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15 May 2021
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Cover Image
Cover Image
The cover shows a section of a surgical specimen from a patient with pancreatic ductal adenocarcinoma. Hematoxylin and eosin staining reveals circumferential perineural invasion with malignant glands encircling a nerve bundle. For details, see the article by Guo and colleagues on page 2807 of this issue. - PDF Icon PDF LinkTable of Contents
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ISSN 1078-0432
EISSN 1557-3265
Highlights
CCR Translations
CCR Perspectives in Regulatory Science and Policy
The State of Melanoma: Emergent Challenges and Opportunities
Michael B. Atkins; Clara Curiel-Lewandrowski; David E. Fisher; Susan M. Swetter; Hensin Tsao; Julio A. Aguirre-Ghiso; Maria S. Soengas; Ashani T. Weeraratna; Keith T. Flaherty; Meenhard Herlyn; Jeffrey A. Sosman; Hussein A. Tawbi; Anna C. Pavlick; Pamela B. Cassidy; Sunandana Chandra; Paul B. Chapman; Adil Daud; Zeynep Eroglu; Laura K. Ferris; Bernard A. Fox; Jeffrey E. Gershenwald; Geoffrey T. Gibney; Douglas Grossman; Brent A. Hanks; Douglas Hanniford; Eva Hernando; Joanne M. Jeter; Douglas B. Johnson; Samir N. Khleif; John M. Kirkwood; Sancy A. Leachman; Darren Mays; Kelly C. Nelson; Vernon K. Sondak; Ryan J. Sullivan; Glenn Merlino; on behalf of the Melanoma Research Foundation
Review
Interventional Radiology for Local Immunotherapy in Oncology
Lambros Tselikas; Stephane Champiat; Rahul A. Sheth; Steve Yevich; Samy Ammari; Frederic Deschamps; Siham Farhane; Charles Roux; Sandrine Susini; Severine Mouraud; Alexandre Delpla; Thibault Raoult; Caroline Robert; Christophe Massard; Fabrice Barlesi; Jean-Charles Soria; Aurélien Marabelle; Thierry de Baere
Perspectives
Clinical Trials: Targeted Therapy
Author Choice
Pacritinib Combined with Sirolimus and Low-Dose Tacrolimus for GVHD Prevention after Allogeneic Hematopoietic Cell Transplantation: Preclinical and Phase I Trial Results
Joseph Pidala; Kelly Walton; Hany Elmariah; Jongphil Kim; Asmita Mishra; Nelli Bejanyan; Taiga Nishihori; Farhad Khimani; Lia Perez; Rawan G. Faramand; Marco L. Davila; Michael L. Nieder; Elizabeth M. Sagatys; Shernan G. Holtan; Nicholas J. Lawrence; Harshani R. Lawrence; Bruce R. Blazar; Claudio Anasetti; Said M. Sebti; Brian C. Betts
Author Choice
Phase I Assessment of Safety and Therapeutic Activity of BAY1436032 in Patients with IDH1-Mutant Solid Tumors
Antje Wick; Oliver Bähr; Martin Schuler; Kristoffer Rohrberg; Sant P. Chawla; Filip Janku; David Schiff; Volker Heinemann; Yoshitaka Narita; Heinz-Josef Lenz; Masafumi Ikeda; Yuichi Ando; Wolfgang Wick; Joachim P. Steinbach; Michael C. Burger; Katharina Wenger; Ulrik Lassen; Kamalesh K. Sankhala; Cristiana Roggia; Isabelle Genvresse; Catya Munhoz; Christine Rentzsch; Susanne Reschke; Simon Langer; Markus Wagner; Stefan Kaulfuss; Charles Cai; Eleni Lagkadinou; Michael Jeffers; Carol Peña; Ghazaleh Tabatabai
A Surgical Window Trial Evaluating Medroxyprogesterone Acetate with or without Entinostat in Patients with Endometrial Cancer and Validation of Biomarkers of Cellular Response
Linda R. Duska; Virginia L. Filiaci; Joan L. Walker; Laura L. Holman; Emily K. Hill; Richard G. Moore; Kari L. Ring; Michael L. Pearl; Carolyn Y. Muller; Christina L. Kushnir; Heather A. Lankes; Megan I. Samuelson; Kelley S. Carrick; Anand Rajan; William H. Rodgers; Elise C. Kohn; Richard Piekarz; Kimberly K. Leslie
Author Choice
Inotuzumab Ozogamicin for Relapsed/Refractory Acute Lymphoblastic Leukemia in the INO-VATE Trial: CD22 Pharmacodynamics, Efficacy, and Safety by Baseline CD22
Hagop M. Kantarjian; Wendy Stock; Ryan D. Cassaday; Daniel J. DeAngelo; Elias Jabbour; Susan M. O'Brien; Matthias Stelljes; Tao Wang; M. Luisa Paccagnella; Kevin Nguyen; Barbara Sleight; Erik Vandendries; Alexander Neuhof; A. Douglas Laird; Anjali S. Advani
