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1 June 2021
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Cover Image
Cover Image
The cover shows a cutaneous papilloma from a female mouse following exposure to the carcinogen DMBA/TPA. For details, see the article by Budden and colleagues on page 3215 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
Reviews
Perspectives
High-Specific-Activity-131I-MIBG versus 177Lu-DOTATATE Targeted Radionuclide Therapy for Metastatic Pheochromocytoma and Paraganglioma
Abhishek Jha; David Taïeb; Jorge A. Carrasquillo; Daniel A. Pryma; Mayank Patel; Corina Millo; Wouter W. de Herder; Jaydira Del Rivero; Joakim Crona; Barry L. Shulkin; Irene Virgolini; Alice P. Chen; Bhagwant R. Mittal; Sandip Basu; Joseph S. Dillon; Thomas A. Hope; Carina Mari Aparici; Andrei H. Iagaru; Rodney J. Hicks; Anca M. Avram; Jonathan R. Strosberg; Ali Cahid Civelek; Frank I. Lin; Neeta Pandit-Taskar; Karel Pacak
Clinical Trials: Targeted Therapy
Differential Outcomes in Codon 12/13 and Codon 61 NRAS-Mutated Cancers in the Phase II NCI-MATCH Trial of Binimetinib in Patients with NRAS-Mutated Tumors
James M. Cleary; Victoria Wang; Rebecca S. Heist; E. Scott Kopetz; Edith P. Mitchell; James A. Zwiebel; Kevin S. Kapner; Helen X. Chen; Shuli Li; Robert J. Gray; Lisa M. McShane; Larry V. Rubinstein; David R. Patton; Funda Meric-Bernstam; Melissa S. Dillmon; P. Mickey Williams; Stanley R. Hamilton; Barbara A. Conley; Andrew J. Aguirre; Peter J. O'Dwyer; Lyndsay N. Harris; Carlos L. Arteaga; Alice P. Chen; Keith T. Flaherty
Author Choice
Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs
Amy K. LeBlanc; Christina N. Mazcko; Aswini Cherukuri; Erika P. Berger; William C. Kisseberth; Megan E. Brown; Susan E. Lana; Kristen Weishaar; Brian K. Flesner; Jeffrey N. Bryan; David M. Vail; Jenna H. Burton; Jennifer L. Willcox; Anthony J. Mutsaers; J. Paul Woods; Nicole C. Northrup; Corey Saba; Kaitlin M. Curran; Haley Leeper; Heather Wilson-Robles; Brandan G. Wustefeld-Janssens; Stephanie Lindley; Annette N. Smith; Nikolaos Dervisis; Shawna Klahn; Mary Lynn Higginbotham; Raelene M. Wouda; Erika Krick; Jennifer A. Mahoney; Cheryl A. London; Lisa G. Barber; Cheryl E. Balkman; Angela L. McCleary-Wheeler; Steven E. Suter; Olya Martin; Antonella Borgatti; Kristine Burgess; Michael O. Childress; Janean L. Fidel; Sara D. Allstadt; Daniel L. Gustafson; Laura E. Selmic; Chand Khanna; Timothy M. Fan
A Randomized Phase II Study of Androgen Deprivation Therapy with or without Palbociclib in RB-positive Metastatic Hormone-Sensitive Prostate Cancer
Phillip L. Palmbos; Stephanie Daignault-Newton; Scott A. Tomlins; Neeraj Agarwal; Przemyslaw Twardowski; Alicia K. Morgans; Wm. Kevin Kelly; Vivek K. Arora; Emmanuel S. Antonarakis; Javed Siddiqui; Jon A. Jacobson; Matthew S. Davenport; Dan R. Robinson; Arul M. Chinnaiyan; Karen E. Knudsen; Maha Hussain
