoffrey Y. Ku; Laura H. Tang; Jaclyn Hechtman; Pari M. Shah; Abraham J. Wu; David R. Jones; Daniela Molena; David B. Solit; Nikolaus Schultz; Michael F. Berger
Obituary
Correction
Correction: Angiokines Associated with Outcomes after Sunitinib or Everolimus Treatment in Patients with Non–Clear Cell Renal Cell Carcinoma
Andrew J. Armstrong; Andrew B. Nixon; Andrea Carmack; Qian Yang; Tim Eisen; Walter M. Stadler; Robert J. Jones; Jorge A. Garcia; Ulka N. Vaishampayan; Joel Picus; Robert E. Hawkins; John D. Hainsworth; Christian K. Kollmannsberger; Theodore F. Logan; Igor Puzanov; Lisa M. Pickering; Christopher W. Ryan; Andrew Protheroe; Daniel J. George; Susan Halabi
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