Clinical Trials: Immunotherapy
Author Choice
Safety, Antitumor Activity, and T-cell Responses in a Dose-Ranging Phase I Trial of the Oncolytic Peptide LTX-315 in Patients with Solid Tumors
James Spicer; Aurélien Marabelle; Jean-Francois Baurain; Nina Louise Jebsen; Dag Erik Jøssang; Ahmad Awada; Rebecca Kristeleit; Delphine Loirat; George Lazaridis; Christiane Jungels; Paal Brunsvig; Berit Nicolaisen; Andrew Saunders; Hamina Patel; Jérôme Galon; Fabienne Hermitte; Ketil André Camilio; Brynjar Mauseth; Vibeke Sundvold; Baldur Sveinbjørnsson; Øystein Rekdal
CRISPR/Cas9-Engineered Universal CD19/CD22 Dual-Targeted CAR-T Cell Therapy for Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia
Yongxian Hu; Yali Zhou; Mingming Zhang; Wengang Ge; Yi Li; Li Yang; Guoqing Wei; Lu Han; Hao Wang; Shuhui Yu; Yi Chen; Yanbin Wang; Xiaohong He; Xingwang Zhang; Ming Gao; Jingjing Yang; Xiuju Li; Jiangtao Ren; He Huang
Safety and Immunogenicity of LY3415244, a Bispecific Antibody Against TIM-3 and PD-L1, in Patients With Advanced Solid Tumors
Matthew D. Hellmann; Nicoletta Bivi; Boris Calderon; Toshio Shimizu; Brant Delafontaine; Zhuqing Tina Liu; Anna M. Szpurka; Victoria Copeland; F. Stephen Hodi; Sylvie Rottey; Philippe Aftimos; Yongzhe Piao; Leena Gandhi; Violeta Regnier Galvao; Ching Ching Leow; Toshihiko Doi
Efficacy of Decitabine plus Anti-PD-1 Camrelizumab in Patients with Hodgkin Lymphoma Who Progressed or Relapsed after PD-1 Blockade Monotherapy
Chunmeng Wang; Yang Liu; Liang Dong; Xiang Li; Qingming Yang; Malcolm V. Brock; Qian Mei; Jiejie Liu; Meixia Chen; Fengxia Shi; Miao Liu; Jing Nie; Weidong Han
Precision Medicine and Imaging
Detection of Aneuploidy in Cerebrospinal Fluid from Patients with Breast Cancer Can Improve Diagnosis of Leptomeningeal Metastases
Lindsay Angus; Teoman Deger; Agnes Jager; John W.M. Martens; Vanja de Weerd; Irene van Heuvel; Martin J. van den Bent; Peter A.E. Sillevis Smitt; Johan M. Kros; Eric M.J. Bindels; Ellen Heitzer; Stefan Sleijfer; Joost L.M. Jongen; Saskia M. Wilting
Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection
Jimmy A. Guo; Hannah I. Hoffman; Stuti G. Shroff; Peter Chen; Peter G. Hwang; Daniel Y. Kim; Daniel W. Kim; Stephanie W. Cheng; Daniel Zhao; Brandon A. Mahal; Mohammed Alshalalfa; Andrzej Niemierko; Jennifer Y. Wo; Jay S. Loeffler; Carlos Fernandez-del Castillo; Tyler Jacks; Andrew J. Aguirre; Theodore S. Hong; Mari Mino-Kenudson; William L. Hwang
Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment
Jennifer Borowsky; Koichiro Haruki; Mai Chan Lau; Andressa Dias Costa; Juha P. Väyrynen; Tomotaka Ugai; Kota Arima; Annacarolina da Silva; Kristen D. Felt; Melissa Zhao; Carino Gurjao; Tyler S. Twombly; Kenji Fujiyoshi; Sara A. Väyrynen; Tsuyoshi Hamada; Kosuke Mima; Susan Bullman; Tabitha A. Harrison; Amanda I. Phipps; Ulrike Peters; Kimmie Ng; Jeffrey A. Meyerhardt; Mingyang Song; Edward L. Giovannucci; Kana Wu; Xuehong Zhang; Gordon J. Freeman; Curtis Huttenhower; Wendy S. Garrett; Andrew T. Chan; Barbara A. Leggett; Vicki L.J. Whitehall; Neal Walker; Ian Brown; Mark Bettington; Reiko Nishihara; Charles S. Fuchs; Jochen K. Lennerz; Marios Giannakis; Jonathan A. Nowak; Shuji Ogino
Dynamic Changes of Post-Radiotherapy Plasma Epstein–Barr Virus DNA in a Randomized Trial of Adjuvant Chemotherapy Versus Observation in Nasopharyngeal Cancer
Edwin Pun Hui; Brigette B.Y. Ma; W.K. Jacky Lam; K.C. Allen Chan; Frankie Mo; Qi-yong Hemis Ai; Ann D. King; Chi Hang Wong; Kenneth C.W. Wong; Daisy C.M. Lam; Macy Tong; Darren M.C. Poon; Leung Li; Thomas K.H. Lau; Kwan Hung Wong; Y.M. Dennis Lo; Anthony T.C. Chan
Author Choice
Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias
Eleonora Mäkelä; Karolina Pavic; Taru Varila; Urpu Salmenniemi; Eliisa Löyttyniemi; Srikar G. Nagelli; Tea Ammunét; Veli-Matti Kähäri; Richard E. Clark; Laura L. Elo; Venkata Kumari Bachanaboyina; Claire M. Lucas; Maija Itälä-Remes; Jukka Westermarck
Translational Cancer Mechanisms and Therapy
Relevance of Molecular Groups in Children with Newly Diagnosed Atypical Teratoid Rhabdoid Tumor: Results from Prospective St. Jude Multi-institutional Trials
Santhosh A. Upadhyaya; Giles W. Robinson; Arzu Onar-Thomas; Brent A. Orr; Pascal Johann; Gang Wu; Catherine A. Billups; Ruth G. Tatevossian; Sandeep Kumar Dhanda; Ashok Srinivasan; Alberto Broniscer; Ibrahim Qaddoumi; Anna Vinitsky; Gregory T. Armstrong; Anne E. Bendel; Tim Hassall; Sonia Partap; Paul G. Fisher; John R. Crawford; Murali Chintagumpala; Eric Bouffet; Sridharan Gururangan; Roya Mostafavi; Robert P. Sanders; Paul Klimo, Jr; Zoltan Patay; Daniel J. Indelicato; Kim E. Nichols; Frederick A. Boop; Thomas E. Merchant; Marcel Kool; David W. Ellison; Amar Gajjar
Clinical Impact of Presurgery Circulating Tumor DNA after Total Neoadjuvant Treatment in Locally Advanced Rectal Cancer: A Biomarker Study from the GEMCAD 1402 Trial
Joana Vidal; David Casadevall; Beatriz Bellosillo; Carles Pericay; Rocio Garcia-Carbonero; Ferran Losa; Laia Layos; Vicente Alonso; Jaume Capdevila; Javier Gallego; Ruth Vera; Antonieta Salud; Marta Martin-Richard; Miguel Nogué; Elena Cillán; Joan Maurel; Iris Faull; Victoria Raymond; Carlos Fernández-Martos; Clara Montagut
Spectrum of Mechanisms of Resistance to Crizotinib and Lorlatinib in ROS1 Fusion–Positive Lung Cancer
Jessica J. Lin; Noura J. Choudhury; Satoshi Yoda; Viola W. Zhu; Ted W. Johnson; Ramin Sakhtemani; Ibiayi Dagogo-Jack; Subba R. Digumarthy; Charlotte Lee; Andrew Do; Jennifer Peterson; Kylie Prutisto-Chang; Wafa Malik; Harper G. Hubbeling; Adam Langenbucher; Adam J. Schoenfeld; Christina J. Falcon; Jennifer S. Temel; Lecia V. Sequist; Beow Y. Yeap; Jochen K. Lennerz; Alice T. Shaw; Michael S. Lawrence; Sai-Hong Ignatius Ou; Aaron N. Hata; Alexander Drilon; Justin F. Gainor
Comprehensive Molecular Characterization and Response to Therapy in Fumarate Hydratase–Deficient Renal Cell Carcinoma
Jack P. Gleeson; Ines Nikolovski; Renzo Dinatale; Mark Zucker; Andrea Knezevic; Sujata Patil; Yasser Ged; Ritesh R. Kotecha; Natalie Shapnik; Samuel Murray; Paul Russo; Jonathan Coleman; Chung Han Lee; Zsofia K. Stadler; A. Ari Hakimi; Darren R. Feldman; Robert J. Motzer; Ed Reznik; Martin H. Voss; Ying-Bei Chen; Maria I. Carlo
Author Choice
Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with EGFR Exon 20 Insertions
Noura J. Choudhury; Adam J. Schoenfeld; Jessica Flynn; Christina J. Falcon; Hira Rizvi; Charles M. Rudin; Mark G. Kris; Maria E. Arcila; Glenn Heller; Helena A. Yu; Marc Ladanyi; Gregory J. Riely
The PSMA-targeting Half-life Extended BiTE Therapy AMG 160 has Potent Antitumor Activity in Preclinical Models of Metastatic Castration-resistant Prostate Cancer
Petra Deegen; Oliver Thomas; Olivier Nolan-Stevaux; Shyun Li; Joachim Wahl; Pamela Bogner; Famke Aeffner; Matthias Friedrich; Michael Z. Liao; Katja Matthes; Doris Rau; Benno Rattel; Tobias Raum; Peter Kufer; Angela Coxon; Julie M. Bailis
The B7-H3–Targeting Antibody–Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models
Nathan M. Kendsersky; Jarrett Lindsay; E. Anders Kolb; Malcolm A. Smith; Beverly A. Teicher; Stephen W. Erickson; Eric J. Earley; Yael P. Mosse; Daniel Martinez; Jennifer Pogoriler; Kateryna Krytska; Khushbu Patel; David Groff; Matthew Tsang; Samson Ghilu; Yifei Wang; Steven Seaman; Yang Feng; Brad St. Croix; Richard Gorlick; Raushan Kurmasheva; Peter J. Houghton; John M. Maris
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