Author Choice
A Phase Ib Open-Label, Dose-Escalation Study of NUC-1031 in Combination with Carboplatin for Recurrent Ovarian Cancer
Farasat Kazmi; Shibani Nicum; Rene L. Roux; Laura Spiers; Chat Gnanaranjan; Ajithkumar Sukumaran; Hani Gabra; Essam Ghazaly; Nigel W. McCracken; David J. Harrison; Sarah P. Blagden
Clinical Trials: Immunotherapy
Pilot Clinical Trial of Perioperative Durvalumab and Tremelimumab in the Treatment of Resectable Colorectal Cancer Liver Metastases
Preeti Kanikarla Marie; Cara Haymaker; Edwin Roger Parra; Young Uk Kim; Rossana Lazcano; Swati Gite; Daniele Lorenzini; Ignacio I. Wistuba; Rebecca S. Slack Tidwell; Xiaofei Song; Wai Chin Foo; Dipen M. Maru; Yun Shin Chun; Andy Futreal; Bryan Kee; David Menter; Luisa Solis; Ching-Wei Tzeng; Christine Parseghian; Kanwal Raghav; Van Morris; Chia-Chi Chang; Robert Jenq; Alda Tam; Chantale Bernatchez; Scott Kopetz; Jean-Nicolas Vauthey; Michael J. Overman
A Phase I Dose-Escalation Study to Evaluate the Safety and Tolerability of Evofosfamide in Combination with Ipilimumab in Advanced Solid Malignancies
Aparna Hegde; Priyamvada Jayaprakash; Coline A. Couillault; Sarina Piha-Paul; Daniel Karp; Jordi Rodon; Shubham Pant; Siqing Fu; Ecaterina E. Dumbrava; Timothy A. Yap; Vivek Subbiah; Priya Bhosale; Cristian Coarfa; Jack P. Higgins; Eric T. Williams; Thomas F. Wilson; JoAnn Lim; Funda Meric-Bernstam; Elizabeth Sumner; Hira Zain; Di Nguyen; Ly M. Nguyen; Kimal Rajapakshe; Michael A. Curran; David S. Hong
Author Choice
Eribulin Plus Pembrolizumab in Patients with Metastatic Triple-Negative Breast Cancer (ENHANCE 1): A Phase Ib/II Study
Sara M. Tolaney; Kevin Kalinsky; Virginia G. Kaklamani; David R. D'Adamo; Gursel Aktan; Michaela L. Tsai; Ruth M. O'Regan; Peter A. Kaufman; Sharon T. Wilks; Eleni Andreopoulou; Debra A. Patt; Yuan Yuan; Grace Wang; Claudio Savulsky; Dongyuan Xing; Ella Kleynerman; Vassiliki Karantza; Sami Diab
Camrelizumab Combined with Chemotherapy Followed by Camrelizumab plus Apatinib as First-line Therapy for Advanced Gastric or Gastroesophageal Junction Adenocarcinoma
Zhi Peng; Jia Wei; Feng Wang; Jieer Ying; Yanhong Deng; Kangsheng Gu; Ying Cheng; Xianglin Yuan; Juxiang Xiao; Yanfei Tai; Linna Wang; Jianjun Zou; Yanqiao Zhang; Lin Shen
Precision Medicine and Imaging
Author Choice
Genomic Analysis of Circulating Tumor DNA in 3,334 Patients with Advanced Prostate Cancer Identifies Targetable BRCA Alterations and AR Resistance Mechanisms
Hanna Tukachinsky; Russell W. Madison; Jon H. Chung; Ole V. Gjoerup; Eric A. Severson; Lucas Dennis; Bernard J. Fendler; Samantha Morley; Lei Zhong; Ryon P. Graf; Jeffrey S. Ross; Brian M. Alexander; Wassim Abida; Simon Chowdhury; Charles J. Ryan; Karim Fizazi; Tony Golsorkhi; Simon P. Watkins; Andrew Simmons; Andrea Loehr; Jeffrey M. Venstrom; Geoffrey R. Oxnard
Independent Validation of the PAM50-Based Chemo-Endocrine Score (CES) in Hormone Receptor–Positive HER2-Positive Breast Cancer Treated with Neoadjuvant Anti–HER2-Based Therapy
Tomás Pascual; Aranzazu Fernandez-Martinez; Maki Tanioka; M. Vittoria Dieci; Sonia Pernas; Joaquin Gavila; Valentina Guarneri; Javier Cortes; Patricia Villagrasa; Núria Chic; Maria Vidal; Barbara Adamo; Montserrat Muñoz; Gaia Griguolo; Antonio Llombart; Pierfranco Conte; Mafalda Oliveira; Benedetta Conte; Laia Paré; Patricia Galvan; Lisa A. Carey; Charles M. Perou; Aleix Prat
Translational Cancer Mechanisms and Therapy
Optimized EGFR Blockade Strategies in EGFR Addicted Gastroesophageal Adenocarcinomas
Simona Corso; Filippo Pietrantonio; Maria Apicella; Cristina Migliore; Daniela Conticelli; Annalisa Petrelli; Laura D'Errico; Stefania Durando; Daniel Moya-Rull; Sara E. Bellomo; Stefano Ughetto; Maurizio Degiuli; Rossella Reddavid; Uberto Fumagalli; Stefano De Pascale; Giovanni Sgroi; Emanuele Rausa; Gian Luca Baiocchi; Sarah Molfino; Giovanni De Manzoni; Maria Bencivenga; Salvatore Siena; Andrea Sartore-Bianchi; Federica Morano; Salvatore Corallo; Michele Prisciandaro; Maria Di Bartolomeo; Annunziata Gloghini; Silvia Marsoni; Antonino Sottile; Anna Sapino; Caterina Marchiò; Asa Dahle-Smith; Zosia Miedzybrodzka; Jessica Lee; Siraj M. Ali; Jeffrey S. Ross; Brian M. Alexander; Vincent A. Miller; Russell Petty; Alexa B. Schrock; Silvia Giordano
Author Choice
The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic NRG1 Fusions
Igor Odintsov; Allan J.W. Lui; Whitney J. Sisso; Eric Gladstone; Zebing Liu; Lukas Delasos; Renate I. Kurth; Exequiel M. Sisso; Morana Vojnic; Inna Khodos; Marissa S. Mattar; Elisa de Stanchina; Shawn M. Leland; Marc Ladanyi; Romel Somwar
Author Choice
An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity
Marta Compte; Seandean L. Harwood; Ainhoa Erce-Llamazares; Antonio Tapia-Galisteo; Eduardo Romero; Irene Ferrer; Eva M. Garrido-Martin; Ana B. Enguita; Maria C. Ochoa; Belén Blanco; Marta Oteo; Nekane Merino; Daniel Nehme-Álvarez; Oana Hangiu; Carmen Domínguez-Alonso; Manuela Zonca; Angel Ramírez-Fernández; Francisco J. Blanco; Miguel A. Morcillo; Ines G. Muñoz; Ignacio Melero; José L. Rodriguez-Peralto; Luis Paz-Ares; Laura Sanz; Luis Alvarez-Vallina
Chromatin Accessibility Identifies Regulatory Elements Predictive of Gene Expression and Disease Outcome in Multiple Myeloma
Benjamin G. Barwick; Vikas A. Gupta; Shannon M. Matulis; Jonathan C. Patton; Doris R. Powell; Yanyan Gu; David L. Jaye; Karen N. Conneely; Yin C. Lin; Craig C. Hofmeister; Ajay K. Nooka; Jonathan J. Keats; Sagar Lonial; Paula M. Vertino; Lawrence H. Boise
Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma
Justine S. Paradis; Monica Acosta; Robert Saddawi-Konefka; Ayush Kishore; Simone Lubrano; Frederico Gomes; Nadia Arang; Manoela Tiago; Silvia Coma; Xingyu Wu; Kyle Ford; Chi-Ping Day; Glenn Merlino; Prashant Mali; Jonathan A. Pachter; Takami Sato; Andrew E. Aplin; J. Silvio Gutkind
Author Choice
Structural Variants at the BRCA1/2 Loci are a Common Source of Homologous Repair Deficiency in High-grade Serous Ovarian Carcinoma
Ailith Ewing; Alison Meynert; Michael Churchman; Graeme R. Grimes; Robert L. Hollis; C. Simon Herrington; Tzyvia Rye; Clare Bartos; Ian Croy; Michelle Ferguson; Mairi Lennie; Trevor McGoldrick; Neil McPhail; Nadeem Siddiqui; Suzanne Dowson; Rosalind Glasspool; Melanie Mackean; Fiona Nussey; Brian McDade; Darren Ennis; Lynn McMahon; Athena Matakidou; Brian Dougherty; Ruth March; J. Carl Barrett; Iain A. McNeish; for the Scottish Genomes Partnership; Andrew V. Biankin; Patricia Roxburgh; Charlie Gourley; Colin A. Semple
Female Immunity Protects from Cutaneous Squamous Cell Carcinoma
Timothy Budden; Caroline Gaudy-Marqueste; Sarah Craig; Yuan Hu; Charles H. Earnshaw; Shilpa Gurung; Amelle Ra; Victoria Akhras; Patrick Shenjere; Ruth Green; Lynne Jamieson; John Lear; Luisa Motta; Carlos Caulín; Deemesh Oudit; Simon J. Furney; Amaya Virós
The Landscape of Alterations in DNA Damage Response Pathways in Colorectal Cancer
Hiroyuki Arai; Andrew Elliott; Joanne Xiu; Jingyuan Wang; Francesca Battaglin; Natsuko Kawanishi; Shivani Soni; Wu Zhang; Joshua Millstein; Davendra Sohal; Richard M. Goldberg; Michael J. Hall; Aaron J. Scott; Moh'd Khushman; Jimmy J. Hwang; Emil Lou; Benjamin A. Weinberg; John L. Marshall; Albert C. Lockhart; Phillip Stafford; Jian Zhang; Roberto Moretto; Chiara Cremolini; W. Michael Korn; Heinz-Josef Lenz
Genomic, Transcriptomic, and Proteomic Profiling of Metastatic Breast Cancer
Argun Akcakanat; Xiaofeng Zheng; Christian X. Cruz Pico; Tae-Beom Kim; Ken Chen; Anil Korkut; Aysegul Sahin; Vijaykumar Holla; Emily Tarco; Gopal Singh; Senthil Damodaran; Gordon B. Mills; Ana Maria Gonzalez-Angulo; Funda Meric-Bernstam
Radium-223 Treatment Increases Immune Checkpoint Expression in Extracellular Vesicles from the Metastatic Prostate Cancer Bone Microenvironment
Ioulia Vardaki; Paul Corn; Emanuela Gentile; Jian H. Song; Namrata Madan; Anh Hoang; Nila Parikh; Leah Guerra; Yu-Chen Lee; Song-Chang Lin; Guoyu Yu; Elmer Santos; Marites P. Melancon; Patricia Troncoso; Nora Navone; Gary E. Gallick; Eleni Efstathiou; Sumit K. Subudhi; Sue-Hwa Lin; Christopher J. Logothetis; Theocharis Panaretakis
Correction
Correction: Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer
Sophie J. Cowman; Daniel G. Fuja; Xian-De Liu; Rebecca S. Slack Tidwell; Neelima Kandula; Deepika Sirohi; Archana M. Agarwal; Lyska L. Emerson; Sheryl R. Tripp; Jeffrey S. Mohlman; Miekan Stonhill; Guillermina Garcia; Christopher J. Conley; Adam A. Olalde; Timothy Sargis; Adela Ramirez-Torres; Jose A. Karam; Christopher G. Wood; Kanishka Sircar; Pheroze Tamboli; Kenneth Boucher; Benjamin Maughan; Benjamin T. Spike; Thai H. Ho; Neeraj Agarwal; Eric Jonasch; Mei Yee Koh
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